LeishMANIAdb
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Putative ribosome biogenesis protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ribosome biogenesis protein
Gene product:
ribosome biogenesis protein - putative
Species:
Leishmania infantum
UniProt:
A4HYZ6_LEIIN
TriTrypDb:
LINF_200021200
Length:
316

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosome biogenesis

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 306

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYZ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYZ6

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006364 rRNA processing 8 11
GO:0006396 RNA processing 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0016072 rRNA metabolic process 7 11
GO:0034470 ncRNA processing 7 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034660 ncRNA metabolic process 6 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:0000027 ribosomal large subunit assembly 7 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0019843 rRNA binding 5 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 32 36 PF00656 0.464
CLV_NRD_NRD_1 274 276 PF00675 0.333
CLV_NRD_NRD_1 280 282 PF00675 0.338
CLV_PCSK_KEX2_1 274 276 PF00082 0.333
CLV_PCSK_KEX2_1 280 282 PF00082 0.338
CLV_PCSK_KEX2_1 7 9 PF00082 0.487
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.487
CLV_PCSK_SKI1_1 170 174 PF00082 0.154
CLV_PCSK_SKI1_1 186 190 PF00082 0.154
CLV_PCSK_SKI1_1 263 267 PF00082 0.393
CLV_PCSK_SKI1_1 60 64 PF00082 0.400
CLV_PCSK_SKI1_1 74 78 PF00082 0.122
CLV_PCSK_SKI1_1 81 85 PF00082 0.142
DEG_APCC_DBOX_1 242 250 PF00400 0.429
DEG_APCC_DBOX_1 80 88 PF00400 0.354
DOC_CKS1_1 196 201 PF01111 0.354
DOC_CYCLIN_RxL_1 167 176 PF00134 0.354
DOC_CYCLIN_RxL_1 61 75 PF00134 0.325
DOC_MAPK_DCC_7 243 251 PF00069 0.449
DOC_MAPK_gen_1 167 175 PF00069 0.399
DOC_MAPK_gen_1 186 196 PF00069 0.448
DOC_MAPK_gen_1 79 87 PF00069 0.397
DOC_MAPK_MEF2A_6 167 175 PF00069 0.354
DOC_MAPK_MEF2A_6 79 87 PF00069 0.397
DOC_PP4_FxxP_1 124 127 PF00568 0.449
DOC_PP4_FxxP_1 196 199 PF00568 0.354
DOC_USP7_MATH_1 303 307 PF00917 0.441
DOC_WW_Pin1_4 195 200 PF00397 0.402
DOC_WW_Pin1_4 230 235 PF00397 0.452
LIG_14-3-3_CanoR_1 102 107 PF00244 0.449
LIG_14-3-3_CanoR_1 186 192 PF00244 0.401
LIG_14-3-3_CanoR_1 211 216 PF00244 0.449
LIG_14-3-3_CanoR_1 243 247 PF00244 0.354
LIG_14-3-3_CanoR_1 55 62 PF00244 0.430
LIG_14-3-3_CanoR_1 74 83 PF00244 0.397
LIG_APCC_ABBAyCdc20_2 170 176 PF00400 0.354
LIG_BIR_II_1 1 5 PF00653 0.546
LIG_BIR_III_3 1 5 PF00653 0.585
LIG_BRCT_BRCA1_1 120 124 PF00533 0.366
LIG_BRCT_BRCA1_1 204 208 PF00533 0.389
LIG_Clathr_ClatBox_1 172 176 PF01394 0.354
LIG_CtBP_PxDLS_1 309 313 PF00389 0.369
LIG_DLG_GKlike_1 211 218 PF00625 0.449
LIG_FHA_1 101 107 PF00498 0.383
LIG_FHA_2 103 109 PF00498 0.449
LIG_FHA_2 153 159 PF00498 0.366
LIG_FHA_2 75 81 PF00498 0.383
LIG_LIR_Apic_2 121 127 PF02991 0.449
LIG_LIR_Gen_1 131 141 PF02991 0.354
LIG_LIR_Gen_1 214 222 PF02991 0.443
LIG_LIR_Nem_3 131 137 PF02991 0.354
LIG_LIR_Nem_3 214 218 PF02991 0.443
LIG_Pex14_1 223 227 PF04695 0.354
LIG_Pex14_2 175 179 PF04695 0.354
LIG_SH2_CRK 168 172 PF00017 0.383
LIG_SH2_CRK 227 231 PF00017 0.383
LIG_SH2_SRC 227 230 PF00017 0.366
LIG_SH2_STAT5 134 137 PF00017 0.408
LIG_SH3_3 138 144 PF00018 0.354
LIG_SH3_3 228 234 PF00018 0.449
LIG_SH3_3 24 30 PF00018 0.703
LIG_SUMO_SIM_anti_2 308 314 PF11976 0.485
LIG_TRFH_1 179 183 PF08558 0.449
LIG_TRFH_1 244 248 PF08558 0.348
LIG_TYR_ITIM 132 137 PF00017 0.341
LIG_WRC_WIRS_1 212 217 PF05994 0.408
MOD_CDK_SPK_2 195 200 PF00069 0.354
MOD_CK1_1 142 148 PF00069 0.449
MOD_CK1_1 233 239 PF00069 0.479
MOD_CK1_1 75 81 PF00069 0.449
MOD_CK2_1 152 158 PF00069 0.366
MOD_CK2_1 233 239 PF00069 0.372
MOD_Cter_Amidation 4 7 PF01082 0.539
MOD_GlcNHglycan 141 144 PF01048 0.249
MOD_GlcNHglycan 263 266 PF01048 0.304
MOD_GlcNHglycan 305 308 PF01048 0.489
MOD_GSK3_1 229 236 PF00069 0.400
MOD_GSK3_1 56 63 PF00069 0.475
MOD_N-GLC_2 253 255 PF02516 0.236
MOD_NEK2_1 166 171 PF00069 0.437
MOD_NEK2_1 261 266 PF00069 0.415
MOD_NEK2_1 33 38 PF00069 0.400
MOD_PKA_1 6 12 PF00069 0.615
MOD_PKA_1 60 66 PF00069 0.378
MOD_PKA_2 242 248 PF00069 0.354
MOD_Plk_1 130 136 PF00069 0.398
MOD_Plk_4 118 124 PF00069 0.362
MOD_Plk_4 130 136 PF00069 0.350
MOD_Plk_4 187 193 PF00069 0.366
MOD_Plk_4 211 217 PF00069 0.408
MOD_Plk_4 233 239 PF00069 0.383
MOD_Plk_4 256 262 PF00069 0.346
MOD_ProDKin_1 195 201 PF00069 0.402
MOD_ProDKin_1 230 236 PF00069 0.452
MOD_SUMO_rev_2 272 279 PF00179 0.350
TRG_DiLeu_BaLyEn_6 168 173 PF01217 0.354
TRG_ENDOCYTIC_2 134 137 PF00928 0.354
TRG_ENDOCYTIC_2 227 230 PF00928 0.427
TRG_ER_diArg_1 279 281 PF00400 0.350
TRG_NLS_MonoExtC_3 5 10 PF00514 0.617
TRG_NLS_MonoExtN_4 6 11 PF00514 0.566
TRG_Pf-PMV_PEXEL_1 280 285 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 81 86 PF00026 0.166

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2X5 Leptomonas seymouri 83% 97%
A0A0S4IP78 Bodo saltans 59% 100%
A0A1X0P6M8 Trypanosomatidae 71% 100%
A0A3S7WW54 Leishmania donovani 100% 100%
D0A0C3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
E9AIL5 Leishmania braziliensis 90% 100%
E9AUU8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O13823 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
P34524 Caenorhabditis elegans 40% 90%
Q08235 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
Q3SZZ0 Bos taurus 41% 90%
Q4QCN5 Leishmania major 97% 100%
Q4QQT6 Rattus norvegicus 37% 90%
Q54JN0 Dictyostelium discoideum 40% 97%
Q5RAN2 Pongo abelii 37% 90%
Q755T8 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 23% 100%
Q8TDN6 Homo sapiens 37% 90%
Q8UVY2 Xenopus laevis 41% 93%
Q9C928 Arabidopsis thaliana 32% 99%
Q9DCA5 Mus musculus 36% 90%
Q9HGL6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
Q9LE16 Arabidopsis thaliana 37% 100%
Q9VZE6 Drosophila melanogaster 40% 88%
V5C1R2 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS