Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ05_LEIIN

TriTrypDb:

LINF_200020400

Length:

952

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	887	891	PF00656	0.819
CLV_NRD_NRD_1	154	156	PF00675	0.748
CLV_NRD_NRD_1	332	334	PF00675	0.577
CLV_NRD_NRD_1	538	540	PF00675	0.451
CLV_NRD_NRD_1	718	720	PF00675	0.769
CLV_NRD_NRD_1	922	924	PF00675	0.625
CLV_PCSK_FUR_1	450	454	PF00082	0.516
CLV_PCSK_KEX2_1	154	156	PF00082	0.748
CLV_PCSK_KEX2_1	332	334	PF00082	0.577
CLV_PCSK_KEX2_1	452	454	PF00082	0.599
CLV_PCSK_KEX2_1	718	720	PF00082	0.776
CLV_PCSK_KEX2_1	867	869	PF00082	0.746
CLV_PCSK_KEX2_1	922	924	PF00082	0.646
CLV_PCSK_KEX2_1	948	950	PF00082	0.829
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.523
CLV_PCSK_PC1ET2_1	867	869	PF00082	0.746
CLV_PCSK_PC1ET2_1	948	950	PF00082	0.829
CLV_PCSK_SKI1_1	244	248	PF00082	0.492
CLV_PCSK_SKI1_1	438	442	PF00082	0.452
CLV_PCSK_SKI1_1	539	543	PF00082	0.609
CLV_PCSK_SKI1_1	62	66	PF00082	0.480
CLV_PCSK_SKI1_1	647	651	PF00082	0.480
CLV_PCSK_SKI1_1	676	680	PF00082	0.533
CLV_PCSK_SKI1_1	86	90	PF00082	0.459
CLV_PCSK_SKI1_1	877	881	PF00082	0.763
CLV_PCSK_SKI1_1	922	926	PF00082	0.621
CLV_PCSK_SKI1_1	948	952	PF00082	0.814
DEG_APCC_DBOX_1	437	445	PF00400	0.449
DEG_APCC_DBOX_1	538	546	PF00400	0.420
DEG_COP1_1	467	476	PF00400	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_SCF_FBW7_2	110	117	PF00400	0.481
DEG_SPOP_SBC_1	505	509	PF00917	0.529
DEG_SPOP_SBC_1	869	873	PF00917	0.725
DOC_CDC14_PxL_1	264	272	PF14671	0.461
DOC_CKS1_1	111	116	PF01111	0.475
DOC_CKS1_1	797	802	PF01111	0.692
DOC_CYCLIN_RxL_1	432	443	PF00134	0.461
DOC_CYCLIN_RxL_1	536	546	PF00134	0.414
DOC_CYCLIN_RxL_1	633	643	PF00134	0.555
DOC_CYCLIN_RxL_1	83	90	PF00134	0.509
DOC_CYCLIN_RxL_1	874	882	PF00134	0.762
DOC_CYCLIN_yClb1_LxF_4	454	460	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	638	644	PF00134	0.617
DOC_MAPK_DCC_7	86	96	PF00069	0.602
DOC_MAPK_gen_1	202	212	PF00069	0.625
DOC_MAPK_gen_1	450	460	PF00069	0.604
DOC_MAPK_gen_1	533	543	PF00069	0.605
DOC_MAPK_gen_1	615	623	PF00069	0.538
DOC_MAPK_gen_1	62	70	PF00069	0.462
DOC_MAPK_gen_1	84	91	PF00069	0.502
DOC_MAPK_MEF2A_6	205	212	PF00069	0.516
DOC_MAPK_MEF2A_6	288	296	PF00069	0.306
DOC_MAPK_MEF2A_6	536	545	PF00069	0.534
DOC_MAPK_NFAT4_5	205	213	PF00069	0.488
DOC_PP1_RVXF_1	242	248	PF00149	0.485
DOC_PP1_RVXF_1	538	545	PF00149	0.416
DOC_PP1_RVXF_1	803	810	PF00149	0.679
DOC_PP2B_LxvP_1	252	255	PF13499	0.500
DOC_PP2B_LxvP_1	638	641	PF13499	0.541
DOC_PP2B_LxvP_1	89	92	PF13499	0.598
DOC_PP4_FxxP_1	544	547	PF00568	0.642
DOC_USP7_MATH_1	102	106	PF00917	0.601
DOC_USP7_MATH_1	191	195	PF00917	0.563
DOC_USP7_MATH_1	229	233	PF00917	0.501
DOC_USP7_MATH_1	260	264	PF00917	0.478
DOC_USP7_MATH_1	344	348	PF00917	0.742
DOC_USP7_MATH_1	411	415	PF00917	0.731
DOC_USP7_MATH_1	488	492	PF00917	0.576
DOC_USP7_MATH_1	496	500	PF00917	0.553
DOC_USP7_MATH_1	505	509	PF00917	0.592
DOC_USP7_MATH_1	567	571	PF00917	0.574
DOC_USP7_MATH_1	656	660	PF00917	0.664
DOC_USP7_MATH_1	701	705	PF00917	0.560
DOC_USP7_MATH_1	717	721	PF00917	0.625
DOC_USP7_MATH_1	856	860	PF00917	0.748
DOC_USP7_MATH_1	869	873	PF00917	0.841
DOC_USP7_MATH_1	888	892	PF00917	0.582
DOC_USP7_MATH_1	914	918	PF00917	0.674
DOC_USP7_MATH_2	641	647	PF00917	0.655
DOC_USP7_UBL2_3	815	819	PF12436	0.750
DOC_USP7_UBL2_3	925	929	PF12436	0.522
DOC_WW_Pin1_4	110	115	PF00397	0.493
DOC_WW_Pin1_4	189	194	PF00397	0.553
DOC_WW_Pin1_4	47	52	PF00397	0.441
DOC_WW_Pin1_4	679	684	PF00397	0.588
DOC_WW_Pin1_4	796	801	PF00397	0.709
DOC_WW_Pin1_4	809	814	PF00397	0.648
DOC_WW_Pin1_4	870	875	PF00397	0.831
DOC_WW_Pin1_4	940	945	PF00397	0.770
LIG_14-3-3_CanoR_1	139	148	PF00244	0.416
LIG_14-3-3_CanoR_1	332	338	PF00244	0.586
LIG_14-3-3_CanoR_1	362	369	PF00244	0.753
LIG_14-3-3_CanoR_1	497	501	PF00244	0.609
LIG_14-3-3_CanoR_1	868	874	PF00244	0.832
LIG_APCC_ABBA_1	396	401	PF00400	0.595
LIG_APCC_ABBA_1	541	546	PF00400	0.464
LIG_APCC_ABBAyCdc20_2	540	546	PF00400	0.465
LIG_BRCT_BRCA1_1	490	494	PF00533	0.557
LIG_Clathr_ClatBox_1	542	546	PF01394	0.435
LIG_eIF4E_1	434	440	PF01652	0.464
LIG_FHA_1	10	16	PF00498	0.592
LIG_FHA_1	106	112	PF00498	0.536
LIG_FHA_1	20	26	PF00498	0.417
LIG_FHA_1	475	481	PF00498	0.690
LIG_FHA_1	505	511	PF00498	0.599
LIG_FHA_1	693	699	PF00498	0.572
LIG_FHA_1	847	853	PF00498	0.822
LIG_FHA_2	318	324	PF00498	0.626
LIG_FHA_2	424	430	PF00498	0.578
LIG_FHA_2	615	621	PF00498	0.537
LIG_LIR_Gen_1	105	114	PF02991	0.560
LIG_LIR_Gen_1	16	25	PF02991	0.487
LIG_LIR_Gen_1	499	505	PF02991	0.500
LIG_LIR_Gen_1	52	61	PF02991	0.615
LIG_LIR_Gen_1	588	595	PF02991	0.459
LIG_LIR_Gen_1	66	74	PF02991	0.268
LIG_LIR_Nem_3	105	109	PF02991	0.592
LIG_LIR_Nem_3	16	20	PF02991	0.492
LIG_LIR_Nem_3	388	393	PF02991	0.540
LIG_LIR_Nem_3	499	504	PF02991	0.504
LIG_LIR_Nem_3	52	57	PF02991	0.507
LIG_LIR_Nem_3	588	592	PF02991	0.457
LIG_LIR_Nem_3	66	70	PF02991	0.269
LIG_LYPXL_S_1	433	437	PF13949	0.557
LIG_LYPXL_yS_3	390	393	PF13949	0.514
LIG_LYPXL_yS_3	434	437	PF13949	0.556
LIG_NRBOX	392	398	PF00104	0.632
LIG_NRBOX	436	442	PF00104	0.571
LIG_NRBOX	526	532	PF00104	0.612
LIG_NRP_CendR_1	949	952	PF00754	0.713
LIG_PCNA_yPIPBox_3	524	536	PF02747	0.529
LIG_REV1ctd_RIR_1	335	343	PF16727	0.637
LIG_REV1ctd_RIR_1	457	466	PF16727	0.541
LIG_SH2_CRK	2	6	PF00017	0.508
LIG_SH2_NCK_1	46	50	PF00017	0.499
LIG_SH2_NCK_1	758	762	PF00017	0.559
LIG_SH2_PTP2	67	70	PF00017	0.439
LIG_SH2_SRC	758	761	PF00017	0.667
LIG_SH2_STAP1	301	305	PF00017	0.478
LIG_SH2_STAT3	664	667	PF00017	0.517
LIG_SH2_STAT5	136	139	PF00017	0.493
LIG_SH2_STAT5	436	439	PF00017	0.576
LIG_SH2_STAT5	603	606	PF00017	0.558
LIG_SH2_STAT5	664	667	PF00017	0.472
LIG_SH2_STAT5	67	70	PF00017	0.431
LIG_SH3_1	719	725	PF00018	0.728
LIG_SH3_3	104	110	PF00018	0.553
LIG_SH3_3	159	165	PF00018	0.657
LIG_SH3_3	190	196	PF00018	0.555
LIG_SH3_3	719	725	PF00018	0.728
LIG_SH3_3	794	800	PF00018	0.742
LIG_SH3_3	872	878	PF00018	0.821
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.581
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.443
LIG_SUMO_SIM_anti_2	704	710	PF11976	0.564
LIG_SUMO_SIM_anti_2	902	907	PF11976	0.827
LIG_SxIP_EBH_1	201	214	PF03271	0.324
LIG_TRAF2_1	487	490	PF00917	0.697
LIG_TRAF2_1	515	518	PF00917	0.550
LIG_TRAF2_1	595	598	PF00917	0.604
LIG_TRAF2_1	821	824	PF00917	0.613
LIG_UBA3_1	920	929	PF00899	0.635
LIG_WRC_WIRS_1	334	339	PF05994	0.696
LIG_WW_1	724	727	PF00397	0.747
LIG_WW_3	723	727	PF00397	0.649
MOD_CDC14_SPxK_1	812	815	PF00782	0.679
MOD_CDK_SPK_2	110	115	PF00069	0.493
MOD_CDK_SPxK_1	809	815	PF00069	0.678
MOD_CDK_SPxxK_3	870	877	PF00069	0.762
MOD_CK1_1	105	111	PF00069	0.591
MOD_CK1_1	142	148	PF00069	0.552
MOD_CK1_1	150	156	PF00069	0.620
MOD_CK1_1	192	198	PF00069	0.644
MOD_CK1_1	231	237	PF00069	0.528
MOD_CK1_1	259	265	PF00069	0.563
MOD_CK1_1	342	348	PF00069	0.644
MOD_CK1_1	45	51	PF00069	0.600
MOD_CK1_1	503	509	PF00069	0.574
MOD_CK1_1	682	688	PF00069	0.656
MOD_CK1_1	7	13	PF00069	0.492
MOD_CK1_1	831	837	PF00069	0.736
MOD_CK1_1	857	863	PF00069	0.837
MOD_CK1_1	891	897	PF00069	0.696
MOD_CK2_1	317	323	PF00069	0.607
MOD_CK2_1	368	374	PF00069	0.796
MOD_CK2_1	614	620	PF00069	0.527
MOD_CK2_1	701	707	PF00069	0.550
MOD_Cter_Amidation	330	333	PF01082	0.579
MOD_GlcNHglycan	143	147	PF01048	0.440
MOD_GlcNHglycan	196	199	PF01048	0.548
MOD_GlcNHglycan	220	223	PF01048	0.496
MOD_GlcNHglycan	231	234	PF01048	0.455
MOD_GlcNHglycan	258	261	PF01048	0.524
MOD_GlcNHglycan	284	287	PF01048	0.616
MOD_GlcNHglycan	344	347	PF01048	0.699
MOD_GlcNHglycan	364	367	PF01048	0.751
MOD_GlcNHglycan	403	406	PF01048	0.715
MOD_GlcNHglycan	489	493	PF01048	0.598
MOD_GlcNHglycan	647	650	PF01048	0.548
MOD_GlcNHglycan	667	670	PF01048	0.355
MOD_GlcNHglycan	7	10	PF01048	0.485
MOD_GlcNHglycan	703	706	PF01048	0.566
MOD_GlcNHglycan	783	786	PF01048	0.641
MOD_GlcNHglycan	834	837	PF01048	0.756
MOD_GlcNHglycan	916	919	PF01048	0.738
MOD_GlcNHglycan	936	939	PF01048	0.504
MOD_GSK3_1	142	149	PF00069	0.563
MOD_GSK3_1	228	235	PF00069	0.501
MOD_GSK3_1	256	263	PF00069	0.526
MOD_GSK3_1	278	285	PF00069	0.570
MOD_GSK3_1	301	308	PF00069	0.588
MOD_GSK3_1	358	365	PF00069	0.674
MOD_GSK3_1	385	392	PF00069	0.613
MOD_GSK3_1	496	503	PF00069	0.551
MOD_GSK3_1	5	12	PF00069	0.476
MOD_GSK3_1	828	835	PF00069	0.744
MOD_GSK3_1	854	861	PF00069	0.763
MOD_GSK3_1	886	893	PF00069	0.726
MOD_GSK3_1	934	941	PF00069	0.838
MOD_LATS_1	866	872	PF00433	0.550
MOD_N-GLC_1	123	128	PF02516	0.543
MOD_N-GLC_1	150	155	PF02516	0.654
MOD_N-GLC_1	55	60	PF02516	0.619
MOD_NEK2_1	123	128	PF00069	0.543
MOD_NEK2_1	147	152	PF00069	0.690
MOD_NEK2_1	218	223	PF00069	0.446
MOD_NEK2_1	271	276	PF00069	0.542
MOD_NEK2_1	42	47	PF00069	0.474
MOD_NEK2_1	500	505	PF00069	0.497
MOD_NEK2_1	614	619	PF00069	0.539
MOD_NEK2_2	496	501	PF00069	0.619
MOD_PIKK_1	317	323	PF00454	0.624
MOD_PIKK_1	339	345	PF00454	0.665
MOD_PIKK_1	892	898	PF00454	0.681
MOD_PIKK_1	9	15	PF00454	0.545
MOD_PKA_2	183	189	PF00069	0.500
MOD_PKA_2	496	502	PF00069	0.569
MOD_PKA_2	701	707	PF00069	0.636
MOD_PKA_2	717	723	PF00069	0.628
MOD_PKA_2	735	741	PF00069	0.658
MOD_PKA_2	857	863	PF00069	0.808
MOD_Plk_1	123	129	PF00069	0.542
MOD_Plk_1	142	148	PF00069	0.330
MOD_Plk_1	376	382	PF00069	0.759
MOD_Plk_1	488	494	PF00069	0.521
MOD_Plk_4	102	108	PF00069	0.597
MOD_Plk_4	123	129	PF00069	0.542
MOD_Plk_4	16	22	PF00069	0.497
MOD_Plk_4	266	272	PF00069	0.517
MOD_Plk_4	278	284	PF00069	0.461
MOD_Plk_4	301	307	PF00069	0.584
MOD_Plk_4	333	339	PF00069	0.591
MOD_Plk_4	36	42	PF00069	0.515
MOD_Plk_4	376	382	PF00069	0.728
MOD_Plk_4	496	502	PF00069	0.596
MOD_Plk_4	526	532	PF00069	0.546
MOD_Plk_4	838	844	PF00069	0.793
MOD_Plk_4	916	922	PF00069	0.751
MOD_ProDKin_1	110	116	PF00069	0.486
MOD_ProDKin_1	189	195	PF00069	0.549
MOD_ProDKin_1	47	53	PF00069	0.440
MOD_ProDKin_1	679	685	PF00069	0.588
MOD_ProDKin_1	796	802	PF00069	0.712
MOD_ProDKin_1	809	815	PF00069	0.650
MOD_ProDKin_1	870	876	PF00069	0.830
MOD_ProDKin_1	940	946	PF00069	0.768
MOD_SUMO_rev_2	893	903	PF00179	0.807
TRG_DiLeu_BaEn_1	66	71	PF01217	0.443
TRG_DiLeu_BaEn_2	116	122	PF01217	0.443
TRG_DiLeu_BaEn_2	455	461	PF01217	0.535
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.445
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.544
TRG_DiLeu_BaLyEn_6	875	880	PF01217	0.765
TRG_ENDOCYTIC_2	2	5	PF00928	0.512
TRG_ENDOCYTIC_2	390	393	PF00928	0.514
TRG_ENDOCYTIC_2	434	437	PF00928	0.463
TRG_ENDOCYTIC_2	67	70	PF00928	0.380
TRG_ER_diArg_1	154	156	PF00400	0.748
TRG_ER_diArg_1	204	207	PF00400	0.345
TRG_ER_diArg_1	332	334	PF00400	0.577
TRG_ER_diArg_1	717	719	PF00400	0.654
TRG_ER_diArg_1	83	86	PF00400	0.502
TRG_ER_diArg_1	921	923	PF00400	0.637
TRG_NES_CRM1_1	117	131	PF08389	0.419
TRG_NLS_MonoExtC_3	947	952	PF00514	0.714
TRG_NLS_MonoExtN_4	945	952	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB01	Leptomonas seymouri	50%	100%
A0A3S5H790	Leishmania donovani	99%	100%
E9AIK7	Leishmania braziliensis	78%	100%
E9AUT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCP4	Leishmania major	92%	100%