LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZ42_LEIIN
TriTrypDb:
LINF_210009700
Length:
414

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Phosphorylation

Amastigote: 287, 289

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZ42
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ42

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003729 mRNA binding 5 1
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 110 112 PF00675 0.349
CLV_NRD_NRD_1 167 169 PF00675 0.484
CLV_NRD_NRD_1 174 176 PF00675 0.489
CLV_NRD_NRD_1 252 254 PF00675 0.715
CLV_NRD_NRD_1 264 266 PF00675 0.537
CLV_NRD_NRD_1 303 305 PF00675 0.697
CLV_NRD_NRD_1 329 331 PF00675 0.675
CLV_NRD_NRD_1 333 335 PF00675 0.624
CLV_NRD_NRD_1 78 80 PF00675 0.410
CLV_PCSK_KEX2_1 110 112 PF00082 0.349
CLV_PCSK_KEX2_1 166 168 PF00082 0.476
CLV_PCSK_KEX2_1 174 176 PF00082 0.484
CLV_PCSK_KEX2_1 333 335 PF00082 0.757
CLV_PCSK_SKI1_1 110 114 PF00082 0.367
CLV_PCSK_SKI1_1 175 179 PF00082 0.530
CLV_PCSK_SKI1_1 349 353 PF00082 0.449
CLV_PCSK_SKI1_1 369 373 PF00082 0.237
CLV_PCSK_SKI1_1 398 402 PF00082 0.488
DOC_ANK_TNKS_1 289 296 PF00023 0.777
DOC_CYCLIN_RxL_1 172 179 PF00134 0.535
DOC_MAPK_gen_1 107 116 PF00069 0.377
DOC_MAPK_gen_1 174 180 PF00069 0.536
DOC_MAPK_gen_1 79 86 PF00069 0.414
DOC_MAPK_MEF2A_6 107 116 PF00069 0.448
DOC_PP1_RVXF_1 367 374 PF00149 0.567
DOC_PP4_FxxP_1 345 348 PF00568 0.367
DOC_USP7_MATH_1 218 222 PF00917 0.729
DOC_USP7_MATH_1 286 290 PF00917 0.736
DOC_USP7_MATH_1 34 38 PF00917 0.442
DOC_USP7_UBL2_3 397 401 PF12436 0.377
DOC_WW_Pin1_4 284 289 PF00397 0.772
DOC_WW_Pin1_4 320 325 PF00397 0.727
DOC_WW_Pin1_4 5 10 PF00397 0.479
LIG_14-3-3_CanoR_1 125 130 PF00244 0.444
LIG_14-3-3_CanoR_1 217 226 PF00244 0.767
LIG_14-3-3_CanoR_1 43 49 PF00244 0.435
LIG_BIR_II_1 1 5 PF00653 0.608
LIG_BRCT_BRCA1_1 361 365 PF00533 0.577
LIG_CaM_IQ_9 177 192 PF13499 0.607
LIG_FHA_1 126 132 PF00498 0.420
LIG_FHA_1 337 343 PF00498 0.600
LIG_FHA_1 86 92 PF00498 0.457
LIG_FHA_2 45 51 PF00498 0.443
LIG_LIR_Gen_1 133 139 PF02991 0.461
LIG_LIR_Gen_1 25 34 PF02991 0.416
LIG_LIR_Gen_1 362 372 PF02991 0.500
LIG_LIR_Gen_1 42 51 PF02991 0.449
LIG_LIR_Nem_3 108 112 PF02991 0.455
LIG_LIR_Nem_3 133 138 PF02991 0.395
LIG_LIR_Nem_3 17 22 PF02991 0.364
LIG_LIR_Nem_3 25 30 PF02991 0.348
LIG_LIR_Nem_3 362 368 PF02991 0.506
LIG_LIR_Nem_3 42 48 PF02991 0.365
LIG_Pex14_2 113 117 PF04695 0.357
LIG_Rb_pABgroove_1 34 42 PF01858 0.448
LIG_SH2_CRK 109 113 PF00017 0.436
LIG_SH2_CRK 45 49 PF00017 0.430
LIG_SH2_STAP1 24 28 PF00017 0.428
LIG_SH2_STAT5 105 108 PF00017 0.461
LIG_SH2_STAT5 135 138 PF00017 0.399
LIG_SH2_STAT5 161 164 PF00017 0.528
LIG_SH3_2 238 243 PF14604 0.693
LIG_SH3_3 223 229 PF00018 0.683
LIG_SH3_3 235 241 PF00018 0.705
LIG_SH3_3 252 258 PF00018 0.527
LIG_SH3_3 264 270 PF00018 0.564
LIG_SH3_3 285 291 PF00018 0.597
LIG_SH3_3 86 92 PF00018 0.457
LIG_SUMO_SIM_par_1 82 88 PF11976 0.471
LIG_TRFH_1 117 121 PF08558 0.377
LIG_WW_3 240 244 PF00397 0.698
MOD_CDC14_SPxK_1 287 290 PF00782 0.774
MOD_CDK_SPxK_1 284 290 PF00069 0.774
MOD_CK1_1 213 219 PF00069 0.716
MOD_CK1_1 336 342 PF00069 0.621
MOD_CK1_1 44 50 PF00069 0.375
MOD_CK2_1 138 144 PF00069 0.519
MOD_CK2_1 383 389 PF00069 0.504
MOD_Cter_Amidation 294 297 PF01082 0.782
MOD_GlcNHglycan 220 223 PF01048 0.686
MOD_GlcNHglycan 335 338 PF01048 0.658
MOD_GlcNHglycan 377 380 PF01048 0.451
MOD_GlcNHglycan 385 388 PF01048 0.446
MOD_GSK3_1 11 18 PF00069 0.414
MOD_GSK3_1 119 126 PF00069 0.416
MOD_GSK3_1 220 227 PF00069 0.687
MOD_GSK3_1 316 323 PF00069 0.721
MOD_GSK3_1 359 366 PF00069 0.562
MOD_NEK2_1 162 167 PF00069 0.534
MOD_NEK2_1 72 77 PF00069 0.412
MOD_PIKK_1 359 365 PF00454 0.568
MOD_PKA_1 333 339 PF00069 0.701
MOD_PKA_2 213 219 PF00069 0.751
MOD_PKA_2 333 339 PF00069 0.550
MOD_PKA_2 34 40 PF00069 0.441
MOD_PKA_2 375 381 PF00069 0.513
MOD_Plk_1 41 47 PF00069 0.394
MOD_Plk_1 72 78 PF00069 0.462
MOD_Plk_2-3 82 88 PF00069 0.471
MOD_Plk_4 15 21 PF00069 0.404
MOD_Plk_4 44 50 PF00069 0.381
MOD_ProDKin_1 284 290 PF00069 0.774
MOD_ProDKin_1 320 326 PF00069 0.727
MOD_ProDKin_1 5 11 PF00069 0.473
MOD_SUMO_for_1 356 359 PF00179 0.501
MOD_SUMO_rev_2 260 267 PF00179 0.712
MOD_SUMO_rev_2 269 276 PF00179 0.724
MOD_SUMO_rev_2 354 358 PF00179 0.458
MOD_SUMO_rev_2 362 371 PF00179 0.471
MOD_SUMO_rev_2 393 400 PF00179 0.505
TRG_ENDOCYTIC_2 109 112 PF00928 0.446
TRG_ENDOCYTIC_2 135 138 PF00928 0.399
TRG_ENDOCYTIC_2 24 27 PF00928 0.368
TRG_ENDOCYTIC_2 45 48 PF00928 0.428
TRG_ER_diArg_1 109 111 PF00400 0.449
TRG_ER_diArg_1 166 168 PF00400 0.475
TRG_ER_diArg_1 183 186 PF00400 0.526
TRG_ER_diArg_1 332 334 PF00400 0.708
TRG_NLS_Bipartite_1 333 353 PF00514 0.616
TRG_NLS_MonoExtN_4 346 353 PF00514 0.508
TRG_Pf-PMV_PEXEL_1 175 179 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P850 Leptomonas seymouri 59% 88%
A0A3Q8IBY3 Leishmania donovani 99% 99%
A0A422MZN2 Trypanosoma rangeli 32% 84%
A4HBP1 Leishmania braziliensis 83% 100%
E9AV10 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 98%
Q4QCH2 Leishmania major 90% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS