WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ14_LEIIN

TriTrypDb:

LINF_200022500

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	419	421	PF00675	0.402
CLV_NRD_NRD_1	615	617	PF00675	0.509
CLV_NRD_NRD_1	8	10	PF00675	0.562
CLV_PCSK_FUR_1	6	10	PF00082	0.446
CLV_PCSK_KEX2_1	201	203	PF00082	0.375
CLV_PCSK_KEX2_1	504	506	PF00082	0.489
CLV_PCSK_KEX2_1	615	617	PF00082	0.483
CLV_PCSK_KEX2_1	8	10	PF00082	0.566
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.375
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.489
CLV_PCSK_SKI1_1	411	415	PF00082	0.438
CLV_PCSK_SKI1_1	515	519	PF00082	0.340
CLV_PCSK_SKI1_1	623	627	PF00082	0.580
CLV_PCSK_SKI1_1	712	716	PF00082	0.508
CLV_PCSK_SKI1_1	727	731	PF00082	0.315
CLV_PCSK_SKI1_1	759	763	PF00082	0.471
CLV_PCSK_SKI1_1	88	92	PF00082	0.425
CLV_PCSK_SKI1_1	9	13	PF00082	0.510
CLV_PCSK_SKI1_1	957	961	PF00082	0.343
DEG_APCC_DBOX_1	514	522	PF00400	0.345
DEG_APCC_DBOX_1	622	630	PF00400	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DOC_MAPK_gen_1	420	427	PF00069	0.375
DOC_MAPK_MEF2A_6	804	811	PF00069	0.382
DOC_MAPK_MEF2A_6	970	978	PF00069	0.558
DOC_PP2B_LxvP_1	369	372	PF13499	0.490
DOC_PP2B_PxIxI_1	804	810	PF00149	0.438
DOC_PP4_FxxP_1	993	996	PF00568	0.455
DOC_USP7_MATH_1	272	276	PF00917	0.508
DOC_USP7_MATH_1	400	404	PF00917	0.414
DOC_USP7_MATH_1	446	450	PF00917	0.485
DOC_USP7_MATH_1	651	655	PF00917	0.550
DOC_USP7_MATH_1	749	753	PF00917	0.363
DOC_USP7_MATH_1	867	871	PF00917	0.321
DOC_USP7_MATH_1	938	942	PF00917	0.518
DOC_USP7_MATH_1	963	967	PF00917	0.576
DOC_USP7_MATH_2	260	266	PF00917	0.452
DOC_WW_Pin1_4	405	410	PF00397	0.402
DOC_WW_Pin1_4	615	620	PF00397	0.546
DOC_WW_Pin1_4	694	699	PF00397	0.638
DOC_WW_Pin1_4	934	939	PF00397	0.437
DOC_WW_Pin1_4	984	989	PF00397	0.367
DOC_WW_Pin1_4	992	997	PF00397	0.345
LIG_14-3-3_CanoR_1	115	123	PF00244	0.427
LIG_14-3-3_CanoR_1	237	243	PF00244	0.538
LIG_14-3-3_CanoR_1	333	340	PF00244	0.315
LIG_14-3-3_CanoR_1	411	418	PF00244	0.415
LIG_14-3-3_CanoR_1	445	451	PF00244	0.498
LIG_14-3-3_CanoR_1	505	509	PF00244	0.552
LIG_14-3-3_CanoR_1	610	615	PF00244	0.539
LIG_14-3-3_CanoR_1	704	709	PF00244	0.496
LIG_14-3-3_CanoR_1	727	732	PF00244	0.537
LIG_14-3-3_CanoR_1	860	867	PF00244	0.421
LIG_14-3-3_CanoR_1	88	93	PF00244	0.542
LIG_Actin_WH2_2	601	617	PF00022	0.420
LIG_AP2alpha_2	748	750	PF02296	0.332
LIG_APCC_ABBA_1	425	430	PF00400	0.377
LIG_BRCT_BRCA1_1	199	203	PF00533	0.443
LIG_BRCT_BRCA1_1	229	233	PF00533	0.364
LIG_BRCT_BRCA1_1	646	650	PF00533	0.463
LIG_BRCT_BRCA1_1	952	956	PF00533	0.519
LIG_Clathr_ClatBox_1	311	315	PF01394	0.409
LIG_eIF4E_1	288	294	PF01652	0.433
LIG_FAT_LD_1	489	497	PF03623	0.420
LIG_FHA_1	103	109	PF00498	0.473
LIG_FHA_1	156	162	PF00498	0.387
LIG_FHA_1	244	250	PF00498	0.513
LIG_FHA_1	307	313	PF00498	0.410
LIG_FHA_1	320	326	PF00498	0.297
LIG_FHA_1	378	384	PF00498	0.418
LIG_FHA_1	40	46	PF00498	0.490
LIG_FHA_1	412	418	PF00498	0.382
LIG_FHA_1	438	444	PF00498	0.371
LIG_FHA_1	588	594	PF00498	0.511
LIG_FHA_1	713	719	PF00498	0.412
LIG_FHA_1	789	795	PF00498	0.531
LIG_FHA_1	915	921	PF00498	0.454
LIG_FHA_2	146	152	PF00498	0.390
LIG_FHA_2	73	79	PF00498	0.401
LIG_FHA_2	826	832	PF00498	0.416
LIG_FHA_2	922	928	PF00498	0.468
LIG_HCF-1_HBM_1	316	319	PF13415	0.439
LIG_LIR_Apic_2	302	307	PF02991	0.438
LIG_LIR_Apic_2	992	996	PF02991	0.487
LIG_LIR_Gen_1	262	272	PF02991	0.573
LIG_LIR_Gen_1	379	389	PF02991	0.360
LIG_LIR_Gen_1	423	428	PF02991	0.450
LIG_LIR_Gen_1	553	562	PF02991	0.451
LIG_LIR_Gen_1	673	682	PF02991	0.413
LIG_LIR_Gen_1	697	708	PF02991	0.608
LIG_LIR_Gen_1	748	758	PF02991	0.434
LIG_LIR_Gen_1	821	830	PF02991	0.317
LIG_LIR_LC3C_4	541	546	PF02991	0.448
LIG_LIR_Nem_3	200	206	PF02991	0.426
LIG_LIR_Nem_3	255	261	PF02991	0.534
LIG_LIR_Nem_3	262	267	PF02991	0.599
LIG_LIR_Nem_3	287	291	PF02991	0.448
LIG_LIR_Nem_3	423	427	PF02991	0.449
LIG_LIR_Nem_3	444	450	PF02991	0.469
LIG_LIR_Nem_3	553	559	PF02991	0.373
LIG_LIR_Nem_3	609	614	PF02991	0.527
LIG_LIR_Nem_3	673	678	PF02991	0.419
LIG_LIR_Nem_3	697	703	PF02991	0.617
LIG_LIR_Nem_3	748	753	PF02991	0.447
LIG_LIR_Nem_3	821	826	PF02991	0.360
LIG_LIR_Nem_3	953	959	PF02991	0.478
LIG_NRBOX	457	463	PF00104	0.460
LIG_NRBOX	561	567	PF00104	0.411
LIG_NRBOX	677	683	PF00104	0.455
LIG_PCNA_yPIPBox_3	448	462	PF02747	0.380
LIG_Pex14_1	26	30	PF04695	0.491
LIG_Pex14_2	169	173	PF04695	0.427
LIG_Pex14_2	607	611	PF04695	0.468
LIG_Pex14_2	810	814	PF04695	0.423
LIG_Pex14_2	981	985	PF04695	0.455
LIG_Pex14_2	993	997	PF04695	0.466
LIG_PTB_Apo_2	814	821	PF02174	0.459
LIG_PTB_Phospho_1	814	820	PF10480	0.460
LIG_SH2_CRK	195	199	PF00017	0.414
LIG_SH2_CRK	245	249	PF00017	0.506
LIG_SH2_CRK	264	268	PF00017	0.392
LIG_SH2_CRK	288	292	PF00017	0.434
LIG_SH2_CRK	304	308	PF00017	0.513
LIG_SH2_CRK	334	338	PF00017	0.371
LIG_SH2_CRK	424	428	PF00017	0.440
LIG_SH2_CRK	475	479	PF00017	0.464
LIG_SH2_NCK_1	304	308	PF00017	0.461
LIG_SH2_NCK_1	579	583	PF00017	0.362
LIG_SH2_PTP2	806	809	PF00017	0.441
LIG_SH2_SRC	127	130	PF00017	0.466
LIG_SH2_SRC	806	809	PF00017	0.389
LIG_SH2_STAP1	195	199	PF00017	0.414
LIG_SH2_STAP1	245	249	PF00017	0.506
LIG_SH2_STAP1	334	338	PF00017	0.402
LIG_SH2_STAP1	483	487	PF00017	0.491
LIG_SH2_STAP1	510	514	PF00017	0.392
LIG_SH2_STAP1	691	695	PF00017	0.607
LIG_SH2_STAT3	691	694	PF00017	0.427
LIG_SH2_STAT5	245	248	PF00017	0.585
LIG_SH2_STAT5	612	615	PF00017	0.533
LIG_SH2_STAT5	792	795	PF00017	0.439
LIG_SH2_STAT5	806	809	PF00017	0.319
LIG_SH2_STAT5	823	826	PF00017	0.273
LIG_SH3_3	1000	1006	PF00018	0.519
LIG_SH3_3	136	142	PF00018	0.428
LIG_SH3_3	212	218	PF00018	0.482
LIG_SH3_3	406	412	PF00018	0.380
LIG_SH3_3	44	50	PF00018	0.643
LIG_SH3_3	524	530	PF00018	0.433
LIG_SH3_3	660	666	PF00018	0.563
LIG_SH3_3	959	965	PF00018	0.352
LIG_SUMO_SIM_anti_2	104	112	PF11976	0.608
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.506
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.379
LIG_SUMO_SIM_anti_2	972	978	PF11976	0.482
LIG_SUMO_SIM_par_1	104	112	PF11976	0.499
LIG_SUMO_SIM_par_1	259	265	PF11976	0.611
LIG_SUMO_SIM_par_1	275	280	PF11976	0.319
LIG_SUMO_SIM_par_1	309	316	PF11976	0.426
LIG_SUMO_SIM_par_1	917	924	PF11976	0.469
LIG_TRAF2_1	313	316	PF00917	0.416
LIG_TRAF2_1	765	768	PF00917	0.445
LIG_TYR_ITIM	193	198	PF00017	0.412
LIG_TYR_ITIM	422	427	PF00017	0.454
LIG_TYR_ITIM	473	478	PF00017	0.440
LIG_UBA3_1	368	373	PF00899	0.436
LIG_UBA3_1	581	588	PF00899	0.570
LIG_WRC_WIRS_1	750	755	PF05994	0.442
LIG_WRC_WIRS_1	944	949	PF05994	0.603
MOD_CDC14_SPxK_1	408	411	PF00782	0.509
MOD_CDK_SPxK_1	405	411	PF00069	0.496
MOD_CK1_1	107	113	PF00069	0.580
MOD_CK1_1	238	244	PF00069	0.648
MOD_CK1_1	270	276	PF00069	0.498
MOD_CK1_1	384	390	PF00069	0.347
MOD_CK1_1	39	45	PF00069	0.623
MOD_CK1_1	468	474	PF00069	0.546
MOD_CK1_1	491	497	PF00069	0.601
MOD_CK1_1	567	573	PF00069	0.404
MOD_CK1_1	634	640	PF00069	0.532
MOD_CK1_1	66	72	PF00069	0.406
MOD_CK1_1	737	743	PF00069	0.399
MOD_CK1_1	835	841	PF00069	0.425
MOD_CK1_1	865	871	PF00069	0.397
MOD_CK1_1	896	902	PF00069	0.370
MOD_CK1_1	914	920	PF00069	0.310
MOD_CK1_1	942	948	PF00069	0.514
MOD_CK1_1	97	103	PF00069	0.548
MOD_CK2_1	145	151	PF00069	0.377
MOD_CK2_1	248	254	PF00069	0.529
MOD_CK2_1	292	298	PF00069	0.413
MOD_CK2_1	503	509	PF00069	0.497
MOD_CK2_1	577	583	PF00069	0.419
MOD_CK2_1	703	709	PF00069	0.460
MOD_CK2_1	762	768	PF00069	0.602
MOD_CK2_1	921	927	PF00069	0.438
MOD_GlcNHglycan	229	232	PF01048	0.477
MOD_GlcNHglycan	237	240	PF01048	0.590
MOD_GlcNHglycan	264	267	PF01048	0.693
MOD_GlcNHglycan	272	275	PF01048	0.506
MOD_GlcNHglycan	467	470	PF01048	0.465
MOD_GlcNHglycan	493	496	PF01048	0.615
MOD_GlcNHglycan	511	514	PF01048	0.248
MOD_GlcNHglycan	670	673	PF01048	0.540
MOD_GlcNHglycan	764	767	PF01048	0.459
MOD_GlcNHglycan	834	837	PF01048	0.490
MOD_GlcNHglycan	841	844	PF01048	0.572
MOD_GlcNHglycan	904	907	PF01048	0.470
MOD_GlcNHglycan	913	916	PF01048	0.376
MOD_GlcNHglycan	948	951	PF01048	0.535
MOD_GlcNHglycan	952	955	PF01048	0.473
MOD_GlcNHglycan	96	99	PF01048	0.615
MOD_GSK3_1	37	44	PF00069	0.426
MOD_GSK3_1	377	384	PF00069	0.382
MOD_GSK3_1	407	414	PF00069	0.396
MOD_GSK3_1	504	511	PF00069	0.484
MOD_GSK3_1	521	528	PF00069	0.399
MOD_GSK3_1	544	551	PF00069	0.505
MOD_GSK3_1	577	584	PF00069	0.377
MOD_GSK3_1	606	613	PF00069	0.511
MOD_GSK3_1	66	73	PF00069	0.542
MOD_GSK3_1	694	701	PF00069	0.496
MOD_GSK3_1	788	795	PF00069	0.445
MOD_GSK3_1	821	828	PF00069	0.511
MOD_GSK3_1	835	842	PF00069	0.438
MOD_GSK3_1	84	91	PF00069	0.294
MOD_GSK3_1	867	874	PF00069	0.464
MOD_GSK3_1	911	918	PF00069	0.384
MOD_GSK3_1	921	928	PF00069	0.329
MOD_GSK3_1	934	941	PF00069	0.425
MOD_GSK3_1	942	949	PF00069	0.600
MOD_N-GLC_1	374	379	PF02516	0.454
MOD_N-GLC_1	88	93	PF02516	0.384
MOD_N-GLC_1	915	920	PF02516	0.387
MOD_N-GLC_1	938	943	PF02516	0.516
MOD_NEK2_1	12	17	PF00069	0.539
MOD_NEK2_1	154	159	PF00069	0.516
MOD_NEK2_1	165	170	PF00069	0.454
MOD_NEK2_1	248	253	PF00069	0.491
MOD_NEK2_1	381	386	PF00069	0.420
MOD_NEK2_1	508	513	PF00069	0.451
MOD_NEK2_1	521	526	PF00069	0.309
MOD_NEK2_1	544	549	PF00069	0.436
MOD_NEK2_1	589	594	PF00069	0.460
MOD_NEK2_1	614	619	PF00069	0.541
MOD_NEK2_1	628	633	PF00069	0.374
MOD_NEK2_1	644	649	PF00069	0.314
MOD_NEK2_1	668	673	PF00069	0.430
MOD_NEK2_1	703	708	PF00069	0.457
MOD_NEK2_1	734	739	PF00069	0.494
MOD_NEK2_1	788	793	PF00069	0.355
MOD_NEK2_1	859	864	PF00069	0.438
MOD_NEK2_1	871	876	PF00069	0.499
MOD_NEK2_1	948	953	PF00069	0.628
MOD_NEK2_2	299	304	PF00069	0.403
MOD_NEK2_2	952	957	PF00069	0.468
MOD_OFUCOSY	520	525	PF10250	0.489
MOD_PIKK_1	683	689	PF00454	0.446
MOD_PIKK_1	70	76	PF00454	0.429
MOD_PIKK_1	853	859	PF00454	0.396
MOD_PK_1	893	899	PF00069	0.428
MOD_PK_1	970	976	PF00069	0.368
MOD_PKA_1	504	510	PF00069	0.434
MOD_PKA_2	114	120	PF00069	0.515
MOD_PKA_2	243	249	PF00069	0.586
MOD_PKA_2	267	273	PF00069	0.602
MOD_PKA_2	332	338	PF00069	0.427
MOD_PKA_2	504	510	PF00069	0.537
MOD_PKA_2	567	573	PF00069	0.424
MOD_PKA_2	614	620	PF00069	0.586
MOD_PKA_2	703	709	PF00069	0.562
MOD_PKA_2	762	768	PF00069	0.417
MOD_PKA_2	859	865	PF00069	0.488
MOD_Plk_1	377	383	PF00069	0.485
MOD_Plk_1	689	695	PF00069	0.583
MOD_Plk_1	720	726	PF00069	0.594
MOD_Plk_1	88	94	PF00069	0.461
MOD_Plk_1	915	921	PF00069	0.495
MOD_Plk_2-3	921	927	PF00069	0.438
MOD_Plk_4	104	110	PF00069	0.531
MOD_Plk_4	272	278	PF00069	0.461
MOD_Plk_4	299	305	PF00069	0.369
MOD_Plk_4	306	312	PF00069	0.390
MOD_Plk_4	377	383	PF00069	0.431
MOD_Plk_4	41	47	PF00069	0.548
MOD_Plk_4	468	474	PF00069	0.423
MOD_Plk_4	488	494	PF00069	0.417
MOD_Plk_4	577	583	PF00069	0.333
MOD_Plk_4	676	682	PF00069	0.398
MOD_Plk_4	727	733	PF00069	0.489
MOD_Plk_4	749	755	PF00069	0.417
MOD_Plk_4	788	794	PF00069	0.477
MOD_Plk_4	821	827	PF00069	0.381
MOD_Plk_4	88	94	PF00069	0.482
MOD_Plk_4	893	899	PF00069	0.432
MOD_Plk_4	943	949	PF00069	0.558
MOD_Plk_4	972	978	PF00069	0.422
MOD_ProDKin_1	405	411	PF00069	0.408
MOD_ProDKin_1	615	621	PF00069	0.539
MOD_ProDKin_1	694	700	PF00069	0.634
MOD_ProDKin_1	934	940	PF00069	0.449
MOD_ProDKin_1	984	990	PF00069	0.362
MOD_ProDKin_1	992	998	PF00069	0.347
MOD_SUMO_for_1	161	164	PF00179	0.418
MOD_SUMO_rev_2	251	258	PF00179	0.429
MOD_SUMO_rev_2	765	772	PF00179	0.510
MOD_SUMO_rev_2	883	888	PF00179	0.356
MOD_SUMO_rev_2	927	934	PF00179	0.475
TRG_DiLeu_BaEn_1	104	109	PF01217	0.401
TRG_DiLeu_BaEn_1	151	156	PF01217	0.598
TRG_DiLeu_BaEn_1	972	977	PF01217	0.488
TRG_DiLeu_BaEn_2	228	234	PF01217	0.444
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.395
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.514
TRG_ENDOCYTIC_2	195	198	PF00928	0.415
TRG_ENDOCYTIC_2	245	248	PF00928	0.618
TRG_ENDOCYTIC_2	264	267	PF00928	0.390
TRG_ENDOCYTIC_2	288	291	PF00928	0.439
TRG_ENDOCYTIC_2	334	337	PF00928	0.375
TRG_ENDOCYTIC_2	424	427	PF00928	0.439
TRG_ENDOCYTIC_2	475	478	PF00928	0.556
TRG_ENDOCYTIC_2	579	582	PF00928	0.358
TRG_ENDOCYTIC_2	806	809	PF00928	0.411
TRG_ENDOCYTIC_2	823	826	PF00928	0.229
TRG_ER_diArg_1	614	616	PF00400	0.482
TRG_ER_diArg_1	645	648	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY6	Leptomonas seymouri	53%	100%
A0A1X0NXF3	Trypanosomatidae	25%	88%
A0A3S7WWC6	Leishmania donovani	100%	100%
C9ZIL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
E9AIM8	Leishmania braziliensis	76%	100%
E9AUW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCM1	Leishmania major	91%	100%
V5BHE3	Trypanosoma cruzi	27%	100%