Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ35_LEIIN

TriTrypDb:

LINF_210009000

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.716
CLV_NRD_NRD_1	10	12	PF00675	0.544
CLV_NRD_NRD_1	121	123	PF00675	0.643
CLV_NRD_NRD_1	147	149	PF00675	0.657
CLV_NRD_NRD_1	220	222	PF00675	0.828
CLV_NRD_NRD_1	36	38	PF00675	0.557
CLV_PCSK_FUR_1	121	125	PF00082	0.648
CLV_PCSK_KEX2_1	10	12	PF00082	0.544
CLV_PCSK_KEX2_1	121	123	PF00082	0.647
CLV_PCSK_KEX2_1	147	149	PF00082	0.657
CLV_PCSK_KEX2_1	199	201	PF00082	0.647
CLV_PCSK_KEX2_1	220	222	PF00082	0.828
CLV_PCSK_KEX2_1	36	38	PF00082	0.561
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.646
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.647
DOC_MAPK_gen_1	92	100	PF00069	0.696
DOC_PP2B_LxvP_1	115	118	PF13499	0.587
DOC_PP4_FxxP_1	269	272	PF00568	0.666
DOC_USP7_MATH_1	2	6	PF00917	0.591
DOC_USP7_MATH_1	219	223	PF00917	0.764
DOC_WW_Pin1_4	129	134	PF00397	0.634
DOC_WW_Pin1_4	179	184	PF00397	0.713
DOC_WW_Pin1_4	207	212	PF00397	0.814
LIG_14-3-3_CanoR_1	49	53	PF00244	0.532
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_FHA_1	246	252	PF00498	0.579
LIG_FHA_1	83	89	PF00498	0.629
LIG_FHA_2	14	20	PF00498	0.508
LIG_FHA_2	147	153	PF00498	0.747
LIG_LIR_Apic_2	267	272	PF02991	0.773
LIG_LIR_Gen_1	17	27	PF02991	0.531
LIG_LIR_Nem_3	17	23	PF02991	0.532
LIG_MYND_1	272	276	PF01753	0.640
LIG_SH2_NCK_1	193	197	PF00017	0.810
LIG_SH2_SRC	193	196	PF00017	0.811
LIG_SH2_STAP1	20	24	PF00017	0.539
LIG_SH2_STAT5	63	66	PF00017	0.510
LIG_SH3_2	216	221	PF14604	0.733
LIG_SH3_2	272	277	PF14604	0.583
LIG_SH3_3	166	172	PF00018	0.672
LIG_SH3_3	180	186	PF00018	0.754
LIG_SH3_3	213	219	PF00018	0.646
LIG_SH3_3	269	275	PF00018	0.590
LIG_WRC_WIRS_1	103	108	PF05994	0.493
LIG_WW_1	190	193	PF00397	0.637
LIG_WW_3	189	193	PF00397	0.636
MOD_CK1_1	167	173	PF00069	0.727
MOD_CK1_1	178	184	PF00069	0.679
MOD_CK1_1	222	228	PF00069	0.653
MOD_CK2_1	13	19	PF00069	0.467
MOD_CK2_1	146	152	PF00069	0.746
MOD_CK2_1	253	259	PF00069	0.713
MOD_Cter_Amidation	197	200	PF01082	0.642
MOD_GlcNHglycan	160	163	PF01048	0.730
MOD_GlcNHglycan	165	169	PF01048	0.688
MOD_GlcNHglycan	177	180	PF01048	0.527
MOD_GlcNHglycan	221	224	PF01048	0.754
MOD_GlcNHglycan	225	228	PF01048	0.741
MOD_GlcNHglycan	245	248	PF01048	0.745
MOD_GlcNHglycan	255	258	PF01048	0.541
MOD_GlcNHglycan	266	269	PF01048	0.710
MOD_GSK3_1	173	180	PF00069	0.781
MOD_GSK3_1	181	188	PF00069	0.683
MOD_GSK3_1	219	226	PF00069	0.714
MOD_GSK3_1	239	246	PF00069	0.681
MOD_NEK2_1	177	182	PF00069	0.753
MOD_NEK2_1	264	269	PF00069	0.762
MOD_PIKK_1	126	132	PF00454	0.761
MOD_PKA_2	146	152	PF00069	0.690
MOD_PKA_2	219	225	PF00069	0.820
MOD_PKA_2	48	54	PF00069	0.535
MOD_PKB_1	124	132	PF00069	0.763
MOD_Plk_4	99	105	PF00069	0.565
MOD_ProDKin_1	129	135	PF00069	0.626
MOD_ProDKin_1	179	185	PF00069	0.712
MOD_ProDKin_1	207	213	PF00069	0.813
TRG_ENDOCYTIC_2	20	23	PF00928	0.538
TRG_ER_diArg_1	121	124	PF00400	0.637
TRG_ER_diArg_1	138	141	PF00400	0.605
TRG_ER_diArg_1	219	221	PF00400	0.821
TRG_ER_diArg_1	9	11	PF00400	0.556
TRG_NLS_MonoExtC_3	121	126	PF00514	0.773
TRG_NLS_MonoExtN_4	121	127	PF00514	0.770
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD3	Leptomonas seymouri	51%	100%
A0A3S7WWE9	Leishmania donovani	99%	100%
A4HBN4	Leishmania braziliensis	74%	98%
E9AV03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q4QCH9	Leishmania major	85%	97%