CHORD domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CHORD - putative

Species:

Leishmania infantum

UniProt:

A4HZ16_LEIIN

TriTrypDb:

LINF_200022700

Length:

296

Annotations

Annotations by Jardim et al.

Metal Binding, CHORD, putative |

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 190

Expansion

Sequence features

A4HZ16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ16

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0051298	centrosome duplication	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.478
CLV_C14_Caspase3-7	247	251	PF00656	0.468
CLV_PCSK_KEX2_1	206	208	PF00082	0.581
CLV_PCSK_KEX2_1	53	55	PF00082	0.491
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.720
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.491
CLV_PCSK_SKI1_1	41	45	PF00082	0.390
CLV_PCSK_SKI1_1	48	52	PF00082	0.413
DEG_Nend_UBRbox_1	1	4	PF02207	0.362
DOC_CYCLIN_RxL_1	35	49	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.492
DOC_MAPK_FxFP_2	175	178	PF00069	0.598
DOC_MAPK_gen_1	48	58	PF00069	0.488
DOC_MAPK_MEF2A_6	179	187	PF00069	0.607
DOC_PP1_RVXF_1	274	281	PF00149	0.545
DOC_PP1_RVXF_1	39	46	PF00149	0.427
DOC_PP2B_LxvP_1	183	186	PF13499	0.559
DOC_PP4_FxxP_1	175	178	PF00568	0.557
DOC_USP7_MATH_1	193	197	PF00917	0.560
DOC_USP7_UBL2_3	93	97	PF12436	0.497
LIG_14-3-3_CanoR_1	167	176	PF00244	0.585
LIG_14-3-3_CanoR_1	41	46	PF00244	0.377
LIG_Actin_WH2_2	91	109	PF00022	0.468
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.506
LIG_deltaCOP1_diTrp_1	153	157	PF00928	0.446
LIG_FHA_1	42	48	PF00498	0.377
LIG_LIR_Gen_1	151	161	PF02991	0.449
LIG_LIR_Gen_1	279	287	PF02991	0.446
LIG_LIR_Gen_1	83	91	PF02991	0.349
LIG_LIR_Nem_3	151	157	PF02991	0.449
LIG_LIR_Nem_3	279	283	PF02991	0.446
LIG_LIR_Nem_3	83	88	PF02991	0.358
LIG_Rb_pABgroove_1	1	9	PF01858	0.294
LIG_REV1ctd_RIR_1	43	52	PF16727	0.433
LIG_SH2_STAT5	4	7	PF00017	0.328
LIG_SH3_3	281	287	PF00018	0.446
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.454
LIG_TRAF2_1	178	181	PF00917	0.602
LIG_TRAF2_2	224	229	PF00917	0.554
LIG_UBA3_1	90	97	PF00899	0.420
LIG_WRC_WIRS_1	42	47	PF05994	0.396
MOD_CK1_1	196	202	PF00069	0.666
MOD_CK1_1	68	74	PF00069	0.413
MOD_CK1_1	77	83	PF00069	0.389
MOD_CK2_1	16	22	PF00069	0.350
MOD_CK2_1	30	36	PF00069	0.452
MOD_Cter_Amidation	147	150	PF01082	0.278
MOD_Cter_Amidation	204	207	PF01082	0.679
MOD_GlcNHglycan	187	190	PF01048	0.502
MOD_GlcNHglycan	195	198	PF01048	0.590
MOD_GlcNHglycan	199	202	PF01048	0.611
MOD_GlcNHglycan	67	70	PF01048	0.427
MOD_GSK3_1	16	23	PF00069	0.562
MOD_GSK3_1	193	200	PF00069	0.601
MOD_N-GLC_2	125	127	PF02516	0.278
MOD_NEK2_1	106	111	PF00069	0.372
MOD_NEK2_1	187	192	PF00069	0.538
MOD_NEK2_1	20	25	PF00069	0.520
MOD_NEK2_1	262	267	PF00069	0.446
MOD_NEK2_1	46	51	PF00069	0.336
MOD_NEK2_1	65	70	PF00069	0.219
MOD_NEK2_1	74	79	PF00069	0.538
MOD_PIKK_1	187	193	PF00454	0.581
MOD_PKA_1	206	212	PF00069	0.640
MOD_PKA_2	106	112	PF00069	0.405
MOD_PKA_2	166	172	PF00069	0.606
MOD_PKA_2	193	199	PF00069	0.437
MOD_PKA_2	206	212	PF00069	0.529
MOD_PKA_2	74	80	PF00069	0.389
MOD_Plk_2-3	153	159	PF00069	0.520
MOD_Plk_4	41	47	PF00069	0.389
MOD_SUMO_for_1	178	181	PF00179	0.553
MOD_SUMO_rev_2	199	208	PF00179	0.564
MOD_SUMO_rev_2	223	232	PF00179	0.441
TRG_DiLeu_BaEn_2	278	284	PF01217	0.457
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.474
TRG_ENDOCYTIC_2	85	88	PF00928	0.345
TRG_ER_diArg_1	72	75	PF00400	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I9	Leptomonas seymouri	67%	100%
A0A0S4J9B3	Bodo saltans	51%	98%
A0A1X0NW45	Trypanosomatidae	47%	97%
A0A3Q8IAQ6	Leishmania donovani	100%	100%
A0A3R7MVQ5	Trypanosoma rangeli	52%	99%
A9YUB1	Sus scrofa	28%	89%
C9ZIN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
D4A4T9	Rattus norvegicus	28%	89%
E9AIN0	Leishmania braziliensis	76%	100%
E9AUW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
G5EEI8	Caenorhabditis elegans	32%	92%
Q29RL2	Bos taurus	28%	89%
Q462R2	Sus scrofa	31%	86%
Q4QCL9	Leishmania major	92%	100%
Q4R7U2	Macaca fascicularis	28%	89%
Q5RD91	Pongo abelii	28%	89%
Q5ZML4	Gallus gallus	28%	89%
Q6EPW7	Oryza sativa subsp. japonica	30%	100%
Q6NUA0	Xenopus laevis	29%	89%
Q7T3F7	Danio rerio	30%	87%
Q9D1P4	Mus musculus	28%	89%
Q9R000	Mus musculus	31%	85%
Q9SE33	Arabidopsis thaliana	30%	100%
Q9UHD1	Homo sapiens	28%	89%
Q9UKP3	Homo sapiens	27%	85%
Q9VCC0	Drosophila melanogaster	28%	84%
V5D8W5	Trypanosoma cruzi	49%	86%