LeishMANIAdb
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Adaptin_N domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Adaptin_N domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HYZ2_LEIIN
TriTrypDb:
LINF_200020300
Length:
965

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HYZ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYZ2

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 1
GO:0009987 cellular process 1 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0003700 DNA-binding transcription factor activity 2 1
GO:0140110 transcription regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 377 381 PF00656 0.579
CLV_C14_Caspase3-7 523 527 PF00656 0.539
CLV_C14_Caspase3-7 818 822 PF00656 0.716
CLV_NRD_NRD_1 138 140 PF00675 0.652
CLV_NRD_NRD_1 162 164 PF00675 0.665
CLV_NRD_NRD_1 209 211 PF00675 0.327
CLV_NRD_NRD_1 312 314 PF00675 0.631
CLV_NRD_NRD_1 467 469 PF00675 0.693
CLV_NRD_NRD_1 55 57 PF00675 0.558
CLV_NRD_NRD_1 944 946 PF00675 0.631
CLV_PCSK_KEX2_1 138 140 PF00082 0.652
CLV_PCSK_KEX2_1 211 213 PF00082 0.360
CLV_PCSK_KEX2_1 227 229 PF00082 0.347
CLV_PCSK_KEX2_1 312 314 PF00082 0.631
CLV_PCSK_KEX2_1 467 469 PF00082 0.693
CLV_PCSK_KEX2_1 556 558 PF00082 0.652
CLV_PCSK_KEX2_1 673 675 PF00082 0.388
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.360
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.347
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.652
CLV_PCSK_PC1ET2_1 673 675 PF00082 0.470
CLV_PCSK_SKI1_1 494 498 PF00082 0.577
CLV_PCSK_SKI1_1 60 64 PF00082 0.677
CLV_PCSK_SKI1_1 633 637 PF00082 0.673
DEG_APCC_DBOX_1 640 648 PF00400 0.386
DEG_SPOP_SBC_1 781 785 PF00917 0.729
DOC_CDC14_PxL_1 295 303 PF14671 0.454
DOC_CDC14_PxL_1 871 879 PF14671 0.780
DOC_CYCLIN_RxL_1 56 67 PF00134 0.310
DOC_CYCLIN_RxL_1 792 802 PF00134 0.727
DOC_CYCLIN_yCln2_LP_2 931 937 PF00134 0.677
DOC_MAPK_DCC_7 560 570 PF00069 0.456
DOC_MAPK_gen_1 15 23 PF00069 0.394
DOC_MAPK_gen_1 312 319 PF00069 0.415
DOC_MAPK_gen_1 53 63 PF00069 0.383
DOC_MAPK_gen_1 69 78 PF00069 0.310
DOC_MAPK_gen_1 903 911 PF00069 0.694
DOC_MAPK_gen_1 945 953 PF00069 0.825
DOC_MAPK_HePTP_8 54 66 PF00069 0.395
DOC_MAPK_JIP1_4 313 319 PF00069 0.372
DOC_MAPK_MEF2A_6 331 339 PF00069 0.441
DOC_MAPK_MEF2A_6 57 66 PF00069 0.379
DOC_MAPK_MEF2A_6 69 78 PF00069 0.330
DOC_MAPK_MEF2A_6 903 911 PF00069 0.764
DOC_MAPK_RevD_3 150 164 PF00069 0.456
DOC_MAPK_RevD_3 452 468 PF00069 0.451
DOC_PP1_RVXF_1 793 800 PF00149 0.763
DOC_PP1_RVXF_1 88 95 PF00149 0.398
DOC_PP1_SILK_1 822 827 PF00149 0.738
DOC_SPAK_OSR1_1 913 917 PF12202 0.679
DOC_USP7_MATH_1 3 7 PF00917 0.569
DOC_USP7_MATH_1 436 440 PF00917 0.480
DOC_USP7_MATH_1 619 623 PF00917 0.603
DOC_USP7_MATH_1 780 784 PF00917 0.780
DOC_USP7_MATH_1 807 811 PF00917 0.684
DOC_USP7_MATH_1 820 824 PF00917 0.618
DOC_USP7_MATH_1 827 831 PF00917 0.688
DOC_USP7_UBL2_3 13 17 PF12436 0.519
DOC_USP7_UBL2_3 211 215 PF12436 0.568
DOC_USP7_UBL2_3 556 560 PF12436 0.445
DOC_USP7_UBL2_3 69 73 PF12436 0.334
DOC_WW_Pin1_4 237 242 PF00397 0.754
DOC_WW_Pin1_4 439 444 PF00397 0.498
DOC_WW_Pin1_4 528 533 PF00397 0.605
DOC_WW_Pin1_4 563 568 PF00397 0.396
DOC_WW_Pin1_4 634 639 PF00397 0.442
DOC_WW_Pin1_4 903 908 PF00397 0.748
LIG_14-3-3_CanoR_1 127 132 PF00244 0.412
LIG_14-3-3_CanoR_1 331 335 PF00244 0.456
LIG_14-3-3_CanoR_1 417 427 PF00244 0.434
LIG_14-3-3_CanoR_1 471 479 PF00244 0.414
LIG_14-3-3_CanoR_1 633 638 PF00244 0.466
LIG_14-3-3_CanoR_1 704 714 PF00244 0.673
LIG_14-3-3_CanoR_1 782 787 PF00244 0.750
LIG_14-3-3_CanoR_1 816 820 PF00244 0.680
LIG_14-3-3_CanoR_1 913 917 PF00244 0.768
LIG_14-3-3_CanoR_1 945 953 PF00244 0.781
LIG_14-3-3_CanoR_1 960 965 PF00244 0.778
LIG_Actin_WH2_2 399 414 PF00022 0.464
LIG_Actin_WH2_2 444 462 PF00022 0.463
LIG_APCC_ABBA_1 21 26 PF00400 0.424
LIG_APCC_ABBA_1 62 67 PF00400 0.313
LIG_APCC_ABBA_1 877 882 PF00400 0.761
LIG_BRCT_BRCA1_1 299 303 PF00533 0.384
LIG_BRCT_BRCA1_1 795 799 PF00533 0.780
LIG_Clathr_ClatBox_1 63 67 PF01394 0.319
LIG_deltaCOP1_diTrp_1 738 748 PF00928 0.688
LIG_EH1_1 644 652 PF00400 0.510
LIG_EVH1_1 871 875 PF00568 0.780
LIG_FHA_1 282 288 PF00498 0.429
LIG_FHA_1 405 411 PF00498 0.445
LIG_FHA_1 444 450 PF00498 0.413
LIG_FHA_1 471 477 PF00498 0.444
LIG_FHA_1 495 501 PF00498 0.377
LIG_FHA_1 536 542 PF00498 0.586
LIG_FHA_1 560 566 PF00498 0.448
LIG_FHA_1 626 632 PF00498 0.577
LIG_FHA_1 634 640 PF00498 0.478
LIG_FHA_1 731 737 PF00498 0.553
LIG_FHA_1 858 864 PF00498 0.707
LIG_FHA_1 866 872 PF00498 0.727
LIG_FHA_2 534 540 PF00498 0.616
LIG_FHA_2 541 547 PF00498 0.513
LIG_FHA_2 6 12 PF00498 0.510
LIG_GBD_Chelix_1 182 190 PF00786 0.564
LIG_GBD_Chelix_1 573 581 PF00786 0.604
LIG_IRF3_LxIS_1 812 818 PF10401 0.717
LIG_LIR_Gen_1 171 179 PF02991 0.402
LIG_LIR_Gen_1 429 437 PF02991 0.427
LIG_LIR_Gen_1 640 651 PF02991 0.362
LIG_LIR_Gen_1 728 737 PF02991 0.594
LIG_LIR_Gen_1 738 748 PF02991 0.627
LIG_LIR_Nem_3 171 176 PF02991 0.404
LIG_LIR_Nem_3 300 306 PF02991 0.390
LIG_LIR_Nem_3 429 434 PF02991 0.418
LIG_LIR_Nem_3 728 732 PF02991 0.601
LIG_LIR_Nem_3 738 744 PF02991 0.645
LIG_NRBOX 429 435 PF00104 0.377
LIG_PCNA_PIPBox_1 424 433 PF02747 0.419
LIG_PCNA_yPIPBox_3 199 212 PF02747 0.462
LIG_PCNA_yPIPBox_3 417 431 PF02747 0.425
LIG_PDZ_Class_1 960 965 PF00595 0.778
LIG_Pex14_2 550 554 PF04695 0.475
LIG_Pex14_2 591 595 PF04695 0.406
LIG_SH2_CRK 173 177 PF00017 0.348
LIG_SH2_CRK 322 326 PF00017 0.448
LIG_SH2_CRK 658 662 PF00017 0.581
LIG_SH2_GRB2like 479 482 PF00017 0.457
LIG_SH2_SRC 479 482 PF00017 0.457
LIG_SH2_SRC 658 661 PF00017 0.576
LIG_SH2_STAP1 173 177 PF00017 0.348
LIG_SH2_STAT5 43 46 PF00017 0.365
LIG_SH2_STAT5 458 461 PF00017 0.367
LIG_SH2_STAT5 479 482 PF00017 0.426
LIG_SH2_STAT5 698 701 PF00017 0.654
LIG_SH2_STAT5 731 734 PF00017 0.617
LIG_SH2_STAT5 910 913 PF00017 0.769
LIG_SH2_STAT5 961 964 PF00017 0.722
LIG_SH3_3 235 241 PF00018 0.695
LIG_SH3_3 293 299 PF00018 0.408
LIG_SH3_3 451 457 PF00018 0.406
LIG_SH3_3 529 535 PF00018 0.592
LIG_SH3_3 859 865 PF00018 0.779
LIG_SH3_3 869 875 PF00018 0.786
LIG_SUMO_SIM_anti_2 566 572 PF11976 0.448
LIG_SUMO_SIM_anti_2 743 748 PF11976 0.680
LIG_SUMO_SIM_par_1 401 408 PF11976 0.407
LIG_SUMO_SIM_par_1 566 572 PF11976 0.424
LIG_SUMO_SIM_par_1 77 83 PF11976 0.418
LIG_TRAF2_1 543 546 PF00917 0.523
LIG_TRAF2_1 751 754 PF00917 0.700
LIG_TYR_ITIM 320 325 PF00017 0.366
LIG_TYR_ITSM 169 176 PF00017 0.409
LIG_UBA3_1 205 211 PF00899 0.297
LIG_UBA3_1 499 507 PF00899 0.387
LIG_UBA3_1 61 69 PF00899 0.384
LIG_WRC_WIRS_1 726 731 PF05994 0.602
LIG_WW_1 907 910 PF00397 0.815
LIG_WW_2 872 875 PF00397 0.778
MOD_CDK_SPxxK_3 237 244 PF00069 0.661
MOD_CDK_SPxxK_3 634 641 PF00069 0.465
MOD_CK1_1 218 224 PF00069 0.673
MOD_CK1_1 237 243 PF00069 0.740
MOD_CK1_1 333 339 PF00069 0.452
MOD_CK1_1 439 445 PF00069 0.437
MOD_CK1_1 533 539 PF00069 0.609
MOD_CK1_1 559 565 PF00069 0.500
MOD_CK1_1 620 626 PF00069 0.559
MOD_CK1_1 637 643 PF00069 0.396
MOD_CK1_1 708 714 PF00069 0.659
MOD_CK1_1 730 736 PF00069 0.667
MOD_CK1_1 769 775 PF00069 0.681
MOD_CK1_1 857 863 PF00069 0.787
MOD_CK1_1 891 897 PF00069 0.786
MOD_CK2_1 43 49 PF00069 0.401
MOD_CK2_1 5 11 PF00069 0.536
MOD_CK2_1 517 523 PF00069 0.498
MOD_CK2_1 533 539 PF00069 0.590
MOD_CK2_1 540 546 PF00069 0.553
MOD_CK2_1 65 71 PF00069 0.477
MOD_CK2_1 679 685 PF00069 0.632
MOD_CK2_1 748 754 PF00069 0.615
MOD_CK2_1 80 86 PF00069 0.371
MOD_Cter_Amidation 465 468 PF01082 0.568
MOD_GlcNHglycan 135 138 PF01048 0.663
MOD_GlcNHglycan 307 310 PF01048 0.623
MOD_GlcNHglycan 391 394 PF01048 0.708
MOD_GlcNHglycan 439 442 PF01048 0.668
MOD_GlcNHglycan 482 485 PF01048 0.703
MOD_GlcNHglycan 528 531 PF01048 0.747
MOD_GlcNHglycan 586 589 PF01048 0.624
MOD_GlcNHglycan 609 612 PF01048 0.812
MOD_GlcNHglycan 619 622 PF01048 0.795
MOD_GlcNHglycan 690 693 PF01048 0.500
MOD_GlcNHglycan 700 703 PF01048 0.379
MOD_GlcNHglycan 776 779 PF01048 0.458
MOD_GlcNHglycan 836 839 PF01048 0.533
MOD_GlcNHglycan 856 859 PF01048 0.342
MOD_GlcNHglycan 883 889 PF01048 0.574
MOD_GlcNHglycan 921 924 PF01048 0.641
MOD_GlcNHglycan 927 930 PF01048 0.563
MOD_GSK3_1 1 8 PF00069 0.558
MOD_GSK3_1 104 111 PF00069 0.379
MOD_GSK3_1 127 134 PF00069 0.451
MOD_GSK3_1 233 240 PF00069 0.773
MOD_GSK3_1 264 271 PF00069 0.400
MOD_GSK3_1 329 336 PF00069 0.439
MOD_GSK3_1 39 46 PF00069 0.405
MOD_GSK3_1 439 446 PF00069 0.480
MOD_GSK3_1 490 497 PF00069 0.442
MOD_GSK3_1 522 529 PF00069 0.580
MOD_GSK3_1 533 540 PF00069 0.604
MOD_GSK3_1 559 566 PF00069 0.430
MOD_GSK3_1 615 622 PF00069 0.597
MOD_GSK3_1 625 632 PF00069 0.553
MOD_GSK3_1 633 640 PF00069 0.369
MOD_GSK3_1 721 728 PF00069 0.597
MOD_GSK3_1 789 796 PF00069 0.758
MOD_GSK3_1 807 814 PF00069 0.592
MOD_GSK3_1 815 822 PF00069 0.628
MOD_GSK3_1 884 891 PF00069 0.773
MOD_GSK3_1 915 922 PF00069 0.759
MOD_N-GLC_1 418 423 PF02516 0.685
MOD_N-GLC_1 480 485 PF02516 0.659
MOD_N-GLC_1 854 859 PF02516 0.530
MOD_N-GLC_2 5 7 PF02516 0.719
MOD_NEK2_1 1 6 PF00069 0.468
MOD_NEK2_1 104 109 PF00069 0.376
MOD_NEK2_1 19 24 PF00069 0.440
MOD_NEK2_1 258 263 PF00069 0.469
MOD_NEK2_1 374 379 PF00069 0.539
MOD_NEK2_1 405 410 PF00069 0.366
MOD_NEK2_1 411 416 PF00069 0.369
MOD_NEK2_1 595 600 PF00069 0.318
MOD_NEK2_1 629 634 PF00069 0.536
MOD_NEK2_1 688 693 PF00069 0.689
MOD_NEK2_1 797 802 PF00069 0.789
MOD_NEK2_1 80 85 PF00069 0.445
MOD_NEK2_1 815 820 PF00069 0.688
MOD_NEK2_2 537 542 PF00069 0.484
MOD_NMyristoyl 1 7 PF02799 0.570
MOD_PIKK_1 127 133 PF00454 0.485
MOD_PIKK_1 418 424 PF00454 0.483
MOD_PIKK_1 790 796 PF00454 0.784
MOD_PIKK_1 857 863 PF00454 0.714
MOD_PKA_1 556 562 PF00069 0.464
MOD_PKA_2 126 132 PF00069 0.434
MOD_PKA_2 281 287 PF00069 0.460
MOD_PKA_2 330 336 PF00069 0.452
MOD_PKA_2 411 417 PF00069 0.414
MOD_PKA_2 470 476 PF00069 0.468
MOD_PKA_2 556 562 PF00069 0.464
MOD_PKA_2 688 694 PF00069 0.673
MOD_PKA_2 781 787 PF00069 0.733
MOD_PKA_2 815 821 PF00069 0.692
MOD_PKA_2 912 918 PF00069 0.712
MOD_Plk_1 218 224 PF00069 0.702
MOD_Plk_1 233 239 PF00069 0.788
MOD_Plk_1 418 424 PF00069 0.454
MOD_Plk_1 769 775 PF00069 0.728
MOD_Plk_1 820 826 PF00069 0.767
MOD_Plk_4 19 25 PF00069 0.412
MOD_Plk_4 297 303 PF00069 0.404
MOD_Plk_4 365 371 PF00069 0.445
MOD_Plk_4 39 45 PF00069 0.378
MOD_Plk_4 426 432 PF00069 0.404
MOD_Plk_4 537 543 PF00069 0.574
MOD_Plk_4 566 572 PF00069 0.448
MOD_Plk_4 74 80 PF00069 0.416
MOD_Plk_4 820 826 PF00069 0.729
MOD_ProDKin_1 237 243 PF00069 0.745
MOD_ProDKin_1 439 445 PF00069 0.492
MOD_ProDKin_1 528 534 PF00069 0.606
MOD_ProDKin_1 563 569 PF00069 0.391
MOD_ProDKin_1 634 640 PF00069 0.439
MOD_ProDKin_1 903 909 PF00069 0.749
MOD_SUMO_rev_2 67 75 PF00179 0.325
MOD_SUMO_rev_2 800 810 PF00179 0.742
TRG_DiLeu_BaEn_1 927 932 PF01217 0.684
TRG_DiLeu_BaEn_3 753 759 PF01217 0.647
TRG_DiLeu_BaLyEn_6 136 141 PF01217 0.369
TRG_DiLeu_BaLyEn_6 406 411 PF01217 0.399
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.456
TRG_ENDOCYTIC_2 173 176 PF00928 0.347
TRG_ENDOCYTIC_2 322 325 PF00928 0.420
TRG_ENDOCYTIC_2 961 964 PF00928 0.722
TRG_ER_diArg_1 138 140 PF00400 0.452
TRG_ER_diArg_1 209 212 PF00400 0.527
TRG_ER_diArg_1 312 314 PF00400 0.408
TRG_Pf-PMV_PEXEL_1 138 143 PF00026 0.609
TRG_Pf-PMV_PEXEL_1 712 717 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 82 86 PF00026 0.583

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU24 Leptomonas seymouri 62% 98%
A0A1X0NW53 Trypanosomatidae 31% 96%
A0A3R7NMU6 Trypanosoma rangeli 32% 100%
A0A3S7WW45 Leishmania donovani 100% 100%
C9ZIP6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 98%
E9AIK6 Leishmania braziliensis 80% 100%
E9AUT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QCP5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS