Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ01_LEIIN

TriTrypDb:

LINF_200021700

Length:

245

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	110	112	PF00082	0.411
CLV_PCSK_KEX2_1	243	245	PF00082	0.582
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.446
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.582
CLV_PCSK_SKI1_1	150	154	PF00082	0.596
CLV_Separin_Metazoa	55	59	PF03568	0.545
DOC_MAPK_gen_1	95	104	PF00069	0.448
DOC_MAPK_MEF2A_6	205	214	PF00069	0.354
DOC_USP7_MATH_1	139	143	PF00917	0.721
DOC_USP7_MATH_1	229	233	PF00917	0.492
DOC_USP7_MATH_1	75	79	PF00917	0.696
DOC_USP7_UBL2_3	93	97	PF12436	0.421
DOC_WW_Pin1_4	181	186	PF00397	0.357
DOC_WW_Pin1_4	64	69	PF00397	0.499
DOC_WW_Pin1_4	9	14	PF00397	0.618
LIG_14-3-3_CanoR_1	111	117	PF00244	0.385
LIG_14-3-3_CanoR_1	16	24	PF00244	0.612
LIG_BIR_II_1	1	5	PF00653	0.435
LIG_FHA_1	52	58	PF00498	0.491
LIG_FHA_2	158	164	PF00498	0.750
LIG_FHA_2	25	31	PF00498	0.497
LIG_Integrin_isoDGR_2	203	205	PF01839	0.494
LIG_LIR_Nem_3	40	45	PF02991	0.430
LIG_Pex14_2	108	112	PF04695	0.348
LIG_RPA_C_Fungi	232	244	PF08784	0.566
LIG_SH2_CRK	45	49	PF00017	0.425
LIG_SH2_GRB2like	219	222	PF00017	0.455
LIG_SH2_NCK_1	45	49	PF00017	0.425
LIG_SH2_PTP2	208	211	PF00017	0.325
LIG_SH2_SRC	208	211	PF00017	0.456
LIG_SH2_SRC	219	222	PF00017	0.510
LIG_SH2_STAP1	219	223	PF00017	0.508
LIG_SH2_STAT3	41	44	PF00017	0.512
LIG_SH2_STAT5	208	211	PF00017	0.325
LIG_SH2_STAT5	42	45	PF00017	0.420
LIG_SH3_3	125	131	PF00018	0.567
LIG_SH3_3	132	138	PF00018	0.709
LIG_SH3_3	184	190	PF00018	0.515
LIG_SH3_3	209	215	PF00018	0.363
LIG_SH3_3	65	71	PF00018	0.544
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.391
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.456
LIG_SUMO_SIM_par_1	210	218	PF11976	0.364
LIG_TRAF2_1	215	218	PF00917	0.450
MOD_CDK_SPxxK_3	9	16	PF00069	0.662
MOD_CK1_1	12	18	PF00069	0.558
MOD_CK1_1	154	160	PF00069	0.688
MOD_CK1_1	2	8	PF00069	0.487
MOD_CK1_1	23	29	PF00069	0.541
MOD_CK2_1	229	235	PF00069	0.442
MOD_GlcNHglycan	142	145	PF01048	0.734
MOD_GlcNHglycan	153	156	PF01048	0.707
MOD_GlcNHglycan	16	19	PF01048	0.585
MOD_GlcNHglycan	175	178	PF01048	0.469
MOD_GlcNHglycan	4	7	PF01048	0.528
MOD_GlcNHglycan	76	80	PF01048	0.596
MOD_GSK3_1	112	119	PF00069	0.362
MOD_GSK3_1	12	19	PF00069	0.600
MOD_GSK3_1	150	157	PF00069	0.645
MOD_GSK3_1	20	27	PF00069	0.586
MOD_GSK3_1	229	236	PF00069	0.526
MOD_GSK3_1	47	54	PF00069	0.495
MOD_N-GLC_1	112	117	PF02516	0.370
MOD_N-GLC_1	139	144	PF02516	0.745
MOD_N-GLC_1	20	25	PF02516	0.598
MOD_NEK2_1	112	117	PF00069	0.351
MOD_NEK2_1	199	204	PF00069	0.342
MOD_PK_1	58	64	PF00069	0.529
MOD_PKA_2	157	163	PF00069	0.539
MOD_Plk_1	112	118	PF00069	0.360
MOD_Plk_1	179	185	PF00069	0.373
MOD_Plk_1	20	26	PF00069	0.631
MOD_Plk_1	58	64	PF00069	0.398
MOD_Plk_4	229	235	PF00069	0.518
MOD_ProDKin_1	181	187	PF00069	0.369
MOD_ProDKin_1	64	70	PF00069	0.509
MOD_ProDKin_1	9	15	PF00069	0.622
MOD_SUMO_rev_2	157	166	PF00179	0.456
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.475
TRG_ENDOCYTIC_2	208	211	PF00928	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J0	Leptomonas seymouri	75%	82%
A0A1X0NWJ0	Trypanosomatidae	53%	90%
A0A3Q8IKS5	Leishmania donovani	98%	100%
A0A422NTQ6	Trypanosoma rangeli	55%	91%
C9ZIM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	91%
E9AIM0	Leishmania braziliensis	83%	100%
E9AUV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCN0	Leishmania major	96%	100%
V5B8D6	Trypanosoma cruzi	55%	90%