RTR1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtr1/RPAP2 family - putative

Species:

Leishmania infantum

UniProt:

A4HZ36_LEIIN

TriTrypDb:

LINF_210009100

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.680
CLV_C14_Caspase3-7	178	182	PF00656	0.527
CLV_C14_Caspase3-7	192	196	PF00656	0.549
CLV_C14_Caspase3-7	352	356	PF00656	0.568
CLV_MEL_PAP_1	297	303	PF00089	0.416
CLV_NRD_NRD_1	173	175	PF00675	0.792
CLV_NRD_NRD_1	18	20	PF00675	0.675
CLV_NRD_NRD_1	227	229	PF00675	0.568
CLV_NRD_NRD_1	299	301	PF00675	0.451
CLV_NRD_NRD_1	469	471	PF00675	0.567
CLV_NRD_NRD_1	505	507	PF00675	0.408
CLV_NRD_NRD_1	589	591	PF00675	0.458
CLV_PCSK_FUR_1	16	20	PF00082	0.555
CLV_PCSK_KEX2_1	173	175	PF00082	0.732
CLV_PCSK_KEX2_1	18	20	PF00082	0.675
CLV_PCSK_KEX2_1	299	301	PF00082	0.451
CLV_PCSK_KEX2_1	343	345	PF00082	0.585
CLV_PCSK_KEX2_1	394	396	PF00082	0.705
CLV_PCSK_KEX2_1	469	471	PF00082	0.567
CLV_PCSK_KEX2_1	505	507	PF00082	0.408
CLV_PCSK_KEX2_1	551	553	PF00082	0.501
CLV_PCSK_KEX2_1	589	591	PF00082	0.458
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.585
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.614
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.475
CLV_PCSK_SKI1_1	107	111	PF00082	0.414
CLV_PCSK_SKI1_1	129	133	PF00082	0.516
CLV_PCSK_SKI1_1	188	192	PF00082	0.545
CLV_PCSK_SKI1_1	220	224	PF00082	0.472
CLV_PCSK_SKI1_1	343	347	PF00082	0.653
CLV_PCSK_SKI1_1	422	426	PF00082	0.468
CLV_PCSK_SKI1_1	483	487	PF00082	0.582
CLV_PCSK_SKI1_1	505	509	PF00082	0.403
CLV_PCSK_SKI1_1	516	520	PF00082	0.397
CLV_PCSK_SKI1_1	521	525	PF00082	0.442
CLV_PCSK_SKI1_1	590	594	PF00082	0.389
CLV_PCSK_SKI1_1	608	612	PF00082	0.446
DEG_APCC_DBOX_1	102	110	PF00400	0.382
DEG_APCC_DBOX_1	219	227	PF00400	0.471
DEG_APCC_DBOX_1	421	429	PF00400	0.466
DEG_APCC_DBOX_1	486	494	PF00400	0.451
DEG_Nend_UBRbox_4	1	3	PF02207	0.507
DEG_SPOP_SBC_1	334	338	PF00917	0.480
DOC_CYCLIN_RxL_1	126	136	PF00134	0.477
DOC_CYCLIN_RxL_1	587	595	PF00134	0.470
DOC_CYCLIN_RxL_1	605	613	PF00134	0.268
DOC_CYCLIN_yCln2_LP_2	649	655	PF00134	0.371
DOC_MAPK_MEF2A_6	374	382	PF00069	0.615
DOC_MAPK_MEF2A_6	487	495	PF00069	0.443
DOC_PP1_RVXF_1	606	612	PF00149	0.403
DOC_PP1_RVXF_1	645	652	PF00149	0.341
DOC_PP1_RVXF_1	69	76	PF00149	0.429
DOC_PP2B_LxvP_1	632	635	PF13499	0.546
DOC_PP4_FxxP_1	284	287	PF00568	0.479
DOC_PP4_FxxP_1	653	656	PF00568	0.395
DOC_USP7_MATH_1	133	137	PF00917	0.697
DOC_USP7_MATH_1	186	190	PF00917	0.647
DOC_USP7_MATH_1	24	28	PF00917	0.492
DOC_USP7_MATH_1	241	245	PF00917	0.596
DOC_USP7_MATH_1	265	269	PF00917	0.607
DOC_USP7_MATH_1	334	338	PF00917	0.461
DOC_USP7_MATH_1	34	38	PF00917	0.531
DOC_USP7_MATH_1	358	362	PF00917	0.672
DOC_USP7_MATH_1	49	53	PF00917	0.651
DOC_USP7_MATH_1	525	529	PF00917	0.438
DOC_USP7_MATH_1	563	567	PF00917	0.514
DOC_USP7_MATH_1	715	719	PF00917	0.350
DOC_WW_Pin1_4	19	24	PF00397	0.560
DOC_WW_Pin1_4	283	288	PF00397	0.606
DOC_WW_Pin1_4	299	304	PF00397	0.343
DOC_WW_Pin1_4	30	35	PF00397	0.521
DOC_WW_Pin1_4	45	50	PF00397	0.555
DOC_WW_Pin1_4	457	462	PF00397	0.633
DOC_WW_Pin1_4	663	668	PF00397	0.425
LIG_14-3-3_CanoR_1	18	23	PF00244	0.600
LIG_14-3-3_CanoR_1	442	448	PF00244	0.561
LIG_14-3-3_CanoR_1	533	538	PF00244	0.403
LIG_Actin_WH2_2	309	326	PF00022	0.414
LIG_Actin_WH2_2	93	109	PF00022	0.419
LIG_BRCT_BRCA1_1	301	305	PF00533	0.496
LIG_BRCT_BRCA1_1	534	538	PF00533	0.444
LIG_BRCT_BRCA1_1	594	598	PF00533	0.455
LIG_BRCT_BRCA1_1	647	651	PF00533	0.364
LIG_Clathr_ClatBox_1	490	494	PF01394	0.489
LIG_Clathr_ClatBox_1	609	613	PF01394	0.382
LIG_DLG_GKlike_1	533	541	PF00625	0.429
LIG_FHA_1	261	267	PF00498	0.600
LIG_FHA_1	502	508	PF00498	0.397
LIG_FHA_1	601	607	PF00498	0.413
LIG_FHA_1	664	670	PF00498	0.469
LIG_FHA_1	75	81	PF00498	0.457
LIG_FHA_2	157	163	PF00498	0.589
LIG_FHA_2	568	574	PF00498	0.623
LIG_FHA_2	706	712	PF00498	0.385
LIG_FHA_2	81	87	PF00498	0.508
LIG_LIR_Gen_1	112	122	PF02991	0.388
LIG_LIR_Gen_1	613	620	PF02991	0.376
LIG_LIR_Gen_1	695	705	PF02991	0.398
LIG_LIR_Nem_3	112	118	PF02991	0.401
LIG_LIR_Nem_3	302	307	PF02991	0.433
LIG_LIR_Nem_3	308	312	PF02991	0.419
LIG_LIR_Nem_3	317	323	PF02991	0.415
LIG_LIR_Nem_3	535	541	PF02991	0.499
LIG_LIR_Nem_3	613	617	PF02991	0.371
LIG_LIR_Nem_3	621	625	PF02991	0.358
LIG_LIR_Nem_3	695	701	PF02991	0.396
LIG_LYPXL_yS_3	309	312	PF13949	0.489
LIG_MLH1_MIPbox_1	301	305	PF16413	0.496
LIG_MYND_1	26	30	PF01753	0.541
LIG_NRBOX	605	611	PF00104	0.376
LIG_PALB2_WD40_1	622	630	PF16756	0.304
LIG_PDZ_Class_3	720	725	PF00595	0.513
LIG_Pex14_2	280	284	PF04695	0.403
LIG_SH2_CRK	307	311	PF00017	0.506
LIG_SH2_CRK	614	618	PF00017	0.437
LIG_SH2_SRC	307	310	PF00017	0.510
LIG_SH2_STAP1	203	207	PF00017	0.533
LIG_SH2_STAP1	293	297	PF00017	0.484
LIG_SH2_STAP1	539	543	PF00017	0.363
LIG_SH2_STAT5	208	211	PF00017	0.486
LIG_SH2_STAT5	304	307	PF00017	0.431
LIG_SH2_STAT5	79	82	PF00017	0.399
LIG_SH3_1	254	260	PF00018	0.632
LIG_SH3_3	20	26	PF00018	0.561
LIG_SH3_3	254	260	PF00018	0.680
LIG_SH3_3	478	484	PF00018	0.762
LIG_SH3_3	86	92	PF00018	0.516
LIG_SUMO_SIM_anti_2	489	494	PF11976	0.440
LIG_SUMO_SIM_par_1	489	494	PF11976	0.440
LIG_TRAF2_1	562	565	PF00917	0.559
LIG_TYR_ITIM	612	617	PF00017	0.368
LIG_UBA3_1	222	230	PF00899	0.473
LIG_WW_3	480	484	PF00397	0.635
MOD_CK1_1	145	151	PF00069	0.586
MOD_CK1_1	168	174	PF00069	0.626
MOD_CK1_1	381	387	PF00069	0.690
MOD_CK1_1	460	466	PF00069	0.637
MOD_CK1_1	529	535	PF00069	0.457
MOD_CK1_1	618	624	PF00069	0.388
MOD_CK1_1	628	634	PF00069	0.410
MOD_CK1_1	641	647	PF00069	0.362
MOD_CK1_1	74	80	PF00069	0.455
MOD_CK2_1	149	155	PF00069	0.663
MOD_CK2_1	157	163	PF00069	0.577
MOD_CK2_1	525	531	PF00069	0.501
MOD_CK2_1	662	668	PF00069	0.436
MOD_CK2_1	80	86	PF00069	0.427
MOD_Cter_Amidation	392	395	PF01082	0.570
MOD_GlcNHglycan	135	138	PF01048	0.599
MOD_GlcNHglycan	149	152	PF01048	0.556
MOD_GlcNHglycan	337	340	PF01048	0.553
MOD_GlcNHglycan	360	363	PF01048	0.738
MOD_GlcNHglycan	364	367	PF01048	0.769
MOD_GlcNHglycan	416	419	PF01048	0.601
MOD_GlcNHglycan	462	465	PF01048	0.684
MOD_GlcNHglycan	472	475	PF01048	0.620
MOD_GlcNHglycan	51	54	PF01048	0.669
MOD_GlcNHglycan	541	544	PF01048	0.395
MOD_GlcNHglycan	55	58	PF01048	0.642
MOD_GlcNHglycan	622	625	PF01048	0.364
MOD_GlcNHglycan	627	630	PF01048	0.392
MOD_GSK3_1	133	140	PF00069	0.581
MOD_GSK3_1	143	150	PF00069	0.540
MOD_GSK3_1	260	267	PF00069	0.602
MOD_GSK3_1	289	296	PF00069	0.448
MOD_GSK3_1	30	37	PF00069	0.530
MOD_GSK3_1	358	365	PF00069	0.631
MOD_GSK3_1	378	385	PF00069	0.487
MOD_GSK3_1	45	52	PF00069	0.583
MOD_GSK3_1	459	466	PF00069	0.636
MOD_GSK3_1	497	504	PF00069	0.385
MOD_GSK3_1	521	528	PF00069	0.518
MOD_GSK3_1	529	536	PF00069	0.479
MOD_GSK3_1	563	570	PF00069	0.518
MOD_GSK3_1	592	599	PF00069	0.395
MOD_GSK3_1	600	607	PF00069	0.348
MOD_GSK3_1	637	644	PF00069	0.466
MOD_GSK3_1	659	666	PF00069	0.584
MOD_N-GLC_1	358	363	PF02516	0.632
MOD_N-GLC_1	497	502	PF02516	0.385
MOD_N-GLC_1	618	623	PF02516	0.312
MOD_N-GLC_1	641	646	PF02516	0.325
MOD_NEK2_1	122	127	PF00069	0.441
MOD_NEK2_1	147	152	PF00069	0.700
MOD_NEK2_1	443	448	PF00069	0.583
MOD_NEK2_1	486	491	PF00069	0.437
MOD_NEK2_1	497	502	PF00069	0.385
MOD_NEK2_1	537	542	PF00069	0.411
MOD_NEK2_1	592	597	PF00069	0.457
MOD_NEK2_1	620	625	PF00069	0.440
MOD_NEK2_1	645	650	PF00069	0.360
MOD_NEK2_1	80	85	PF00069	0.417
MOD_NEK2_2	186	191	PF00069	0.548
MOD_PIKK_1	91	97	PF00454	0.563
MOD_PKA_1	18	24	PF00069	0.559
MOD_PKA_2	102	108	PF00069	0.431
MOD_PKA_2	18	24	PF00069	0.607
MOD_PKA_2	43	49	PF00069	0.623
MOD_PKA_2	441	447	PF00069	0.549
MOD_PKA_2	486	492	PF00069	0.428
MOD_PKA_2	529	535	PF00069	0.521
MOD_PKB_1	16	24	PF00069	0.558
MOD_PKB_1	174	182	PF00069	0.604
MOD_Plk_1	143	149	PF00069	0.576
MOD_Plk_1	289	295	PF00069	0.487
MOD_Plk_1	563	569	PF00069	0.515
MOD_Plk_1	618	624	PF00069	0.322
MOD_Plk_1	641	647	PF00069	0.331
MOD_Plk_2-3	102	108	PF00069	0.471
MOD_Plk_2-3	157	163	PF00069	0.595
MOD_Plk_2-3	550	556	PF00069	0.453
MOD_Plk_4	293	299	PF00069	0.490
MOD_Plk_4	308	314	PF00069	0.332
MOD_Plk_4	486	492	PF00069	0.428
MOD_Plk_4	533	539	PF00069	0.489
MOD_Plk_4	641	647	PF00069	0.464
MOD_Plk_4	71	77	PF00069	0.563
MOD_Plk_4	715	721	PF00069	0.377
MOD_ProDKin_1	19	25	PF00069	0.563
MOD_ProDKin_1	283	289	PF00069	0.604
MOD_ProDKin_1	299	305	PF00069	0.336
MOD_ProDKin_1	30	36	PF00069	0.518
MOD_ProDKin_1	45	51	PF00069	0.558
MOD_ProDKin_1	457	463	PF00069	0.634
MOD_ProDKin_1	663	669	PF00069	0.413
TRG_DiLeu_BaEn_1	383	388	PF01217	0.615
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.576
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.395
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.369
TRG_ENDOCYTIC_2	115	118	PF00928	0.416
TRG_ENDOCYTIC_2	309	312	PF00928	0.422
TRG_ENDOCYTIC_2	614	617	PF00928	0.363
TRG_ER_diArg_1	15	18	PF00400	0.554
TRG_ER_diArg_1	173	176	PF00400	0.751
TRG_ER_diArg_1	298	300	PF00400	0.459
TRG_ER_diArg_1	469	471	PF00400	0.567
TRG_ER_diArg_1	505	507	PF00400	0.408
TRG_ER_diArg_1	514	517	PF00400	0.419
TRG_NES_CRM1_1	710	724	PF08389	0.459
TRG_NLS_MonoExtN_4	225	232	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	344	349	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT3	Leptomonas seymouri	49%	100%
A0A3Q8IF20	Leishmania donovani	99%	100%
A4HBN5	Leishmania braziliensis	77%	99%
E9AV04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCH8	Leishmania major	91%	99%