LeishMANIAdb
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Putative la RNA binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative la RNA binding protein
Gene product:
la RNA binding protein - putative
Species:
Leishmania infantum
UniProt:
A4HZ53_LEIIN
TriTrypDb:
LINF_210011000
Length:
336

Annotations

Annotations by Jardim et al.

RNA Processing, la RNA binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0005654 nucleoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZ53
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ53

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 1
GO:0008033 tRNA processing 8 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 151 155 PF00656 0.391
CLV_NRD_NRD_1 125 127 PF00675 0.354
CLV_NRD_NRD_1 191 193 PF00675 0.545
CLV_NRD_NRD_1 330 332 PF00675 0.703
CLV_NRD_NRD_1 80 82 PF00675 0.358
CLV_NRD_NRD_1 9 11 PF00675 0.296
CLV_PCSK_KEX2_1 125 127 PF00082 0.354
CLV_PCSK_KEX2_1 193 195 PF00082 0.593
CLV_PCSK_KEX2_1 330 332 PF00082 0.631
CLV_PCSK_KEX2_1 80 82 PF00082 0.357
CLV_PCSK_KEX2_1 9 11 PF00082 0.296
CLV_PCSK_PC1ET2_1 193 195 PF00082 0.593
CLV_PCSK_SKI1_1 23 27 PF00082 0.219
CLV_PCSK_SKI1_1 278 282 PF00082 0.553
CLV_PCSK_SKI1_1 82 86 PF00082 0.529
DOC_CKS1_1 210 215 PF01111 0.604
DOC_MAPK_gen_1 140 149 PF00069 0.356
DOC_MAPK_gen_1 7 14 PF00069 0.287
DOC_MAPK_HePTP_8 137 149 PF00069 0.475
DOC_MAPK_MEF2A_6 140 149 PF00069 0.334
DOC_PP1_RVXF_1 8 15 PF00149 0.419
DOC_USP7_MATH_1 103 107 PF00917 0.398
DOC_USP7_MATH_1 136 140 PF00917 0.524
DOC_USP7_MATH_1 216 220 PF00917 0.407
DOC_USP7_MATH_1 63 67 PF00917 0.469
DOC_WW_Pin1_4 209 214 PF00397 0.549
LIG_14-3-3_CanoR_1 278 283 PF00244 0.428
LIG_14-3-3_CanoR_1 49 54 PF00244 0.430
LIG_APCC_ABBA_1 259 264 PF00400 0.370
LIG_BIR_II_1 1 5 PF00653 0.491
LIG_BIR_III_2 83 87 PF00653 0.489
LIG_FHA_1 102 108 PF00498 0.366
LIG_FHA_1 174 180 PF00498 0.372
LIG_FHA_1 93 99 PF00498 0.352
LIG_FHA_2 151 157 PF00498 0.289
LIG_FHA_2 252 258 PF00498 0.469
LIG_LIR_Apic_2 95 100 PF02991 0.348
LIG_LIR_Gen_1 13 22 PF02991 0.419
LIG_LIR_Gen_1 144 150 PF02991 0.327
LIG_LIR_Gen_1 230 240 PF02991 0.390
LIG_LIR_Gen_1 46 53 PF02991 0.436
LIG_LIR_Nem_3 13 19 PF02991 0.419
LIG_LIR_Nem_3 144 149 PF02991 0.321
LIG_LIR_Nem_3 230 235 PF02991 0.381
LIG_LIR_Nem_3 36 41 PF02991 0.419
LIG_LIR_Nem_3 46 50 PF02991 0.419
LIG_PCNA_yPIPBox_3 117 126 PF02747 0.186
LIG_Pex14_1 124 128 PF04695 0.356
LIG_SH2_CRK 165 169 PF00017 0.507
LIG_SH2_PTP2 97 100 PF00017 0.358
LIG_SH2_SRC 178 181 PF00017 0.535
LIG_SH2_STAT5 127 130 PF00017 0.415
LIG_SH2_STAT5 15 18 PF00017 0.419
LIG_SH2_STAT5 178 181 PF00017 0.375
LIG_SH2_STAT5 249 252 PF00017 0.360
LIG_SH2_STAT5 97 100 PF00017 0.358
LIG_SH3_3 156 162 PF00018 0.487
LIG_SH3_3 207 213 PF00018 0.565
LIG_SH3_3 247 253 PF00018 0.368
LIG_TRAF2_1 240 243 PF00917 0.395
LIG_TRAF2_1 254 257 PF00917 0.389
LIG_WRC_WIRS_1 44 49 PF05994 0.419
LIG_WW_1 162 165 PF00397 0.419
MOD_CK1_1 274 280 PF00069 0.514
MOD_CK1_1 88 94 PF00069 0.384
MOD_CK2_1 150 156 PF00069 0.334
MOD_CK2_1 251 257 PF00069 0.474
MOD_Cter_Amidation 328 331 PF01082 0.677
MOD_GlcNHglycan 114 117 PF01048 0.452
MOD_GlcNHglycan 170 173 PF01048 0.511
MOD_GlcNHglycan 206 209 PF01048 0.670
MOD_GlcNHglycan 223 226 PF01048 0.281
MOD_GSK3_1 112 119 PF00069 0.419
MOD_GSK3_1 217 224 PF00069 0.386
MOD_GSK3_1 274 281 PF00069 0.474
MOD_GSK3_1 88 95 PF00069 0.360
MOD_N-GLC_1 217 222 PF02516 0.434
MOD_NEK2_1 26 31 PF00069 0.505
MOD_NEK2_1 271 276 PF00069 0.467
MOD_PIKK_1 185 191 PF00454 0.595
MOD_PKA_2 221 227 PF00069 0.398
MOD_Plk_1 217 223 PF00069 0.427
MOD_Plk_1 92 98 PF00069 0.424
MOD_Plk_4 116 122 PF00069 0.458
MOD_Plk_4 141 147 PF00069 0.342
MOD_Plk_4 92 98 PF00069 0.351
MOD_ProDKin_1 209 215 PF00069 0.530
MOD_SUMO_rev_2 230 238 PF00179 0.436
MOD_SUMO_rev_2 242 247 PF00179 0.335
MOD_SUMO_rev_2 293 300 PF00179 0.432
MOD_SUMO_rev_2 52 60 PF00179 0.445
TRG_ENDOCYTIC_2 165 168 PF00928 0.443
TRG_ENDOCYTIC_2 249 252 PF00928 0.373
TRG_ER_diArg_1 124 126 PF00400 0.335
TRG_ER_diArg_1 192 195 PF00400 0.639
TRG_ER_diArg_1 79 81 PF00400 0.328
TRG_ER_diArg_1 8 10 PF00400 0.496
TRG_ER_FFAT_2 108 119 PF00635 0.501
TRG_NLS_MonoExtC_3 191 196 PF00514 0.576
TRG_NLS_MonoExtN_4 190 196 PF00514 0.570
TRG_Pf-PMV_PEXEL_1 58 62 PF00026 0.267

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDU8 Leptomonas seymouri 84% 98%
A0A0S4JIJ0 Bodo saltans 60% 97%
A0A1X0NXX1 Trypanosomatidae 63% 100%
A0A3Q8IB28 Leishmania donovani 100% 100%
A0A3R7NHU1 Trypanosoma rangeli 62% 99%
A4HBQ1 Leishmania braziliensis 92% 100%
D0A1Q9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AV21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
P10881 Bos taurus 29% 83%
P32067 Mus musculus 27% 81%
P38656 Rattus norvegicus 27% 81%
P40796 Drosophila melanogaster 25% 86%
Q4QCG1 Leishmania major 97% 100%
V5DH11 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS