Cell division cycle protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle protein-like protein

Species:

Leishmania infantum

UniProt:

A4HZ08_LEIIN

TriTrypDb:

LINF_200020700

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HZ08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ08

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0051301	cell division	2	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.601
CLV_C14_Caspase3-7	599	603	PF00656	0.333
CLV_C14_Caspase3-7	628	632	PF00656	0.335
CLV_C14_Caspase3-7	772	776	PF00656	0.615
CLV_MEL_PAP_1	364	370	PF00089	0.559
CLV_NRD_NRD_1	214	216	PF00675	0.656
CLV_NRD_NRD_1	264	266	PF00675	0.393
CLV_NRD_NRD_1	389	391	PF00675	0.539
CLV_NRD_NRD_1	443	445	PF00675	0.610
CLV_NRD_NRD_1	460	462	PF00675	0.559
CLV_NRD_NRD_1	549	551	PF00675	0.355
CLV_NRD_NRD_1	557	559	PF00675	0.355
CLV_NRD_NRD_1	696	698	PF00675	0.597
CLV_PCSK_KEX2_1	264	266	PF00082	0.402
CLV_PCSK_KEX2_1	389	391	PF00082	0.539
CLV_PCSK_KEX2_1	462	464	PF00082	0.747
CLV_PCSK_KEX2_1	549	551	PF00082	0.354
CLV_PCSK_KEX2_1	557	559	PF00082	0.353
CLV_PCSK_KEX2_1	695	697	PF00082	0.586
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.747
CLV_PCSK_PC1ET2_1	695	697	PF00082	0.633
CLV_PCSK_PC7_1	692	698	PF00082	0.584
CLV_PCSK_SKI1_1	135	139	PF00082	0.615
CLV_PCSK_SKI1_1	151	155	PF00082	0.654
CLV_PCSK_SKI1_1	183	187	PF00082	0.500
CLV_PCSK_SKI1_1	237	241	PF00082	0.552
CLV_PCSK_SKI1_1	423	427	PF00082	0.588
CLV_PCSK_SKI1_1	528	532	PF00082	0.390
CLV_PCSK_SKI1_1	540	544	PF00082	0.315
DEG_APCC_DBOX_1	236	244	PF00400	0.546
DEG_APCC_DBOX_1	264	272	PF00400	0.533
DEG_SPOP_SBC_1	296	300	PF00917	0.689
DEG_SPOP_SBC_1	376	380	PF00917	0.381
DEG_SPOP_SBC_1	673	677	PF00917	0.427
DEG_SPOP_SBC_1	791	795	PF00917	0.479
DOC_CYCLIN_RxL_1	546	555	PF00134	0.447
DOC_CYCLIN_RxL_1	55	63	PF00134	0.572
DOC_CYCLIN_yClb5_NLxxxL_5	264	272	PF00134	0.509
DOC_MAPK_gen_1	461	467	PF00069	0.703
DOC_MAPK_gen_1	557	564	PF00069	0.424
DOC_MAPK_gen_1	660	670	PF00069	0.335
DOC_MAPK_JIP1_4	660	666	PF00069	0.335
DOC_MAPK_MEF2A_6	660	668	PF00069	0.335
DOC_PP2B_LxvP_1	10	13	PF13499	0.652
DOC_PP2B_LxvP_1	287	290	PF13499	0.570
DOC_PP2B_LxvP_1	522	525	PF13499	0.570
DOC_PP2B_LxvP_1	551	554	PF13499	0.447
DOC_PP2B_LxvP_1	604	607	PF13499	0.335
DOC_PP2B_LxvP_1	808	811	PF13499	0.452
DOC_USP7_MATH_1	296	300	PF00917	0.647
DOC_USP7_MATH_1	396	400	PF00917	0.646
DOC_USP7_MATH_1	472	476	PF00917	0.730
DOC_USP7_MATH_1	481	485	PF00917	0.720
DOC_USP7_MATH_1	535	539	PF00917	0.355
DOC_USP7_MATH_1	674	678	PF00917	0.545
DOC_USP7_MATH_1	747	751	PF00917	0.704
DOC_USP7_MATH_1	783	787	PF00917	0.661
DOC_USP7_MATH_1	791	795	PF00917	0.568
DOC_WW_Pin1_4	230	235	PF00397	0.537
DOC_WW_Pin1_4	244	249	PF00397	0.494
DOC_WW_Pin1_4	303	308	PF00397	0.544
DOC_WW_Pin1_4	357	362	PF00397	0.523
DOC_WW_Pin1_4	749	754	PF00397	0.630
DOC_WW_Pin1_4	775	780	PF00397	0.736
LIG_14-3-3_CanoR_1	124	130	PF00244	0.719
LIG_14-3-3_CanoR_1	142	150	PF00244	0.578
LIG_14-3-3_CanoR_1	161	165	PF00244	0.442
LIG_14-3-3_CanoR_1	187	196	PF00244	0.476
LIG_14-3-3_CanoR_1	374	384	PF00244	0.476
LIG_14-3-3_CanoR_1	621	627	PF00244	0.335
LIG_14-3-3_CanoR_1	696	703	PF00244	0.704
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BRCT_BRCA1_1	225	229	PF00533	0.437
LIG_Clathr_ClatBox_1	274	278	PF01394	0.539
LIG_Clathr_ClatBox_1	310	314	PF01394	0.348
LIG_CSL_BTD_1	15	18	PF09270	0.552
LIG_FHA_1	124	130	PF00498	0.740
LIG_FHA_1	188	194	PF00498	0.436
LIG_FHA_1	245	251	PF00498	0.517
LIG_FHA_1	3	9	PF00498	0.589
LIG_FHA_1	300	306	PF00498	0.529
LIG_FHA_1	329	335	PF00498	0.445
LIG_FHA_1	352	358	PF00498	0.411
LIG_FHA_1	386	392	PF00498	0.515
LIG_FHA_1	405	411	PF00498	0.581
LIG_FHA_1	441	447	PF00498	0.769
LIG_FHA_1	512	518	PF00498	0.514
LIG_FHA_1	539	545	PF00498	0.297
LIG_FHA_1	569	575	PF00498	0.480
LIG_FHA_1	57	63	PF00498	0.641
LIG_FHA_1	711	717	PF00498	0.618
LIG_FHA_1	730	736	PF00498	0.614
LIG_FHA_1	755	761	PF00498	0.613
LIG_FHA_2	128	134	PF00498	0.683
LIG_FHA_2	136	142	PF00498	0.652
LIG_FHA_2	271	277	PF00498	0.514
LIG_FHA_2	377	383	PF00498	0.536
LIG_FHA_2	609	615	PF00498	0.447
LIG_FHA_2	626	632	PF00498	0.339
LIG_FHA_2	791	797	PF00498	0.655
LIG_Integrin_isoDGR_2	122	124	PF01839	0.670
LIG_Integrin_RGD_1	773	775	PF01839	0.615
LIG_LIR_Gen_1	176	185	PF02991	0.565
LIG_LIR_Gen_1	490	498	PF02991	0.543
LIG_LIR_Gen_1	72	81	PF02991	0.621
LIG_LIR_Nem_3	176	181	PF02991	0.573
LIG_LIR_Nem_3	490	495	PF02991	0.440
LIG_LIR_Nem_3	72	78	PF02991	0.596
LIG_MYND_1	749	753	PF01753	0.664
LIG_NRBOX	223	229	PF00104	0.547
LIG_NRBOX	238	244	PF00104	0.313
LIG_NRBOX	622	628	PF00104	0.335
LIG_Pex14_1	75	79	PF04695	0.474
LIG_PTAP_UEV_1	436	441	PF05743	0.582
LIG_Rb_pABgroove_1	579	587	PF01858	0.402
LIG_SH2_CRK	101	105	PF00017	0.527
LIG_SH2_CRK	178	182	PF00017	0.599
LIG_SH2_CRK	492	496	PF00017	0.447
LIG_SH2_SRC	809	812	PF00017	0.485
LIG_SH2_STAP1	492	496	PF00017	0.572
LIG_SH2_STAT5	386	389	PF00017	0.476
LIG_SH2_STAT5	727	730	PF00017	0.593
LIG_SH3_3	21	27	PF00018	0.638
LIG_SH3_3	283	289	PF00018	0.513
LIG_SH3_3	434	440	PF00018	0.660
LIG_SH3_3	655	661	PF00018	0.447
LIG_SH3_3	743	749	PF00018	0.777
LIG_SH3_3	88	94	PF00018	0.486
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.521
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.479
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.412
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.535
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.335
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.438
LIG_SUMO_SIM_anti_2	713	719	PF11976	0.607
LIG_SUMO_SIM_par_1	270	276	PF11976	0.479
LIG_SUMO_SIM_par_1	308	315	PF11976	0.445
LIG_SUMO_SIM_par_1	422	429	PF11976	0.504
LIG_SUMO_SIM_par_1	514	521	PF11976	0.535
LIG_SUMO_SIM_par_1	641	647	PF11976	0.446
LIG_SUMO_SIM_par_1	712	719	PF11976	0.631
LIG_WRC_WIRS_1	350	355	PF05994	0.482
LIG_WW_3	605	609	PF00397	0.335
LIG_WW_3	745	749	PF00397	0.676
MOD_CDK_SPxxK_3	230	237	PF00069	0.527
MOD_CK1_1	112	118	PF00069	0.713
MOD_CK1_1	160	166	PF00069	0.537
MOD_CK1_1	220	226	PF00069	0.601
MOD_CK1_1	295	301	PF00069	0.641
MOD_CK1_1	474	480	PF00069	0.722
MOD_CK1_1	538	544	PF00069	0.335
MOD_CK1_1	568	574	PF00069	0.402
MOD_CK1_1	647	653	PF00069	0.424
MOD_CK2_1	125	131	PF00069	0.655
MOD_CK2_1	135	141	PF00069	0.585
MOD_CK2_1	146	152	PF00069	0.628
MOD_CK2_1	270	276	PF00069	0.441
MOD_CK2_1	349	355	PF00069	0.461
MOD_CK2_1	375	381	PF00069	0.476
MOD_CK2_1	47	53	PF00069	0.680
MOD_CK2_1	608	614	PF00069	0.447
MOD_CK2_1	749	755	PF00069	0.546
MOD_Cter_Amidation	547	550	PF01082	0.402
MOD_GlcNHglycan	114	117	PF01048	0.758
MOD_GlcNHglycan	219	222	PF01048	0.605
MOD_GlcNHglycan	294	297	PF01048	0.708
MOD_GlcNHglycan	437	440	PF01048	0.706
MOD_GlcNHglycan	474	477	PF01048	0.778
MOD_GlcNHglycan	535	538	PF01048	0.339
MOD_GlcNHglycan	646	649	PF01048	0.366
MOD_GlcNHglycan	677	680	PF01048	0.541
MOD_GSK3_1	123	130	PF00069	0.712
MOD_GSK3_1	183	190	PF00069	0.530
MOD_GSK3_1	292	299	PF00069	0.615
MOD_GSK3_1	322	329	PF00069	0.553
MOD_GSK3_1	396	403	PF00069	0.560
MOD_GSK3_1	413	420	PF00069	0.487
MOD_GSK3_1	431	438	PF00069	0.614
MOD_GSK3_1	440	447	PF00069	0.711
MOD_GSK3_1	471	478	PF00069	0.693
MOD_GSK3_1	48	55	PF00069	0.708
MOD_GSK3_1	538	545	PF00069	0.364
MOD_GSK3_1	56	63	PF00069	0.560
MOD_GSK3_1	587	594	PF00069	0.445
MOD_GSK3_1	608	615	PF00069	0.382
MOD_GSK3_1	621	628	PF00069	0.346
MOD_GSK3_1	65	72	PF00069	0.384
MOD_GSK3_1	668	675	PF00069	0.624
MOD_N-GLC_1	615	620	PF02516	0.417
MOD_NEK2_1	243	248	PF00069	0.548
MOD_NEK2_1	292	297	PF00069	0.713
MOD_NEK2_1	326	331	PF00069	0.502
MOD_NEK2_1	341	346	PF00069	0.548
MOD_NEK2_1	375	380	PF00069	0.573
MOD_NEK2_1	400	405	PF00069	0.612
MOD_NEK2_1	412	417	PF00069	0.369
MOD_NEK2_1	56	61	PF00069	0.613
MOD_NEK2_1	584	589	PF00069	0.408
MOD_NEK2_1	65	70	PF00069	0.444
MOD_PIKK_1	232	238	PF00454	0.581
MOD_PIKK_1	625	631	PF00454	0.447
MOD_PKA_1	444	450	PF00069	0.599
MOD_PKA_1	696	702	PF00069	0.711
MOD_PKA_2	123	129	PF00069	0.688
MOD_PKA_2	143	149	PF00069	0.618
MOD_PKA_2	160	166	PF00069	0.546
MOD_PKA_2	609	615	PF00069	0.378
MOD_PKA_2	696	702	PF00069	0.716
MOD_PKA_2	747	753	PF00069	0.649
MOD_Plk_1	176	182	PF00069	0.393
MOD_Plk_1	619	625	PF00069	0.335
MOD_Plk_1	73	79	PF00069	0.586
MOD_Plk_2-3	270	276	PF00069	0.520
MOD_Plk_4	160	166	PF00069	0.404
MOD_Plk_4	176	182	PF00069	0.522
MOD_Plk_4	223	229	PF00069	0.403
MOD_Plk_4	246	252	PF00069	0.500
MOD_Plk_4	270	276	PF00069	0.424
MOD_Plk_4	322	328	PF00069	0.469
MOD_Plk_4	431	437	PF00069	0.561
MOD_Plk_4	52	58	PF00069	0.654
MOD_Plk_4	565	571	PF00069	0.355
MOD_Plk_4	622	628	PF00069	0.335
MOD_ProDKin_1	230	236	PF00069	0.533
MOD_ProDKin_1	244	250	PF00069	0.494
MOD_ProDKin_1	303	309	PF00069	0.535
MOD_ProDKin_1	357	363	PF00069	0.526
MOD_ProDKin_1	749	755	PF00069	0.629
MOD_ProDKin_1	775	781	PF00069	0.742
TRG_DiLeu_BaEn_1	176	181	PF01217	0.567
TRG_DiLeu_BaEn_1	270	275	PF01217	0.454
TRG_DiLeu_BaEn_1	314	319	PF01217	0.452
TRG_DiLeu_BaEn_1	719	724	PF01217	0.597
TRG_DiLeu_BaEn_4	176	182	PF01217	0.568
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.534
TRG_ENDOCYTIC_2	101	104	PF00928	0.536
TRG_ENDOCYTIC_2	178	181	PF00928	0.518
TRG_ENDOCYTIC_2	492	495	PF00928	0.429
TRG_ER_diArg_1	142	145	PF00400	0.547
TRG_ER_diArg_1	264	266	PF00400	0.515
TRG_ER_diArg_1	389	391	PF00400	0.541
TRG_ER_diArg_1	549	551	PF00400	0.354
TRG_ER_diArg_1	557	559	PF00400	0.353
TRG_ER_diArg_1	607	610	PF00400	0.355
TRG_NES_CRM1_1	507	521	PF08389	0.539
TRG_NLS_Bipartite_1	444	465	PF00514	0.566
TRG_NLS_MonoExtC_3	460	466	PF00514	0.570
TRG_NLS_MonoExtC_3	694	700	PF00514	0.640
TRG_NLS_MonoExtN_4	692	699	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E7	Leptomonas seymouri	52%	100%
A0A1X0NXH5	Trypanosomatidae	33%	100%
A0A3Q8IBN9	Leishmania donovani	99%	100%
A0A3R7NWG6	Trypanosoma rangeli	34%	100%
C9ZIP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AIL0	Leishmania braziliensis	76%	100%
E9AUU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCP1	Leishmania major	92%	100%
V5BCV9	Trypanosoma cruzi	34%	100%