Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ56_LEIIN

TriTrypDb:

LINF_210011300

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.743
CLV_NRD_NRD_1	162	164	PF00675	0.667
CLV_NRD_NRD_1	203	205	PF00675	0.742
CLV_NRD_NRD_1	213	215	PF00675	0.676
CLV_NRD_NRD_1	267	269	PF00675	0.785
CLV_NRD_NRD_1	338	340	PF00675	0.811
CLV_NRD_NRD_1	428	430	PF00675	0.544
CLV_NRD_NRD_1	432	434	PF00675	0.570
CLV_NRD_NRD_1	52	54	PF00675	0.636
CLV_NRD_NRD_1	66	68	PF00675	0.537
CLV_PCSK_FUR_1	433	437	PF00082	0.543
CLV_PCSK_KEX2_1	202	204	PF00082	0.812
CLV_PCSK_KEX2_1	213	215	PF00082	0.653
CLV_PCSK_KEX2_1	267	269	PF00082	0.761
CLV_PCSK_KEX2_1	302	304	PF00082	0.791
CLV_PCSK_KEX2_1	338	340	PF00082	0.716
CLV_PCSK_KEX2_1	402	404	PF00082	0.827
CLV_PCSK_KEX2_1	432	434	PF00082	0.570
CLV_PCSK_KEX2_1	435	437	PF00082	0.553
CLV_PCSK_KEX2_1	52	54	PF00082	0.636
CLV_PCSK_KEX2_1	66	68	PF00082	0.537
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.810
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.791
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.827
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.538
CLV_PCSK_SKI1_1	268	272	PF00082	0.785
CLV_PCSK_SKI1_1	299	303	PF00082	0.815
CLV_PCSK_SKI1_1	365	369	PF00082	0.556
CLV_PCSK_SKI1_1	403	407	PF00082	0.815
CLV_PCSK_SKI1_1	45	49	PF00082	0.510
CLV_PCSK_SKI1_1	92	96	PF00082	0.715
DEG_APCC_DBOX_1	87	95	PF00400	0.599
DEG_Nend_UBRbox_1	1	4	PF02207	0.679
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.549
DOC_MAPK_DCC_7	141	150	PF00069	0.637
DOC_MAPK_gen_1	406	416	PF00069	0.622
DOC_MAPK_MEF2A_6	141	150	PF00069	0.524
DOC_MAPK_MEF2A_6	409	416	PF00069	0.598
DOC_MAPK_RevD_3	148	164	PF00069	0.626
DOC_PP2B_LxvP_1	142	145	PF13499	0.546
DOC_PP2B_LxvP_1	358	361	PF13499	0.661
DOC_PP2B_LxvP_1	383	386	PF13499	0.623
DOC_PP4_FxxP_1	387	390	PF00568	0.670
DOC_USP7_MATH_1	240	244	PF00917	0.736
DOC_USP7_MATH_1	270	274	PF00917	0.743
DOC_USP7_MATH_1	280	284	PF00917	0.767
DOC_USP7_MATH_1	318	322	PF00917	0.699
DOC_USP7_MATH_1	372	376	PF00917	0.489
DOC_USP7_MATH_1	401	405	PF00917	0.720
DOC_USP7_UBL2_3	402	406	PF12436	0.819
DOC_WW_Pin1_4	104	109	PF00397	0.597
DOC_WW_Pin1_4	247	252	PF00397	0.753
DOC_WW_Pin1_4	283	288	PF00397	0.700
DOC_WW_Pin1_4	386	391	PF00397	0.649
DOC_WW_Pin1_4	404	409	PF00397	0.686
LIG_14-3-3_CanoR_1	192	200	PF00244	0.663
LIG_14-3-3_CanoR_1	2	8	PF00244	0.669
LIG_14-3-3_CanoR_1	267	277	PF00244	0.687
LIG_14-3-3_CanoR_1	317	323	PF00244	0.665
LIG_14-3-3_CanoR_1	325	330	PF00244	0.674
LIG_14-3-3_CanoR_1	45	54	PF00244	0.621
LIG_Clathr_ClatBox_1	68	72	PF01394	0.641
LIG_EH1_1	129	137	PF00400	0.408
LIG_eIF4E_1	130	136	PF01652	0.382
LIG_FHA_1	126	132	PF00498	0.478
LIG_FHA_1	154	160	PF00498	0.620
LIG_FHA_1	195	201	PF00498	0.786
LIG_FHA_2	93	99	PF00498	0.683
LIG_LIR_Gen_1	154	162	PF02991	0.526
LIG_LIR_Gen_1	166	175	PF02991	0.546
LIG_LIR_Gen_1	366	376	PF02991	0.505
LIG_LIR_Gen_1	41	50	PF02991	0.501
LIG_LIR_Nem_3	112	117	PF02991	0.524
LIG_LIR_Nem_3	125	130	PF02991	0.362
LIG_LIR_Nem_3	154	160	PF02991	0.518
LIG_LIR_Nem_3	166	171	PF02991	0.545
LIG_LIR_Nem_3	366	371	PF02991	0.513
LIG_LIR_Nem_3	41	46	PF02991	0.507
LIG_LIR_Nem_3	418	422	PF02991	0.527
LIG_MYND_1	177	181	PF01753	0.709
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.711
LIG_SH2_CRK	117	121	PF00017	0.542
LIG_SH2_STAT5	130	133	PF00017	0.585
LIG_SH2_STAT5	43	46	PF00017	0.522
LIG_SH2_STAT5	93	96	PF00017	0.616
LIG_SH3_1	327	333	PF00018	0.616
LIG_SH3_2	177	182	PF14604	0.714
LIG_SH3_2	334	339	PF14604	0.616
LIG_SH3_3	103	109	PF00018	0.594
LIG_SH3_3	133	139	PF00018	0.537
LIG_SH3_3	141	147	PF00018	0.530
LIG_SH3_3	174	180	PF00018	0.671
LIG_SH3_3	274	280	PF00018	0.736
LIG_SH3_3	327	333	PF00018	0.714
LIG_SH3_CIN85_PxpxPR_1	333	338	PF14604	0.615
LIG_SUMO_SIM_par_1	146	152	PF11976	0.629
LIG_TRAF2_1	36	39	PF00917	0.539
LIG_TRAF2_1	423	426	PF00917	0.513
LIG_TYR_ITIM	115	120	PF00017	0.659
LIG_WW_3	160	164	PF00397	0.662
LIG_WW_3	179	183	PF00397	0.469
MOD_CDK_SPK_2	404	409	PF00069	0.686
MOD_CK1_1	107	113	PF00069	0.560
MOD_CK1_1	125	131	PF00069	0.474
MOD_CK1_1	283	289	PF00069	0.790
MOD_CK1_1	321	327	PF00069	0.748
MOD_CK1_1	389	395	PF00069	0.691
MOD_CK1_1	396	402	PF00069	0.805
MOD_CK1_1	404	410	PF00069	0.681
MOD_CK2_1	372	378	PF00069	0.501
MOD_GlcNHglycan	124	127	PF01048	0.470
MOD_GlcNHglycan	20	23	PF01048	0.557
MOD_GlcNHglycan	217	220	PF01048	0.735
MOD_GlcNHglycan	242	245	PF01048	0.781
MOD_GlcNHglycan	257	260	PF01048	0.580
MOD_GlcNHglycan	272	275	PF01048	0.640
MOD_GlcNHglycan	29	32	PF01048	0.562
MOD_GlcNHglycan	299	302	PF01048	0.809
MOD_GlcNHglycan	3	6	PF01048	0.737
MOD_GlcNHglycan	304	308	PF01048	0.756
MOD_GlcNHglycan	395	398	PF01048	0.717
MOD_GlcNHglycan	403	406	PF01048	0.759
MOD_GSK3_1	100	107	PF00069	0.613
MOD_GSK3_1	191	198	PF00069	0.720
MOD_GSK3_1	205	212	PF00069	0.811
MOD_GSK3_1	23	30	PF00069	0.774
MOD_GSK3_1	240	247	PF00069	0.834
MOD_GSK3_1	266	273	PF00069	0.823
MOD_GSK3_1	279	286	PF00069	0.646
MOD_GSK3_1	289	296	PF00069	0.681
MOD_GSK3_1	303	310	PF00069	0.562
MOD_GSK3_1	317	324	PF00069	0.601
MOD_GSK3_1	389	396	PF00069	0.666
MOD_LATS_1	90	96	PF00433	0.709
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	100	105	PF00069	0.591
MOD_NEK2_1	153	158	PF00069	0.606
MOD_NEK2_1	209	214	PF00069	0.816
MOD_NEK2_2	372	377	PF00069	0.492
MOD_PIKK_1	100	106	PF00454	0.585
MOD_PIKK_1	289	295	PF00454	0.828
MOD_PIKK_1	325	331	PF00454	0.813
MOD_PKA_1	213	219	PF00069	0.602
MOD_PKA_2	1	7	PF00069	0.700
MOD_PKA_2	191	197	PF00069	0.694
MOD_PKA_2	213	219	PF00069	0.746
MOD_PKA_2	266	272	PF00069	0.720
MOD_PKA_2	393	399	PF00069	0.696
MOD_PKA_2	428	434	PF00069	0.556
MOD_Plk_1	372	378	PF00069	0.599
MOD_Plk_4	318	324	PF00069	0.653
MOD_ProDKin_1	104	110	PF00069	0.592
MOD_ProDKin_1	247	253	PF00069	0.751
MOD_ProDKin_1	283	289	PF00069	0.700
MOD_ProDKin_1	386	392	PF00069	0.651
MOD_ProDKin_1	404	410	PF00069	0.681
MOD_SUMO_for_1	301	304	PF00179	0.788
TRG_ENDOCYTIC_2	117	120	PF00928	0.651
TRG_ENDOCYTIC_2	168	171	PF00928	0.644
TRG_ENDOCYTIC_2	43	46	PF00928	0.507
TRG_ER_diArg_1	203	205	PF00400	0.665
TRG_ER_diArg_1	223	226	PF00400	0.732
TRG_ER_diArg_1	337	339	PF00400	0.825
TRG_ER_diArg_1	52	54	PF00400	0.532
TRG_ER_diArg_1	65	67	PF00400	0.535
TRG_NLS_MonoExtC_3	428	433	PF00514	0.558
TRG_NLS_MonoExtN_4	201	206	PF00514	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U2	Leptomonas seymouri	44%	100%
A0A3S7WWD6	Leishmania donovani	100%	100%
A4HBQ4	Leishmania braziliensis	76%	100%
E9AV24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCF8	Leishmania major	92%	100%