Dihydrolipoamide acetyltransferaselike protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrolipoamide acetyltransferase precursorlike protein

Species:

Leishmania infantum

UniProt:

A4HZ54_LEIIN

TriTrypDb:

LINF_210011100

Length:

394

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, Dihydrolipoamide acetyltransferaselike E3BP

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	8
GO:0045254	pyruvate dehydrogenase complex	4	8
GO:1902494	catalytic complex	2	8
GO:1990204	oxidoreductase complex	3	8
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HZ54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ54

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	8
GO:0006084	acetyl-CoA metabolic process	5	8
GO:0006085	acetyl-CoA biosynthetic process	6	8
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	7	8
GO:0006090	pyruvate metabolic process	7	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006163	purine nucleotide metabolic process	5	8
GO:0006164	purine nucleotide biosynthetic process	6	8
GO:0006637	acyl-CoA metabolic process	4	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006753	nucleoside phosphate metabolic process	4	8
GO:0006790	sulfur compound metabolic process	3	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009117	nucleotide metabolic process	5	8
GO:0009150	purine ribonucleotide metabolic process	6	8
GO:0009152	purine ribonucleotide biosynthetic process	7	8
GO:0009165	nucleotide biosynthetic process	6	8
GO:0009259	ribonucleotide metabolic process	5	8
GO:0009260	ribonucleotide biosynthetic process	6	8
GO:0009987	cellular process	1	8
GO:0018130	heterocycle biosynthetic process	4	8
GO:0019438	aromatic compound biosynthetic process	4	8
GO:0019637	organophosphate metabolic process	3	8
GO:0019693	ribose phosphate metabolic process	4	8
GO:0019752	carboxylic acid metabolic process	5	8
GO:0032787	monocarboxylic acid metabolic process	6	8
GO:0033865	nucleoside bisphosphate metabolic process	5	8
GO:0033866	nucleoside bisphosphate biosynthetic process	6	8
GO:0033875	ribonucleoside bisphosphate metabolic process	6	8
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	8
GO:0034032	purine nucleoside bisphosphate metabolic process	5	8
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034654	nucleobase-containing compound biosynthetic process	4	8
GO:0035383	thioester metabolic process	3	8
GO:0035384	thioester biosynthetic process	4	8
GO:0043436	oxoacid metabolic process	4	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0044272	sulfur compound biosynthetic process	4	8
GO:0044281	small molecule metabolic process	2	8
GO:0046390	ribose phosphate biosynthetic process	5	8
GO:0046483	heterocycle metabolic process	3	8
GO:0055086	nucleobase-containing small molecule metabolic process	3	8
GO:0071616	acyl-CoA biosynthetic process	5	8
GO:0071704	organic substance metabolic process	2	8
GO:0072521	purine-containing compound metabolic process	4	8
GO:0072522	purine-containing compound biosynthetic process	5	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901137	carbohydrate derivative biosynthetic process	4	8
GO:1901293	nucleoside phosphate biosynthetic process	5	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	3	6
GO:0016407	acetyltransferase activity	5	6
GO:0016417	S-acyltransferase activity	5	6
GO:0016418	S-acetyltransferase activity	6	6
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.581
CLV_PCSK_KEX2_1	3	5	PF00082	0.581
CLV_PCSK_SKI1_1	302	306	PF00082	0.446
CLV_PCSK_SKI1_1	4	8	PF00082	0.643
DEG_APCC_DBOX_1	2	10	PF00400	0.560
DOC_MAPK_gen_1	3	9	PF00069	0.519
DOC_MAPK_gen_1	376	384	PF00069	0.550
DOC_PP1_RVXF_1	2	9	PF00149	0.528
DOC_USP7_MATH_1	240	244	PF00917	0.647
DOC_USP7_MATH_1	248	252	PF00917	0.479
DOC_USP7_MATH_1	254	258	PF00917	0.528
DOC_USP7_MATH_1	349	353	PF00917	0.593
DOC_USP7_MATH_1	92	96	PF00917	0.492
DOC_USP7_UBL2_3	340	344	PF12436	0.637
DOC_USP7_UBL2_3	386	390	PF12436	0.583
DOC_WW_Pin1_4	144	149	PF00397	0.311
DOC_WW_Pin1_4	18	23	PF00397	0.288
DOC_WW_Pin1_4	98	103	PF00397	0.663
LIG_14-3-3_CanoR_1	3	7	PF00244	0.574
LIG_14-3-3_CanoR_1	302	312	PF00244	0.495
LIG_Actin_WH2_2	348	363	PF00022	0.666
LIG_BIR_III_4	230	234	PF00653	0.546
LIG_BRCT_BRCA1_1	168	172	PF00533	0.320
LIG_BRCT_BRCA1_1	42	46	PF00533	0.320
LIG_Clathr_ClatBox_1	9	13	PF01394	0.484
LIG_FHA_1	150	156	PF00498	0.272
LIG_FHA_1	207	213	PF00498	0.324
LIG_FHA_1	24	30	PF00498	0.288
LIG_FHA_1	370	376	PF00498	0.534
LIG_FHA_1	81	87	PF00498	0.272
LIG_FHA_2	152	158	PF00498	0.280
LIG_FHA_2	26	32	PF00498	0.288
LIG_LIR_Gen_1	169	180	PF02991	0.279
LIG_LIR_Gen_1	354	364	PF02991	0.584
LIG_LIR_Gen_1	43	54	PF02991	0.291
LIG_LIR_Nem_3	169	175	PF02991	0.279
LIG_LIR_Nem_3	354	359	PF02991	0.562
LIG_LIR_Nem_3	43	49	PF02991	0.276
LIG_MYND_1	144	148	PF01753	0.311
LIG_MYND_1	18	22	PF01753	0.288
LIG_Pex14_1	8	12	PF04695	0.510
LIG_Pex14_2	12	16	PF04695	0.439
LIG_SH2_CRK	356	360	PF00017	0.591
LIG_SH2_CRK	366	370	PF00017	0.568
LIG_SH2_GRB2like	184	187	PF00017	0.311
LIG_SH2_GRB2like	58	61	PF00017	0.288
LIG_SH2_STAP1	184	188	PF00017	0.311
LIG_SH2_STAP1	58	62	PF00017	0.288
LIG_SH2_STAT5	100	103	PF00017	0.573
LIG_SH2_STAT5	184	187	PF00017	0.311
LIG_SH2_STAT5	192	195	PF00017	0.311
LIG_SH2_STAT5	197	200	PF00017	0.311
LIG_SH2_STAT5	58	61	PF00017	0.288
LIG_SH2_STAT5	66	69	PF00017	0.287
LIG_SH2_STAT5	71	74	PF00017	0.288
LIG_SH3_3	12	18	PF00018	0.364
LIG_SH3_3	138	144	PF00018	0.297
LIG_SH3_3	229	235	PF00018	0.610
LIG_SH3_3	342	348	PF00018	0.510
LIG_SH3_3	356	362	PF00018	0.605
LIG_SH3_4	386	393	PF00018	0.615
LIG_SH3_5	312	316	PF00018	0.547
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.311
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.342
LIG_UBA3_1	378	386	PF00899	0.510
MOD_CK1_1	149	155	PF00069	0.279
MOD_CK1_1	23	29	PF00069	0.288
MOD_CK1_1	257	263	PF00069	0.631
MOD_CK1_1	275	281	PF00069	0.386
MOD_CK1_1	306	312	PF00069	0.596
MOD_CK2_1	151	157	PF00069	0.280
MOD_CK2_1	25	31	PF00069	0.288
MOD_GlcNHglycan	189	192	PF01048	0.436
MOD_GlcNHglycan	202	205	PF01048	0.221
MOD_GlcNHglycan	237	240	PF01048	0.623
MOD_GlcNHglycan	241	245	PF01048	0.570
MOD_GlcNHglycan	250	253	PF01048	0.519
MOD_GlcNHglycan	256	259	PF01048	0.602
MOD_GlcNHglycan	274	277	PF01048	0.266
MOD_GlcNHglycan	287	291	PF01048	0.388
MOD_GlcNHglycan	296	299	PF01048	0.501
MOD_GlcNHglycan	307	311	PF01048	0.414
MOD_GlcNHglycan	351	354	PF01048	0.601
MOD_GlcNHglycan	63	66	PF01048	0.358
MOD_GlcNHglycan	76	79	PF01048	0.345
MOD_GSK3_1	365	372	PF00069	0.565
MOD_N-GLC_1	316	321	PF02516	0.599
MOD_NEK2_1	2	7	PF00069	0.575
MOD_NEK2_1	378	383	PF00069	0.476
MOD_PKA_2	2	8	PF00069	0.575
MOD_Plk_2-3	151	157	PF00069	0.311
MOD_Plk_2-3	25	31	PF00069	0.288
MOD_Plk_4	151	157	PF00069	0.329
MOD_Plk_4	25	31	PF00069	0.288
MOD_ProDKin_1	144	150	PF00069	0.311
MOD_ProDKin_1	18	24	PF00069	0.288
MOD_ProDKin_1	98	104	PF00069	0.668
TRG_ENDOCYTIC_2	356	359	PF00928	0.593
TRG_ENDOCYTIC_2	366	369	PF00928	0.573
TRG_ER_diArg_1	2	4	PF00400	0.585
TRG_ER_diLys_1	390	394	PF00400	0.590
TRG_NLS_MonoExtC_3	158	164	PF00514	0.300
TRG_NLS_MonoExtC_3	32	38	PF00514	0.273
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L7	Leptomonas seymouri	71%	98%
A0A1X0NXH9	Trypanosomatidae	55%	100%
A0A3S7WWI7	Leishmania donovani	100%	100%
A4HBQ2	Leishmania braziliensis	76%	100%
E9AV22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P35489	Acholeplasma laidlawii	25%	72%
Q4QCG0	Leishmania major	95%	100%