C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYY9_LEIIN

TriTrypDb:

LINF_200019900

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.391
CLV_PCSK_KEX2_1	113	115	PF00082	0.450
CLV_PCSK_KEX2_1	177	179	PF00082	0.560
CLV_PCSK_KEX2_1	62	64	PF00082	0.444
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.560
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.434
CLV_PCSK_SKI1_1	107	111	PF00082	0.447
CLV_PCSK_SKI1_1	113	117	PF00082	0.371
CLV_PCSK_SKI1_1	76	80	PF00082	0.410
DEG_MDM2_SWIB_1	70	78	PF02201	0.364
DOC_CKS1_1	221	226	PF01111	0.587
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.521
DOC_MAPK_gen_1	113	121	PF00069	0.381
DOC_MAPK_gen_1	62	73	PF00069	0.394
DOC_MAPK_HePTP_8	17	29	PF00069	0.394
DOC_MAPK_MEF2A_6	113	121	PF00069	0.341
DOC_MAPK_MEF2A_6	20	29	PF00069	0.356
DOC_MAPK_MEF2A_6	66	75	PF00069	0.361
DOC_PP2B_LxvP_1	195	198	PF13499	0.621
DOC_USP7_MATH_1	155	159	PF00917	0.657
DOC_USP7_MATH_1	169	173	PF00917	0.591
DOC_WW_Pin1_4	119	124	PF00397	0.384
DOC_WW_Pin1_4	149	154	PF00397	0.584
DOC_WW_Pin1_4	220	225	PF00397	0.590
LIG_14-3-3_CanoR_1	113	118	PF00244	0.435
LIG_14-3-3_CanoR_1	20	24	PF00244	0.450
LIG_14-3-3_CanoR_1	35	44	PF00244	0.387
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.371
LIG_deltaCOP1_diTrp_1	72	79	PF00928	0.376
LIG_FHA_1	114	120	PF00498	0.450
LIG_FHA_2	120	126	PF00498	0.375
LIG_FHA_2	171	177	PF00498	0.646
LIG_IBAR_NPY_1	154	156	PF08397	0.590
LIG_LIR_Gen_1	85	96	PF02991	0.387
LIG_LIR_Nem_3	22	26	PF02991	0.339
LIG_LYPXL_S_1	199	203	PF13949	0.605
LIG_LYPXL_yS_3	200	203	PF13949	0.619
LIG_MYND_1	197	201	PF01753	0.579
LIG_Pex14_2	49	53	PF04695	0.383
LIG_Pex14_2	70	74	PF04695	0.345
LIG_SH2_CRK	141	145	PF00017	0.647
LIG_SH2_NCK_1	156	160	PF00017	0.579
LIG_SH2_PTP2	26	29	PF00017	0.351
LIG_SH2_STAP1	156	160	PF00017	0.689
LIG_SH2_STAT5	156	159	PF00017	0.678
LIG_SH2_STAT5	161	164	PF00017	0.631
LIG_SH2_STAT5	217	220	PF00017	0.558
LIG_SH2_STAT5	26	29	PF00017	0.351
LIG_SH3_1	178	184	PF00018	0.618
LIG_SH3_3	130	136	PF00018	0.611
LIG_SH3_3	178	184	PF00018	0.671
LIG_SH3_3	195	201	PF00018	0.589
LIG_SH3_3	218	224	PF00018	0.591
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.343
LIG_SUMO_SIM_par_1	2	7	PF11976	0.332
LIG_UBA3_1	69	76	PF00899	0.349
LIG_WW_1	197	200	PF00397	0.536
MOD_CK1_1	219	225	PF00069	0.603
MOD_CK1_1	33	39	PF00069	0.354
MOD_CK1_1	82	88	PF00069	0.368
MOD_CK2_1	170	176	PF00069	0.593
MOD_Cter_Amidation	111	114	PF01082	0.463
MOD_GlcNHglycan	157	160	PF01048	0.690
MOD_GlcNHglycan	211	214	PF01048	0.697
MOD_GlcNHglycan	218	221	PF01048	0.574
MOD_GlcNHglycan	39	42	PF01048	0.479
MOD_GSK3_1	115	122	PF00069	0.395
MOD_GSK3_1	15	22	PF00069	0.467
MOD_GSK3_1	216	223	PF00069	0.666
MOD_GSK3_1	33	40	PF00069	0.319
MOD_N-GLC_2	164	166	PF02516	0.612
MOD_NEK2_1	126	131	PF00069	0.611
MOD_NEK2_1	170	175	PF00069	0.550
MOD_NEK2_1	19	24	PF00069	0.427
MOD_NEK2_1	79	84	PF00069	0.459
MOD_NEK2_2	74	79	PF00069	0.361
MOD_PIKK_1	179	185	PF00454	0.744
MOD_PIKK_1	201	207	PF00454	0.639
MOD_PIKK_1	222	228	PF00454	0.661
MOD_PIKK_1	77	83	PF00454	0.381
MOD_PK_1	230	236	PF00069	0.608
MOD_PKA_1	113	119	PF00069	0.440
MOD_PKA_2	113	119	PF00069	0.397
MOD_PKA_2	19	25	PF00069	0.429
MOD_PKA_2	58	64	PF00069	0.507
MOD_Plk_1	230	236	PF00069	0.634
MOD_Plk_1	4	10	PF00069	0.342
MOD_Plk_1	99	105	PF00069	0.441
MOD_Plk_4	4	10	PF00069	0.360
MOD_Plk_4	74	80	PF00069	0.362
MOD_ProDKin_1	119	125	PF00069	0.391
MOD_ProDKin_1	149	155	PF00069	0.582
MOD_ProDKin_1	220	226	PF00069	0.587
TRG_ENDOCYTIC_2	200	203	PF00928	0.585
TRG_ENDOCYTIC_2	26	29	PF00928	0.351
TRG_ER_diArg_1	66	69	PF00400	0.412
TRG_ER_diLys_1	238	242	PF00400	0.602
TRG_NES_CRM1_1	135	146	PF08389	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P409	Leptomonas seymouri	49%	86%
A0A3Q8IDQ9	Leishmania donovani	99%	100%
E9AIK3	Leishmania braziliensis	68%	100%
E9AUT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCP8	Leishmania major	90%	100%