LeishMANIAdb
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Dihydrolipoamide acetyltransferaselike protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dihydrolipoamide acetyltransferaselike protein
Gene product:
dihydrolipoamide acetyltransferase precursorlike protein
Species:
Leishmania infantum
UniProt:
A4HZ54_LEIIN
TriTrypDb:
LINF_210011100
Length:
394

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, Dihydrolipoamide acetyltransferaselike E3BP

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 8
GO:0045254 pyruvate dehydrogenase complex 4 8
GO:1902494 catalytic complex 2 8
GO:1990204 oxidoreductase complex 3 8
GO:0005967 mitochondrial pyruvate dehydrogenase complex 3 1
GO:0098798 mitochondrial protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZ54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ54

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 8
GO:0006084 acetyl-CoA metabolic process 5 8
GO:0006085 acetyl-CoA biosynthetic process 6 8
GO:0006086 acetyl-CoA biosynthetic process from pyruvate 7 8
GO:0006090 pyruvate metabolic process 7 8
GO:0006139 nucleobase-containing compound metabolic process 3 8
GO:0006163 purine nucleotide metabolic process 5 8
GO:0006164 purine nucleotide biosynthetic process 6 8
GO:0006637 acyl-CoA metabolic process 4 8
GO:0006725 cellular aromatic compound metabolic process 3 8
GO:0006753 nucleoside phosphate metabolic process 4 8
GO:0006790 sulfur compound metabolic process 3 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009058 biosynthetic process 2 8
GO:0009117 nucleotide metabolic process 5 8
GO:0009150 purine ribonucleotide metabolic process 6 8
GO:0009152 purine ribonucleotide biosynthetic process 7 8
GO:0009165 nucleotide biosynthetic process 6 8
GO:0009259 ribonucleotide metabolic process 5 8
GO:0009260 ribonucleotide biosynthetic process 6 8
GO:0009987 cellular process 1 8
GO:0018130 heterocycle biosynthetic process 4 8
GO:0019438 aromatic compound biosynthetic process 4 8
GO:0019637 organophosphate metabolic process 3 8
GO:0019693 ribose phosphate metabolic process 4 8
GO:0019752 carboxylic acid metabolic process 5 8
GO:0032787 monocarboxylic acid metabolic process 6 8
GO:0033865 nucleoside bisphosphate metabolic process 5 8
GO:0033866 nucleoside bisphosphate biosynthetic process 6 8
GO:0033875 ribonucleoside bisphosphate metabolic process 6 8
GO:0034030 ribonucleoside bisphosphate biosynthetic process 7 8
GO:0034032 purine nucleoside bisphosphate metabolic process 5 8
GO:0034033 purine nucleoside bisphosphate biosynthetic process 6 8
GO:0034641 cellular nitrogen compound metabolic process 3 8
GO:0034654 nucleobase-containing compound biosynthetic process 4 8
GO:0035383 thioester metabolic process 3 8
GO:0035384 thioester biosynthetic process 4 8
GO:0043436 oxoacid metabolic process 4 8
GO:0043603 amide metabolic process 3 8
GO:0043604 amide biosynthetic process 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044271 cellular nitrogen compound biosynthetic process 4 8
GO:0044272 sulfur compound biosynthetic process 4 8
GO:0044281 small molecule metabolic process 2 8
GO:0046390 ribose phosphate biosynthetic process 5 8
GO:0046483 heterocycle metabolic process 3 8
GO:0055086 nucleobase-containing small molecule metabolic process 3 8
GO:0071616 acyl-CoA biosynthetic process 5 8
GO:0071704 organic substance metabolic process 2 8
GO:0072521 purine-containing compound metabolic process 4 8
GO:0072522 purine-containing compound biosynthetic process 5 8
GO:0090407 organophosphate biosynthetic process 4 8
GO:1901135 carbohydrate derivative metabolic process 3 8
GO:1901137 carbohydrate derivative biosynthetic process 4 8
GO:1901293 nucleoside phosphate biosynthetic process 5 8
GO:1901360 organic cyclic compound metabolic process 3 8
GO:1901362 organic cyclic compound biosynthetic process 4 8
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity 3 6
GO:0016407 acetyltransferase activity 5 6
GO:0016417 S-acyltransferase activity 5 6
GO:0016418 S-acetyltransferase activity 6 6
GO:0016740 transferase activity 2 8
GO:0016746 acyltransferase activity 3 6
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 6
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.581
CLV_PCSK_KEX2_1 3 5 PF00082 0.581
CLV_PCSK_SKI1_1 302 306 PF00082 0.446
CLV_PCSK_SKI1_1 4 8 PF00082 0.643
DEG_APCC_DBOX_1 2 10 PF00400 0.560
DOC_MAPK_gen_1 3 9 PF00069 0.519
DOC_MAPK_gen_1 376 384 PF00069 0.550
DOC_PP1_RVXF_1 2 9 PF00149 0.528
DOC_USP7_MATH_1 240 244 PF00917 0.647
DOC_USP7_MATH_1 248 252 PF00917 0.479
DOC_USP7_MATH_1 254 258 PF00917 0.528
DOC_USP7_MATH_1 349 353 PF00917 0.593
DOC_USP7_MATH_1 92 96 PF00917 0.492
DOC_USP7_UBL2_3 340 344 PF12436 0.637
DOC_USP7_UBL2_3 386 390 PF12436 0.583
DOC_WW_Pin1_4 144 149 PF00397 0.311
DOC_WW_Pin1_4 18 23 PF00397 0.288
DOC_WW_Pin1_4 98 103 PF00397 0.663
LIG_14-3-3_CanoR_1 3 7 PF00244 0.574
LIG_14-3-3_CanoR_1 302 312 PF00244 0.495
LIG_Actin_WH2_2 348 363 PF00022 0.666
LIG_BIR_III_4 230 234 PF00653 0.546
LIG_BRCT_BRCA1_1 168 172 PF00533 0.320
LIG_BRCT_BRCA1_1 42 46 PF00533 0.320
LIG_Clathr_ClatBox_1 9 13 PF01394 0.484
LIG_FHA_1 150 156 PF00498 0.272
LIG_FHA_1 207 213 PF00498 0.324
LIG_FHA_1 24 30 PF00498 0.288
LIG_FHA_1 370 376 PF00498 0.534
LIG_FHA_1 81 87 PF00498 0.272
LIG_FHA_2 152 158 PF00498 0.280
LIG_FHA_2 26 32 PF00498 0.288
LIG_LIR_Gen_1 169 180 PF02991 0.279
LIG_LIR_Gen_1 354 364 PF02991 0.584
LIG_LIR_Gen_1 43 54 PF02991 0.291
LIG_LIR_Nem_3 169 175 PF02991 0.279
LIG_LIR_Nem_3 354 359 PF02991 0.562
LIG_LIR_Nem_3 43 49 PF02991 0.276
LIG_MYND_1 144 148 PF01753 0.311
LIG_MYND_1 18 22 PF01753 0.288
LIG_Pex14_1 8 12 PF04695 0.510
LIG_Pex14_2 12 16 PF04695 0.439
LIG_SH2_CRK 356 360 PF00017 0.591
LIG_SH2_CRK 366 370 PF00017 0.568
LIG_SH2_GRB2like 184 187 PF00017 0.311
LIG_SH2_GRB2like 58 61 PF00017 0.288
LIG_SH2_STAP1 184 188 PF00017 0.311
LIG_SH2_STAP1 58 62 PF00017 0.288
LIG_SH2_STAT5 100 103 PF00017 0.573
LIG_SH2_STAT5 184 187 PF00017 0.311
LIG_SH2_STAT5 192 195 PF00017 0.311
LIG_SH2_STAT5 197 200 PF00017 0.311
LIG_SH2_STAT5 58 61 PF00017 0.288
LIG_SH2_STAT5 66 69 PF00017 0.287
LIG_SH2_STAT5 71 74 PF00017 0.288
LIG_SH3_3 12 18 PF00018 0.364
LIG_SH3_3 138 144 PF00018 0.297
LIG_SH3_3 229 235 PF00018 0.610
LIG_SH3_3 342 348 PF00018 0.510
LIG_SH3_3 356 362 PF00018 0.605
LIG_SH3_4 386 393 PF00018 0.615
LIG_SH3_5 312 316 PF00018 0.547
LIG_SUMO_SIM_anti_2 209 215 PF11976 0.311
LIG_SUMO_SIM_anti_2 83 90 PF11976 0.342
LIG_UBA3_1 378 386 PF00899 0.510
MOD_CK1_1 149 155 PF00069 0.279
MOD_CK1_1 23 29 PF00069 0.288
MOD_CK1_1 257 263 PF00069 0.631
MOD_CK1_1 275 281 PF00069 0.386
MOD_CK1_1 306 312 PF00069 0.596
MOD_CK2_1 151 157 PF00069 0.280
MOD_CK2_1 25 31 PF00069 0.288
MOD_GlcNHglycan 189 192 PF01048 0.436
MOD_GlcNHglycan 202 205 PF01048 0.221
MOD_GlcNHglycan 237 240 PF01048 0.623
MOD_GlcNHglycan 241 245 PF01048 0.570
MOD_GlcNHglycan 250 253 PF01048 0.519
MOD_GlcNHglycan 256 259 PF01048 0.602
MOD_GlcNHglycan 274 277 PF01048 0.266
MOD_GlcNHglycan 287 291 PF01048 0.388
MOD_GlcNHglycan 296 299 PF01048 0.501
MOD_GlcNHglycan 307 311 PF01048 0.414
MOD_GlcNHglycan 351 354 PF01048 0.601
MOD_GlcNHglycan 63 66 PF01048 0.358
MOD_GlcNHglycan 76 79 PF01048 0.345
MOD_GSK3_1 365 372 PF00069 0.565
MOD_N-GLC_1 316 321 PF02516 0.599
MOD_NEK2_1 2 7 PF00069 0.575
MOD_NEK2_1 378 383 PF00069 0.476
MOD_PKA_2 2 8 PF00069 0.575
MOD_Plk_2-3 151 157 PF00069 0.311
MOD_Plk_2-3 25 31 PF00069 0.288
MOD_Plk_4 151 157 PF00069 0.329
MOD_Plk_4 25 31 PF00069 0.288
MOD_ProDKin_1 144 150 PF00069 0.311
MOD_ProDKin_1 18 24 PF00069 0.288
MOD_ProDKin_1 98 104 PF00069 0.668
TRG_ENDOCYTIC_2 356 359 PF00928 0.593
TRG_ENDOCYTIC_2 366 369 PF00928 0.573
TRG_ER_diArg_1 2 4 PF00400 0.585
TRG_ER_diLys_1 390 394 PF00400 0.590
TRG_NLS_MonoExtC_3 158 164 PF00514 0.300
TRG_NLS_MonoExtC_3 32 38 PF00514 0.273
TRG_Pf-PMV_PEXEL_1 302 307 PF00026 0.567

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7L7 Leptomonas seymouri 71% 98%
A0A1X0NXH9 Trypanosomatidae 55% 100%
A0A3S7WWI7 Leishmania donovani 100% 100%
A4HBQ2 Leishmania braziliensis 76% 100%
E9AV22 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P35489 Acholeplasma laidlawii 25% 72%
Q4QCG0 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS