SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYY6_LEIIN

TriTrypDb:

LINF_200019600

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	235	241	PF00089	0.474
CLV_NRD_NRD_1	153	155	PF00675	0.573
CLV_NRD_NRD_1	93	95	PF00675	0.415
CLV_PCSK_FUR_1	150	154	PF00082	0.605
CLV_PCSK_KEX2_1	152	154	PF00082	0.503
CLV_PCSK_KEX2_1	93	95	PF00082	0.416
CLV_PCSK_SKI1_1	111	115	PF00082	0.349
CLV_PCSK_SKI1_1	153	157	PF00082	0.518
CLV_PCSK_SKI1_1	66	70	PF00082	0.406
CLV_PCSK_SKI1_1	82	86	PF00082	0.486
DEG_APCC_DBOX_1	110	118	PF00400	0.363
DEG_COP1_1	168	178	PF00400	0.491
DOC_CDC14_PxL_1	172	180	PF14671	0.396
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.394
DOC_MAPK_DCC_7	64	74	PF00069	0.480
DOC_MAPK_MEF2A_6	66	75	PF00069	0.517
DOC_PP2B_LxvP_1	99	102	PF13499	0.477
DOC_PP4_MxPP_1	1	4	PF00568	0.525
DOC_WW_Pin1_4	182	187	PF00397	0.504
DOC_WW_Pin1_4	39	44	PF00397	0.434
DOC_WW_Pin1_4	94	99	PF00397	0.491
LIG_14-3-3_CanoR_1	225	235	PF00244	0.420
LIG_Clathr_ClatBox_1	72	76	PF01394	0.504
LIG_FHA_1	13	19	PF00498	0.513
LIG_FHA_1	183	189	PF00498	0.414
LIG_FHA_1	219	225	PF00498	0.495
LIG_LIR_Gen_1	135	142	PF02991	0.568
LIG_LIR_Gen_1	170	180	PF02991	0.535
LIG_LIR_Gen_1	25	35	PF02991	0.388
LIG_LIR_Gen_1	45	56	PF02991	0.236
LIG_LIR_Nem_3	135	139	PF02991	0.506
LIG_LIR_Nem_3	170	175	PF02991	0.444
LIG_LIR_Nem_3	25	31	PF02991	0.375
LIG_LIR_Nem_3	45	51	PF02991	0.236
LIG_LIR_Nem_3	76	80	PF02991	0.502
LIG_MYND_1	176	180	PF01753	0.382
LIG_NRBOX	87	93	PF00104	0.482
LIG_PCNA_PIPBox_1	84	93	PF02747	0.462
LIG_PCNA_yPIPBox_3	81	94	PF02747	0.482
LIG_Pex14_1	151	155	PF04695	0.622
LIG_Pex14_2	237	241	PF04695	0.437
LIG_SH2_CRK	136	140	PF00017	0.564
LIG_SH2_CRK	172	176	PF00017	0.403
LIG_SH2_CRK	48	52	PF00017	0.534
LIG_SH2_GRB2like	47	50	PF00017	0.525
LIG_SH2_STAP1	136	140	PF00017	0.536
LIG_SH2_STAT5	136	139	PF00017	0.492
LIG_SH2_STAT5	28	31	PF00017	0.413
LIG_SH3_3	183	189	PF00018	0.433
LIG_SH3_3	37	43	PF00018	0.483
LIG_SH3_3	65	71	PF00018	0.388
LIG_SH3_3	95	101	PF00018	0.512
LIG_SH3_5	43	47	PF00018	0.544
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.512
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.431
LIG_SUMO_SIM_par_1	70	76	PF11976	0.512
LIG_TRFH_1	172	176	PF08558	0.403
LIG_TRFH_1	48	52	PF08558	0.524
LIG_TYR_ITIM	105	110	PF00017	0.450
LIG_TYR_ITIM	134	139	PF00017	0.484
MOD_CDK_SPK_2	39	44	PF00069	0.522
MOD_CK1_1	132	138	PF00069	0.571
MOD_CK1_1	157	163	PF00069	0.635
MOD_CK1_1	42	48	PF00069	0.456
MOD_GlcNHglycan	131	134	PF01048	0.568
MOD_GSK3_1	154	161	PF00069	0.631
MOD_N-GLC_1	226	231	PF02516	0.400
MOD_NEK2_1	12	17	PF00069	0.518
MOD_NEK2_1	134	139	PF00069	0.493
MOD_NEK2_1	226	231	PF00069	0.407
MOD_PIKK_1	226	232	PF00454	0.444
MOD_PK_1	154	160	PF00069	0.573
MOD_PKB_1	152	160	PF00069	0.601
MOD_Plk_4	154	160	PF00069	0.593
MOD_Plk_4	174	180	PF00069	0.233
MOD_Plk_4	83	89	PF00069	0.387
MOD_ProDKin_1	182	188	PF00069	0.504
MOD_ProDKin_1	39	45	PF00069	0.432
MOD_ProDKin_1	94	100	PF00069	0.484
TRG_DiLeu_BaEn_1	170	175	PF01217	0.463
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.377
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.519
TRG_ENDOCYTIC_2	107	110	PF00928	0.448
TRG_ENDOCYTIC_2	136	139	PF00928	0.473
TRG_ENDOCYTIC_2	172	175	PF00928	0.413
TRG_ENDOCYTIC_2	28	31	PF00928	0.430
TRG_ENDOCYTIC_2	47	50	PF00928	0.369
TRG_ER_diArg_1	151	154	PF00400	0.581
TRG_ER_diArg_1	92	94	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5T0	Leptomonas seymouri	82%	72%
A0A0S4IJP6	Bodo saltans	26%	76%
A0A1X0NW56	Trypanosomatidae	58%	70%
A0A3R7RG23	Trypanosoma rangeli	56%	71%
A0A3S7WW32	Leishmania donovani	100%	72%
C9ZIJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	69%
E9AIK0	Leishmania braziliensis	92%	100%
E9AUT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QCQ1	Leishmania major	97%	100%
V5BDU9	Trypanosoma cruzi	54%	72%