LeishMANIAdb
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Putative RNA helicase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative RNA helicase
Gene product:
RNA helicase - putative
Species:
Leishmania infantum
UniProt:
A4HZ60_LEIIN
TriTrypDb:
LINF_210011700
Length:
697

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA helicase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZ60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ60

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003676 nucleic acid binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004386 helicase activity 2 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 261 265 PF00656 0.735
CLV_C14_Caspase3-7 331 335 PF00656 0.555
CLV_C14_Caspase3-7 7 11 PF00656 0.620
CLV_MEL_PAP_1 307 313 PF00089 0.391
CLV_NRD_NRD_1 16 18 PF00675 0.686
CLV_NRD_NRD_1 165 167 PF00675 0.169
CLV_NRD_NRD_1 243 245 PF00675 0.722
CLV_NRD_NRD_1 316 318 PF00675 0.385
CLV_NRD_NRD_1 325 327 PF00675 0.398
CLV_NRD_NRD_1 52 54 PF00675 0.514
CLV_PCSK_FUR_1 14 18 PF00082 0.637
CLV_PCSK_KEX2_1 16 18 PF00082 0.705
CLV_PCSK_KEX2_1 165 167 PF00082 0.285
CLV_PCSK_KEX2_1 238 240 PF00082 0.642
CLV_PCSK_KEX2_1 316 318 PF00082 0.385
CLV_PCSK_PC1ET2_1 238 240 PF00082 0.642
CLV_PCSK_SKI1_1 101 105 PF00082 0.253
CLV_PCSK_SKI1_1 130 134 PF00082 0.350
CLV_PCSK_SKI1_1 165 169 PF00082 0.236
CLV_PCSK_SKI1_1 17 21 PF00082 0.650
CLV_PCSK_SKI1_1 316 320 PF00082 0.396
CLV_PCSK_SKI1_1 401 405 PF00082 0.477
CLV_PCSK_SKI1_1 420 424 PF00082 0.441
CLV_PCSK_SKI1_1 484 488 PF00082 0.313
CLV_PCSK_SKI1_1 535 539 PF00082 0.355
CLV_PCSK_SKI1_1 558 562 PF00082 0.378
CLV_PCSK_SKI1_1 656 660 PF00082 0.593
CLV_PCSK_SKI1_1 71 75 PF00082 0.522
CLV_PCSK_SKI1_1 90 94 PF00082 0.405
DEG_APCC_DBOX_1 164 172 PF00400 0.400
DEG_SPOP_SBC_1 442 446 PF00917 0.708
DOC_CYCLIN_RxL_1 127 135 PF00134 0.519
DOC_CYCLIN_RxL_1 515 526 PF00134 0.453
DOC_CYCLIN_RxL_1 653 661 PF00134 0.531
DOC_CYCLIN_yClb1_LxF_4 319 325 PF00134 0.394
DOC_CYCLIN_yClb5_NLxxxL_5 646 655 PF00134 0.439
DOC_CYCLIN_yCln2_LP_2 651 657 PF00134 0.448
DOC_MAPK_gen_1 16 27 PF00069 0.570
DOC_MAPK_gen_1 316 324 PF00069 0.418
DOC_MAPK_gen_1 552 562 PF00069 0.564
DOC_MAPK_gen_1 632 640 PF00069 0.601
DOC_MAPK_MEF2A_6 174 182 PF00069 0.466
DOC_MAPK_MEF2A_6 632 640 PF00069 0.590
DOC_PP1_RVXF_1 410 417 PF00149 0.335
DOC_PP1_RVXF_1 46 52 PF00149 0.535
DOC_PP1_RVXF_1 516 523 PF00149 0.453
DOC_PP2B_LxvP_1 531 534 PF13499 0.453
DOC_PP4_FxxP_1 675 678 PF00568 0.370
DOC_USP7_MATH_1 265 269 PF00917 0.755
DOC_USP7_MATH_1 328 332 PF00917 0.397
DOC_USP7_MATH_1 468 472 PF00917 0.728
DOC_USP7_MATH_1 537 541 PF00917 0.538
DOC_USP7_MATH_1 593 597 PF00917 0.586
DOC_USP7_MATH_1 613 617 PF00917 0.703
DOC_USP7_MATH_1 619 623 PF00917 0.485
DOC_USP7_UBL2_3 319 323 PF12436 0.436
DOC_USP7_UBL2_3 452 456 PF12436 0.734
DOC_USP7_UBL2_3 457 461 PF12436 0.647
DOC_USP7_UBL2_3 635 639 PF12436 0.605
DOC_USP7_UBL2_3 656 660 PF12436 0.430
DOC_USP7_UBL2_3 81 85 PF12436 0.390
DOC_WW_Pin1_4 288 293 PF00397 0.503
DOC_WW_Pin1_4 445 450 PF00397 0.706
LIG_14-3-3_CanoR_1 239 246 PF00244 0.756
LIG_14-3-3_CanoR_1 310 318 PF00244 0.525
LIG_14-3-3_CanoR_1 395 403 PF00244 0.417
LIG_14-3-3_CanoR_1 484 493 PF00244 0.535
LIG_14-3-3_CanoR_1 546 556 PF00244 0.470
LIG_14-3-3_CanoR_1 66 71 PF00244 0.476
LIG_14-3-3_CanoR_1 676 685 PF00244 0.506
LIG_Actin_WH2_2 164 181 PF00022 0.521
LIG_Actin_WH2_2 192 207 PF00022 0.416
LIG_Actin_WH2_2 307 325 PF00022 0.441
LIG_Actin_WH2_2 644 662 PF00022 0.418
LIG_APCC_ABBA_1 379 384 PF00400 0.452
LIG_BIR_II_1 1 5 PF00653 0.698
LIG_BRCT_BRCA1_1 539 543 PF00533 0.550
LIG_EH_1 628 632 PF12763 0.441
LIG_FHA_1 162 168 PF00498 0.453
LIG_FHA_1 175 181 PF00498 0.453
LIG_FHA_1 20 26 PF00498 0.564
LIG_FHA_1 387 393 PF00498 0.455
LIG_FHA_1 548 554 PF00498 0.519
LIG_FHA_1 576 582 PF00498 0.550
LIG_FHA_1 77 83 PF00498 0.457
LIG_FHA_2 219 225 PF00498 0.569
LIG_FHA_2 33 39 PF00498 0.532
LIG_FHA_2 421 427 PF00498 0.512
LIG_FHA_2 521 527 PF00498 0.550
LIG_FHA_2 647 653 PF00498 0.437
LIG_FHA_2 691 697 PF00498 0.540
LIG_GBD_Chelix_1 196 204 PF00786 0.240
LIG_Integrin_isoDGR_2 105 107 PF01839 0.350
LIG_Integrin_isoDGR_2 410 412 PF01839 0.488
LIG_LIR_Apic_2 120 126 PF02991 0.453
LIG_LIR_Gen_1 34 45 PF02991 0.414
LIG_LIR_Gen_1 521 530 PF02991 0.478
LIG_LIR_LC3C_4 622 627 PF02991 0.475
LIG_LIR_Nem_3 34 40 PF02991 0.389
LIG_LIR_Nem_3 521 525 PF02991 0.453
LIG_LIR_Nem_3 86 92 PF02991 0.502
LIG_Pex14_2 150 154 PF04695 0.453
LIG_RPA_C_Fungi 48 60 PF08784 0.500
LIG_SH2_CRK 100 104 PF00017 0.296
LIG_SH2_CRK 123 127 PF00017 0.296
LIG_SH2_CRK 369 373 PF00017 0.374
LIG_SH2_CRK 633 637 PF00017 0.549
LIG_SH2_NCK_1 633 637 PF00017 0.549
LIG_SH2_STAT3 172 175 PF00017 0.378
LIG_SH2_STAT3 367 370 PF00017 0.430
LIG_SH2_STAT3 692 695 PF00017 0.538
LIG_SH2_STAT5 345 348 PF00017 0.327
LIG_SH2_STAT5 633 636 PF00017 0.553
LIG_SH2_STAT5 692 695 PF00017 0.517
LIG_SH3_3 550 556 PF00018 0.388
LIG_SH3_3 624 630 PF00018 0.414
LIG_SH3_3 635 641 PF00018 0.507
LIG_SH3_4 635 642 PF00018 0.567
LIG_SUMO_SIM_par_1 370 376 PF11976 0.437
LIG_TRAF2_1 222 225 PF00917 0.645
LIG_TRAF2_1 253 256 PF00917 0.720
LIG_TRAF2_1 693 696 PF00917 0.487
LIG_UBA3_1 321 327 PF00899 0.390
MOD_CDC14_SPxK_1 291 294 PF00782 0.463
MOD_CDK_SPxK_1 288 294 PF00069 0.468
MOD_CDK_SPxxK_3 445 452 PF00069 0.627
MOD_CK1_1 117 123 PF00069 0.296
MOD_CK1_1 2 8 PF00069 0.707
MOD_CK1_1 447 453 PF00069 0.607
MOD_CK1_1 471 477 PF00069 0.608
MOD_CK1_1 69 75 PF00069 0.502
MOD_CK2_1 218 224 PF00069 0.556
MOD_CK2_1 420 426 PF00069 0.513
MOD_CK2_1 49 55 PF00069 0.514
MOD_CK2_1 665 671 PF00069 0.518
MOD_CK2_1 690 696 PF00069 0.552
MOD_Cter_Amidation 235 238 PF01082 0.751
MOD_Cter_Amidation 314 317 PF01082 0.379
MOD_Cter_Amidation 454 457 PF01082 0.732
MOD_GlcNHglycan 10 13 PF01048 0.614
MOD_GlcNHglycan 116 119 PF01048 0.314
MOD_GlcNHglycan 241 244 PF01048 0.750
MOD_GlcNHglycan 311 314 PF01048 0.602
MOD_GlcNHglycan 375 378 PF01048 0.640
MOD_GlcNHglycan 449 452 PF01048 0.759
MOD_GlcNHglycan 461 464 PF01048 0.715
MOD_GlcNHglycan 595 598 PF01048 0.669
MOD_GlcNHglycan 607 610 PF01048 0.663
MOD_GlcNHglycan 641 644 PF01048 0.400
MOD_GSK3_1 110 117 PF00069 0.296
MOD_GSK3_1 428 435 PF00069 0.524
MOD_GSK3_1 437 444 PF00069 0.649
MOD_GSK3_1 470 477 PF00069 0.613
MOD_GSK3_1 520 527 PF00069 0.433
MOD_GSK3_1 69 76 PF00069 0.533
MOD_LATS_1 112 118 PF00433 0.296
MOD_LATS_1 64 70 PF00433 0.494
MOD_N-GLC_1 328 333 PF02516 0.432
MOD_NEK2_1 200 205 PF00069 0.332
MOD_NEK2_1 386 391 PF00069 0.545
MOD_NEK2_1 475 480 PF00069 0.539
MOD_NEK2_1 49 54 PF00069 0.581
MOD_NEK2_1 631 636 PF00069 0.545
MOD_NEK2_1 75 80 PF00069 0.512
MOD_NEK2_1 83 88 PF00069 0.385
MOD_NEK2_2 619 624 PF00069 0.500
MOD_OFUCOSY 385 390 PF10250 0.410
MOD_PIKK_1 485 491 PF00454 0.312
MOD_PK_1 66 72 PF00069 0.463
MOD_PKA_2 309 315 PF00069 0.391
MOD_PKA_2 631 637 PF00069 0.571
MOD_Plk_1 303 309 PF00069 0.394
MOD_Plk_1 404 410 PF00069 0.538
MOD_Plk_4 21 27 PF00069 0.555
MOD_Plk_4 388 394 PF00069 0.504
MOD_Plk_4 477 483 PF00069 0.552
MOD_Plk_4 524 530 PF00069 0.363
MOD_Plk_4 539 545 PF00069 0.231
MOD_ProDKin_1 288 294 PF00069 0.502
MOD_ProDKin_1 445 451 PF00069 0.707
TRG_DiLeu_BaEn_1 129 134 PF01217 0.432
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.411
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.384
TRG_ENDOCYTIC_2 100 103 PF00928 0.296
TRG_ENDOCYTIC_2 368 371 PF00928 0.397
TRG_ER_diArg_1 14 17 PF00400 0.632
TRG_ER_diArg_1 165 167 PF00400 0.178
TRG_ER_diArg_1 316 318 PF00400 0.366
TRG_NLS_MonoCore_2 237 242 PF00514 0.715
TRG_NLS_MonoExtC_3 16 21 PF00514 0.668
TRG_NLS_MonoExtC_3 236 241 PF00514 0.719
TRG_NLS_MonoExtN_4 14 21 PF00514 0.724
TRG_NLS_MonoExtN_4 235 242 PF00514 0.678
TRG_Pf-PMV_PEXEL_1 130 135 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 401 405 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 484 489 PF00026 0.432

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P856 Leptomonas seymouri 65% 100%
A0A0S4J214 Bodo saltans 45% 100%
A0A1X0NXJ9 Trypanosomatidae 48% 100%
A0A3R7MLR3 Trypanosoma rangeli 49% 100%
A0A3S7WWF8 Leishmania donovani 99% 100%
A4HBQ8 Leishmania braziliensis 82% 100%
D0A1I1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AV28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 99%
Q4QCF4 Leishmania major 94% 100%
V5BDT6 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS