LeishMANIAdb
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Putative soluble n-ethylmaleimide sensitive factor

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative soluble n-ethylmaleimide sensitive factor
Gene product:
SNAP protein - putative
Species:
Leishmania infantum
UniProt:
A4HYZ8_LEIIN
TriTrypDb:
LINF_200021400
Length:
282

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, soluble n-ethylmaleimide sensitive factor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031201 SNARE complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HYZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYZ8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 13
GO:0006886 intracellular protein transport 4 13
GO:0008104 protein localization 4 13
GO:0009987 cellular process 1 13
GO:0015031 protein transport 4 13
GO:0033036 macromolecule localization 2 13
GO:0045184 establishment of protein localization 3 13
GO:0046907 intracellular transport 3 13
GO:0051179 localization 1 13
GO:0051234 establishment of localization 2 13
GO:0051641 cellular localization 2 13
GO:0051649 establishment of localization in cell 3 13
GO:0070727 cellular macromolecule localization 3 13
GO:0071702 organic substance transport 4 13
GO:0071705 nitrogen compound transport 4 13
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0035494 SNARE complex disassembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 1
GO:0005483 soluble NSF attachment protein activity 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019905 syntaxin binding 4 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0060090 molecular adaptor activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 121 125 PF00656 0.451
CLV_C14_Caspase3-7 2 6 PF00656 0.419
CLV_C14_Caspase3-7 211 215 PF00656 0.416
CLV_NRD_NRD_1 260 262 PF00675 0.451
CLV_PCSK_SKI1_1 107 111 PF00082 0.451
CLV_PCSK_SKI1_1 16 20 PF00082 0.341
CLV_PCSK_SKI1_1 191 195 PF00082 0.337
CLV_PCSK_SKI1_1 213 217 PF00082 0.410
DOC_CYCLIN_RxL_1 101 111 PF00134 0.451
DOC_CYCLIN_yCln2_LP_2 177 183 PF00134 0.451
DOC_MAPK_gen_1 13 20 PF00069 0.441
DOC_MAPK_gen_1 227 237 PF00069 0.451
DOC_MAPK_gen_1 84 93 PF00069 0.356
DOC_MAPK_MEF2A_6 230 239 PF00069 0.451
DOC_MAPK_MEF2A_6 249 256 PF00069 0.302
DOC_MAPK_MEF2A_6 267 274 PF00069 0.197
DOC_MAPK_MEF2A_6 86 95 PF00069 0.346
DOC_PP1_RVXF_1 105 111 PF00149 0.259
DOC_USP7_UBL2_3 13 17 PF12436 0.362
DOC_USP7_UBL2_3 59 63 PF12436 0.419
LIG_APCC_ABBAyCdc20_2 164 170 PF00400 0.419
LIG_BIR_II_1 1 5 PF00653 0.341
LIG_BIR_III_2 124 128 PF00653 0.451
LIG_CaM_IQ_9 254 269 PF13499 0.451
LIG_FHA_1 266 272 PF00498 0.337
LIG_FHA_2 241 247 PF00498 0.431
LIG_FHA_2 85 91 PF00498 0.466
LIG_LIR_Gen_1 231 242 PF02991 0.367
LIG_LIR_Gen_1 24 35 PF02991 0.473
LIG_LIR_Nem_3 231 237 PF02991 0.444
LIG_LIR_Nem_3 24 30 PF02991 0.415
LIG_Pex14_2 19 23 PF04695 0.451
LIG_REV1ctd_RIR_1 17 25 PF16727 0.394
LIG_SH2_CRK 197 201 PF00017 0.473
LIG_SH2_GRB2like 135 138 PF00017 0.441
LIG_SH2_NCK_1 169 173 PF00017 0.419
LIG_SH2_NCK_1 197 201 PF00017 0.473
LIG_SH2_NCK_1 50 54 PF00017 0.379
LIG_SH2_STAP1 129 133 PF00017 0.392
LIG_SH2_STAP1 162 166 PF00017 0.337
LIG_SH2_STAP1 169 173 PF00017 0.407
LIG_SH2_STAT3 128 131 PF00017 0.438
LIG_SH2_STAT5 135 138 PF00017 0.312
LIG_SH2_STAT5 188 191 PF00017 0.434
LIG_SH2_STAT5 225 228 PF00017 0.330
LIG_SUMO_SIM_anti_2 268 274 PF11976 0.362
LIG_TRAF2_1 115 118 PF00917 0.446
LIG_UBA3_1 149 154 PF00899 0.451
LIG_UBA3_1 256 262 PF00899 0.443
MOD_CK1_1 3 9 PF00069 0.393
MOD_CK2_1 112 118 PF00069 0.403
MOD_GlcNHglycan 102 105 PF01048 0.490
MOD_GlcNHglycan 120 123 PF01048 0.281
MOD_GlcNHglycan 2 5 PF01048 0.353
MOD_GlcNHglycan 220 223 PF01048 0.426
MOD_NEK2_1 252 257 PF00069 0.441
MOD_PKA_2 100 106 PF00069 0.473
MOD_Plk_2-3 240 246 PF00069 0.451
MOD_Plk_4 252 258 PF00069 0.337
MOD_Plk_4 3 9 PF00069 0.419
MOD_Plk_4 84 90 PF00069 0.451
MOD_SUMO_rev_2 139 143 PF00179 0.413
MOD_SUMO_rev_2 259 268 PF00179 0.334
MOD_SUMO_rev_2 6 15 PF00179 0.356
TRG_DiLeu_BaEn_1 233 238 PF01217 0.451
TRG_DiLeu_BaLyEn_6 104 109 PF01217 0.451
TRG_ENDOCYTIC_2 169 172 PF00928 0.353
TRG_ENDOCYTIC_2 197 200 PF00928 0.472
TRG_ENDOCYTIC_2 77 80 PF00928 0.451
TRG_NES_CRM1_1 246 259 PF08389 0.373
TRG_Pf-PMV_PEXEL_1 107 111 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 261 265 PF00026 0.337

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHW7 Leptomonas seymouri 83% 100%
A0A0N1PFE2 Leptomonas seymouri 24% 97%
A0A0S4J4X9 Bodo saltans 25% 98%
A0A0S4JSU5 Bodo saltans 51% 100%
A0A0S4JTB3 Bodo saltans 51% 100%
A0A1X0NRZ7 Trypanosomatidae 25% 97%
A0A1X0NWB5 Trypanosomatidae 57% 100%
A0A3R7P116 Trypanosoma rangeli 28% 97%
A0A3S5IRU0 Trypanosoma rangeli 53% 100%
A0A3S7WW84 Leishmania donovani 99% 100%
A0A3S7X611 Leishmania donovani 23% 97%
A4HKT1 Leishmania braziliensis 24% 100%
A4I8B0 Leishmania infantum 23% 97%
C9ZIM9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0AAI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 96%
E9AIL7 Leishmania braziliensis 93% 100%
E9AUV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9B369 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
O90758 Fowlpox virus (strain NVSL) 25% 98%
P28663 Mus musculus 29% 95%
P32602 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 97%
P54920 Homo sapiens 28% 96%
P54921 Rattus norvegicus 28% 96%
P78603 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 29% 98%
P81125 Bos taurus 28% 96%
P81126 Bos taurus 29% 95%
P85969 Rattus norvegicus 29% 95%
P93798 Vitis vinifera 29% 98%
Q23983 Drosophila melanogaster 29% 97%
Q4Q4Y5 Leishmania major 24% 100%
Q4QCN3 Leishmania major 98% 100%
Q54NP6 Dictyostelium discoideum 30% 97%
Q75D68 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 97%
Q9DB05 Mus musculus 28% 96%
Q9H115 Homo sapiens 29% 95%
Q9J5J0 Fowlpox virus (strain NVSL) 25% 100%
Q9LXZ5 Arabidopsis thaliana 24% 74%
Q9M5P8 Solanum tuberosum 30% 98%
Q9P4D0 Komagataella phaffii (strain GS115 / ATCC 20864) 27% 95%
Q9P4X4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 98%
Q9P6A5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 97%
Q9SPE6 Arabidopsis thaliana 33% 98%
V5BCV5 Trypanosoma cruzi 56% 100%
V5BHZ3 Trypanosoma cruzi 25% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS