Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta - putative

Species:

Leishmania infantum

UniProt:

A4HZ61_LEIIN

TriTrypDb:

LINF_210011800

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005657	replication fork	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0090734	site of DNA damage	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ61

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.683
CLV_C14_Caspase3-7	388	392	PF00656	0.694
CLV_C14_Caspase3-7	398	402	PF00656	0.566
CLV_NRD_NRD_1	200	202	PF00675	0.280
CLV_NRD_NRD_1	490	492	PF00675	0.631
CLV_NRD_NRD_1	538	540	PF00675	0.839
CLV_NRD_NRD_1	645	647	PF00675	0.717
CLV_NRD_NRD_1	750	752	PF00675	0.631
CLV_NRD_NRD_1	83	85	PF00675	0.325
CLV_NRD_NRD_1	93	95	PF00675	0.304
CLV_PCSK_KEX2_1	200	202	PF00082	0.280
CLV_PCSK_KEX2_1	490	492	PF00082	0.631
CLV_PCSK_KEX2_1	538	540	PF00082	0.841
CLV_PCSK_KEX2_1	647	649	PF00082	0.728
CLV_PCSK_KEX2_1	697	699	PF00082	0.718
CLV_PCSK_KEX2_1	750	752	PF00082	0.631
CLV_PCSK_KEX2_1	83	85	PF00082	0.322
CLV_PCSK_KEX2_1	93	95	PF00082	0.322
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.716
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.681
CLV_PCSK_SKI1_1	137	141	PF00082	0.322
CLV_PCSK_SKI1_1	253	257	PF00082	0.311
CLV_PCSK_SKI1_1	429	433	PF00082	0.483
CLV_PCSK_SKI1_1	527	531	PF00082	0.528
CLV_PCSK_SKI1_1	750	754	PF00082	0.760
CLV_Separin_Metazoa	221	225	PF03568	0.522
DEG_APCC_DBOX_1	167	175	PF00400	0.595
DEG_APCC_DBOX_1	92	100	PF00400	0.553
DEG_SCF_FBW7_1	543	548	PF00400	0.616
DOC_CYCLIN_RxL_1	250	261	PF00134	0.522
DOC_MAPK_DCC_7	93	101	PF00069	0.553
DOC_MAPK_gen_1	468	478	PF00069	0.544
DOC_MAPK_gen_1	496	504	PF00069	0.501
DOC_MAPK_gen_1	747	757	PF00069	0.654
DOC_MAPK_MEF2A_6	144	151	PF00069	0.511
DOC_MAPK_MEF2A_6	471	480	PF00069	0.519
DOC_MAPK_MEF2A_6	93	101	PF00069	0.511
DOC_MAPK_RevD_3	187	201	PF00069	0.520
DOC_PP2B_LxvP_1	304	307	PF13499	0.441
DOC_PP2B_LxvP_1	574	577	PF13499	0.532
DOC_PP4_FxxP_1	219	222	PF00568	0.522
DOC_PP4_FxxP_1	315	318	PF00568	0.451
DOC_USP7_MATH_1	179	183	PF00917	0.531
DOC_USP7_MATH_1	307	311	PF00917	0.418
DOC_USP7_MATH_1	331	335	PF00917	0.557
DOC_USP7_MATH_1	439	443	PF00917	0.510
DOC_USP7_MATH_1	567	571	PF00917	0.689
DOC_USP7_MATH_1	616	620	PF00917	0.601
DOC_USP7_MATH_1	631	635	PF00917	0.737
DOC_USP7_MATH_1	7	11	PF00917	0.607
DOC_USP7_MATH_1	732	736	PF00917	0.681
DOC_USP7_MATH_1	767	771	PF00917	0.614
DOC_USP7_UBL2_3	554	558	PF12436	0.566
DOC_WW_Pin1_4	18	23	PF00397	0.601
DOC_WW_Pin1_4	539	544	PF00397	0.732
DOC_WW_Pin1_4	545	550	PF00397	0.701
DOC_WW_Pin1_4	57	62	PF00397	0.522
DOC_WW_Pin1_4	612	617	PF00397	0.553
DOC_WW_Pin1_4	641	646	PF00397	0.671
DOC_WW_Pin1_4	698	703	PF00397	0.696
DOC_WW_Pin1_4	712	717	PF00397	0.736
DOC_WW_Pin1_4	85	90	PF00397	0.513
LIG_14-3-3_CanoR_1	121	129	PF00244	0.484
LIG_14-3-3_CanoR_1	17	22	PF00244	0.603
LIG_14-3-3_CanoR_1	211	216	PF00244	0.522
LIG_14-3-3_CanoR_1	26	33	PF00244	0.432
LIG_14-3-3_CanoR_1	309	318	PF00244	0.434
LIG_14-3-3_CanoR_1	461	469	PF00244	0.578
LIG_14-3-3_CanoR_1	750	756	PF00244	0.690
LIG_APCC_ABBAyCdc20_2	268	274	PF00400	0.522
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BIR_III_4	368	372	PF00653	0.575
LIG_BIR_III_4	401	405	PF00653	0.392
LIG_BRCT_BRCA1_1	237	241	PF00533	0.522
LIG_BRCT_BRCA1_1	311	315	PF00533	0.419
LIG_BRCT_BRCA1_1	433	437	PF00533	0.462
LIG_CSL_BTD_1	764	767	PF09270	0.633
LIG_eIF4E_1	250	256	PF01652	0.522
LIG_FHA_1	122	128	PF00498	0.589
LIG_FHA_1	192	198	PF00498	0.498
LIG_FHA_1	301	307	PF00498	0.445
LIG_FHA_1	358	364	PF00498	0.430
LIG_FHA_1	739	745	PF00498	0.739
LIG_FHA_1	752	758	PF00498	0.564
LIG_FHA_2	10	16	PF00498	0.592
LIG_FHA_2	386	392	PF00498	0.607
LIG_FHA_2	419	425	PF00498	0.563
LIG_FHA_2	720	726	PF00498	0.668
LIG_GBD_Chelix_1	454	462	PF00786	0.384
LIG_Integrin_RGD_1	385	387	PF01839	0.630
LIG_LIR_Apic_2	111	117	PF02991	0.511
LIG_LIR_Apic_2	312	318	PF02991	0.436
LIG_LIR_Apic_2	345	350	PF02991	0.433
LIG_LIR_Gen_1	157	167	PF02991	0.522
LIG_LIR_Gen_1	42	53	PF02991	0.522
LIG_LIR_Gen_1	457	465	PF02991	0.462
LIG_LIR_Gen_1	521	529	PF02991	0.594
LIG_LIR_Gen_1	60	70	PF02991	0.522
LIG_LIR_Gen_1	622	632	PF02991	0.614
LIG_LIR_Nem_3	157	163	PF02991	0.480
LIG_LIR_Nem_3	42	48	PF02991	0.522
LIG_LIR_Nem_3	457	462	PF02991	0.447
LIG_LIR_Nem_3	521	525	PF02991	0.575
LIG_LIR_Nem_3	60	65	PF02991	0.522
LIG_LIR_Nem_3	622	627	PF02991	0.601
LIG_LIR_Nem_3	69	73	PF02991	0.522
LIG_PCNA_PIPBox_1	720	729	PF02747	0.665
LIG_SH2_NCK_1	45	49	PF00017	0.522
LIG_SH2_PTP2	160	163	PF00017	0.522
LIG_SH2_SRC	160	163	PF00017	0.492
LIG_SH2_STAP1	277	281	PF00017	0.522
LIG_SH2_STAP1	465	469	PF00017	0.573
LIG_SH2_STAT3	498	501	PF00017	0.576
LIG_SH2_STAT5	114	117	PF00017	0.553
LIG_SH2_STAT5	160	163	PF00017	0.522
LIG_SH2_STAT5	483	486	PF00017	0.522
LIG_SH3_1	114	120	PF00018	0.511
LIG_SH3_2	549	554	PF14604	0.571
LIG_SH3_3	114	120	PF00018	0.511
LIG_SH3_3	186	192	PF00018	0.522
LIG_SH3_3	21	27	PF00018	0.510
LIG_SH3_3	419	425	PF00018	0.499
LIG_SH3_3	499	505	PF00018	0.532
LIG_SH3_3	537	543	PF00018	0.676
LIG_SH3_3	546	552	PF00018	0.589
LIG_SH3_3	557	563	PF00018	0.782
LIG_SH3_3	70	76	PF00018	0.522
LIG_SH3_3	761	767	PF00018	0.712
LIG_SH3_4	298	305	PF00018	0.454
LIG_SH3_4	554	561	PF00018	0.562
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.509
LIG_SUMO_SIM_anti_2	583	588	PF11976	0.518
LIG_SUMO_SIM_par_1	302	308	PF11976	0.446
LIG_SUMO_SIM_par_1	580	585	PF11976	0.447
LIG_SUMO_SIM_par_1	665	672	PF11976	0.675
LIG_TRAF2_1	167	170	PF00917	0.414
LIG_TRFH_1	85	89	PF08558	0.431
MOD_CDC14_SPxK_1	615	618	PF00782	0.539
MOD_CDC14_SPxK_1	644	647	PF00782	0.674
MOD_CDK_SPK_2	18	23	PF00069	0.585
MOD_CDK_SPK_2	641	646	PF00069	0.671
MOD_CDK_SPxK_1	612	618	PF00069	0.549
MOD_CDK_SPxK_1	641	647	PF00069	0.672
MOD_CDK_SPxxK_3	641	648	PF00069	0.674
MOD_CDK_SPxxK_3	698	705	PF00069	0.688
MOD_CK1_1	442	448	PF00069	0.530
MOD_CK1_1	625	631	PF00069	0.581
MOD_CK1_1	634	640	PF00069	0.690
MOD_CK1_1	743	749	PF00069	0.680
MOD_CK1_1	770	776	PF00069	0.623
MOD_CK2_1	460	466	PF00069	0.577
MOD_CK2_1	734	740	PF00069	0.772
MOD_CK2_1	770	776	PF00069	0.667
MOD_CK2_1	85	91	PF00069	0.371
MOD_Cter_Amidation	695	698	PF01082	0.676
MOD_DYRK1A_RPxSP_1	539	543	PF00069	0.672
MOD_DYRK1A_RPxSP_1	698	702	PF00069	0.673
MOD_GlcNHglycan	208	211	PF01048	0.343
MOD_GlcNHglycan	278	282	PF01048	0.387
MOD_GlcNHglycan	28	31	PF01048	0.578
MOD_GlcNHglycan	293	296	PF01048	0.459
MOD_GlcNHglycan	308	312	PF01048	0.442
MOD_GlcNHglycan	319	322	PF01048	0.473
MOD_GlcNHglycan	333	336	PF01048	0.344
MOD_GlcNHglycan	380	383	PF01048	0.592
MOD_GlcNHglycan	444	447	PF01048	0.439
MOD_GlcNHglycan	570	573	PF01048	0.756
MOD_GlcNHglycan	611	615	PF01048	0.708
MOD_GlcNHglycan	624	627	PF01048	0.578
MOD_GlcNHglycan	633	636	PF01048	0.688
MOD_GlcNHglycan	650	653	PF01048	0.634
MOD_GlcNHglycan	707	710	PF01048	0.653
MOD_GlcNHglycan	734	737	PF01048	0.689
MOD_GlcNHglycan	778	781	PF01048	0.538
MOD_GSK3_1	121	128	PF00069	0.387
MOD_GSK3_1	206	213	PF00069	0.343
MOD_GSK3_1	460	467	PF00069	0.578
MOD_GSK3_1	541	548	PF00069	0.697
MOD_GSK3_1	550	557	PF00069	0.650
MOD_GSK3_1	563	570	PF00069	0.665
MOD_GSK3_1	612	619	PF00069	0.748
MOD_GSK3_1	696	703	PF00069	0.650
MOD_GSK3_1	728	735	PF00069	0.744
MOD_GSK3_1	772	779	PF00069	0.695
MOD_GSK3_1	99	106	PF00069	0.431
MOD_N-GLC_1	677	682	PF02516	0.682
MOD_NEK2_1	235	240	PF00069	0.489
MOD_NEK2_1	431	436	PF00069	0.400
MOD_OFUCOSY	355	361	PF10250	0.358
MOD_PIKK_1	700	706	PF00454	0.579
MOD_PKA_1	750	756	PF00069	0.515
MOD_PKA_2	210	216	PF00069	0.387
MOD_PKA_2	460	466	PF00069	0.544
MOD_PKA_2	728	734	PF00069	0.666
MOD_PKA_2	750	756	PF00069	0.646
MOD_PKB_1	646	654	PF00069	0.723
MOD_Plk_1	582	588	PF00069	0.403
MOD_Plk_2-3	677	683	PF00069	0.738
MOD_Plk_4	300	306	PF00069	0.447
MOD_Plk_4	582	588	PF00069	0.442
MOD_Plk_4	66	72	PF00069	0.365
MOD_ProDKin_1	18	24	PF00069	0.598
MOD_ProDKin_1	539	545	PF00069	0.733
MOD_ProDKin_1	57	63	PF00069	0.387
MOD_ProDKin_1	612	618	PF00069	0.549
MOD_ProDKin_1	641	647	PF00069	0.672
MOD_ProDKin_1	698	704	PF00069	0.698
MOD_ProDKin_1	712	718	PF00069	0.734
MOD_ProDKin_1	85	91	PF00069	0.375
MOD_SUMO_rev_2	381	390	PF00179	0.637
MOD_SUMO_rev_2	692	699	PF00179	0.705
MOD_SUMO_rev_2	95	102	PF00179	0.266
TRG_DiLeu_BaEn_1	252	257	PF01217	0.489
TRG_DiLeu_BaEn_1	472	477	PF01217	0.523
TRG_DiLeu_BaEn_1	521	526	PF01217	0.456
TRG_DiLeu_BaEn_3	758	764	PF01217	0.538
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.387
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.405
TRG_ENDOCYTIC_2	160	163	PF00928	0.387
TRG_ENDOCYTIC_2	272	275	PF00928	0.387
TRG_ENDOCYTIC_2	45	48	PF00928	0.387
TRG_ER_diArg_1	267	270	PF00400	0.396
TRG_ER_diArg_1	412	415	PF00400	0.419
TRG_ER_diArg_1	538	540	PF00400	0.680
TRG_ER_diArg_1	589	592	PF00400	0.521
TRG_ER_diArg_1	645	648	PF00400	0.722
TRG_ER_diArg_1	749	751	PF00400	0.642
TRG_ER_diArg_1	82	84	PF00400	0.392
TRG_ER_diArg_1	92	94	PF00400	0.363
TRG_NES_CRM1_1	583	595	PF08389	0.365
TRG_NLS_MonoExtC_3	645	650	PF00514	0.713
TRG_NLS_MonoExtN_4	645	651	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	52%	99%
A0A3S5H795	Leishmania donovani	93%	100%
A4HBQ9	Leishmania braziliensis	80%	100%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AV29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QCF3	Leishmania major	92%	100%
Q8H2D5	Arabidopsis thaliana	27%	100%