Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ59_LEIIN

TriTrypDb:

LINF_210011600

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	27	29	PF00675	0.559
CLV_NRD_NRD_1	4	6	PF00675	0.547
CLV_NRD_NRD_1	68	70	PF00675	0.552
CLV_NRD_NRD_1	95	97	PF00675	0.460
CLV_PCSK_KEX2_1	27	29	PF00082	0.559
CLV_PCSK_KEX2_1	4	6	PF00082	0.574
CLV_PCSK_KEX2_1	67	69	PF00082	0.563
CLV_PCSK_SKI1_1	386	390	PF00082	0.495
CLV_PCSK_SKI1_1	402	406	PF00082	0.402
CLV_PCSK_SKI1_1	422	426	PF00082	0.303
CLV_PCSK_SKI1_1	508	512	PF00082	0.406
CLV_Separin_Metazoa	99	103	PF03568	0.468
DEG_APCC_DBOX_1	26	34	PF00400	0.567
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DEG_SPOP_SBC_1	141	145	PF00917	0.525
DEG_SPOP_SBC_1	49	53	PF00917	0.579
DOC_CKS1_1	493	498	PF01111	0.546
DOC_CKS1_1	527	532	PF01111	0.430
DOC_MAPK_gen_1	177	186	PF00069	0.430
DOC_MAPK_gen_1	96	103	PF00069	0.432
DOC_MAPK_MEF2A_6	395	403	PF00069	0.513
DOC_PP2B_LxvP_1	45	48	PF13499	0.605
DOC_USP7_MATH_1	26	30	PF00917	0.649
DOC_USP7_MATH_1	278	282	PF00917	0.669
DOC_USP7_MATH_1	378	382	PF00917	0.288
DOC_USP7_MATH_1	38	42	PF00917	0.542
DOC_USP7_MATH_1	48	52	PF00917	0.560
DOC_USP7_MATH_1	75	79	PF00917	0.596
DOC_USP7_MATH_1	8	12	PF00917	0.548
DOC_WW_Pin1_4	221	226	PF00397	0.428
DOC_WW_Pin1_4	489	494	PF00397	0.653
DOC_WW_Pin1_4	526	531	PF00397	0.418
DOC_WW_Pin1_4	53	58	PF00397	0.613
LIG_14-3-3_CanoR_1	140	149	PF00244	0.513
LIG_14-3-3_CanoR_1	179	184	PF00244	0.416
LIG_14-3-3_CanoR_1	243	251	PF00244	0.488
LIG_14-3-3_CanoR_1	27	37	PF00244	0.612
LIG_14-3-3_CanoR_1	336	341	PF00244	0.573
LIG_14-3-3_CanoR_1	59	65	PF00244	0.698
LIG_14-3-3_CanoR_1	69	79	PF00244	0.515
LIG_FHA_1	10	16	PF00498	0.560
LIG_FHA_1	154	160	PF00498	0.426
LIG_FHA_1	162	168	PF00498	0.402
LIG_FHA_1	255	261	PF00498	0.529
LIG_FHA_1	32	38	PF00498	0.761
LIG_FHA_1	351	357	PF00498	0.480
LIG_FHA_2	134	140	PF00498	0.635
LIG_FHA_2	164	170	PF00498	0.457
LIG_FHA_2	203	209	PF00498	0.472
LIG_FHA_2	315	321	PF00498	0.536
LIG_FHA_2	337	343	PF00498	0.528
LIG_FHA_2	418	424	PF00498	0.479
LIG_FHA_2	427	433	PF00498	0.395
LIG_Integrin_isoDGR_2	170	172	PF01839	0.550
LIG_LIR_Apic_2	271	277	PF02991	0.424
LIG_LIR_Gen_1	357	365	PF02991	0.506
LIG_LIR_Gen_1	443	454	PF02991	0.363
LIG_LIR_Gen_1	509	519	PF02991	0.452
LIG_LIR_Nem_3	151	157	PF02991	0.355
LIG_LIR_Nem_3	215	220	PF02991	0.471
LIG_LIR_Nem_3	222	226	PF02991	0.408
LIG_LIR_Nem_3	228	234	PF02991	0.382
LIG_LIR_Nem_3	357	362	PF02991	0.550
LIG_LIR_Nem_3	443	449	PF02991	0.361
LIG_LIR_Nem_3	509	514	PF02991	0.482
LIG_NRBOX	384	390	PF00104	0.438
LIG_PAM2_1	140	152	PF00658	0.495
LIG_Pex14_1	227	231	PF04695	0.412
LIG_Pex14_1	340	344	PF04695	0.518
LIG_SH2_CRK	231	235	PF00017	0.471
LIG_SH2_PTP2	359	362	PF00017	0.507
LIG_SH2_STAT5	162	165	PF00017	0.359
LIG_SH2_STAT5	18	21	PF00017	0.563
LIG_SH2_STAT5	223	226	PF00017	0.403
LIG_SH2_STAT5	359	362	PF00017	0.536
LIG_SH3_3	487	493	PF00018	0.676
LIG_SH3_3	524	530	PF00018	0.437
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.423
LIG_SUMO_SIM_par_1	163	169	PF11976	0.412
LIG_SUMO_SIM_par_1	246	252	PF11976	0.385
LIG_TRAF2_1	205	208	PF00917	0.442
LIG_TRAF2_1	339	342	PF00917	0.527
LIG_TYR_ITSM	227	234	PF00017	0.478
MOD_CDK_SPK_2	526	531	PF00069	0.361
MOD_CDK_SPxK_1	53	59	PF00069	0.600
MOD_CK1_1	187	193	PF00069	0.313
MOD_CK1_1	22	28	PF00069	0.683
MOD_CK1_1	247	253	PF00069	0.476
MOD_CK1_1	254	260	PF00069	0.451
MOD_CK1_1	281	287	PF00069	0.599
MOD_CK1_1	29	35	PF00069	0.549
MOD_CK1_1	327	333	PF00069	0.460
MOD_CK1_1	379	385	PF00069	0.420
MOD_CK1_1	492	498	PF00069	0.467
MOD_CK1_1	53	59	PF00069	0.626
MOD_CK1_1	71	77	PF00069	0.792
MOD_CK2_1	133	139	PF00069	0.633
MOD_CK2_1	163	169	PF00069	0.436
MOD_CK2_1	202	208	PF00069	0.488
MOD_CK2_1	336	342	PF00069	0.537
MOD_CK2_1	378	384	PF00069	0.474
MOD_CK2_1	417	423	PF00069	0.464
MOD_CK2_1	426	432	PF00069	0.405
MOD_Cter_Amidation	94	97	PF01082	0.464
MOD_GlcNHglycan	231	234	PF01048	0.409
MOD_GlcNHglycan	24	27	PF01048	0.681
MOD_GlcNHglycan	253	256	PF01048	0.466
MOD_GlcNHglycan	279	283	PF01048	0.649
MOD_GlcNHglycan	287	290	PF01048	0.579
MOD_GlcNHglycan	295	299	PF01048	0.349
MOD_GlcNHglycan	326	329	PF01048	0.511
MOD_GlcNHglycan	381	384	PF01048	0.436
MOD_GlcNHglycan	462	465	PF01048	0.565
MOD_GlcNHglycan	73	76	PF01048	0.630
MOD_GlcNHglycan	79	82	PF01048	0.632
MOD_GSK3_1	128	135	PF00069	0.606
MOD_GSK3_1	184	191	PF00069	0.315
MOD_GSK3_1	22	29	PF00069	0.702
MOD_GSK3_1	221	228	PF00069	0.487
MOD_GSK3_1	229	236	PF00069	0.405
MOD_GSK3_1	243	250	PF00069	0.468
MOD_GSK3_1	262	269	PF00069	0.291
MOD_GSK3_1	281	288	PF00069	0.639
MOD_GSK3_1	33	40	PF00069	0.662
MOD_GSK3_1	488	495	PF00069	0.623
MOD_GSK3_1	49	56	PF00069	0.570
MOD_GSK3_1	69	76	PF00069	0.588
MOD_NEK2_1	128	133	PF00069	0.531
MOD_NEK2_1	163	168	PF00069	0.469
MOD_NEK2_1	249	254	PF00069	0.382
MOD_NEK2_1	350	355	PF00069	0.454
MOD_NEK2_2	397	402	PF00069	0.424
MOD_NEK2_2	417	422	PF00069	0.288
MOD_PIKK_1	194	200	PF00454	0.418
MOD_PIKK_1	281	287	PF00454	0.646
MOD_PK_1	179	185	PF00069	0.414
MOD_PKA_1	68	74	PF00069	0.549
MOD_PKA_2	229	235	PF00069	0.405
MOD_PKA_2	26	32	PF00069	0.567
MOD_PKA_2	335	341	PF00069	0.579
MOD_PKA_2	350	356	PF00069	0.355
MOD_PKA_2	68	74	PF00069	0.592
MOD_PKB_1	67	75	PF00069	0.588
MOD_Plk_1	468	474	PF00069	0.660
MOD_Plk_1	57	63	PF00069	0.616
MOD_Plk_2-3	202	208	PF00069	0.488
MOD_Plk_4	163	169	PF00069	0.556
MOD_Plk_4	179	185	PF00069	0.462
MOD_Plk_4	244	250	PF00069	0.574
MOD_Plk_4	426	432	PF00069	0.586
MOD_ProDKin_1	221	227	PF00069	0.425
MOD_ProDKin_1	489	495	PF00069	0.640
MOD_ProDKin_1	526	532	PF00069	0.431
MOD_ProDKin_1	53	59	PF00069	0.618
TRG_DiLeu_BaEn_1	384	389	PF01217	0.475
TRG_DiLeu_BaEn_1	99	104	PF01217	0.464
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.501
TRG_DiLeu_LyEn_5	99	104	PF01217	0.464
TRG_ENDOCYTIC_2	162	165	PF00928	0.387
TRG_ENDOCYTIC_2	223	226	PF00928	0.485
TRG_ENDOCYTIC_2	231	234	PF00928	0.463
TRG_ENDOCYTIC_2	242	245	PF00928	0.357
TRG_ENDOCYTIC_2	359	362	PF00928	0.539
TRG_ER_diArg_1	3	5	PF00400	0.576
TRG_ER_diArg_1	360	363	PF00400	0.524
TRG_ER_diArg_1	67	69	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM65	Leptomonas seymouri	37%	88%
A0A3S7WWF0	Leishmania donovani	100%	100%
A4HBQ7	Leishmania braziliensis	75%	100%
E9AV27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCF5	Leishmania major	93%	100%