LeishMANIAdb
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Putative axoneme central apparatus protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative axoneme central apparatus protein
Gene product:
paralyzed flagella protein 16
Species:
Leishmania infantum
UniProt:
A4HYY3_LEIIN
TriTrypDb:
LINF_200019300
Length:
510

Annotations

Annotations by Jardim et al.

Structural Proteins, axoneme central apparatus

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0005930 axoneme 2 1
GO:0015630 microtubule cytoskeleton 6 1
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0005929 cilium 4 1
GO:0031514 motile cilium 5 1
GO:0042995 cell projection 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0120025 plasma membrane bounded cell projection 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYY3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYY3

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0001578 microtubule bundle formation 4 1
GO:0003341 cilium movement 4 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022607 cellular component assembly 4 1
GO:0035082 axoneme assembly 5 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0060294 cilium movement involved in cell motility 5 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 184 186 PF00082 0.203
CLV_PCSK_KEX2_1 226 228 PF00082 0.276
CLV_PCSK_KEX2_1 401 403 PF00082 0.305
CLV_PCSK_KEX2_1 448 450 PF00082 0.303
CLV_PCSK_PC1ET2_1 184 186 PF00082 0.203
CLV_PCSK_PC1ET2_1 226 228 PF00082 0.316
CLV_PCSK_PC1ET2_1 401 403 PF00082 0.282
CLV_PCSK_PC1ET2_1 448 450 PF00082 0.303
CLV_PCSK_SKI1_1 255 259 PF00082 0.260
CLV_PCSK_SKI1_1 4 8 PF00082 0.450
CLV_PCSK_SKI1_1 401 405 PF00082 0.269
CLV_PCSK_SKI1_1 47 51 PF00082 0.277
DOC_CYCLIN_RxL_1 44 53 PF00134 0.279
DOC_CYCLIN_yCln2_LP_2 45 51 PF00134 0.272
DOC_MAPK_DCC_7 166 174 PF00069 0.203
DOC_MAPK_MEF2A_6 166 174 PF00069 0.203
DOC_MAPK_RevD_3 170 185 PF00069 0.203
DOC_PP1_RVXF_1 15 21 PF00149 0.268
DOC_USP7_MATH_1 237 241 PF00917 0.283
DOC_USP7_MATH_1 390 394 PF00917 0.319
DOC_USP7_MATH_1 467 471 PF00917 0.367
DOC_USP7_MATH_1 69 73 PF00917 0.356
DOC_USP7_UBL2_3 401 405 PF12436 0.288
DOC_WW_Pin1_4 111 116 PF00397 0.303
DOC_WW_Pin1_4 195 200 PF00397 0.371
DOC_WW_Pin1_4 279 284 PF00397 0.268
DOC_WW_Pin1_4 386 391 PF00397 0.416
DOC_WW_Pin1_4 488 493 PF00397 0.295
LIG_14-3-3_CanoR_1 185 194 PF00244 0.218
LIG_14-3-3_CanoR_1 455 461 PF00244 0.263
LIG_14-3-3_CanoR_1 67 75 PF00244 0.353
LIG_Actin_WH2_2 169 186 PF00022 0.203
LIG_BIR_II_1 1 5 PF00653 0.375
LIG_BRCT_BRCA1_1 101 105 PF00533 0.246
LIG_FHA_1 280 286 PF00498 0.259
LIG_FHA_1 324 330 PF00498 0.249
LIG_FHA_1 84 90 PF00498 0.414
LIG_FHA_2 138 144 PF00498 0.218
LIG_FHA_2 188 194 PF00498 0.218
LIG_FHA_2 21 27 PF00498 0.241
LIG_FHA_2 495 501 PF00498 0.314
LIG_FHA_2 7 13 PF00498 0.372
LIG_LIR_Apic_2 385 390 PF02991 0.301
LIG_LIR_Apic_2 488 492 PF02991 0.434
LIG_LIR_LC3C_4 245 248 PF02991 0.244
LIG_LIR_Nem_3 251 256 PF02991 0.250
LIG_LIR_Nem_3 9 13 PF02991 0.437
LIG_MYND_1 415 419 PF01753 0.262
LIG_MYND_3 414 418 PF01753 0.249
LIG_Pex14_1 147 151 PF04695 0.243
LIG_Pex14_2 253 257 PF04695 0.243
LIG_PTB_Apo_2 476 483 PF02174 0.343
LIG_SH2_CRK 437 441 PF00017 0.387
LIG_SH2_SRC 413 416 PF00017 0.399
LIG_SH2_STAP1 437 441 PF00017 0.387
LIG_SH2_STAP1 494 498 PF00017 0.305
LIG_SH2_STAT3 505 508 PF00017 0.448
LIG_SH2_STAT5 151 154 PF00017 0.203
LIG_SH2_STAT5 301 304 PF00017 0.278
LIG_SH2_STAT5 319 322 PF00017 0.225
LIG_SH2_STAT5 387 390 PF00017 0.294
LIG_SH2_STAT5 413 416 PF00017 0.385
LIG_SH2_STAT5 432 435 PF00017 0.125
LIG_SH3_3 173 179 PF00018 0.203
LIG_SH3_3 409 415 PF00018 0.266
LIG_SH3_3 420 426 PF00018 0.251
LIG_SUMO_SIM_par_1 47 53 PF11976 0.279
LIG_TRAF2_1 71 74 PF00917 0.373
LIG_WRC_WIRS_1 7 12 PF05994 0.441
MOD_CK1_1 321 327 PF00069 0.324
MOD_CK1_1 389 395 PF00069 0.429
MOD_CK1_1 53 59 PF00069 0.366
MOD_CK2_1 137 143 PF00069 0.236
MOD_CK2_1 467 473 PF00069 0.365
MOD_CK2_1 494 500 PF00069 0.323
MOD_CK2_1 6 12 PF00069 0.441
MOD_CK2_1 68 74 PF00069 0.356
MOD_GlcNHglycan 101 104 PF01048 0.243
MOD_GlcNHglycan 143 146 PF01048 0.176
MOD_GlcNHglycan 320 323 PF01048 0.318
MOD_GlcNHglycan 366 369 PF01048 0.313
MOD_GlcNHglycan 59 62 PF01048 0.251
MOD_GlcNHglycan 80 83 PF01048 0.296
MOD_GSK3_1 137 144 PF00069 0.219
MOD_GSK3_1 301 308 PF00069 0.380
MOD_GSK3_1 386 393 PF00069 0.411
MOD_GSK3_1 467 474 PF00069 0.360
MOD_GSK3_1 53 60 PF00069 0.270
MOD_N-GLC_1 69 74 PF02516 0.345
MOD_N-GLC_2 479 481 PF02516 0.263
MOD_NEK2_1 20 25 PF00069 0.260
MOD_NEK2_1 201 206 PF00069 0.441
MOD_NEK2_1 323 328 PF00069 0.247
MOD_NEK2_1 471 476 PF00069 0.412
MOD_NEK2_1 50 55 PF00069 0.338
MOD_NEK2_1 88 93 PF00069 0.307
MOD_NEK2_2 179 184 PF00069 0.215
MOD_PIKK_1 121 127 PF00454 0.204
MOD_PIKK_1 83 89 PF00454 0.408
MOD_PKA_2 364 370 PF00069 0.274
MOD_Plk_1 179 185 PF00069 0.203
MOD_Plk_4 201 207 PF00069 0.398
MOD_Plk_4 494 500 PF00069 0.308
MOD_ProDKin_1 111 117 PF00069 0.238
MOD_ProDKin_1 195 201 PF00069 0.366
MOD_ProDKin_1 279 285 PF00069 0.263
MOD_ProDKin_1 386 392 PF00069 0.410
MOD_ProDKin_1 488 494 PF00069 0.292
MOD_SUMO_for_1 447 450 PF00179 0.290
MOD_SUMO_for_1 463 466 PF00179 0.311
MOD_SUMO_rev_2 220 225 PF00179 0.262
TRG_DiLeu_BaEn_1 242 247 PF01217 0.243
TRG_DiLeu_BaEn_1 284 289 PF01217 0.258
TRG_DiLeu_BaLyEn_6 213 218 PF01217 0.252
TRG_DiLeu_BaLyEn_6 379 384 PF01217 0.289
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.254
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.264
TRG_ENDOCYTIC_2 437 440 PF00928 0.393
TRG_ER_diArg_1 17 20 PF00400 0.360
TRG_Pf-PMV_PEXEL_1 4 8 PF00026 0.307
TRG_Pf-PMV_PEXEL_1 47 52 PF00026 0.271

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE96 Leptomonas seymouri 94% 100%
A0A0S4J9K3 Bodo saltans 81% 100%
A0A1X0NXK0 Trypanosomatidae 86% 99%
A0A3Q8IEY0 Leishmania donovani 100% 100%
A0A3R7K990 Trypanosoma rangeli 86% 99%
B6HJ92 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 24% 92%
C9ZIJ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 99%
E9AIJ7 Leishmania braziliensis 97% 100%
E9AUS9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O35345 Mus musculus 21% 95%
O60684 Homo sapiens 21% 95%
O75602 Homo sapiens 63% 100%
P52292 Homo sapiens 22% 96%
P52293 Mus musculus 22% 96%
Q0V7M0 Bos taurus 21% 95%
Q4QCQ4 Leishmania major 99% 100%
Q5RBV0 Pongo abelii 21% 95%
Q5ZML1 Gallus gallus 21% 95%
Q9JLI7 Mus musculus 63% 100%
V5D560 Trypanosoma cruzi 86% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS