Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ58_LEIIN

TriTrypDb:

LINF_210011500

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.594
CLV_C14_Caspase3-7	72	76	PF00656	0.579
CLV_NRD_NRD_1	261	263	PF00675	0.585
CLV_NRD_NRD_1	303	305	PF00675	0.619
CLV_NRD_NRD_1	368	370	PF00675	0.605
CLV_NRD_NRD_1	385	387	PF00675	0.577
CLV_NRD_NRD_1	60	62	PF00675	0.542
CLV_PCSK_KEX2_1	263	265	PF00082	0.591
CLV_PCSK_KEX2_1	303	305	PF00082	0.619
CLV_PCSK_KEX2_1	370	372	PF00082	0.599
CLV_PCSK_KEX2_1	385	387	PF00082	0.586
CLV_PCSK_KEX2_1	60	62	PF00082	0.542
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.561
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.591
CLV_PCSK_SKI1_1	279	283	PF00082	0.648
DEG_SCF_TRCP1_1	75	80	PF00400	0.612
DEG_SPOP_SBC_1	47	51	PF00917	0.643
DOC_CKS1_1	71	76	PF01111	0.563
DOC_MAPK_gen_1	262	271	PF00069	0.631
DOC_PP2B_LxvP_1	239	242	PF13499	0.470
DOC_PP2B_LxvP_1	310	313	PF13499	0.655
DOC_PP2B_LxvP_1	87	90	PF13499	0.529
DOC_PP2B_PxIxI_1	89	95	PF00149	0.522
DOC_USP7_MATH_1	176	180	PF00917	0.697
DOC_USP7_MATH_1	20	24	PF00917	0.554
DOC_USP7_MATH_1	208	212	PF00917	0.641
DOC_USP7_MATH_1	320	324	PF00917	0.675
DOC_USP7_MATH_1	355	359	PF00917	0.636
DOC_USP7_MATH_1	47	51	PF00917	0.650
DOC_WW_Pin1_4	181	186	PF00397	0.631
DOC_WW_Pin1_4	204	209	PF00397	0.509
DOC_WW_Pin1_4	70	75	PF00397	0.560
DOC_WW_Pin1_4	99	104	PF00397	0.672
LIG_14-3-3_CanoR_1	225	230	PF00244	0.425
LIG_14-3-3_CanoR_1	262	271	PF00244	0.634
LIG_14-3-3_CanoR_1	303	313	PF00244	0.722
LIG_14-3-3_CanoR_1	356	363	PF00244	0.560
LIG_14-3-3_CanoR_1	4	12	PF00244	0.599
LIG_APCC_ABBA_1	337	342	PF00400	0.561
LIG_FHA_1	121	127	PF00498	0.668
LIG_FHA_1	181	187	PF00498	0.579
LIG_FHA_1	188	194	PF00498	0.462
LIG_FHA_1	26	32	PF00498	0.670
LIG_FHA_1	294	300	PF00498	0.560
LIG_FHA_1	305	311	PF00498	0.712
LIG_FHA_2	232	238	PF00498	0.456
LIG_FHA_2	52	58	PF00498	0.578
LIG_LIR_Apic_2	65	70	PF02991	0.592
LIG_LIR_Gen_1	223	233	PF02991	0.482
LIG_LIR_Nem_3	223	229	PF02991	0.477
LIG_LIR_Nem_3	247	252	PF02991	0.552
LIG_LIR_Nem_3	375	381	PF02991	0.697
LIG_LIR_Nem_3	62	67	PF02991	0.637
LIG_LYPXL_yS_3	249	252	PF13949	0.538
LIG_NRP_CendR_1	385	388	PF00754	0.650
LIG_PCNA_yPIPBox_3	156	167	PF02747	0.607
LIG_PTB_Apo_2	52	59	PF02174	0.615
LIG_PTB_Phospho_1	52	58	PF10480	0.616
LIG_SH2_NCK_1	15	19	PF00017	0.610
LIG_SH2_SRC	221	224	PF00017	0.393
LIG_SH2_STAP1	218	222	PF00017	0.513
LIG_SH2_STAP1	226	230	PF00017	0.442
LIG_SH2_STAT5	340	343	PF00017	0.725
LIG_SH2_STAT5	380	383	PF00017	0.652
LIG_SH3_1	202	208	PF00018	0.541
LIG_SH3_3	122	128	PF00018	0.684
LIG_SH3_3	179	185	PF00018	0.623
LIG_SH3_3	202	208	PF00018	0.508
LIG_SH3_3	235	241	PF00018	0.452
LIG_SH3_3	247	253	PF00018	0.535
LIG_SH3_3	26	32	PF00018	0.585
LIG_SH3_3	314	320	PF00018	0.665
LIG_SH3_3	68	74	PF00018	0.611
LIG_SUMO_SIM_par_1	242	247	PF11976	0.527
LIG_SUMO_SIM_par_1	90	95	PF11976	0.522
LIG_TRAF2_1	283	286	PF00917	0.557
LIG_TYR_ITSM	245	252	PF00017	0.537
LIG_WRC_WIRS_1	226	231	PF05994	0.478
MOD_CDK_SPK_2	99	104	PF00069	0.556
MOD_CK1_1	102	108	PF00069	0.686
MOD_CK1_1	111	117	PF00069	0.645
MOD_CK1_1	120	126	PF00069	0.551
MOD_CK1_1	207	213	PF00069	0.496
MOD_CK1_1	228	234	PF00069	0.498
MOD_CK1_1	321	327	PF00069	0.679
MOD_CK1_1	329	335	PF00069	0.569
MOD_CK1_1	8	14	PF00069	0.628
MOD_CK2_1	113	119	PF00069	0.776
MOD_Cter_Amidation	383	386	PF01082	0.576
MOD_GlcNHglycan	320	323	PF01048	0.684
MOD_GlcNHglycan	350	353	PF01048	0.698
MOD_GlcNHglycan	357	360	PF01048	0.741
MOD_GlcNHglycan	7	10	PF01048	0.754
MOD_GlcNHglycan	75	78	PF01048	0.782
MOD_GlcNHglycan	83	86	PF01048	0.777
MOD_GlcNHglycan	87	90	PF01048	0.539
MOD_GSK3_1	113	120	PF00069	0.761
MOD_GSK3_1	176	183	PF00069	0.570
MOD_GSK3_1	187	194	PF00069	0.513
MOD_GSK3_1	20	27	PF00069	0.656
MOD_GSK3_1	204	211	PF00069	0.510
MOD_GSK3_1	224	231	PF00069	0.364
MOD_GSK3_1	244	251	PF00069	0.625
MOD_GSK3_1	265	272	PF00069	0.573
MOD_GSK3_1	318	325	PF00069	0.684
MOD_GSK3_1	47	54	PF00069	0.664
MOD_GSK3_1	69	76	PF00069	0.663
MOD_GSK3_1	77	84	PF00069	0.732
MOD_N-GLC_1	346	351	PF02516	0.554
MOD_NEK2_1	180	185	PF00069	0.574
MOD_NEK2_1	244	249	PF00069	0.555
MOD_NEK2_1	269	274	PF00069	0.657
MOD_NEK2_1	293	298	PF00069	0.703
MOD_NEK2_2	113	118	PF00069	0.569
MOD_PIKK_1	228	234	PF00454	0.488
MOD_PKA_1	262	268	PF00069	0.638
MOD_PKA_2	117	123	PF00069	0.751
MOD_PKA_2	224	230	PF00069	0.474
MOD_PKA_2	355	361	PF00069	0.689
MOD_Plk_1	20	26	PF00069	0.580
MOD_Plk_1	277	283	PF00069	0.658
MOD_Plk_4	21	27	PF00069	0.654
MOD_Plk_4	225	231	PF00069	0.445
MOD_Plk_4	244	250	PF00069	0.539
MOD_Plk_4	277	283	PF00069	0.625
MOD_ProDKin_1	181	187	PF00069	0.615
MOD_ProDKin_1	204	210	PF00069	0.501
MOD_ProDKin_1	70	76	PF00069	0.562
MOD_ProDKin_1	99	105	PF00069	0.672
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.594
TRG_ENDOCYTIC_2	226	229	PF00928	0.473
TRG_ENDOCYTIC_2	249	252	PF00928	0.538
TRG_ENDOCYTIC_2	378	381	PF00928	0.581
TRG_ER_diArg_1	302	304	PF00400	0.619
TRG_ER_diArg_1	385	388	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I5	Leptomonas seymouri	39%	81%
A0A3S7WWD4	Leishmania donovani	100%	100%
A4HBQ6	Leishmania braziliensis	65%	98%
E9AV26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QCF6	Leishmania major	88%	100%