Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta - putative

Species:

Leishmania infantum

UniProt:

A4HZ62_LEIIN

TriTrypDb:

LINF_210011900

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005657	replication fork	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0090734	site of DNA damage	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ62

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003684	damaged DNA binding	5	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.696
CLV_C14_Caspase3-7	563	567	PF00656	0.584
CLV_C14_Caspase3-7	593	597	PF00656	0.664
CLV_NRD_NRD_1	180	182	PF00675	0.405
CLV_NRD_NRD_1	355	357	PF00675	0.689
CLV_NRD_NRD_1	358	360	PF00675	0.682
CLV_NRD_NRD_1	427	429	PF00675	0.253
CLV_NRD_NRD_1	543	545	PF00675	0.544
CLV_NRD_NRD_1	64	66	PF00675	0.332
CLV_NRD_NRD_1	646	648	PF00675	0.513
CLV_PCSK_FUR_1	356	360	PF00082	0.648
CLV_PCSK_KEX2_1	180	182	PF00082	0.405
CLV_PCSK_KEX2_1	357	359	PF00082	0.695
CLV_PCSK_KEX2_1	364	366	PF00082	0.620
CLV_PCSK_KEX2_1	427	429	PF00082	0.253
CLV_PCSK_KEX2_1	543	545	PF00082	0.605
CLV_PCSK_KEX2_1	64	66	PF00082	0.405
CLV_PCSK_KEX2_1	646	648	PF00082	0.572
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.680
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.647
CLV_PCSK_PC7_1	353	359	PF00082	0.600
CLV_PCSK_SKI1_1	117	121	PF00082	0.336
CLV_PCSK_SKI1_1	233	237	PF00082	0.405
CLV_PCSK_SKI1_1	647	651	PF00082	0.506
CLV_PCSK_SKI1_1	684	688	PF00082	0.605
CLV_Separin_Metazoa	201	205	PF03568	0.605
CLV_Separin_Metazoa	424	428	PF03568	0.496
DEG_APCC_DBOX_1	147	155	PF00400	0.605
DEG_SCF_FBW7_1	530	537	PF00400	0.508
DEG_SPOP_SBC_1	382	386	PF00917	0.483
DEG_SPOP_SBC_1	667	671	PF00917	0.460
DOC_CYCLIN_RxL_1	230	241	PF00134	0.605
DOC_MAPK_gen_1	427	433	PF00069	0.453
DOC_MAPK_gen_1	451	459	PF00069	0.594
DOC_MAPK_gen_1	646	656	PF00069	0.501
DOC_MAPK_RevD_3	167	181	PF00069	0.503
DOC_PP2B_LxvP_1	284	287	PF13499	0.454
DOC_PP2B_LxvP_1	723	726	PF13499	0.660
DOC_PP2B_LxvP_1	728	731	PF13499	0.591
DOC_PP4_FxxP_1	199	202	PF00568	0.605
DOC_PP4_FxxP_1	295	298	PF00568	0.564
DOC_USP7_MATH_1	159	163	PF00917	0.539
DOC_USP7_MATH_1	287	291	PF00917	0.497
DOC_USP7_MATH_1	311	315	PF00917	0.526
DOC_USP7_MATH_1	505	509	PF00917	0.549
DOC_USP7_MATH_1	523	527	PF00917	0.533
DOC_USP7_MATH_1	534	538	PF00917	0.519
DOC_USP7_MATH_1	667	671	PF00917	0.533
DOC_WW_Pin1_4	123	128	PF00397	0.475
DOC_WW_Pin1_4	367	372	PF00397	0.496
DOC_WW_Pin1_4	38	43	PF00397	0.605
DOC_WW_Pin1_4	530	535	PF00397	0.582
DOC_WW_Pin1_4	630	635	PF00397	0.723
DOC_WW_Pin1_4	657	662	PF00397	0.633
DOC_WW_Pin1_4	670	675	PF00397	0.584
DOC_WW_Pin1_4	731	736	PF00397	0.637
DOC_WW_Pin1_4	81	86	PF00397	0.536
LIG_14-3-3_CanoR_1	191	196	PF00244	0.605
LIG_14-3-3_CanoR_1	289	298	PF00244	0.538
LIG_14-3-3_CanoR_1	365	373	PF00244	0.517
LIG_14-3-3_CanoR_1	418	424	PF00244	0.518
LIG_14-3-3_CanoR_1	451	456	PF00244	0.559
LIG_14-3-3_CanoR_1	551	556	PF00244	0.623
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.495
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BIR_III_4	348	352	PF00653	0.690
LIG_BRCT_BRCA1_1	217	221	PF00533	0.605
LIG_BRCT_BRCA1_1	291	295	PF00533	0.521
LIG_BRCT_BRCA1_1	412	416	PF00533	0.488
LIG_eIF4E_1	230	236	PF01652	0.605
LIG_FHA_1	124	130	PF00498	0.475
LIG_FHA_1	172	178	PF00498	0.520
LIG_FHA_1	281	287	PF00498	0.455
LIG_FHA_1	338	344	PF00498	0.544
LIG_FHA_1	418	424	PF00498	0.518
LIG_FHA_1	432	438	PF00498	0.494
LIG_FHA_1	465	471	PF00498	0.555
LIG_FHA_1	472	478	PF00498	0.485
LIG_FHA_1	508	514	PF00498	0.503
LIG_FHA_1	522	528	PF00498	0.610
LIG_FHA_1	622	628	PF00498	0.655
LIG_FHA_1	631	637	PF00498	0.583
LIG_FHA_1	643	649	PF00498	0.513
LIG_FHA_1	738	744	PF00498	0.602
LIG_FHA_2	419	425	PF00498	0.518
LIG_FHA_2	531	537	PF00498	0.512
LIG_LIR_Apic_2	292	298	PF02991	0.445
LIG_LIR_Apic_2	325	330	PF02991	0.443
LIG_LIR_Gen_1	137	147	PF02991	0.488
LIG_LIR_Gen_1	23	34	PF02991	0.488
LIG_LIR_Gen_1	439	448	PF02991	0.523
LIG_LIR_Gen_1	673	682	PF02991	0.469
LIG_LIR_Nem_3	137	143	PF02991	0.546
LIG_LIR_Nem_3	23	29	PF02991	0.488
LIG_LIR_Nem_3	385	391	PF02991	0.369
LIG_LIR_Nem_3	413	419	PF02991	0.518
LIG_LIR_Nem_3	439	444	PF02991	0.523
LIG_LIR_Nem_3	46	51	PF02991	0.465
LIG_LIR_Nem_3	673	679	PF02991	0.463
LIG_PCNA_PIPBox_1	553	562	PF02747	0.541
LIG_PCNA_yPIPBox_3	547	560	PF02747	0.590
LIG_PTB_Apo_2	458	465	PF02174	0.549
LIG_SH2_NCK_1	26	30	PF00017	0.488
LIG_SH2_PTP2	140	143	PF00017	0.605
LIG_SH2_SRC	140	143	PF00017	0.605
LIG_SH2_STAP1	257	261	PF00017	0.488
LIG_SH2_STAT5	140	143	PF00017	0.605
LIG_SH2_STAT5	388	391	PF00017	0.403
LIG_SH3_3	166	172	PF00018	0.488
LIG_SH3_3	472	478	PF00018	0.579
LIG_SH3_3	51	57	PF00018	0.488
LIG_SH3_3	712	718	PF00018	0.781
LIG_SH3_3	729	735	PF00018	0.474
LIG_SH3_4	278	285	PF00018	0.403
LIG_SUMO_SIM_anti_2	624	631	PF11976	0.685
LIG_SUMO_SIM_anti_2	740	746	PF11976	0.634
LIG_SUMO_SIM_anti_2	753	760	PF11976	0.571
LIG_SUMO_SIM_par_1	282	288	PF11976	0.561
LIG_SUMO_SIM_par_1	41	46	PF11976	0.464
LIG_SUMO_SIM_par_1	429	436	PF11976	0.475
LIG_SUMO_SIM_par_1	473	479	PF11976	0.472
LIG_SUMO_SIM_par_1	624	631	PF11976	0.559
LIG_SUMO_SIM_par_1	739	746	PF11976	0.603
LIG_SUMO_SIM_par_1	79	84	PF11976	0.516
LIG_TRAF2_1	147	150	PF00917	0.431
LIG_TRAF2_1	686	689	PF00917	0.653
LIG_UBA3_1	675	684	PF00899	0.475
LIG_WRC_WIRS_1	556	561	PF05994	0.624
LIG_WRC_WIRS_1	609	614	PF05994	0.470
MOD_CDK_SPxxK_3	81	88	PF00069	0.379
MOD_CK1_1	471	477	PF00069	0.385
MOD_CK1_1	518	524	PF00069	0.372
MOD_CK1_1	597	603	PF00069	0.592
MOD_CK1_1	6	12	PF00069	0.524
MOD_CK1_1	611	617	PF00069	0.514
MOD_CK1_1	67	73	PF00069	0.364
MOD_CK1_1	670	676	PF00069	0.493
MOD_CK2_1	132	138	PF00069	0.272
MOD_CK2_1	418	424	PF00069	0.358
MOD_CK2_1	436	442	PF00069	0.473
MOD_CK2_1	657	663	PF00069	0.621
MOD_Cter_Amidation	354	357	PF01082	0.627
MOD_Cter_Amidation	362	365	PF01082	0.583
MOD_GlcNHglycan	188	191	PF01048	0.394
MOD_GlcNHglycan	258	262	PF01048	0.337
MOD_GlcNHglycan	273	276	PF01048	0.411
MOD_GlcNHglycan	288	292	PF01048	0.328
MOD_GlcNHglycan	299	302	PF01048	0.450
MOD_GlcNHglycan	313	316	PF01048	0.319
MOD_GlcNHglycan	519	523	PF01048	0.363
MOD_GlcNHglycan	538	541	PF01048	0.633
MOD_GlcNHglycan	562	565	PF01048	0.646
MOD_GlcNHglycan	570	573	PF01048	0.684
MOD_GlcNHglycan	576	579	PF01048	0.681
MOD_GlcNHglycan	720	723	PF01048	0.603
MOD_GSK3_1	101	108	PF00069	0.501
MOD_GSK3_1	186	193	PF00069	0.394
MOD_GSK3_1	3	10	PF00069	0.604
MOD_GSK3_1	406	413	PF00069	0.317
MOD_GSK3_1	43	50	PF00069	0.303
MOD_GSK3_1	432	439	PF00069	0.333
MOD_GSK3_1	464	471	PF00069	0.364
MOD_GSK3_1	505	512	PF00069	0.473
MOD_GSK3_1	530	537	PF00069	0.662
MOD_GSK3_1	551	558	PF00069	0.781
MOD_GSK3_1	611	618	PF00069	0.658
MOD_GSK3_1	666	673	PF00069	0.598
MOD_GSK3_1	691	698	PF00069	0.691
MOD_GSK3_1	726	733	PF00069	0.635
MOD_LATS_1	449	455	PF00433	0.303
MOD_LATS_1	549	555	PF00433	0.663
MOD_N-GLC_1	471	476	PF02516	0.228
MOD_N-GLC_1	597	602	PF02516	0.785
MOD_N-GLC_1	67	72	PF02516	0.303
MOD_NEK2_1	215	220	PF00069	0.462
MOD_NEK2_1	406	411	PF00069	0.343
MOD_NEK2_1	43	48	PF00069	0.303
MOD_NEK2_1	464	469	PF00069	0.374
MOD_NEK2_1	555	560	PF00069	0.647
MOD_NEK2_1	610	615	PF00069	0.650
MOD_NEK2_1	675	680	PF00069	0.527
MOD_NEK2_1	89	94	PF00069	0.242
MOD_OFUCOSY	335	341	PF10250	0.581
MOD_OGLYCOS	657	662	PF02709	0.558
MOD_PIKK_1	383	389	PF00454	0.325
MOD_PIKK_1	43	49	PF00454	0.265
MOD_PIKK_1	668	674	PF00454	0.457
MOD_PIKK_1	91	97	PF00454	0.318
MOD_PKA_1	64	70	PF00069	0.364
MOD_PKA_2	190	196	PF00069	0.501
MOD_PKA_2	417	423	PF00069	0.389
MOD_PKA_2	464	470	PF00069	0.318
MOD_PKA_2	64	70	PF00069	0.376
MOD_Plk_1	397	403	PF00069	0.450
MOD_Plk_1	442	448	PF00069	0.379
MOD_Plk_1	471	477	PF00069	0.228
MOD_Plk_2-3	132	138	PF00069	0.272
MOD_Plk_2-3	754	760	PF00069	0.676
MOD_Plk_4	280	286	PF00069	0.397
MOD_Plk_4	397	403	PF00069	0.417
MOD_Plk_4	406	412	PF00069	0.268
MOD_Plk_4	47	53	PF00069	0.501
MOD_Plk_4	523	529	PF00069	0.541
MOD_Plk_4	551	557	PF00069	0.657
MOD_Plk_4	623	629	PF00069	0.694
MOD_Plk_4	675	681	PF00069	0.504
MOD_Plk_4	754	760	PF00069	0.658
MOD_ProDKin_1	123	129	PF00069	0.318
MOD_ProDKin_1	367	373	PF00069	0.489
MOD_ProDKin_1	38	44	PF00069	0.501
MOD_ProDKin_1	530	536	PF00069	0.582
MOD_ProDKin_1	630	636	PF00069	0.724
MOD_ProDKin_1	657	663	PF00069	0.634
MOD_ProDKin_1	670	676	PF00069	0.585
MOD_ProDKin_1	731	737	PF00069	0.640
MOD_ProDKin_1	81	87	PF00069	0.403
TRG_AP2beta_CARGO_1	442	451	PF09066	0.318
TRG_DiLeu_BaEn_1	232	237	PF01217	0.337
TRG_DiLeu_BaEn_4	442	448	PF01217	0.318
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.501
TRG_ENDOCYTIC_2	140	143	PF00928	0.501
TRG_ENDOCYTIC_2	252	255	PF00928	0.396
TRG_ENDOCYTIC_2	26	29	PF00928	0.337
TRG_ENDOCYTIC_2	441	444	PF00928	0.298
TRG_ER_diArg_1	247	250	PF00400	0.396
TRG_ER_diArg_1	356	359	PF00400	0.649
TRG_ER_diArg_1	391	394	PF00400	0.359
TRG_ER_diArg_1	426	428	PF00400	0.288
TRG_ER_diArg_1	450	453	PF00400	0.379
TRG_ER_diArg_1	63	65	PF00400	0.409
TRG_ER_diArg_1	646	648	PF00400	0.513
TRG_NES_CRM1_1	479	493	PF08389	0.379
TRG_NLS_MonoCore_2	355	360	PF00514	0.645
TRG_NLS_MonoExtC_3	355	360	PF00514	0.696
TRG_NLS_MonoExtN_4	353	360	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NXK7	Trypanosomatidae	42%	100%
A4HBR0	Leishmania braziliensis	78%	100%
D0A1I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QCF2	Leishmania major	93%	100%