DUF4123 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ68_LEIIN

TriTrypDb:

LINF_210012500

Length:

148

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.470
CLV_NRD_NRD_1	20	22	PF00675	0.487
CLV_NRD_NRD_1	5	7	PF00675	0.466
CLV_PCSK_KEX2_1	20	22	PF00082	0.431
CLV_PCSK_SKI1_1	133	137	PF00082	0.354
CLV_PCSK_SKI1_1	39	43	PF00082	0.490
DEG_MDM2_SWIB_1	51	58	PF02201	0.457
DOC_CDC14_PxL_1	105	113	PF14671	0.531
DOC_MAPK_gen_1	102	110	PF00069	0.634
DOC_MAPK_gen_1	36	44	PF00069	0.436
DOC_PP1_RVXF_1	102	108	PF00149	0.415
DOC_PP1_RVXF_1	131	137	PF00149	0.320
DOC_PP1_RVXF_1	74	80	PF00149	0.375
DOC_PP2B_LxvP_1	44	47	PF13499	0.400
DOC_PP4_FxxP_1	119	122	PF00568	0.500
DOC_USP7_MATH_1	85	89	PF00917	0.558
LIG_14-3-3_CanoR_1	104	108	PF00244	0.578
LIG_14-3-3_CanoR_1	76	86	PF00244	0.375
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	115	119	PF00533	0.550
LIG_BRCT_BRCA1_1	87	91	PF00533	0.420
LIG_FHA_1	78	84	PF00498	0.483
LIG_Integrin_isoDGR_2	4	6	PF01839	0.530
LIG_LIR_Apic_2	116	122	PF02991	0.528
LIG_LIR_LC3C_4	125	129	PF02991	0.364
LIG_LIR_Nem_3	106	110	PF02991	0.613
LIG_LIR_Nem_3	53	58	PF02991	0.413
LIG_MLH1_MIPbox_1	115	119	PF16413	0.550
LIG_MYND_1	109	113	PF01753	0.529
LIG_PCNA_yPIPBox_3	120	133	PF02747	0.404
LIG_Pex14_1	114	118	PF04695	0.472
LIG_Pex14_2	51	55	PF04695	0.390
LIG_REV1ctd_RIR_1	116	121	PF16727	0.537
LIG_SH2_PTP2	96	99	PF00017	0.419
LIG_SH2_SRC	96	99	PF00017	0.419
LIG_SH2_STAT5	10	13	PF00017	0.571
LIG_SH2_STAT5	141	144	PF00017	0.464
LIG_SH2_STAT5	96	99	PF00017	0.414
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.392
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.406
LIG_SUMO_SIM_par_1	125	131	PF11976	0.392
LIG_SxIP_EBH_1	104	114	PF03271	0.549
LIG_TRAF2_1	122	125	PF00917	0.389
LIG_WRC_WIRS_1	115	120	PF05994	0.562
LIG_WRC_WIRS_1	51	56	PF05994	0.419
MOD_Cter_Amidation	4	7	PF01082	0.567
MOD_GlcNHglycan	80	83	PF01048	0.411
MOD_NEK2_1	75	80	PF00069	0.378
MOD_NEK2_2	114	119	PF00069	0.594
MOD_PKA_2	103	109	PF00069	0.553
MOD_PKA_2	35	41	PF00069	0.409
MOD_PKA_2	75	81	PF00069	0.379
MOD_Plk_4	114	120	PF00069	0.454
MOD_Plk_4	40	46	PF00069	0.388
MOD_Plk_4	50	56	PF00069	0.336
MOD_SUMO_rev_2	33	41	PF00179	0.445
TRG_DiLeu_BaEn_1	40	45	PF01217	0.369
TRG_DiLeu_BaEn_2	102	108	PF01217	0.492
TRG_ENDOCYTIC_2	96	99	PF00928	0.414
TRG_ER_diArg_1	19	21	PF00400	0.440
TRG_PTS2	1	29	PF00400	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P861	Leptomonas seymouri	74%	100%
A0A0S4JGA4	Bodo saltans	41%	100%
A0A1X0NXL6	Trypanosomatidae	45%	100%
A0A3S7WWF3	Leishmania donovani	100%	100%
A4HBR5	Leishmania braziliensis	91%	100%
D0A1G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AV35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCE6	Leishmania major	96%	100%