Ubiquitin-conjugating enzyme-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme-like protein

Species:

Leishmania infantum

UniProt:

A4HZ43_LEIIN

TriTrypDb:

LINF_210009800

Length:

270

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin-conjugating enzyme-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	10
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4HZ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ43

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.300
CLV_NRD_NRD_1	201	203	PF00675	0.261
CLV_NRD_NRD_1	216	218	PF00675	0.166
CLV_NRD_NRD_1	30	32	PF00675	0.289
CLV_PCSK_FUR_1	31	35	PF00082	0.318
CLV_PCSK_KEX2_1	33	35	PF00082	0.241
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.257
CLV_PCSK_SKI1_1	33	37	PF00082	0.295
CLV_Separin_Metazoa	258	262	PF03568	0.462
DOC_CDC14_PxL_1	137	145	PF14671	0.415

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L1	Leptomonas seymouri	83%	97%
A0A1X0NXG4	Trypanosomatidae	56%	94%
A0A3Q8IBV2	Leishmania donovani	100%	100%
A4HBP2	Leishmania braziliensis	86%	100%
A5PLL7	Homo sapiens	41%	100%
A6QLM0	Bos taurus	39%	100%
D0A1P4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	90%
E9AV11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O04584	Arabidopsis thaliana	26%	92%
O81006	Arabidopsis thaliana	29%	97%

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