Putative pumilio protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 9 - putative

Species:

Leishmania infantum

UniProt:

A4HYY0_LEIIN

TriTrypDb:

LINF_200019000

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HYY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYY0

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.534
CLV_NRD_NRD_1	131	133	PF00675	0.627
CLV_NRD_NRD_1	19	21	PF00675	0.567
CLV_NRD_NRD_1	237	239	PF00675	0.461
CLV_NRD_NRD_1	246	248	PF00675	0.393
CLV_NRD_NRD_1	362	364	PF00675	0.358
CLV_NRD_NRD_1	532	534	PF00675	0.638
CLV_PCSK_KEX2_1	131	133	PF00082	0.627
CLV_PCSK_KEX2_1	19	21	PF00082	0.497
CLV_PCSK_KEX2_1	237	239	PF00082	0.461
CLV_PCSK_KEX2_1	246	248	PF00082	0.393
CLV_PCSK_KEX2_1	362	364	PF00082	0.358
CLV_PCSK_KEX2_1	403	405	PF00082	0.455
CLV_PCSK_KEX2_1	429	431	PF00082	0.525
CLV_PCSK_KEX2_1	532	534	PF00082	0.639
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.455
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.525
CLV_PCSK_SKI1_1	163	167	PF00082	0.419
CLV_PCSK_SKI1_1	292	296	PF00082	0.383
CLV_PCSK_SKI1_1	362	366	PF00082	0.383
CLV_PCSK_SKI1_1	410	414	PF00082	0.440
CLV_PCSK_SKI1_1	456	460	PF00082	0.537
CLV_PCSK_SKI1_1	507	511	PF00082	0.601
CLV_Separin_Metazoa	289	293	PF03568	0.516
CLV_Separin_Metazoa	504	508	PF03568	0.591
DEG_APCC_DBOX_1	236	244	PF00400	0.402
DEG_APCC_DBOX_1	291	299	PF00400	0.516
DEG_APCC_DBOX_1	362	370	PF00400	0.387
DEG_APCC_DBOX_1	49	57	PF00400	0.473
DOC_CYCLIN_RxL_1	359	368	PF00134	0.392
DOC_MAPK_gen_1	188	196	PF00069	0.470
DOC_MAPK_MEF2A_6	188	196	PF00069	0.470
DOC_PP4_FxxP_1	45	48	PF00568	0.575
DOC_USP7_MATH_1	36	40	PF00917	0.648
DOC_USP7_MATH_1	475	479	PF00917	0.609
DOC_USP7_MATH_1	49	53	PF00917	0.470
DOC_USP7_MATH_1	512	516	PF00917	0.596
DOC_USP7_MATH_1	87	91	PF00917	0.650
DOC_USP7_UBL2_3	421	425	PF12436	0.441
DOC_WW_Pin1_4	156	161	PF00397	0.423
DOC_WW_Pin1_4	69	74	PF00397	0.628
LIG_14-3-3_CanoR_1	146	153	PF00244	0.582
LIG_14-3-3_CanoR_1	237	241	PF00244	0.397
LIG_14-3-3_CanoR_1	320	328	PF00244	0.400
LIG_14-3-3_CanoR_1	50	54	PF00244	0.473
LIG_14-3-3_CanoR_1	507	512	PF00244	0.603
LIG_14-3-3_CterR_2	541	546	PF00244	0.625
LIG_Actin_WH2_1	174	192	PF00022	0.582
LIG_Actin_WH2_1	362	379	PF00022	0.560
LIG_Actin_WH2_2	175	192	PF00022	0.580
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_CaM_IQ_9	413	429	PF13499	0.560
LIG_EH1_1	386	394	PF00400	0.386
LIG_FHA_1	128	134	PF00498	0.502
LIG_FHA_1	212	218	PF00498	0.358
LIG_FHA_1	330	336	PF00498	0.511
LIG_FHA_2	202	208	PF00498	0.358
LIG_LIR_Apic_2	44	48	PF02991	0.576
LIG_LIR_Gen_1	510	520	PF02991	0.596
LIG_LIR_Nem_3	304	309	PF02991	0.358
LIG_LIR_Nem_3	382	387	PF02991	0.398
LIG_LIR_Nem_3	401	405	PF02991	0.287
LIG_LIR_Nem_3	510	516	PF02991	0.573
LIG_SH2_SRC	463	466	PF00017	0.529
LIG_SH2_SRC	503	506	PF00017	0.565
LIG_SH2_STAT3	309	312	PF00017	0.358
LIG_SH2_STAT3	534	537	PF00017	0.616
LIG_SH2_STAT5	12	15	PF00017	0.481
LIG_SH2_STAT5	235	238	PF00017	0.576
LIG_SH2_STAT5	264	267	PF00017	0.396
LIG_SH2_STAT5	326	329	PF00017	0.397
LIG_SH3_1	499	505	PF00018	0.577
LIG_SH3_2	502	507	PF14604	0.569
LIG_SH3_3	120	126	PF00018	0.587
LIG_SH3_3	25	31	PF00018	0.544
LIG_SH3_3	367	373	PF00018	0.566
LIG_SH3_3	393	399	PF00018	0.572
LIG_SH3_3	428	434	PF00018	0.681
LIG_SH3_3	43	49	PF00018	0.634
LIG_SH3_3	499	505	PF00018	0.599
LIG_SH3_3	53	59	PF00018	0.536
LIG_SUMO_SIM_par_1	93	98	PF11976	0.582
LIG_UBA3_1	335	342	PF00899	0.358
LIG_WW_3	47	51	PF00397	0.566
LIG_WW_3	504	508	PF00397	0.568
MOD_CDK_SPxxK_3	156	163	PF00069	0.419
MOD_CK1_1	180	186	PF00069	0.525
MOD_CK1_1	233	239	PF00069	0.418
MOD_CK1_1	318	324	PF00069	0.365
MOD_CK1_1	482	488	PF00069	0.603
MOD_CK1_1	61	67	PF00069	0.628
MOD_CK2_1	201	207	PF00069	0.358
MOD_CK2_1	239	245	PF00069	0.394
MOD_CK2_1	482	488	PF00069	0.718
MOD_GlcNHglycan	133	136	PF01048	0.547
MOD_GlcNHglycan	250	254	PF01048	0.575
MOD_GlcNHglycan	3	6	PF01048	0.629
MOD_GlcNHglycan	38	41	PF01048	0.589
MOD_GlcNHglycan	477	480	PF01048	0.547
MOD_GlcNHglycan	491	494	PF01048	0.568
MOD_GlcNHglycan	518	521	PF01048	0.622
MOD_GlcNHglycan	528	531	PF01048	0.621
MOD_GlcNHglycan	89	92	PF01048	0.567
MOD_GSK3_1	109	116	PF00069	0.623
MOD_GSK3_1	127	134	PF00069	0.580
MOD_GSK3_1	14	21	PF00069	0.667
MOD_GSK3_1	207	214	PF00069	0.358
MOD_GSK3_1	315	322	PF00069	0.357
MOD_GSK3_1	475	482	PF00069	0.559
MOD_GSK3_1	483	490	PF00069	0.674
MOD_GSK3_1	512	519	PF00069	0.659
MOD_N-GLC_2	228	230	PF02516	0.385
MOD_NEK2_1	221	226	PF00069	0.430
MOD_NEK2_1	265	270	PF00069	0.410
MOD_NEK2_1	336	341	PF00069	0.516
MOD_PIKK_1	169	175	PF00454	0.603
MOD_PIKK_1	230	236	PF00454	0.419
MOD_PIKK_1	265	271	PF00454	0.404
MOD_PKA_1	131	137	PF00069	0.565
MOD_PKA_2	131	137	PF00069	0.582
MOD_PKA_2	145	151	PF00069	0.396
MOD_PKA_2	18	24	PF00069	0.589
MOD_PKA_2	236	242	PF00069	0.392
MOD_PKA_2	319	325	PF00069	0.414
MOD_PKA_2	479	485	PF00069	0.660
MOD_PKA_2	49	55	PF00069	0.473
MOD_Plk_1	249	255	PF00069	0.566
MOD_Plk_4	177	183	PF00069	0.493
MOD_Plk_4	221	227	PF00069	0.426
MOD_Plk_4	239	245	PF00069	0.268
MOD_Plk_4	41	47	PF00069	0.605
MOD_ProDKin_1	156	162	PF00069	0.419
MOD_ProDKin_1	69	75	PF00069	0.630
MOD_SUMO_for_1	420	423	PF00179	0.437
TRG_DiLeu_BaEn_2	503	509	PF01217	0.607
TRG_ENDOCYTIC_2	384	387	PF00928	0.384
TRG_ER_diArg_1	131	133	PF00400	0.631
TRG_ER_diArg_1	187	190	PF00400	0.588
TRG_ER_diArg_1	361	363	PF00400	0.358
TRG_ER_diArg_1	408	411	PF00400	0.440
TRG_ER_diArg_1	532	534	PF00400	0.651
TRG_NES_CRM1_1	184	195	PF08389	0.412
TRG_NES_CRM1_1	293	304	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR0	Leptomonas seymouri	50%	83%
A0A3Q8IA47	Leishmania donovani	96%	93%
A0A3S7WW64	Leishmania donovani	99%	100%
A4HYX9	Leishmania infantum	79%	100%
E8NHJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AIJ1	Leishmania braziliensis	92%	100%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCQ8	Leishmania major	97%	100%
Q4QCQ9	Leishmania major	75%	100%