Thioesterase superfamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ49_LEIIN

TriTrypDb:

LINF_210010400

Length:

214

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	154	156	PF00082	0.400
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.426
CLV_PCSK_SKI1_1	180	184	PF00082	0.526
CLV_PCSK_SKI1_1	189	193	PF00082	0.377
CLV_PCSK_SKI1_1	7	11	PF00082	0.391
CLV_PCSK_SKI1_1	94	98	PF00082	0.434
DOC_MAPK_gen_1	135	145	PF00069	0.462
DOC_MAPK_JIP1_4	92	98	PF00069	0.387
DOC_MAPK_MEF2A_6	45	53	PF00069	0.392
DOC_MAPK_MEF2A_6	7	14	PF00069	0.472
DOC_PP1_RVXF_1	92	99	PF00149	0.506
DOC_PP2B_LxvP_1	10	13	PF13499	0.380
DOC_USP7_MATH_1	119	123	PF00917	0.518
DOC_USP7_MATH_1	33	37	PF00917	0.419
DOC_WW_Pin1_4	29	34	PF00397	0.447
LIG_14-3-3_CanoR_1	123	128	PF00244	0.405
LIG_14-3-3_CanoR_1	27	33	PF00244	0.358
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_CSL_BTD_1	10	13	PF09270	0.355
LIG_CSL_BTD_1	57	60	PF09270	0.371
LIG_EH1_1	111	119	PF00400	0.385
LIG_FHA_1	108	114	PF00498	0.395
LIG_FHA_2	182	188	PF00498	0.453
LIG_PTB_Apo_2	15	22	PF02174	0.433
LIG_SH2_STAP1	195	199	PF00017	0.468
LIG_SH2_STAT5	158	161	PF00017	0.477
LIG_SUMO_SIM_anti_2	139	148	PF11976	0.433
LIG_SUMO_SIM_par_1	139	148	PF11976	0.374
MOD_CK1_1	107	113	PF00069	0.358
MOD_CK1_1	181	187	PF00069	0.504
MOD_CK1_1	206	212	PF00069	0.456
MOD_CK1_1	3	9	PF00069	0.444
MOD_CK1_1	32	38	PF00069	0.426
MOD_CK2_1	181	187	PF00069	0.506
MOD_Cter_Amidation	152	155	PF01082	0.393
MOD_GlcNHglycan	199	202	PF01048	0.518
MOD_GlcNHglycan	74	77	PF01048	0.393
MOD_GSK3_1	100	107	PF00069	0.326
MOD_GSK3_1	119	126	PF00069	0.379
MOD_GSK3_1	203	210	PF00069	0.367
MOD_GSK3_1	28	35	PF00069	0.504
MOD_NEK2_1	100	105	PF00069	0.319
MOD_NEK2_1	208	213	PF00069	0.628
MOD_NEK2_1	21	26	PF00069	0.477
MOD_NEK2_1	28	33	PF00069	0.436
MOD_NEK2_1	63	68	PF00069	0.459
MOD_PK_1	123	129	PF00069	0.402
MOD_PK_1	178	184	PF00069	0.400
MOD_Plk_1	178	184	PF00069	0.400
MOD_Plk_1	94	100	PF00069	0.331
MOD_Plk_4	203	209	PF00069	0.412
MOD_Plk_4	63	69	PF00069	0.369
MOD_ProDKin_1	29	35	PF00069	0.438
MOD_SUMO_for_1	44	47	PF00179	0.405
MOD_SUMO_rev_2	139	144	PF00179	0.371
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.415
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.337
TRG_NES_CRM1_1	61	73	PF08389	0.384
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P855	Leptomonas seymouri	53%	100%
A0A0N0P8I2	Leptomonas seymouri	29%	91%
A0A1X0NXQ6	Trypanosomatidae	26%	93%
A0A1X0NZ15	Trypanosomatidae	29%	99%
A0A3S7WWD9	Leishmania donovani	99%	100%
A0A422NBM7	Trypanosoma rangeli	32%	100%
A4HBP7	Leishmania braziliensis	78%	99%
D0A1Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AV17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCG5	Leishmania major	93%	100%