Cytosolic Fe-S cluster assembly factor NUBP1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide-binding protein - putative

Species:

Leishmania infantum

UniProt:

A4HZ65_LEIIN

TriTrypDb:

LINF_210012200

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4HZ65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ65

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0002097	tRNA wobble base modification	7	1
GO:0002098	tRNA wobble uridine modification	8	1
GO:0002143	tRNA wobble position uridine thiolation	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034227	tRNA thio-modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016530	metallochaperone activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140104	molecular carrier activity	1	12
GO:0140657	ATP-dependent activity	1	12
GO:0140663	ATP-dependent FeS chaperone activity	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.333
CLV_NRD_NRD_1	148	150	PF00675	0.250
CLV_NRD_NRD_1	213	215	PF00675	0.256
CLV_NRD_NRD_1	256	258	PF00675	0.255
CLV_PCSK_KEX2_1	213	215	PF00082	0.235
CLV_PCSK_SKI1_1	155	159	PF00082	0.235
DEG_APCC_DBOX_1	48	56	PF00400	0.346
DEG_SCF_FBW7_1	170	177	PF00400	0.235
DOC_CKS1_1	171	176	PF01111	0.269
DOC_CKS1_1	201	206	PF01111	0.235
DOC_CYCLIN_yClb5_NLxxxL_5	161	170	PF00134	0.256
DOC_MAPK_DCC_7	221	229	PF00069	0.296
DOC_MAPK_gen_1	221	229	PF00069	0.236
DOC_MAPK_gen_1	257	265	PF00069	0.447
DOC_MAPK_MEF2A_6	221	229	PF00069	0.296
DOC_MAPK_MEF2A_6	39	47	PF00069	0.360
DOC_PP1_RVXF_1	157	164	PF00149	0.235
DOC_PP1_RVXF_1	212	219	PF00149	0.215
DOC_PP1_RVXF_1	73	80	PF00149	0.235
DOC_PP4_FxxP_1	145	148	PF00568	0.243
DOC_PP4_FxxP_1	236	239	PF00568	0.235
DOC_PP4_FxxP_1	269	272	PF00568	0.250
DOC_USP7_MATH_1	111	115	PF00917	0.329
DOC_USP7_MATH_1	175	179	PF00917	0.235
DOC_USP7_UBL2_3	155	159	PF12436	0.250
DOC_WW_Pin1_4	13	18	PF00397	0.453
DOC_WW_Pin1_4	170	175	PF00397	0.271
DOC_WW_Pin1_4	200	205	PF00397	0.235
LIG_14-3-3_CanoR_1	84	89	PF00244	0.380
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_3	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	244	248	PF00533	0.237
LIG_BRCT_BRCA1_1	265	269	PF00533	0.250
LIG_BRCT_BRCA1_2	244	250	PF00533	0.380
LIG_Clathr_ClatBox_1	90	94	PF01394	0.294
LIG_FHA_1	190	196	PF00498	0.308
LIG_FHA_1	72	78	PF00498	0.296
LIG_FHA_2	175	181	PF00498	0.235
LIG_FHA_2	304	310	PF00498	0.383
LIG_FHA_2	311	317	PF00498	0.288
LIG_GBD_Chelix_1	314	322	PF00786	0.295
LIG_LIR_Apic_2	234	239	PF02991	0.260
LIG_LIR_Apic_2	266	272	PF02991	0.237
LIG_LIR_Nem_3	160	166	PF02991	0.283
LIG_LIR_Nem_3	292	296	PF02991	0.380
LIG_NRBOX	165	171	PF00104	0.380
LIG_SH2_STAT5	134	137	PF00017	0.250
LIG_SH2_STAT5	296	299	PF00017	0.414
LIG_SH3_3	11	17	PF00018	0.419
LIG_SH3_3	275	281	PF00018	0.235
LIG_SH3_3	35	41	PF00018	0.444
LIG_SH3_3	95	101	PF00018	0.250
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.242
LIG_SUMO_SIM_par_1	119	125	PF11976	0.235
LIG_SUMO_SIM_par_1	167	173	PF11976	0.380
LIG_TRAF2_1	249	252	PF00917	0.300
LIG_TRAF2_1	286	289	PF00917	0.235
MOD_CDK_SPxK_1	200	206	PF00069	0.380
MOD_CK1_1	300	306	PF00069	0.453
MOD_CK1_1	71	77	PF00069	0.235
MOD_CK2_1	174	180	PF00069	0.249
MOD_CK2_1	289	295	PF00069	0.345
MOD_Cter_Amidation	255	258	PF01082	0.325
MOD_GlcNHglycan	113	116	PF01048	0.244
MOD_GlcNHglycan	233	236	PF01048	0.235
MOD_GlcNHglycan	298	302	PF01048	0.299
MOD_GlcNHglycan	35	38	PF01048	0.442
MOD_GlcNHglycan	62	65	PF01048	0.271
MOD_GSK3_1	170	177	PF00069	0.235
MOD_GSK3_1	297	304	PF00069	0.336
MOD_N-GLC_1	125	130	PF02516	0.362
MOD_N-GLC_1	231	236	PF02516	0.258
MOD_N-GLC_2	217	219	PF02516	0.294
MOD_NEK2_1	188	193	PF00069	0.329
MOD_NEK2_1	302	307	PF00069	0.505
MOD_NEK2_1	318	323	PF00069	0.423
MOD_NEK2_1	60	65	PF00069	0.235
MOD_PIKK_1	242	248	PF00454	0.318
MOD_PK_1	84	90	PF00069	0.300
MOD_PKA_2	101	107	PF00069	0.269
MOD_PKA_2	263	269	PF00069	0.273
MOD_Plk_1	125	131	PF00069	0.235
MOD_Plk_2-3	289	295	PF00069	0.329
MOD_Plk_4	125	131	PF00069	0.229
MOD_Plk_4	183	189	PF00069	0.235
MOD_ProDKin_1	13	19	PF00069	0.442
MOD_ProDKin_1	170	176	PF00069	0.271
MOD_ProDKin_1	200	206	PF00069	0.235
MOD_SUMO_for_1	249	252	PF00179	0.300
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.356
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.484
TRG_ER_diArg_1	212	214	PF00400	0.269
TRG_NES_CRM1_1	160	172	PF08389	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT32	Leptomonas seymouri	39%	100%
A0A0N1I422	Leptomonas seymouri	41%	100%
A0A0N1I939	Leptomonas seymouri	83%	100%
A0A0S4IUN9	Bodo saltans	38%	100%
A0A0S4JE42	Bodo saltans	64%	100%
A0A1X0NQL6	Trypanosomatidae	39%	100%
A0A1X0NSI2	Trypanosomatidae	45%	100%
A0A1X0NZ57	Trypanosomatidae	74%	100%
A0A3Q8IBU2	Leishmania donovani	100%	100%
A0A3Q8IET9	Leishmania donovani	37%	100%
A0A3Q8IFM3	Leishmania donovani	39%	100%
A0A3R7KED8	Trypanosoma rangeli	72%	100%
A0A422NVG5	Trypanosoma rangeli	46%	100%
A1C4X8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	43%	100%
A1C7T4	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	55%	95%
A4HBR3	Leishmania braziliensis	92%	100%
A4HEP9	Leishmania braziliensis	41%	99%
A4HGU9	Leishmania braziliensis	40%	100%
A4I1X9	Leishmania infantum	39%	100%
A4I3X9	Leishmania infantum	37%	100%
A4QNM5	Xenopus tropicalis	46%	100%
A7RUD5	Nematostella vectensis	50%	100%
A7SE07	Nematostella vectensis	50%	100%
A8PW87	Brugia malayi	48%	100%
A8WWQ7	Caenorhabditis briggsae	47%	100%
A9V7A1	Monosiga brevicollis	43%	100%
B0X4N8	Culex quinquefasciatus	48%	98%
B0XDJ0	Culex quinquefasciatus	50%	100%
B3M9R3	Drosophila ananassae	48%	100%
B3MU92	Drosophila ananassae	46%	100%
B3NIP2	Drosophila erecta	49%	100%
B3NNJ9	Drosophila erecta	45%	100%
B3RPX4	Trichoplax adhaerens	49%	100%
B4G8R5	Drosophila persimilis	46%	100%
B4H7P4	Drosophila persimilis	45%	100%
B4I540	Drosophila sechellia	45%	100%
B4IAD1	Drosophila sechellia	49%	100%
B4IUH5	Drosophila yakuba	49%	100%
B4IYG8	Drosophila grimshawi	49%	100%
B4JBI7	Drosophila grimshawi	46%	100%
B4KHX1	Drosophila mojavensis	46%	100%
B4KY56	Drosophila mojavensis	50%	100%
B4LGB4	Drosophila virilis	49%	100%
B4LUF5	Drosophila virilis	47%	100%
B4N1C3	Drosophila willistoni	51%	100%
B4N4D9	Drosophila willistoni	47%	100%
B4P9A8	Drosophila yakuba	44%	100%
B4PES4	Drosophila yakuba	49%	100%
B4Q7F5	Drosophila simulans	44%	100%
B4QJ46	Drosophila simulans	49%	100%
C9ZS40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A1H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A946	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AV32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AY25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B069	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O24999	Helicobacter pylori (strain ATCC 700392 / 26695)	36%	89%
O49472	Arabidopsis thaliana	40%	100%
O58667	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	100%
O66946	Aquifex aeolicus (strain VF5)	37%	90%
O94442	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
P0AF08	Escherichia coli (strain K12)	33%	89%
P0AF09	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	33%	89%
P0C8Q1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	98%
P0CO88	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	53%	97%
P0CO89	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	53%	97%
P0CO90	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	42%	99%
P0CO91	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	42%	99%
P40558	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P45135	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	88%
P50863	Bacillus subtilis (strain 168)	31%	93%
P52920	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	100%
P53381	Clostridium perfringens (strain 13 / Type A)	35%	100%
P53382	Mycobacterium leprae (strain TN)	41%	85%
P53383	Synechocystis sp. (strain PCC 6803 / Kazusa)	38%	93%
P53384	Homo sapiens	54%	100%
P65442	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	39%	86%
P72190	Pseudomonas fragi	36%	100%
P9WJN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	39%	86%
P9WJN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	39%	86%
Q0CE30	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	43%	100%
Q0CVD6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	50%	94%
Q0UAM9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	41%	100%
Q0UI56	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	60%	96%
Q16H50	Aedes aegypti	50%	100%
Q16T79	Aedes aegypti	50%	100%
Q1DSY6	Coccidioides immitis (strain RS)	39%	95%
Q1EAU8	Coccidioides immitis (strain RS)	55%	96%
Q1RHB0	Rickettsia bellii (strain RML369-C)	34%	100%
Q24K00	Bos taurus	52%	100%
Q29DB7	Drosophila pseudoobscura pseudoobscura	47%	100%
Q29MT7	Drosophila pseudoobscura pseudoobscura	46%	100%
Q2GWZ4	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	45%	100%
Q2H317	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	55%	96%
Q2UA27	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	44%	100%
Q2UDE2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	58%	100%
Q3B7Q7	Danio rerio	47%	100%
Q3KQF0	Xenopus laevis	52%	100%
Q3MHY6	Bos taurus	47%	100%
Q4HZ34	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	58%	96%
Q4I174	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	47%	100%
Q4P8S7	Ustilago maydis (strain 521 / FGSC 9021)	41%	91%
Q4Q816	Leishmania major	38%	100%
Q4Q9E8	Leishmania major	39%	100%
Q4QCE9	Leishmania major	99%	100%
Q4UKB5	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	34%	100%
Q4WEN1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	100%
Q4WZS2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	55%	95%
Q54F15	Dictyostelium discoideum	37%	100%
Q57731	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	41%	100%
Q59MP1	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	99%
Q59YD9	Candida albicans (strain SC5314 / ATCC MYA-2876)	46%	100%
Q5BBC5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	56%	96%
Q5EB25	Xenopus tropicalis	52%	100%
Q5I050	Xenopus laevis	51%	100%
Q5I0L4	Rattus norvegicus	52%	100%
Q5ZKV4	Gallus gallus	47%	100%
Q68FS1	Rattus norvegicus	45%	100%
Q68XP6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	33%	100%
Q6BTZ6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	52%	99%
Q6BWQ9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	44%	100%
Q6C5D0	Yarrowia lipolytica (strain CLIB 122 / E 150)	48%	100%
Q6C7A6	Yarrowia lipolytica (strain CLIB 122 / E 150)	53%	96%
Q6CE48	Yarrowia lipolytica (strain CLIB 122 / E 150)	39%	100%
Q6CMN0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	54%	100%
Q6CQV4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	45%	100%
Q6DEE4	Xenopus laevis	50%	100%
Q6FPP7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q6LZC5	Methanococcus maripaludis (strain S2 / LL)	42%	100%
Q6P298	Danio rerio	52%	100%
Q754X6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	53%	98%
Q75AC3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	46%	100%
Q76NZ7	Dictyostelium discoideum	46%	100%
Q7PV10	Anopheles gambiae	50%	100%
Q7QGS3	Anopheles gambiae	49%	100%
Q7S8Z0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	55%	95%
Q874M2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	51%	98%
Q8H1Q2	Arabidopsis thaliana	48%	93%
Q8T2F3	Dictyostelium discoideum	53%	100%
Q8TB37	Homo sapiens	35%	100%
Q8U1R0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	100%
Q8X0F1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	46%	100%
Q8ZNN5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	89%
Q92JA4	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	35%	100%
Q93459	Caenorhabditis elegans	48%	100%
Q97ZW4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	39%	100%
Q9CWD8	Mus musculus	35%	100%
Q9R060	Mus musculus	53%	100%
Q9R061	Mus musculus	45%	100%
Q9RVM9	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	41%	93%
Q9V0D9	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
Q9VJI9	Drosophila melanogaster	44%	100%
Q9VPD2	Drosophila melanogaster	49%	100%
Q9Y5Y2	Homo sapiens	45%	100%
Q9ZE27	Rickettsia prowazekii (strain Madrid E)	33%	100%
Q9ZMM5	Helicobacter pylori (strain J99 / ATCC 700824)	36%	89%
V5BGR5	Trypanosoma cruzi	40%	100%
V5DEP1	Trypanosoma cruzi	72%	100%
V5DR48	Trypanosoma cruzi	46%	100%