Putative ribosome biogenesis protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis protein - putative

Species:

Leishmania infantum

UniProt:

A4HYZ6_LEIIN

TriTrypDb:

LINF_200021200

Length:

316

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosome biogenesis

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Phosphorylation

Amastigote: 306

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HYZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYZ6

Function

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Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	11

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.464
CLV_NRD_NRD_1	274	276	PF00675	0.333
CLV_NRD_NRD_1	280	282	PF00675	0.338
CLV_PCSK_KEX2_1	274	276	PF00082	0.333
CLV_PCSK_KEX2_1	280	282	PF00082	0.338
CLV_PCSK_KEX2_1	7	9	PF00082	0.487
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.487
CLV_PCSK_SKI1_1	170	174	PF00082	0.154
CLV_PCSK_SKI1_1	186	190	PF00082	0.154
CLV_PCSK_SKI1_1	263	267	PF00082	0.393

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X5	Leptomonas seymouri	83%	97%
A0A0S4IP78	Bodo saltans	59%	100%
A0A1X0P6M8	Trypanosomatidae	71%	100%
A0A3S7WW54	Leishmania donovani	100%	100%
D0A0C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AIL5	Leishmania braziliensis	90%	100%
E9AUU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13823	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P34524	Caenorhabditis elegans	40%	90%
Q08235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%

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