CID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ57_LEIIN

TriTrypDb:

LINF_210011400

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.522
CLV_NRD_NRD_1	125	127	PF00675	0.551
CLV_NRD_NRD_1	273	275	PF00675	0.540
CLV_NRD_NRD_1	382	384	PF00675	0.555
CLV_NRD_NRD_1	456	458	PF00675	0.555
CLV_PCSK_KEX2_1	120	122	PF00082	0.421
CLV_PCSK_KEX2_1	125	127	PF00082	0.451
CLV_PCSK_KEX2_1	273	275	PF00082	0.540
CLV_PCSK_KEX2_1	458	460	PF00082	0.608
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.608
CLV_PCSK_PC7_1	121	127	PF00082	0.466
CLV_PCSK_SKI1_1	241	245	PF00082	0.532
CLV_PCSK_SKI1_1	274	278	PF00082	0.504
CLV_PCSK_SKI1_1	368	372	PF00082	0.693
CLV_PCSK_SKI1_1	450	454	PF00082	0.617
CLV_Separin_Metazoa	247	251	PF03568	0.560
DEG_APCC_DBOX_1	308	316	PF00400	0.563
DEG_COP1_1	205	213	PF00400	0.486
DEG_Nend_UBRbox_2	1	3	PF02207	0.389
DEG_SCF_FBW7_1	210	216	PF00400	0.529
DEG_SPOP_SBC_1	166	170	PF00917	0.564
DEG_SPOP_SBC_1	178	182	PF00917	0.539
DEG_SPOP_SBC_1	279	283	PF00917	0.592
DEG_SPOP_SBC_1	75	79	PF00917	0.616
DOC_CKS1_1	210	215	PF01111	0.539
DOC_MAPK_MEF2A_6	241	248	PF00069	0.418
DOC_MAPK_NFAT4_5	241	249	PF00069	0.438
DOC_PP1_RVXF_1	424	430	PF00149	0.646
DOC_PP4_FxxP_1	254	257	PF00568	0.582
DOC_PP4_FxxP_1	412	415	PF00568	0.524
DOC_USP7_MATH_1	166	170	PF00917	0.714
DOC_USP7_MATH_1	179	183	PF00917	0.527
DOC_USP7_MATH_1	185	189	PF00917	0.713
DOC_USP7_MATH_1	202	206	PF00917	0.578
DOC_USP7_MATH_1	211	215	PF00917	0.587
DOC_USP7_MATH_1	222	226	PF00917	0.320
DOC_USP7_MATH_1	279	283	PF00917	0.689
DOC_USP7_MATH_1	73	77	PF00917	0.600
DOC_USP7_MATH_1	99	103	PF00917	0.403
DOC_USP7_UBL2_3	142	146	PF12436	0.553
DOC_WW_Pin1_4	183	188	PF00397	0.605
DOC_WW_Pin1_4	200	205	PF00397	0.689
DOC_WW_Pin1_4	209	214	PF00397	0.658
DOC_WW_Pin1_4	280	285	PF00397	0.644
DOC_WW_Pin1_4	356	361	PF00397	0.512
DOC_WW_Pin1_4	71	76	PF00397	0.530
LIG_14-3-3_CanoR_1	221	231	PF00244	0.613
LIG_14-3-3_CanoR_1	259	263	PF00244	0.608
LIG_14-3-3_CanoR_1	47	53	PF00244	0.508
LIG_APCC_ABBAyCdc20_2	241	247	PF00400	0.420
LIG_BRCT_BRCA1_1	250	254	PF00533	0.604
LIG_BRCT_BRCA1_1	260	264	PF00533	0.468
LIG_BRCT_BRCA1_1	358	362	PF00533	0.587
LIG_deltaCOP1_diTrp_1	91	100	PF00928	0.348
LIG_EH1_1	56	64	PF00400	0.329
LIG_FHA_1	132	138	PF00498	0.470
LIG_FHA_1	195	201	PF00498	0.668
LIG_FHA_1	350	356	PF00498	0.561
LIG_FHA_2	136	142	PF00498	0.441
LIG_FHA_2	5	11	PF00498	0.519
LIG_FHA_2	75	81	PF00498	0.602
LIG_LIR_Apic_2	205	211	PF02991	0.491
LIG_LIR_Apic_2	251	257	PF02991	0.517
LIG_LIR_Gen_1	359	370	PF02991	0.561
LIG_LIR_Nem_3	359	365	PF02991	0.554
LIG_LIR_Nem_3	376	381	PF02991	0.558
LIG_LIR_Nem_3	394	400	PF02991	0.599
LIG_LIR_Nem_3	54	60	PF02991	0.338
LIG_LIR_Nem_3	91	95	PF02991	0.379
LIG_NRBOX	311	317	PF00104	0.494
LIG_PDZ_Class_3	459	464	PF00595	0.728
LIG_SH2_CRK	208	212	PF00017	0.575
LIG_SH2_NCK_1	208	212	PF00017	0.484
LIG_SH2_PTP2	357	360	PF00017	0.596
LIG_SH2_STAP1	366	370	PF00017	0.511
LIG_SH2_STAP1	397	401	PF00017	0.610
LIG_SH2_STAT3	366	369	PF00017	0.610
LIG_SH2_STAT5	245	248	PF00017	0.440
LIG_SH2_STAT5	357	360	PF00017	0.528
LIG_SH2_STAT5	397	400	PF00017	0.609
LIG_SH3_3	125	131	PF00018	0.470
LIG_SH3_3	207	213	PF00018	0.642
LIG_UBA3_1	136	142	PF00899	0.385
MOD_CDC14_SPxK_1	283	286	PF00782	0.518
MOD_CDK_SPxK_1	280	286	PF00069	0.492
MOD_CK1_1	160	166	PF00069	0.637
MOD_CK1_1	169	175	PF00069	0.581
MOD_CK1_1	186	192	PF00069	0.707
MOD_CK1_1	209	215	PF00069	0.630
MOD_CK1_1	258	264	PF00069	0.581
MOD_CK1_1	280	286	PF00069	0.616
MOD_CK1_1	349	355	PF00069	0.596
MOD_CK1_1	391	397	PF00069	0.703
MOD_CK1_1	74	80	PF00069	0.596
MOD_CK2_1	135	141	PF00069	0.399
MOD_CK2_1	229	235	PF00069	0.475
MOD_CK2_1	4	10	PF00069	0.431
MOD_CK2_1	74	80	PF00069	0.615
MOD_Cter_Amidation	455	458	PF01082	0.606
MOD_GlcNHglycan	181	184	PF01048	0.609
MOD_GlcNHglycan	204	207	PF01048	0.649
MOD_GlcNHglycan	26	29	PF01048	0.447
MOD_GlcNHglycan	288	291	PF01048	0.642
MOD_GlcNHglycan	330	333	PF01048	0.696
MOD_GlcNHglycan	348	351	PF01048	0.506
MOD_GlcNHglycan	390	393	PF01048	0.677
MOD_GlcNHglycan	71	74	PF01048	0.586
MOD_GSK3_1	131	138	PF00069	0.489
MOD_GSK3_1	153	160	PF00069	0.664
MOD_GSK3_1	161	168	PF00069	0.604
MOD_GSK3_1	179	186	PF00069	0.575
MOD_GSK3_1	187	194	PF00069	0.710
MOD_GSK3_1	200	207	PF00069	0.679
MOD_GSK3_1	209	216	PF00069	0.647
MOD_GSK3_1	229	236	PF00069	0.433
MOD_GSK3_1	274	281	PF00069	0.553
MOD_GSK3_1	346	353	PF00069	0.561
MOD_GSK3_1	356	363	PF00069	0.462
MOD_GSK3_1	373	380	PF00069	0.616
MOD_GSK3_1	391	398	PF00069	0.673
MOD_GSK3_1	442	449	PF00069	0.710
MOD_GSK3_1	63	70	PF00069	0.466
MOD_GSK3_1	71	78	PF00069	0.582
MOD_LATS_1	253	259	PF00433	0.571
MOD_N-GLC_1	160	165	PF02516	0.645
MOD_NEK2_1	223	228	PF00069	0.526
MOD_NEK2_1	248	253	PF00069	0.631
MOD_NEK2_1	278	283	PF00069	0.522
MOD_NEK2_1	396	401	PF00069	0.603
MOD_NEK2_1	63	68	PF00069	0.454
MOD_NEK2_2	99	104	PF00069	0.489
MOD_PIKK_1	248	254	PF00454	0.501
MOD_PIKK_1	442	448	PF00454	0.566
MOD_PKA_1	457	463	PF00069	0.617
MOD_PKA_2	12	18	PF00069	0.630
MOD_PKA_2	223	229	PF00069	0.532
MOD_PKA_2	258	264	PF00069	0.609
MOD_PKA_2	308	314	PF00069	0.674
MOD_PKA_2	373	379	PF00069	0.561
MOD_PKA_2	46	52	PF00069	0.511
MOD_PKB_1	455	463	PF00069	0.614
MOD_Plk_1	274	280	PF00069	0.570
MOD_Plk_1	442	448	PF00069	0.628
MOD_Plk_1	63	69	PF00069	0.455
MOD_Plk_4	350	356	PF00069	0.643
MOD_Plk_4	396	402	PF00069	0.633
MOD_ProDKin_1	183	189	PF00069	0.603
MOD_ProDKin_1	200	206	PF00069	0.686
MOD_ProDKin_1	209	215	PF00069	0.646
MOD_ProDKin_1	280	286	PF00069	0.651
MOD_ProDKin_1	356	362	PF00069	0.505
MOD_ProDKin_1	71	77	PF00069	0.533
MOD_SUMO_for_1	145	148	PF00179	0.591
MOD_SUMO_for_1	402	405	PF00179	0.532
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.481
TRG_ENDOCYTIC_2	245	248	PF00928	0.461
TRG_ER_diArg_1	119	121	PF00400	0.523
TRG_ER_diArg_1	125	127	PF00400	0.552
TRG_ER_diArg_1	272	274	PF00400	0.529
TRG_NES_CRM1_1	310	325	PF08389	0.522
TRG_NLS_MonoExtC_3	456	461	PF00514	0.610
TRG_NLS_MonoExtN_4	455	461	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P858	Leptomonas seymouri	53%	100%
A0A1X0NY71	Trypanosomatidae	28%	100%
A0A3Q8IL02	Leishmania donovani	99%	100%
A0A422NH97	Trypanosoma rangeli	31%	100%
A4HBQ5	Leishmania braziliensis	80%	99%
D0A1I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AV25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QCF7	Leishmania major	94%	100%
V5DEP6	Trypanosoma cruzi	31%	100%