LeishMANIAdb
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Ubiquitin-conjugating enzyme-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-conjugating enzyme-like protein
Gene product:
ubiquitin-conjugating enzyme-like protein
Species:
Leishmania infantum
UniProt:
A4HZ43_LEIIN
TriTrypDb:
LINF_210009800
Length:
270

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin-conjugating enzyme-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005635 nuclear envelope 4 1
GO:0005783 endoplasmic reticulum 5 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HZ43
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ43

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 10
GO:0006629 lipid metabolic process 3 10
GO:0006631 fatty acid metabolic process 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0019752 carboxylic acid metabolic process 5 10
GO:0032787 monocarboxylic acid metabolic process 6 10
GO:0043436 oxoacid metabolic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044255 cellular lipid metabolic process 3 10
GO:0044281 small molecule metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 17 19 PF00675 0.300
CLV_NRD_NRD_1 201 203 PF00675 0.261
CLV_NRD_NRD_1 216 218 PF00675 0.166
CLV_NRD_NRD_1 30 32 PF00675 0.289
CLV_PCSK_FUR_1 31 35 PF00082 0.318
CLV_PCSK_KEX2_1 33 35 PF00082 0.241
CLV_PCSK_PC1ET2_1 33 35 PF00082 0.257
CLV_PCSK_SKI1_1 33 37 PF00082 0.295
CLV_Separin_Metazoa 258 262 PF03568 0.462
DOC_CDC14_PxL_1 137 145 PF14671 0.415
DOC_CKS1_1 98 103 PF01111 0.415
DOC_CYCLIN_RxL_1 30 37 PF00134 0.512
DOC_CYCLIN_yCln2_LP_2 210 216 PF00134 0.484
DOC_MAPK_gen_1 199 209 PF00069 0.507
DOC_MAPK_MEF2A_6 167 175 PF00069 0.523
DOC_MAPK_MEF2A_6 202 211 PF00069 0.499
DOC_MAPK_RevD_3 205 218 PF00069 0.418
DOC_USP7_MATH_1 195 199 PF00917 0.484
DOC_USP7_UBL2_3 19 23 PF12436 0.495
DOC_WW_Pin1_4 209 214 PF00397 0.432
DOC_WW_Pin1_4 97 102 PF00397 0.415
LIG_AP2alpha_2 222 224 PF02296 0.499
LIG_BIR_II_1 1 5 PF00653 0.647
LIG_BRCT_BRCA1_1 240 244 PF00533 0.499
LIG_CSL_BTD_1 71 74 PF09270 0.250
LIG_FHA_1 134 140 PF00498 0.447
LIG_FHA_1 175 181 PF00498 0.434
LIG_FHA_1 183 189 PF00498 0.470
LIG_FHA_1 225 231 PF00498 0.444
LIG_FHA_1 254 260 PF00498 0.415
LIG_FHA_2 129 135 PF00498 0.433
LIG_LIR_Apic_2 231 237 PF02991 0.499
LIG_LIR_Apic_2 96 101 PF02991 0.415
LIG_LIR_Gen_1 177 184 PF02991 0.449
LIG_LIR_Nem_3 103 109 PF02991 0.432
LIG_LIR_Nem_3 177 182 PF02991 0.451
LIG_LIR_Nem_3 242 248 PF02991 0.535
LIG_Pex14_1 72 76 PF04695 0.367
LIG_Pex14_2 109 113 PF04695 0.415
LIG_Pex14_2 174 178 PF04695 0.491
LIG_SH2_CRK 147 151 PF00017 0.462
LIG_SH2_STAT5 160 163 PF00017 0.524
LIG_SH2_STAT5 228 231 PF00017 0.415
LIG_SH2_STAT5 29 32 PF00017 0.480
LIG_SH2_STAT5 40 43 PF00017 0.250
LIG_SH2_STAT5 58 61 PF00017 0.255
LIG_SH3_3 135 141 PF00018 0.446
LIG_SH3_3 68 74 PF00018 0.230
LIG_SH3_3 98 104 PF00018 0.458
LIG_TYR_ITIM 145 150 PF00017 0.499
LIG_UBA3_1 210 218 PF00899 0.484
LIG_WRC_WIRS_1 106 111 PF05994 0.429
LIG_WRC_WIRS_1 175 180 PF05994 0.441
MOD_CK1_1 250 256 PF00069 0.458
MOD_CK1_1 42 48 PF00069 0.274
MOD_CK2_1 1 7 PF00069 0.671
MOD_CK2_1 109 115 PF00069 0.415
MOD_GlcNHglycan 155 158 PF01048 0.299
MOD_GlcNHglycan 3 6 PF01048 0.470
MOD_GlcNHglycan 41 44 PF01048 0.367
MOD_GlcNHglycan 87 90 PF01048 0.331
MOD_GSK3_1 105 112 PF00069 0.462
MOD_GSK3_1 128 135 PF00069 0.415
MOD_GSK3_1 149 156 PF00069 0.456
MOD_GSK3_1 224 231 PF00069 0.441
MOD_GSK3_1 247 254 PF00069 0.539
MOD_GSK3_1 47 54 PF00069 0.307
MOD_N-GLC_1 153 158 PF02516 0.259
MOD_NEK2_1 1 6 PF00069 0.603
MOD_NEK2_1 109 114 PF00069 0.444
MOD_NEK2_1 128 133 PF00069 0.509
MOD_NEK2_1 174 179 PF00069 0.415
MOD_NEK2_1 224 229 PF00069 0.458
MOD_NEK2_1 238 243 PF00069 0.458
MOD_NEK2_1 251 256 PF00069 0.427
MOD_NEK2_1 41 46 PF00069 0.293
MOD_NEK2_1 47 52 PF00069 0.253
MOD_OFUCOSY 49 55 PF10250 0.357
MOD_PKA_2 150 156 PF00069 0.496
MOD_Plk_1 118 124 PF00069 0.486
MOD_Plk_1 133 139 PF00069 0.383
MOD_Plk_1 224 230 PF00069 0.415
MOD_Plk_1 263 269 PF00069 0.565
MOD_Plk_4 105 111 PF00069 0.475
MOD_Plk_4 174 180 PF00069 0.461
MOD_Plk_4 247 253 PF00069 0.432
MOD_Plk_4 263 269 PF00069 0.514
MOD_Plk_4 42 48 PF00069 0.299
MOD_ProDKin_1 209 215 PF00069 0.432
MOD_ProDKin_1 97 103 PF00069 0.415
TRG_DiLeu_BaLyEn_6 135 140 PF01217 0.415
TRG_DiLeu_BaLyEn_6 234 239 PF01217 0.484
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.518
TRG_ENDOCYTIC_2 147 150 PF00928 0.459
TRG_ENDOCYTIC_2 58 61 PF00928 0.327
TRG_LysEnd_GGAAcLL_1 264 270 PF00790 0.522
TRG_NLS_Bipartite_1 18 36 PF00514 0.529
TRG_NLS_MonoCore_2 30 35 PF00514 0.514
TRG_NLS_MonoExtC_3 31 37 PF00514 0.507
TRG_NLS_MonoExtN_4 31 36 PF00514 0.514
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7L1 Leptomonas seymouri 83% 97%
A0A1X0NXG4 Trypanosomatidae 56% 94%
A0A3Q8IBV2 Leishmania donovani 100% 100%
A4HBP2 Leishmania braziliensis 86% 100%
A5PLL7 Homo sapiens 41% 100%
A6QLM0 Bos taurus 39% 100%
D0A1P4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 90%
E9AV11 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O04584 Arabidopsis thaliana 26% 92%
O81006 Arabidopsis thaliana 29% 97%
Q4QCH1 Leishmania major 97% 100%
Q5UR78 Acanthamoeba polyphaga mimivirus 31% 100%
Q99LQ7 Mus musculus 41% 100%
Q9AE87 Myxococcus xanthus 34% 96%
Q9SZ42 Arabidopsis thaliana 29% 84%
V5B0L9 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS