Translation initiation factor IF-2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYZ9_LEIIN

TriTrypDb:

LINF_200021500

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	37	39	PF00082	0.707
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.707
CLV_PCSK_SKI1_1	97	101	PF00082	0.488
DEG_COP1_1	63	73	PF00400	0.579
DEG_SCF_FBW7_2	62	68	PF00400	0.599
DEG_SPOP_SBC_1	151	155	PF00917	0.641
DOC_CKS1_1	212	217	PF01111	0.603
DOC_CKS1_1	62	67	PF01111	0.650
DOC_CKS1_1	70	75	PF01111	0.595
DOC_CKS1_1	98	103	PF01111	0.485
DOC_CYCLIN_yClb5_NLxxxL_5	7	13	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.574
DOC_MAPK_gen_1	37	43	PF00069	0.688
DOC_PP2B_LxvP_1	50	53	PF13499	0.567
DOC_USP7_MATH_1	3	7	PF00917	0.495
DOC_USP7_MATH_1	39	43	PF00917	0.679
DOC_USP7_MATH_1	60	64	PF00917	0.646
DOC_WW_Pin1_4	16	21	PF00397	0.662
DOC_WW_Pin1_4	211	216	PF00397	0.596
DOC_WW_Pin1_4	61	66	PF00397	0.687
DOC_WW_Pin1_4	69	74	PF00397	0.628
DOC_WW_Pin1_4	97	102	PF00397	0.487
LIG_14-3-3_CanoR_1	195	203	PF00244	0.599
LIG_14-3-3_CanoR_1	218	228	PF00244	0.597
LIG_14-3-3_CanoR_1	38	44	PF00244	0.688
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_FHA_2	29	35	PF00498	0.659
LIG_FHA_2	98	104	PF00498	0.486
LIG_LIR_Apic_2	211	215	PF02991	0.593
LIG_LIR_Gen_1	229	239	PF02991	0.517
LIG_LIR_Gen_1	80	91	PF02991	0.617
LIG_LIR_Nem_3	80	86	PF02991	0.630
LIG_PCNA_yPIPBox_3	170	179	PF02747	0.620
LIG_RPA_C_Insects	2	17	PF08784	0.616
LIG_SH2_CRK	169	173	PF00017	0.567
LIG_SH2_CRK	212	216	PF00017	0.601
LIG_SH2_CRK	83	87	PF00017	0.626
LIG_SH2_NCK_1	83	87	PF00017	0.626
LIG_SH2_STAP1	221	225	PF00017	0.650
LIG_SH2_STAP1	231	235	PF00017	0.630
LIG_SH2_STAT3	203	206	PF00017	0.644
LIG_SH2_STAT3	239	242	PF00017	0.649
LIG_SH2_STAT5	83	86	PF00017	0.633
LIG_SH3_1	257	263	PF00018	0.616
LIG_SH3_2	256	261	PF14604	0.621
LIG_SH3_3	107	113	PF00018	0.591
LIG_SH3_3	136	142	PF00018	0.618
LIG_SH3_3	165	171	PF00018	0.585
LIG_SH3_3	20	26	PF00018	0.616
LIG_SH3_3	204	210	PF00018	0.640
LIG_SH3_3	253	259	PF00018	0.617
LIG_SH3_3	33	39	PF00018	0.658
LIG_SH3_3	42	48	PF00018	0.594
LIG_SH3_3	59	65	PF00018	0.524
LIG_SH3_3	67	73	PF00018	0.603
LIG_SH3_3	86	92	PF00018	0.523
LIG_SH3_5	172	176	PF00018	0.579
LIG_TYR_ITIM	81	86	PF00017	0.628
LIG_WW_1	255	258	PF00397	0.615
LIG_WW_3	258	262	PF00397	0.627
MOD_CDK_SPxxK_3	211	218	PF00069	0.601
MOD_CK1_1	19	25	PF00069	0.649
MOD_CK1_1	2	8	PF00069	0.614
MOD_CK1_1	219	225	PF00069	0.571
MOD_CK1_1	63	69	PF00069	0.700
MOD_CK2_1	74	80	PF00069	0.590
MOD_CK2_1	97	103	PF00069	0.488
MOD_GlcNHglycan	1	4	PF01048	0.630
MOD_GlcNHglycan	218	221	PF01048	0.626
MOD_GlcNHglycan	223	226	PF01048	0.603
MOD_GSK3_1	147	154	PF00069	0.645
MOD_GSK3_1	216	223	PF00069	0.622
MOD_NEK2_1	234	239	PF00069	0.599
MOD_NEK2_1	82	87	PF00069	0.483
MOD_Plk_4	19	25	PF00069	0.627
MOD_ProDKin_1	16	22	PF00069	0.668
MOD_ProDKin_1	211	217	PF00069	0.599
MOD_ProDKin_1	61	67	PF00069	0.687
MOD_ProDKin_1	69	75	PF00069	0.627
MOD_ProDKin_1	97	103	PF00069	0.488
MOD_SUMO_rev_2	27	31	PF00179	0.607
MOD_SUMO_rev_2	42	48	PF00179	0.585
TRG_ENDOCYTIC_2	231	234	PF00928	0.680
TRG_ENDOCYTIC_2	83	86	PF00928	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW51	Leishmania donovani	99%	100%
E9AIL8	Leishmania braziliensis	67%	97%
E9AUV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCN2	Leishmania major	86%	100%