LeishMANIAdb
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ATP-binding cassette protein subfamily E, member 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-binding cassette protein subfamily E, member 1
Gene product:
ATP-binding cassette protein subfamily E - member 1 - putative
Species:
Leishmania infantum
UniProt:
A4HZ70_LEIIN
TriTrypDb:
LINF_210012700
Length:
659

Annotations

Annotations by Jardim et al.

Transporters, ATP-binding cassette E, member 1 ABCE1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZ70
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ70

Function

Biological processes
Term Name Level Count
GO:0000054 ribosomal subunit export from nucleus 3 1
GO:0006413 translational initiation 3 1
GO:0006415 translational termination 6 1
GO:0006810 transport 3 1
GO:0006913 nucleocytoplasmic transport 5 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0033750 ribosome localization 3 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0046907 intracellular transport 3 1
GO:0051168 nuclear export 6 1
GO:0051169 nuclear transport 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051640 organelle localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051656 establishment of organelle localization 3 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0005215 transporter activity 1 1
GO:0005506 iron ion binding 6 1
GO:0015399 primary active transmembrane transporter activity 4 1
GO:0022804 active transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0042626 ATPase-coupled transmembrane transporter activity 2 1
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043024 ribosomal small subunit binding 4 1
GO:0043169 cation binding 3 1
GO:0044877 protein-containing complex binding 2 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0140657 ATP-dependent activity 1 1
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 376 380 PF00656 0.278
CLV_C14_Caspase3-7 622 626 PF00656 0.692
CLV_NRD_NRD_1 26 28 PF00675 0.413
CLV_NRD_NRD_1 352 354 PF00675 0.620
CLV_NRD_NRD_1 575 577 PF00675 0.394
CLV_NRD_NRD_1 653 655 PF00675 0.710
CLV_PCSK_KEX2_1 351 353 PF00082 0.560
CLV_PCSK_KEX2_1 513 515 PF00082 0.341
CLV_PCSK_KEX2_1 520 522 PF00082 0.351
CLV_PCSK_KEX2_1 575 577 PF00082 0.394
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.544
CLV_PCSK_PC1ET2_1 513 515 PF00082 0.341
CLV_PCSK_PC1ET2_1 520 522 PF00082 0.351
CLV_PCSK_SKI1_1 173 177 PF00082 0.282
CLV_PCSK_SKI1_1 202 206 PF00082 0.300
CLV_PCSK_SKI1_1 268 272 PF00082 0.344
CLV_PCSK_SKI1_1 433 437 PF00082 0.282
CLV_PCSK_SKI1_1 455 459 PF00082 0.282
CLV_PCSK_SKI1_1 510 514 PF00082 0.329
CLV_PCSK_SKI1_1 521 525 PF00082 0.310
CLV_PCSK_SKI1_1 565 569 PF00082 0.388
DOC_ANK_TNKS_1 642 649 PF00023 0.598
DOC_CKS1_1 484 489 PF01111 0.321
DOC_CYCLIN_yClb5_NLxxxL_5 78 87 PF00134 0.384
DOC_CYCLIN_yCln2_LP_2 484 490 PF00134 0.282
DOC_MAPK_gen_1 202 211 PF00069 0.325
DOC_MAPK_gen_1 331 339 PF00069 0.383
DOC_MAPK_gen_1 565 574 PF00069 0.360
DOC_MAPK_MEF2A_6 314 321 PF00069 0.319
DOC_MAPK_MEF2A_6 477 484 PF00069 0.282
DOC_MAPK_MEF2A_6 565 574 PF00069 0.360
DOC_PP2B_LxvP_1 105 108 PF13499 0.337
DOC_SPAK_OSR1_1 232 236 PF12202 0.282
DOC_USP7_MATH_1 359 363 PF00917 0.421
DOC_USP7_UBL2_3 132 136 PF12436 0.255
DOC_USP7_UBL2_3 423 427 PF12436 0.282
DOC_USP7_UBL2_3 615 619 PF12436 0.714
DOC_USP7_UBL2_3 633 637 PF12436 0.556
DOC_WW_Pin1_4 483 488 PF00397 0.311
DOC_WW_Pin1_4 543 548 PF00397 0.413
DOC_WW_Pin1_4 552 557 PF00397 0.230
LIG_14-3-3_CanoR_1 258 267 PF00244 0.380
LIG_14-3-3_CanoR_1 268 278 PF00244 0.413
LIG_14-3-3_CanoR_1 565 571 PF00244 0.495
LIG_AP2alpha_1 320 324 PF02296 0.328
LIG_APCC_ABBA_1 245 250 PF00400 0.282
LIG_APCC_ABBA_1 317 322 PF00400 0.318
LIG_deltaCOP1_diTrp_1 145 155 PF00928 0.302
LIG_FHA_1 272 278 PF00498 0.471
LIG_FHA_1 325 331 PF00498 0.376
LIG_FHA_1 336 342 PF00498 0.417
LIG_FHA_1 392 398 PF00498 0.282
LIG_FHA_1 449 455 PF00498 0.282
LIG_FHA_1 520 526 PF00498 0.350
LIG_FHA_1 544 550 PF00498 0.402
LIG_FHA_2 195 201 PF00498 0.394
LIG_FHA_2 374 380 PF00498 0.337
LIG_FHA_2 429 435 PF00498 0.282
LIG_FHA_2 456 462 PF00498 0.282
LIG_FHA_2 604 610 PF00498 0.548
LIG_IRF3_LxIS_1 412 418 PF10401 0.282
LIG_LIR_Apic_2 442 447 PF02991 0.282
LIG_LIR_Gen_1 145 155 PF02991 0.299
LIG_LIR_Gen_1 206 214 PF02991 0.300
LIG_LIR_Gen_1 252 261 PF02991 0.339
LIG_LIR_Gen_1 273 284 PF02991 0.318
LIG_LIR_Gen_1 291 301 PF02991 0.314
LIG_LIR_Gen_1 394 404 PF02991 0.300
LIG_LIR_Nem_3 145 151 PF02991 0.299
LIG_LIR_Nem_3 206 211 PF02991 0.300
LIG_LIR_Nem_3 252 257 PF02991 0.338
LIG_LIR_Nem_3 273 279 PF02991 0.330
LIG_LIR_Nem_3 291 296 PF02991 0.301
LIG_LIR_Nem_3 438 444 PF02991 0.321
LIG_LYPXL_yS_3 358 361 PF13949 0.352
LIG_PCNA_yPIPBox_3 183 195 PF02747 0.413
LIG_PCNA_yPIPBox_3 423 436 PF02747 0.282
LIG_Pex14_2 320 324 PF04695 0.328
LIG_SH2_CRK 298 302 PF00017 0.346
LIG_SH2_CRK 304 308 PF00017 0.305
LIG_SH2_CRK 75 79 PF00017 0.300
LIG_SH2_GRB2like 142 145 PF00017 0.309
LIG_SH2_NCK_1 248 252 PF00017 0.358
LIG_SH2_PTP2 276 279 PF00017 0.303
LIG_SH2_SRC 248 251 PF00017 0.325
LIG_SH2_SRC 254 257 PF00017 0.300
LIG_SH2_SRC 276 279 PF00017 0.381
LIG_SH2_SRC 499 502 PF00017 0.336
LIG_SH2_STAT3 419 422 PF00017 0.282
LIG_SH2_STAT5 154 157 PF00017 0.305
LIG_SH2_STAT5 163 166 PF00017 0.344
LIG_SH2_STAT5 180 183 PF00017 0.282
LIG_SH2_STAT5 207 210 PF00017 0.333
LIG_SH2_STAT5 254 257 PF00017 0.338
LIG_SH2_STAT5 276 279 PF00017 0.303
LIG_SH2_STAT5 444 447 PF00017 0.413
LIG_SH2_STAT5 491 494 PF00017 0.282
LIG_SH2_STAT5 499 502 PF00017 0.336
LIG_SH2_STAT5 535 538 PF00017 0.340
LIG_SH2_STAT5 602 605 PF00017 0.440
LIG_SH3_3 304 310 PF00018 0.337
LIG_SH3_3 407 413 PF00018 0.425
LIG_SH3_3 450 456 PF00018 0.282
LIG_SH3_4 615 622 PF00018 0.658
LIG_SUMO_SIM_anti_2 125 132 PF11976 0.318
LIG_SUMO_SIM_anti_2 14 22 PF11976 0.282
LIG_SUMO_SIM_anti_2 283 288 PF11976 0.377
LIG_SUMO_SIM_anti_2 378 388 PF11976 0.282
LIG_SUMO_SIM_par_1 276 281 PF11976 0.301
LIG_SUMO_SIM_par_1 378 388 PF11976 0.335
LIG_SUMO_SIM_par_1 455 461 PF11976 0.300
LIG_TRAF2_1 458 461 PF00917 0.282
LIG_TYR_ITSM 272 279 PF00017 0.466
LIG_UBA3_1 559 568 PF00899 0.356
LIG_WRC_WIRS_1 365 370 PF05994 0.414
MOD_CK1_1 11 17 PF00069 0.282
MOD_CK1_1 269 275 PF00069 0.485
MOD_CK1_1 50 56 PF00069 0.428
MOD_CK1_1 519 525 PF00069 0.483
MOD_CK2_1 223 229 PF00069 0.282
MOD_CK2_1 375 381 PF00069 0.282
MOD_CK2_1 455 461 PF00069 0.282
MOD_CK2_1 603 609 PF00069 0.668
MOD_CK2_1 82 88 PF00069 0.425
MOD_Cter_Amidation 612 615 PF01082 0.685
MOD_Cter_Amidation 652 655 PF01082 0.759
MOD_GlcNHglycan 225 228 PF01048 0.286
MOD_GlcNHglycan 470 473 PF01048 0.282
MOD_GlcNHglycan 494 499 PF01048 0.282
MOD_GlcNHglycan 598 601 PF01048 0.574
MOD_GSK3_1 119 126 PF00069 0.282
MOD_GSK3_1 364 371 PF00069 0.462
MOD_GSK3_1 373 380 PF00069 0.266
MOD_GSK3_1 47 54 PF00069 0.496
MOD_GSK3_1 566 573 PF00069 0.374
MOD_N-GLC_1 119 124 PF02516 0.282
MOD_N-GLC_1 468 473 PF02516 0.325
MOD_N-GLC_1 549 554 PF02516 0.493
MOD_N-GLC_1 570 575 PF02516 0.439
MOD_N-GLC_2 389 391 PF02516 0.282
MOD_NEK2_1 271 276 PF00069 0.503
MOD_NEK2_1 415 420 PF00069 0.297
MOD_NEK2_1 428 433 PF00069 0.366
MOD_NEK2_1 435 440 PF00069 0.231
MOD_NEK2_1 566 571 PF00069 0.378
MOD_PIKK_1 638 644 PF00454 0.619
MOD_PK_1 587 593 PF00069 0.422
MOD_PKA_2 11 17 PF00069 0.358
MOD_PKA_2 155 161 PF00069 0.282
MOD_PKA_2 231 237 PF00069 0.300
MOD_PKA_2 259 265 PF00069 0.384
MOD_PKA_2 88 94 PF00069 0.450
MOD_Plk_1 200 206 PF00069 0.358
MOD_Plk_1 218 224 PF00069 0.413
MOD_Plk_1 282 288 PF00069 0.300
MOD_Plk_1 570 576 PF00069 0.363
MOD_Plk_1 8 14 PF00069 0.584
MOD_Plk_2-3 200 206 PF00069 0.358
MOD_Plk_2-3 250 256 PF00069 0.334
MOD_Plk_2-3 373 379 PF00069 0.278
MOD_Plk_4 126 132 PF00069 0.318
MOD_Plk_4 250 256 PF00069 0.373
MOD_Plk_4 282 288 PF00069 0.379
MOD_Plk_4 392 398 PF00069 0.282
MOD_Plk_4 531 537 PF00069 0.314
MOD_ProDKin_1 483 489 PF00069 0.311
MOD_ProDKin_1 543 549 PF00069 0.416
MOD_ProDKin_1 552 558 PF00069 0.235
MOD_SUMO_rev_2 210 217 PF00179 0.413
MOD_SUMO_rev_2 589 599 PF00179 0.428
MOD_SUMO_rev_2 625 635 PF00179 0.778
TRG_DiLeu_BaEn_1 381 386 PF01217 0.282
TRG_DiLeu_BaEn_4 8 14 PF01217 0.508
TRG_ENDOCYTIC_2 254 257 PF00928 0.338
TRG_ENDOCYTIC_2 276 279 PF00928 0.303
TRG_ENDOCYTIC_2 304 307 PF00928 0.305
TRG_ENDOCYTIC_2 358 361 PF00928 0.352
TRG_ENDOCYTIC_2 602 605 PF00928 0.404
TRG_ENDOCYTIC_2 75 78 PF00928 0.300
TRG_ER_diArg_1 257 260 PF00400 0.342
TRG_ER_diArg_1 574 576 PF00400 0.371
TRG_ER_diArg_1 581 584 PF00400 0.373
TRG_Pf-PMV_PEXEL_1 433 437 PF00026 0.413

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7M4 Leptomonas seymouri 90% 99%
A0A1X0NXL9 Trypanosomatidae 82% 100%
A0A3S7WWG1 Leishmania donovani 100% 100%
A0A422NHA0 Trypanosoma rangeli 82% 100%
A4HBR7 Leishmania braziliensis 93% 100%
D0A1G9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 81% 100%
E9AV37 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
G0SEV9 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 63% 100%
O60102 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 61% 100%
P33916 Escherichia coli (strain K12) 25% 100%
P36947 Bacillus subtilis (strain 168) 24% 100%
P61221 Homo sapiens 63% 100%
P61222 Mus musculus 63% 100%
P9WQK2 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 23% 100%
P9WQK3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 23% 100%
Q03195 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 64% 100%
Q322L1 Shigella boydii serotype 4 (strain Sb227) 24% 100%
Q3K3R2 Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) 22% 100%
Q3Z2S7 Shigella sonnei (strain Ss046) 24% 100%
Q4QCE4 Leishmania major 98% 100%
Q58129 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 47% 100%
Q6HI76 Bacillus thuringiensis subsp. konkukian (strain 97-27) 25% 100%
Q73R11 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 24% 100%
Q81PZ8 Bacillus anthracis 25% 100%
Q83KP2 Shigella flexneri 23% 100%
Q87FK7 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 24% 100%
Q8E7N9 Streptococcus agalactiae serotype III (strain NEM316) 22% 100%
Q8G838 Bifidobacterium longum (strain NCC 2705) 24% 84%
Q8LPJ4 Arabidopsis thaliana 65% 100%
Q8SRV5 Encephalitozoon cuniculi (strain GB-M1) 23% 100%
Q97X60 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 23% 100%
Q9LID6 Arabidopsis thaliana 62% 100%
Q9VSS1 Drosophila melanogaster 65% 100%
Q9WXX0 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 22% 100%
V5BDT2 Trypanosoma cruzi 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS