LeishMANIAdb
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Putative mitochondrial processing peptidase alpha subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial processing peptidase alpha subunit
Gene product:
mitochondrial processing peptidase alpha subunit - putative
Species:
Leishmania infantum
UniProt:
A4HZ33_LEIIN
TriTrypDb:
LINF_210008800
Length:
467

Annotations

Annotations by Jardim et al.

Proteases, mitochondrial processing peptidase alpha subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZ33
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ33

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 22
GO:0043167 ion binding 2 22
GO:0043169 cation binding 3 22
GO:0046872 metal ion binding 4 22
GO:0003824 catalytic activity 1 6
GO:0004175 endopeptidase activity 4 6
GO:0004222 metalloendopeptidase activity 5 6
GO:0008233 peptidase activity 3 6
GO:0008237 metallopeptidase activity 4 6
GO:0016787 hydrolase activity 2 6
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 159 163 PF00656 0.230
CLV_C14_Caspase3-7 92 96 PF00656 0.258
CLV_NRD_NRD_1 129 131 PF00675 0.262
CLV_PCSK_KEX2_1 119 121 PF00082 0.234
CLV_PCSK_KEX2_1 129 131 PF00082 0.232
CLV_PCSK_KEX2_1 388 390 PF00082 0.442
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.239
CLV_PCSK_PC1ET2_1 388 390 PF00082 0.442
CLV_PCSK_SKI1_1 208 212 PF00082 0.318
CLV_PCSK_SKI1_1 21 25 PF00082 0.501
CLV_PCSK_SKI1_1 222 226 PF00082 0.232
CLV_PCSK_SKI1_1 368 372 PF00082 0.425
CLV_PCSK_SKI1_1 446 450 PF00082 0.270
CLV_PCSK_SKI1_1 86 90 PF00082 0.336
DEG_APCC_DBOX_1 221 229 PF00400 0.228
DEG_Nend_Nbox_1 1 3 PF02207 0.455
DEG_SCF_FBW7_1 75 82 PF00400 0.210
DEG_SPOP_SBC_1 373 377 PF00917 0.191
DOC_CKS1_1 76 81 PF01111 0.210
DOC_MAPK_FxFP_2 456 459 PF00069 0.407
DOC_PP1_RVXF_1 118 125 PF00149 0.258
DOC_PP2B_LxvP_1 191 194 PF13499 0.317
DOC_PP4_FxxP_1 15 18 PF00568 0.401
DOC_PP4_FxxP_1 346 349 PF00568 0.277
DOC_PP4_FxxP_1 456 459 PF00568 0.407
DOC_USP7_MATH_1 327 331 PF00917 0.503
DOC_USP7_MATH_1 349 353 PF00917 0.222
DOC_USP7_MATH_1 39 43 PF00917 0.477
DOC_USP7_MATH_1 59 63 PF00917 0.286
DOC_USP7_UBL2_3 241 245 PF12436 0.529
DOC_WW_Pin1_4 33 38 PF00397 0.425
DOC_WW_Pin1_4 413 418 PF00397 0.339
DOC_WW_Pin1_4 75 80 PF00397 0.210
LIG_14-3-3_CanoR_1 103 112 PF00244 0.257
LIG_14-3-3_CanoR_1 120 125 PF00244 0.363
LIG_14-3-3_CanoR_1 204 211 PF00244 0.417
LIG_14-3-3_CanoR_1 21 30 PF00244 0.427
LIG_14-3-3_CanoR_1 3 11 PF00244 0.388
LIG_14-3-3_CanoR_1 348 358 PF00244 0.264
LIG_14-3-3_CanoR_1 50 59 PF00244 0.349
LIG_APCC_ABBA_1 63 68 PF00400 0.262
LIG_BIR_III_2 68 72 PF00653 0.363
LIG_BRCT_BRCA1_1 374 378 PF00533 0.449
LIG_BRCT_BRCA1_1 454 458 PF00533 0.324
LIG_BRCT_BRCA1_1 95 99 PF00533 0.258
LIG_Clathr_ClatBox_1 98 102 PF01394 0.230
LIG_deltaCOP1_diTrp_1 131 137 PF00928 0.223
LIG_deltaCOP1_diTrp_1 212 218 PF00928 0.312
LIG_eIF4E_1 350 356 PF01652 0.266
LIG_FHA_1 140 146 PF00498 0.241
LIG_FHA_1 3 9 PF00498 0.513
LIG_FHA_1 314 320 PF00498 0.329
LIG_FHA_1 44 50 PF00498 0.421
LIG_FHA_1 76 82 PF00498 0.236
LIG_FHA_2 286 292 PF00498 0.398
LIG_LIR_Apic_2 12 18 PF02991 0.493
LIG_LIR_Apic_2 131 136 PF02991 0.223
LIG_LIR_Apic_2 167 173 PF02991 0.230
LIG_LIR_Apic_2 454 459 PF02991 0.393
LIG_LIR_Gen_1 134 145 PF02991 0.258
LIG_LIR_Gen_1 406 417 PF02991 0.305
LIG_LIR_Nem_3 134 140 PF02991 0.258
LIG_LIR_Nem_3 406 412 PF02991 0.338
LIG_LIR_Nem_3 455 461 PF02991 0.339
LIG_PDZ_Class_1 462 467 PF00595 0.291
LIG_Pex14_1 133 137 PF04695 0.223
LIG_Pex14_1 214 218 PF04695 0.341
LIG_SH2_CRK 73 77 PF00017 0.237
LIG_SH2_NCK_1 350 354 PF00017 0.310
LIG_SH2_NCK_1 66 70 PF00017 0.290
LIG_SH2_NCK_1 73 77 PF00017 0.253
LIG_SH2_PTP2 395 398 PF00017 0.206
LIG_SH2_SRC 324 327 PF00017 0.446
LIG_SH2_SRC 66 69 PF00017 0.233
LIG_SH2_SRC 73 76 PF00017 0.228
LIG_SH2_STAP1 11 15 PF00017 0.567
LIG_SH2_STAP1 279 283 PF00017 0.354
LIG_SH2_STAP1 314 318 PF00017 0.277
LIG_SH2_STAP1 324 328 PF00017 0.321
LIG_SH2_STAT3 11 14 PF00017 0.536
LIG_SH2_STAT3 341 344 PF00017 0.418
LIG_SH2_STAT5 121 124 PF00017 0.272
LIG_SH2_STAT5 358 361 PF00017 0.348
LIG_SH2_STAT5 395 398 PF00017 0.413
LIG_SH2_STAT5 409 412 PF00017 0.317
LIG_SH2_STAT5 83 86 PF00017 0.304
LIG_SH3_3 141 147 PF00018 0.298
LIG_SH3_3 225 231 PF00018 0.299
LIG_SH3_3 297 303 PF00018 0.439
LIG_TRAF2_1 419 422 PF00917 0.479
LIG_WRPW_2 347 350 PF00400 0.266
MOD_CK1_1 19 25 PF00069 0.531
MOD_CK1_1 416 422 PF00069 0.417
MOD_CK1_1 428 434 PF00069 0.325
MOD_CK2_1 149 155 PF00069 0.257
MOD_CK2_1 416 422 PF00069 0.406
MOD_Cter_Amidation 127 130 PF01082 0.231
MOD_GlcNHglycan 21 24 PF01048 0.458
MOD_GlcNHglycan 246 249 PF01048 0.416
MOD_GlcNHglycan 329 332 PF01048 0.508
MOD_GlcNHglycan 351 354 PF01048 0.240
MOD_GlcNHglycan 427 430 PF01048 0.418
MOD_GSK3_1 101 108 PF00069 0.269
MOD_GSK3_1 313 320 PF00069 0.405
MOD_GSK3_1 327 334 PF00069 0.481
MOD_GSK3_1 39 46 PF00069 0.369
MOD_GSK3_1 412 419 PF00069 0.346
MOD_GSK3_1 75 82 PF00069 0.321
MOD_GSK3_1 89 96 PF00069 0.213
MOD_NEK2_1 105 110 PF00069 0.173
MOD_NEK2_1 139 144 PF00069 0.297
MOD_NEK2_1 2 7 PF00069 0.414
MOD_NEK2_1 412 417 PF00069 0.288
MOD_NEK2_1 460 465 PF00069 0.310
MOD_NEK2_1 89 94 PF00069 0.239
MOD_PKA_2 105 111 PF00069 0.200
MOD_PKA_2 157 163 PF00069 0.230
MOD_PKA_2 2 8 PF00069 0.408
MOD_PKA_2 203 209 PF00069 0.429
MOD_Plk_1 101 107 PF00069 0.239
MOD_Plk_1 94 100 PF00069 0.239
MOD_Plk_4 366 372 PF00069 0.410
MOD_Plk_4 79 85 PF00069 0.264
MOD_Plk_4 94 100 PF00069 0.220
MOD_ProDKin_1 33 39 PF00069 0.423
MOD_ProDKin_1 413 419 PF00069 0.341
MOD_ProDKin_1 75 81 PF00069 0.210
TRG_DiLeu_BaLyEn_6 394 399 PF01217 0.279
TRG_ENDOCYTIC_2 239 242 PF00928 0.348
TRG_ENDOCYTIC_2 395 398 PF00928 0.361
TRG_ENDOCYTIC_2 409 412 PF00928 0.290
TRG_ENDOCYTIC_2 73 76 PF00928 0.180
TRG_Pf-PMV_PEXEL_1 321 325 PF00026 0.270
TRG_Pf-PMV_PEXEL_1 397 401 PF00026 0.355

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM61 Leptomonas seymouri 78% 100%
A0A0N1PFG1 Leptomonas seymouri 41% 89%
A0A0S4IY11 Bodo saltans 50% 96%
A0A0S4JST8 Bodo saltans 42% 99%
A0A1X0NPP7 Trypanosomatidae 40% 89%
A0A1X0NXN6 Trypanosomatidae 60% 100%
A0A3Q8IBQ6 Leishmania donovani 40% 88%
A0A3R7JXS6 Trypanosoma rangeli 62% 100%
A0A3R7MEV0 Trypanosoma rangeli 41% 89%
A0A3S7WWC3 Leishmania donovani 100% 100%
A4H775 Leishmania braziliensis 39% 100%
A4HBN2 Leishmania braziliensis 90% 100%
A4HVL5 Leishmania infantum 39% 100%
D0A6P1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 90%
E9APB1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AV01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O60044 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
O75439 Homo sapiens 22% 96%
P10507 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
P11913 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 24% 98%
P11914 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 97%
P22695 Homo sapiens 22% 100%
P23004 Bos taurus 22% 100%
P29677 Solanum tuberosum 22% 93%
P32551 Rattus norvegicus 24% 100%
P43265 Euglena gracilis 24% 99%
Q03346 Rattus norvegicus 24% 96%
Q0P5M8 Bos taurus 21% 89%
Q10713 Homo sapiens 21% 89%
Q23295 Caenorhabditis elegans 24% 100%
Q3SZ71 Bos taurus 23% 95%
Q4QCI1 Leishmania major 97% 100%
Q4QG67 Leishmania major 40% 100%
Q54F93 Dictyostelium discoideum 23% 100%
Q5R513 Pongo abelii 21% 89%
Q5REK3 Pongo abelii 22% 96%
Q9CXT8 Mus musculus 23% 96%
Q9DB77 Mus musculus 23% 100%
Q9DC61 Mus musculus 21% 89%
V5BB16 Trypanosoma cruzi 39% 84%
V5BQ54 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS