Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ44_LEIIN

TriTrypDb:

LINF_210009900

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.534
CLV_C14_Caspase3-7	170	174	PF00656	0.479
CLV_MEL_PAP_1	81	87	PF00089	0.610
CLV_NRD_NRD_1	207	209	PF00675	0.531
CLV_NRD_NRD_1	59	61	PF00675	0.522
CLV_PCSK_KEX2_1	206	208	PF00082	0.534
CLV_PCSK_KEX2_1	59	61	PF00082	0.532
CLV_PCSK_SKI1_1	151	155	PF00082	0.445
CLV_PCSK_SKI1_1	2	6	PF00082	0.504
DEG_APCC_DBOX_1	150	158	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.518
DOC_CYCLIN_RxL_1	174	185	PF00134	0.560
DOC_MAPK_gen_1	206	213	PF00069	0.564
DOC_MAPK_gen_1	35	45	PF00069	0.430
DOC_MAPK_gen_1	59	68	PF00069	0.543
DOC_MAPK_MEF2A_6	38	47	PF00069	0.426
DOC_MAPK_NFAT4_5	38	46	PF00069	0.430
DOC_PP2B_LxvP_1	179	182	PF13499	0.554
DOC_USP7_MATH_1	161	165	PF00917	0.545
DOC_USP7_MATH_1	77	81	PF00917	0.594
DOC_USP7_MATH_1	88	92	PF00917	0.510
LIG_14-3-3_CanoR_1	208	214	PF00244	0.550
LIG_14-3-3_CanoR_1	90	94	PF00244	0.567
LIG_Actin_WH2_2	47	64	PF00022	0.520
LIG_APCC_ABBA_1	43	48	PF00400	0.430
LIG_BIR_III_4	201	205	PF00653	0.478
LIG_FHA_1	143	149	PF00498	0.518
LIG_FHA_1	174	180	PF00498	0.582
LIG_FHA_2	240	246	PF00498	0.566
LIG_GBD_Chelix_1	139	147	PF00786	0.470
LIG_Integrin_isoDGR_2	219	221	PF01839	0.570
LIG_Integrin_RGD_1	235	237	PF01839	0.520
LIG_LIR_Gen_1	18	26	PF02991	0.450
LIG_LIR_Nem_3	18	24	PF02991	0.454
LIG_LIR_Nem_3	92	98	PF02991	0.486
LIG_SH2_PTP2	108	111	PF00017	0.569
LIG_SH2_STAT5	108	111	PF00017	0.642
LIG_SH2_STAT5	98	101	PF00017	0.649
LIG_SH3_3	63	69	PF00018	0.516
LIG_TRAF2_1	242	245	PF00917	0.563
MOD_CK1_1	129	135	PF00069	0.504
MOD_CK1_1	80	86	PF00069	0.613
MOD_CK1_1	89	95	PF00069	0.495
MOD_CK2_1	239	245	PF00069	0.570
MOD_GlcNHglycan	100	103	PF01048	0.513
MOD_GlcNHglycan	163	166	PF01048	0.516
MOD_GlcNHglycan	192	195	PF01048	0.581
MOD_GlcNHglycan	216	219	PF01048	0.593
MOD_GlcNHglycan	30	33	PF01048	0.381
MOD_GSK3_1	169	176	PF00069	0.566
MOD_GSK3_1	184	191	PF00069	0.410
MOD_GSK3_1	72	79	PF00069	0.627
MOD_N-GLC_1	39	44	PF02516	0.434
MOD_NEK2_1	126	131	PF00069	0.651
MOD_NEK2_1	184	189	PF00069	0.483
MOD_NEK2_1	190	195	PF00069	0.518
MOD_NEK2_2	39	44	PF00069	0.532
MOD_PKA_2	89	95	PF00069	0.568
MOD_Plk_1	39	45	PF00069	0.458
MOD_Plk_2-3	167	173	PF00069	0.544
MOD_Plk_4	209	215	PF00069	0.541
MOD_Plk_4	77	83	PF00069	0.645
TRG_DiLeu_BaEn_1	149	154	PF01217	0.507
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.505
TRG_ER_diArg_1	206	208	PF00400	0.534
TRG_ER_diArg_1	59	62	PF00400	0.524
TRG_NES_CRM1_1	25	37	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE19	Leptomonas seymouri	43%	100%
A0A3Q8IBT2	Leishmania donovani	100%	100%
E9AV12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCH0	Leishmania major	88%	100%