Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ45_LEIIN

TriTrypDb:

LINF_210010000

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.786
CLV_C14_Caspase3-7	309	313	PF00656	0.769
CLV_NRD_NRD_1	185	187	PF00675	0.852
CLV_NRD_NRD_1	233	235	PF00675	0.794
CLV_NRD_NRD_1	335	337	PF00675	0.644
CLV_NRD_NRD_1	378	380	PF00675	0.604
CLV_NRD_NRD_1	414	416	PF00675	0.766
CLV_NRD_NRD_1	520	522	PF00675	0.688
CLV_NRD_NRD_1	88	90	PF00675	0.699
CLV_PCSK_KEX2_1	184	186	PF00082	0.846
CLV_PCSK_KEX2_1	378	380	PF00082	0.604
CLV_PCSK_KEX2_1	414	416	PF00082	0.766
CLV_PCSK_KEX2_1	520	522	PF00082	0.688
CLV_PCSK_KEX2_1	88	90	PF00082	0.699
CLV_PCSK_PC7_1	410	416	PF00082	0.735
CLV_PCSK_SKI1_1	157	161	PF00082	0.626
CLV_PCSK_SKI1_1	17	21	PF00082	0.679
CLV_PCSK_SKI1_1	230	234	PF00082	0.808
CLV_PCSK_SKI1_1	410	414	PF00082	0.740
CLV_PCSK_SKI1_1	42	46	PF00082	0.662
CLV_Separin_Metazoa	79	83	PF03568	0.631
DEG_APCC_DBOX_1	73	81	PF00400	0.630
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DEG_SCF_FBW7_2	352	357	PF00400	0.777
DOC_CDC14_PxL_1	695	703	PF14671	0.530
DOC_CKS1_1	133	138	PF01111	0.729
DOC_CKS1_1	464	469	PF01111	0.748
DOC_MAPK_gen_1	632	641	PF00069	0.745
DOC_MAPK_gen_1	88	95	PF00069	0.657
DOC_MAPK_MEF2A_6	619	627	PF00069	0.709
DOC_PP2B_LxvP_1	580	583	PF13499	0.710
DOC_PP4_FxxP_1	652	655	PF00568	0.516
DOC_PP4_MxPP_1	25	28	PF00568	0.746
DOC_USP7_MATH_1	145	149	PF00917	0.655
DOC_USP7_MATH_1	171	175	PF00917	0.677
DOC_USP7_MATH_1	189	193	PF00917	0.549
DOC_USP7_MATH_1	21	25	PF00917	0.737
DOC_USP7_MATH_1	299	303	PF00917	0.635
DOC_USP7_MATH_1	313	317	PF00917	0.635
DOC_USP7_MATH_1	323	327	PF00917	0.777
DOC_USP7_MATH_1	454	458	PF00917	0.833
DOC_USP7_MATH_1	603	607	PF00917	0.778
DOC_USP7_MATH_1	615	619	PF00917	0.616
DOC_USP7_UBL2_3	11	15	PF12436	0.489
DOC_USP7_UBL2_3	689	693	PF12436	0.542
DOC_WW_Pin1_4	132	137	PF00397	0.737
DOC_WW_Pin1_4	350	355	PF00397	0.853
DOC_WW_Pin1_4	463	468	PF00397	0.810
DOC_WW_Pin1_4	472	477	PF00397	0.764
DOC_WW_Pin1_4	507	512	PF00397	0.679
LIG_14-3-3_CanoR_1	121	131	PF00244	0.785
LIG_14-3-3_CanoR_1	29	37	PF00244	0.795
LIG_14-3-3_CanoR_1	367	374	PF00244	0.676
LIG_14-3-3_CanoR_1	42	51	PF00244	0.470
LIG_14-3-3_CanoR_1	470	476	PF00244	0.824
LIG_BIR_III_2	312	316	PF00653	0.764
LIG_BIR_III_2	338	342	PF00653	0.670
LIG_BRCT_BRCA1_1	597	601	PF00533	0.691
LIG_CtBP_PxDLS_1	341	345	PF00389	0.670
LIG_FHA_1	293	299	PF00498	0.783
LIG_FHA_1	347	353	PF00498	0.737
LIG_FHA_1	383	389	PF00498	0.730
LIG_FHA_1	464	470	PF00498	0.679
LIG_FHA_1	494	500	PF00498	0.608
LIG_FHA_1	535	541	PF00498	0.721
LIG_FHA_1	642	648	PF00498	0.668
LIG_FHA_1	82	88	PF00498	0.647
LIG_FHA_2	231	237	PF00498	0.790
LIG_FHA_2	477	483	PF00498	0.744
LIG_FHA_2	529	535	PF00498	0.727
LIG_FHA_2	660	666	PF00498	0.642
LIG_FHA_2	71	77	PF00498	0.642
LIG_Integrin_RGD_1	310	312	PF01839	0.638
LIG_LIR_Apic_2	650	655	PF02991	0.610
LIG_LIR_Gen_1	264	275	PF02991	0.630
LIG_LIR_Gen_1	46	55	PF02991	0.621
LIG_LIR_Gen_1	660	669	PF02991	0.561
LIG_LIR_Gen_1	7	16	PF02991	0.552
LIG_LIR_Nem_3	245	251	PF02991	0.615
LIG_LIR_Nem_3	264	270	PF02991	0.628
LIG_LIR_Nem_3	40	44	PF02991	0.713
LIG_LIR_Nem_3	46	51	PF02991	0.546
LIG_LIR_Nem_3	660	664	PF02991	0.577
LIG_LIR_Nem_3	679	683	PF02991	0.374
LIG_PDZ_Class_2	701	706	PF00595	0.655
LIG_Pex14_2	41	45	PF04695	0.610
LIG_SH2_CRK	267	271	PF00017	0.629
LIG_SH2_NCK_1	267	271	PF00017	0.629
LIG_SH2_SRC	203	206	PF00017	0.612
LIG_SH2_STAP1	384	388	PF00017	0.811
LIG_SH2_STAP1	448	452	PF00017	0.714
LIG_SH2_STAT5	203	206	PF00017	0.725
LIG_SH2_STAT5	384	387	PF00017	0.753
LIG_SH2_STAT5	659	662	PF00017	0.462
LIG_SH3_2	195	200	PF14604	0.709
LIG_SH3_3	130	136	PF00018	0.817
LIG_SH3_3	192	198	PF00018	0.748
LIG_SH3_3	461	467	PF00018	0.813
LIG_SH3_3	477	483	PF00018	0.602
LIG_SH3_3	498	504	PF00018	0.814
LIG_SH3_3	549	555	PF00018	0.588
LIG_SH3_3	60	66	PF00018	0.586
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.618
LIG_SUMO_SIM_par_1	168	174	PF11976	0.624
LIG_SUMO_SIM_par_1	450	457	PF11976	0.615
LIG_TRAF2_1	73	76	PF00917	0.653
LIG_TRFH_1	2	6	PF08558	0.601
LIG_UBA3_1	228	235	PF00899	0.616
LIG_WW_3	26	30	PF00397	0.830
MOD_CDC14_SPxK_1	475	478	PF00782	0.750
MOD_CDK_SPxK_1	472	478	PF00069	0.752
MOD_CDK_SPxxK_3	132	139	PF00069	0.728
MOD_CDK_SPxxK_3	463	470	PF00069	0.746
MOD_CK1_1	345	351	PF00069	0.833
MOD_CK1_1	40	46	PF00069	0.691
MOD_CK1_1	474	480	PF00069	0.852
MOD_CK1_1	510	516	PF00069	0.810
MOD_CK1_1	526	532	PF00069	0.555
MOD_CK1_1	610	616	PF00069	0.743
MOD_CK1_1	637	643	PF00069	0.591
MOD_CK2_1	122	128	PF00069	0.687
MOD_CK2_1	340	346	PF00069	0.847
MOD_CK2_1	659	665	PF00069	0.639
MOD_CK2_1	70	76	PF00069	0.664
MOD_GlcNHglycan	112	115	PF01048	0.772
MOD_GlcNHglycan	117	120	PF01048	0.733
MOD_GlcNHglycan	125	128	PF01048	0.616
MOD_GlcNHglycan	173	176	PF01048	0.670
MOD_GlcNHglycan	191	194	PF01048	0.614
MOD_GlcNHglycan	213	217	PF01048	0.614
MOD_GlcNHglycan	236	239	PF01048	0.777
MOD_GlcNHglycan	279	283	PF01048	0.625
MOD_GlcNHglycan	300	304	PF01048	0.778
MOD_GlcNHglycan	325	328	PF01048	0.856
MOD_GlcNHglycan	388	391	PF01048	0.856
MOD_GlcNHglycan	444	447	PF01048	0.704
MOD_GlcNHglycan	485	489	PF01048	0.825
MOD_GlcNHglycan	528	531	PF01048	0.762
MOD_GlcNHglycan	552	555	PF01048	0.649
MOD_GlcNHglycan	597	600	PF01048	0.747
MOD_GSK3_1	230	237	PF00069	0.714
MOD_GSK3_1	29	36	PF00069	0.734
MOD_GSK3_1	314	321	PF00069	0.737
MOD_GSK3_1	342	349	PF00069	0.798
MOD_GSK3_1	382	389	PF00069	0.790
MOD_GSK3_1	470	477	PF00069	0.827
MOD_GSK3_1	510	517	PF00069	0.738
MOD_GSK3_1	519	526	PF00069	0.682
MOD_GSK3_1	603	610	PF00069	0.733
MOD_GSK3_1	637	644	PF00069	0.640
MOD_LATS_1	468	474	PF00433	0.776
MOD_N-GLC_1	242	247	PF02516	0.616
MOD_N-GLC_1	350	355	PF02516	0.814
MOD_N-GLC_1	608	613	PF02516	0.721
MOD_NEK2_1	374	379	PF00069	0.743
MOD_NEK2_1	607	612	PF00069	0.717
MOD_NEK2_2	21	26	PF00069	0.720
MOD_PIKK_1	236	242	PF00454	0.824
MOD_PIKK_1	396	402	PF00454	0.855
MOD_PIKK_1	514	520	PF00454	0.810
MOD_PKA_1	234	240	PF00069	0.823
MOD_PKA_1	520	526	PF00069	0.764
MOD_PKA_2	292	298	PF00069	0.608
MOD_PKA_2	366	372	PF00069	0.624
MOD_PKA_2	382	388	PF00069	0.576
MOD_PKA_2	519	525	PF00069	0.759
MOD_PKA_2	631	637	PF00069	0.805
MOD_PKA_2	81	87	PF00069	0.633
MOD_PKB_1	415	423	PF00069	0.713
MOD_Plk_1	212	218	PF00069	0.706
MOD_Plk_1	242	248	PF00069	0.616
MOD_Plk_1	418	424	PF00069	0.740
MOD_Plk_1	637	643	PF00069	0.654
MOD_Plk_4	243	249	PF00069	0.762
MOD_Plk_4	534	540	PF00069	0.736
MOD_Plk_4	545	551	PF00069	0.467
MOD_Plk_4	556	562	PF00069	0.475
MOD_Plk_4	603	609	PF00069	0.717
MOD_ProDKin_1	132	138	PF00069	0.731
MOD_ProDKin_1	350	356	PF00069	0.850
MOD_ProDKin_1	463	469	PF00069	0.815
MOD_ProDKin_1	472	478	PF00069	0.764
MOD_ProDKin_1	507	513	PF00069	0.677
MOD_SUMO_for_1	10	13	PF00179	0.481
MOD_SUMO_rev_2	316	326	PF00179	0.637
MOD_SUMO_rev_2	429	437	PF00179	0.689
MOD_SUMO_rev_2	7	16	PF00179	0.701
TRG_DiLeu_BaEn_1	330	335	PF01217	0.630
TRG_DiLeu_BaEn_1	76	81	PF01217	0.618
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.674
TRG_ENDOCYTIC_2	2	5	PF00928	0.524
TRG_ENDOCYTIC_2	267	270	PF00928	0.631
TRG_ENDOCYTIC_2	48	51	PF00928	0.614
TRG_ENDOCYTIC_2	680	683	PF00928	0.694
TRG_ER_diArg_1	184	186	PF00400	0.846
TRG_ER_diArg_1	413	415	PF00400	0.846
TRG_ER_diArg_1	583	586	PF00400	0.647
TRG_ER_diArg_1	87	89	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA94	Leishmania donovani	99%	77%
A4HBP4	Leishmania braziliensis	59%	100%
E9AV13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QCG9	Leishmania major	86%	100%