Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYY7_LEIIN

TriTrypDb:

LINF_200019700

Length:

145

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HYY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.486
CLV_NRD_NRD_1	133	135	PF00675	0.568
CLV_NRD_NRD_1	39	41	PF00675	0.516
CLV_NRD_NRD_1	48	50	PF00675	0.577
CLV_PCSK_KEX2_1	100	102	PF00082	0.414
CLV_PCSK_KEX2_1	132	134	PF00082	0.571
CLV_PCSK_KEX2_1	82	84	PF00082	0.551
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.551
DEG_ODPH_VHL_1	14	27	PF01847	0.490
DEG_SIAH_1	113	121	PF03145	0.610
DOC_MAPK_gen_1	100	109	PF00069	0.457
DOC_USP7_MATH_1	141	145	PF00917	0.707
DOC_USP7_MATH_1	42	46	PF00917	0.633
DOC_WW_Pin1_4	18	23	PF00397	0.687
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_FHA_1	121	127	PF00498	0.596
LIG_FHA_1	19	25	PF00498	0.658
LIG_FHA_1	30	36	PF00498	0.596
LIG_FHA_2	21	27	PF00498	0.627
LIG_GBD_Chelix_1	68	76	PF00786	0.542
LIG_SH3_3	111	117	PF00018	0.639
LIG_SH3_3	59	65	PF00018	0.645
LIG_TRAF2_1	10	13	PF00917	0.544
LIG_TRAF2_1	53	56	PF00917	0.672
LIG_TRAF2_1	77	80	PF00917	0.511
LIG_TRAF2_1	93	96	PF00917	0.512
LIG_UBA3_1	72	81	PF00899	0.566
LIG_WRC_WIRS_1	121	126	PF05994	0.455
LIG_WW_3	46	50	PF00397	0.620
MOD_CK2_1	20	26	PF00069	0.633
MOD_CK2_1	72	78	PF00069	0.467
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	91	94	PF01048	0.554
MOD_GSK3_1	64	71	PF00069	0.526
MOD_N-GLC_1	109	114	PF02516	0.556
MOD_NEK2_1	72	77	PF00069	0.580
MOD_PIKK_1	91	97	PF00454	0.547
MOD_Plk_1	127	133	PF00069	0.501
MOD_Plk_4	120	126	PF00069	0.633
MOD_Plk_4	20	26	PF00069	0.531
MOD_Plk_4	64	70	PF00069	0.534
MOD_ProDKin_1	18	24	PF00069	0.685
MOD_SUMO_rev_2	75	84	PF00179	0.499
TRG_ER_diArg_1	131	134	PF00400	0.566
TRG_ER_diArg_1	99	101	PF00400	0.529
TRG_NLS_MonoCore_2	39	44	PF00514	0.533
TRG_NLS_MonoExtN_4	37	44	PF00514	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD35	Leptomonas seymouri	69%	100%
A0A0S4ISW9	Bodo saltans	38%	74%
A0A1X0NW52	Trypanosomatidae	43%	78%
A0A3R7N8A8	Trypanosoma rangeli	42%	81%
A0A3S7WW97	Leishmania donovani	100%	100%
C9ZIJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	86%
E9AIK1	Leishmania braziliensis	80%	100%
E9AUT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QCQ0	Leishmania major	94%	100%