Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ64_LEIIN

TriTrypDb:

LINF_210012100

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.644
CLV_C14_Caspase3-7	503	507	PF00656	0.511
CLV_C14_Caspase3-7	81	85	PF00656	0.439
CLV_NRD_NRD_1	390	392	PF00675	0.517
CLV_NRD_NRD_1	397	399	PF00675	0.484
CLV_NRD_NRD_1	470	472	PF00675	0.478
CLV_NRD_NRD_1	55	57	PF00675	0.507
CLV_NRD_NRD_1	749	751	PF00675	0.481
CLV_NRD_NRD_1	764	766	PF00675	0.439
CLV_NRD_NRD_1	790	792	PF00675	0.431
CLV_PCSK_FUR_1	395	399	PF00082	0.479
CLV_PCSK_FUR_1	47	51	PF00082	0.531
CLV_PCSK_FUR_1	53	57	PF00082	0.502
CLV_PCSK_KEX2_1	390	392	PF00082	0.517
CLV_PCSK_KEX2_1	397	399	PF00082	0.484
CLV_PCSK_KEX2_1	407	409	PF00082	0.481
CLV_PCSK_KEX2_1	470	472	PF00082	0.478
CLV_PCSK_KEX2_1	49	51	PF00082	0.537
CLV_PCSK_KEX2_1	53	55	PF00082	0.511
CLV_PCSK_KEX2_1	749	751	PF00082	0.481
CLV_PCSK_KEX2_1	764	766	PF00082	0.439
CLV_PCSK_KEX2_1	789	791	PF00082	0.452
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.481
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.537
CLV_PCSK_PC7_1	50	56	PF00082	0.524
CLV_PCSK_PC7_1	745	751	PF00082	0.441
CLV_PCSK_SKI1_1	287	291	PF00082	0.571
CLV_PCSK_SKI1_1	297	301	PF00082	0.363
CLV_PCSK_SKI1_1	461	465	PF00082	0.483
CLV_PCSK_SKI1_1	470	474	PF00082	0.361
CLV_PCSK_SKI1_1	511	515	PF00082	0.459
CLV_PCSK_SKI1_1	524	528	PF00082	0.412
CLV_PCSK_SKI1_1	648	652	PF00082	0.455
CLV_PCSK_SKI1_1	658	662	PF00082	0.452
CLV_PCSK_SKI1_1	774	778	PF00082	0.443
CLV_PCSK_SKI1_1	790	794	PF00082	0.455
DEG_APCC_DBOX_1	396	404	PF00400	0.437
DEG_APCC_DBOX_1	523	531	PF00400	0.500
DOC_CKS1_1	288	293	PF01111	0.542
DOC_CKS1_1	30	35	PF01111	0.488
DOC_CKS1_1	486	491	PF01111	0.521
DOC_MAPK_FxFP_2	100	103	PF00069	0.444
DOC_MAPK_gen_1	176	184	PF00069	0.416
DOC_MAPK_gen_1	470	478	PF00069	0.479
DOC_MAPK_MEF2A_6	122	129	PF00069	0.528
DOC_MAPK_MEF2A_6	142	149	PF00069	0.455
DOC_MAPK_MEF2A_6	239	247	PF00069	0.401
DOC_MAPK_MEF2A_6	470	478	PF00069	0.403
DOC_MAPK_NFAT4_5	142	150	PF00069	0.489
DOC_PP1_RVXF_1	396	403	PF00149	0.494
DOC_PP2B_LxvP_1	701	704	PF13499	0.392
DOC_PP2B_PxIxI_1	192	198	PF00149	0.409
DOC_PP4_FxxP_1	100	103	PF00568	0.444
DOC_PP4_FxxP_1	641	644	PF00568	0.515
DOC_USP7_MATH_1	163	167	PF00917	0.395
DOC_USP7_MATH_1	270	274	PF00917	0.704
DOC_USP7_MATH_1	289	293	PF00917	0.363
DOC_USP7_MATH_1	355	359	PF00917	0.683
DOC_USP7_MATH_1	542	546	PF00917	0.714
DOC_USP7_MATH_1	558	562	PF00917	0.582
DOC_USP7_MATH_1	580	584	PF00917	0.658
DOC_USP7_MATH_1	650	654	PF00917	0.395
DOC_USP7_MATH_1	663	667	PF00917	0.583
DOC_USP7_MATH_1	70	74	PF00917	0.473
DOC_USP7_MATH_1	93	97	PF00917	0.420
DOC_WW_Pin1_4	287	292	PF00397	0.619
DOC_WW_Pin1_4	29	34	PF00397	0.489
DOC_WW_Pin1_4	318	323	PF00397	0.424
DOC_WW_Pin1_4	368	373	PF00397	0.593
DOC_WW_Pin1_4	384	389	PF00397	0.492
DOC_WW_Pin1_4	470	475	PF00397	0.403
DOC_WW_Pin1_4	485	490	PF00397	0.422
DOC_WW_Pin1_4	682	687	PF00397	0.717
DOC_WW_Pin1_4	711	716	PF00397	0.557
DOC_WW_Pin1_4	79	84	PF00397	0.533
LIG_14-3-3_CanoR_1	12	18	PF00244	0.490
LIG_14-3-3_CanoR_1	461	467	PF00244	0.489
LIG_14-3-3_CanoR_1	511	517	PF00244	0.433
LIG_14-3-3_CanoR_1	593	600	PF00244	0.493
LIG_14-3-3_CanoR_1	652	662	PF00244	0.531
LIG_Actin_WH2_2	273	289	PF00022	0.537
LIG_Actin_WH2_2	327	345	PF00022	0.379
LIG_BRCT_BRCA1_1	56	60	PF00533	0.508
LIG_BRCT_BRCA1_1	689	693	PF00533	0.521
LIG_deltaCOP1_diTrp_1	624	631	PF00928	0.501
LIG_deltaCOP1_diTrp_1	736	744	PF00928	0.358
LIG_eIF4E_1	649	655	PF01652	0.396
LIG_EVH1_1	661	665	PF00568	0.574
LIG_FHA_1	471	477	PF00498	0.419
LIG_FHA_1	512	518	PF00498	0.539
LIG_FHA_1	547	553	PF00498	0.796
LIG_FHA_1	594	600	PF00498	0.559
LIG_FHA_1	649	655	PF00498	0.466
LIG_FHA_2	413	419	PF00498	0.499
LIG_FHA_2	695	701	PF00498	0.422
LIG_Integrin_RGD_1	554	556	PF01839	0.513
LIG_LIR_Apic_2	29	33	PF02991	0.488
LIG_LIR_Gen_1	561	570	PF02991	0.594
LIG_LIR_Nem_3	561	565	PF02991	0.540
LIG_LIR_Nem_3	583	589	PF02991	0.596
LIG_LIR_Nem_3	645	649	PF02991	0.388
LIG_MYND_1	659	663	PF01753	0.592
LIG_RPA_C_Fungi	7	19	PF08784	0.487
LIG_SH2_CRK	587	591	PF00017	0.507
LIG_SH2_CRK	639	643	PF00017	0.427
LIG_SH2_NCK_1	710	714	PF00017	0.646
LIG_SH2_NCK_1	92	96	PF00017	0.420
LIG_SH2_SRC	92	95	PF00017	0.420
LIG_SH2_STAP1	694	698	PF00017	0.484
LIG_SH2_STAT5	144	147	PF00017	0.597
LIG_SH2_STAT5	574	577	PF00017	0.665
LIG_SH3_1	712	718	PF00018	0.516
LIG_SH3_2	683	688	PF14604	0.680
LIG_SH3_3	288	294	PF00018	0.643
LIG_SH3_3	366	372	PF00018	0.565
LIG_SH3_3	450	456	PF00018	0.574
LIG_SH3_3	656	662	PF00018	0.458
LIG_SH3_3	664	670	PF00018	0.589
LIG_SH3_3	680	686	PF00018	0.633
LIG_SH3_3	712	718	PF00018	0.573
LIG_SH3_CIN85_PxpxPR_1	320	325	PF14604	0.385
LIG_Sin3_3	727	734	PF02671	0.369
LIG_SUMO_SIM_anti_2	475	480	PF11976	0.391
LIG_SUMO_SIM_anti_2	697	703	PF11976	0.388
LIG_SUMO_SIM_par_1	242	251	PF11976	0.387
LIG_TRAF2_1	183	186	PF00917	0.530
LIG_TRAF2_1	371	374	PF00917	0.509
LIG_TRAF2_1	415	418	PF00917	0.528
LIG_TRAF2_1	769	772	PF00917	0.543
LIG_WRC_WIRS_1	164	169	PF05994	0.374
LIG_WRC_WIRS_1	252	257	PF05994	0.378
LIG_WRC_WIRS_1	40	45	PF05994	0.507
LIG_WW_3	714	718	PF00397	0.552
MOD_CDC14_SPxK_1	387	390	PF00782	0.559
MOD_CDC14_SPxK_1	685	688	PF00782	0.675
MOD_CDC14_SPxK_1	714	717	PF00782	0.530
MOD_CDK_SPxK_1	384	390	PF00069	0.545
MOD_CDK_SPxK_1	682	688	PF00069	0.684
MOD_CDK_SPxK_1	711	717	PF00069	0.549
MOD_CDK_SPxxK_3	290	297	PF00069	0.386
MOD_CDK_SPxxK_3	318	325	PF00069	0.368
MOD_CDK_SPxxK_3	384	391	PF00069	0.548
MOD_CK1_1	159	165	PF00069	0.446
MOD_CK1_1	251	257	PF00069	0.378
MOD_CK1_1	26	32	PF00069	0.519
MOD_CK1_1	263	269	PF00069	0.502
MOD_CK1_1	271	277	PF00069	0.649
MOD_CK1_1	433	439	PF00069	0.414
MOD_CK1_1	449	455	PF00069	0.579
MOD_CK1_1	519	525	PF00069	0.423
MOD_CK1_1	592	598	PF00069	0.521
MOD_CK1_1	653	659	PF00069	0.522
MOD_CK1_1	687	693	PF00069	0.576
MOD_CK1_1	79	85	PF00069	0.458
MOD_CK2_1	247	253	PF00069	0.473
MOD_CK2_1	368	374	PF00069	0.582
MOD_CK2_1	412	418	PF00069	0.500
MOD_CK2_1	694	700	PF00069	0.473
MOD_CMANNOS	306	309	PF00535	0.373
MOD_Cter_Amidation	51	54	PF01082	0.527
MOD_GlcNHglycan	161	164	PF01048	0.426
MOD_GlcNHglycan	25	28	PF01048	0.504
MOD_GlcNHglycan	270	273	PF01048	0.730
MOD_GlcNHglycan	301	304	PF01048	0.507
MOD_GlcNHglycan	362	365	PF01048	0.645
MOD_GlcNHglycan	392	395	PF01048	0.527
MOD_GlcNHglycan	432	435	PF01048	0.432
MOD_GlcNHglycan	448	451	PF01048	0.574
MOD_GlcNHglycan	536	540	PF01048	0.654
MOD_GlcNHglycan	544	547	PF01048	0.674
MOD_GlcNHglycan	678	681	PF01048	0.606
MOD_GlcNHglycan	689	692	PF01048	0.492
MOD_GlcNHglycan	73	76	PF01048	0.474
MOD_GlcNHglycan	78	81	PF01048	0.459
MOD_GSK3_1	123	130	PF00069	0.529
MOD_GSK3_1	155	162	PF00069	0.423
MOD_GSK3_1	247	254	PF00069	0.449
MOD_GSK3_1	260	267	PF00069	0.530
MOD_GSK3_1	356	363	PF00069	0.578
MOD_GSK3_1	368	375	PF00069	0.520
MOD_GSK3_1	442	449	PF00069	0.441
MOD_GSK3_1	462	469	PF00069	0.534
MOD_GSK3_1	488	495	PF00069	0.594
MOD_GSK3_1	512	519	PF00069	0.561
MOD_GSK3_1	542	549	PF00069	0.713
MOD_GSK3_1	588	595	PF00069	0.540
MOD_GSK3_1	8	15	PF00069	0.489
MOD_LATS_1	39	45	PF00433	0.506
MOD_N-GLC_1	546	551	PF02516	0.714
MOD_NEK2_1	127	132	PF00069	0.514
MOD_NEK2_1	155	160	PF00069	0.452
MOD_NEK2_1	255	260	PF00069	0.513
MOD_NEK2_1	262	267	PF00069	0.581
MOD_NEK2_1	301	306	PF00069	0.558
MOD_NEK2_1	466	471	PF00069	0.423
MOD_NEK2_1	589	594	PF00069	0.539
MOD_NEK2_1	64	69	PF00069	0.476
MOD_NEK2_1	758	763	PF00069	0.496
MOD_NEK2_1	78	83	PF00069	0.435
MOD_PIKK_1	260	266	PF00454	0.561
MOD_PIKK_1	301	307	PF00454	0.355
MOD_PIKK_1	528	534	PF00454	0.560
MOD_PKA_1	390	396	PF00069	0.493
MOD_PKA_1	54	60	PF00069	0.509
MOD_PKA_1	749	755	PF00069	0.460
MOD_PKA_2	13	19	PF00069	0.495
MOD_PKA_2	136	142	PF00069	0.500
MOD_PKA_2	218	224	PF00069	0.396
MOD_PKA_2	390	396	PF00069	0.493
MOD_PKA_2	519	525	PF00069	0.423
MOD_PKA_2	528	534	PF00069	0.470
MOD_PKA_2	54	60	PF00069	0.509
MOD_PKA_2	592	598	PF00069	0.487
MOD_PKA_2	749	755	PF00069	0.513
MOD_Plk_1	248	254	PF00069	0.473
MOD_Plk_1	373	379	PF00069	0.497
MOD_Plk_1	398	404	PF00069	0.557
MOD_Plk_1	492	498	PF00069	0.521
MOD_Plk_4	123	129	PF00069	0.518
MOD_Plk_4	163	169	PF00069	0.420
MOD_Plk_4	251	257	PF00069	0.378
MOD_Plk_4	356	362	PF00069	0.642
MOD_Plk_4	398	404	PF00069	0.544
MOD_Plk_4	512	518	PF00069	0.421
MOD_Plk_4	570	576	PF00069	0.712
MOD_Plk_4	595	601	PF00069	0.541
MOD_Plk_4	694	700	PF00069	0.333
MOD_Plk_4	758	764	PF00069	0.457
MOD_ProDKin_1	287	293	PF00069	0.605
MOD_ProDKin_1	29	35	PF00069	0.488
MOD_ProDKin_1	318	324	PF00069	0.418
MOD_ProDKin_1	368	374	PF00069	0.587
MOD_ProDKin_1	384	390	PF00069	0.492
MOD_ProDKin_1	470	476	PF00069	0.402
MOD_ProDKin_1	485	491	PF00069	0.424
MOD_ProDKin_1	682	688	PF00069	0.717
MOD_ProDKin_1	711	717	PF00069	0.553
MOD_ProDKin_1	79	85	PF00069	0.529
TRG_DiLeu_BaEn_4	417	423	PF01217	0.472
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.377
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.567
TRG_ENDOCYTIC_2	144	147	PF00928	0.597
TRG_ENDOCYTIC_2	587	590	PF00928	0.512
TRG_ENDOCYTIC_2	638	641	PF00928	0.413
TRG_ER_diArg_1	145	148	PF00400	0.487
TRG_ER_diArg_1	19	22	PF00400	0.486
TRG_ER_diArg_1	337	340	PF00400	0.457
TRG_ER_diArg_1	390	392	PF00400	0.533
TRG_ER_diArg_1	408	411	PF00400	0.589
TRG_ER_diArg_1	470	472	PF00400	0.479
TRG_ER_diArg_1	53	56	PF00400	0.518
TRG_ER_diArg_1	748	750	PF00400	0.464
TRG_ER_diArg_1	763	765	PF00400	0.406
TRG_ER_diArg_1	788	791	PF00400	0.443
TRG_NES_CRM1_1	602	615	PF08389	0.434
TRG_NLS_Bipartite_1	390	411	PF00514	0.474
TRG_NLS_MonoExtN_4	404	411	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAU6	Leptomonas seymouri	51%	100%
A0A3Q8IBW5	Leishmania donovani	100%	100%
A4HBR2	Leishmania braziliensis	77%	100%
E9AV31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCF0	Leishmania major	94%	100%