Putative pumillio protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 9 - putative

Species:

Leishmania infantum

UniProt:

A4HYX9_LEIIN

TriTrypDb:

LINF_200018900

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HYX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYX9

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.534
CLV_C14_Caspase3-7	554	558	PF00656	0.613
CLV_NRD_NRD_1	130	132	PF00675	0.626
CLV_NRD_NRD_1	23	25	PF00675	0.698
CLV_NRD_NRD_1	236	238	PF00675	0.516
CLV_NRD_NRD_1	245	247	PF00675	0.474
CLV_NRD_NRD_1	361	363	PF00675	0.417
CLV_NRD_NRD_1	569	571	PF00675	0.650
CLV_PCSK_KEX2_1	130	132	PF00082	0.626
CLV_PCSK_KEX2_1	236	238	PF00082	0.516
CLV_PCSK_KEX2_1	245	247	PF00082	0.474
CLV_PCSK_KEX2_1	361	363	PF00082	0.417
CLV_PCSK_KEX2_1	402	404	PF00082	0.514
CLV_PCSK_KEX2_1	428	430	PF00082	0.581
CLV_PCSK_KEX2_1	569	571	PF00082	0.652
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.514
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.581
CLV_PCSK_SKI1_1	162	166	PF00082	0.477
CLV_PCSK_SKI1_1	291	295	PF00082	0.439
CLV_PCSK_SKI1_1	361	365	PF00082	0.450
CLV_PCSK_SKI1_1	409	413	PF00082	0.500
CLV_Separin_Metazoa	288	292	PF03568	0.516
DEG_APCC_DBOX_1	235	243	PF00400	0.463
DEG_APCC_DBOX_1	290	298	PF00400	0.516
DEG_APCC_DBOX_1	361	369	PF00400	0.450
DEG_APCC_DBOX_1	500	508	PF00400	0.560
DOC_CYCLIN_RxL_1	358	367	PF00134	0.424
DOC_MAPK_FxFP_2	533	536	PF00069	0.636
DOC_MAPK_gen_1	187	195	PF00069	0.470
DOC_MAPK_MEF2A_6	187	195	PF00069	0.470
DOC_PP2B_LxvP_1	453	456	PF13499	0.611
DOC_PP4_FxxP_1	44	47	PF00568	0.653
DOC_PP4_FxxP_1	533	536	PF00568	0.636
DOC_PP4_FxxP_1	580	583	PF00568	0.587
DOC_USP7_MATH_1	35	39	PF00917	0.657
DOC_USP7_MATH_1	480	484	PF00917	0.702
DOC_USP7_MATH_1	86	90	PF00917	0.683
DOC_USP7_UBL2_3	420	424	PF12436	0.501
DOC_WW_Pin1_4	155	160	PF00397	0.486
DOC_WW_Pin1_4	48	53	PF00397	0.558
DOC_WW_Pin1_4	562	567	PF00397	0.636
DOC_WW_Pin1_4	68	73	PF00397	0.640
LIG_14-3-3_CanoR_1	12	22	PF00244	0.635
LIG_14-3-3_CanoR_1	145	152	PF00244	0.583
LIG_14-3-3_CanoR_1	236	240	PF00244	0.460
LIG_14-3-3_CanoR_1	319	327	PF00244	0.472
LIG_14-3-3_CanoR_1	451	456	PF00244	0.609
LIG_Actin_WH2_1	173	191	PF00022	0.581
LIG_Actin_WH2_1	361	378	PF00022	0.561
LIG_Actin_WH2_2	174	191	PF00022	0.579
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_CaM_IQ_9	412	428	PF13499	0.560
LIG_EH1_1	385	393	PF00400	0.446
LIG_FHA_1	127	133	PF00498	0.501
LIG_FHA_1	211	217	PF00498	0.417
LIG_FHA_1	329	335	PF00498	0.517
LIG_FHA_1	471	477	PF00498	0.694
LIG_FHA_2	201	207	PF00498	0.417
LIG_FHA_2	456	462	PF00498	0.628
LIG_HCF-1_HBM_1	525	528	PF13415	0.534
LIG_LIR_Apic_2	43	47	PF02991	0.653
LIG_LIR_Apic_2	531	536	PF02991	0.638
LIG_LIR_Nem_3	303	308	PF02991	0.417
LIG_LIR_Nem_3	381	386	PF02991	0.464
LIG_LIR_Nem_3	400	404	PF02991	0.286
LIG_PDZ_Class_2	583	588	PF00595	0.597
LIG_Pex14_2	580	584	PF04695	0.589
LIG_SH2_STAT3	308	311	PF00017	0.417
LIG_SH2_STAT5	234	237	PF00017	0.579
LIG_SH2_STAT5	263	266	PF00017	0.444
LIG_SH2_STAT5	325	328	PF00017	0.471
LIG_SH2_STAT5	494	497	PF00017	0.806
LIG_SH3_3	119	125	PF00018	0.650
LIG_SH3_3	366	372	PF00018	0.565
LIG_SH3_3	392	398	PF00018	0.588
LIG_SH3_3	42	48	PF00018	0.653
LIG_SH3_3	427	433	PF00018	0.704
LIG_SH3_3	462	468	PF00018	0.623
LIG_SH3_3	52	58	PF00018	0.487
LIG_SH3_3	558	564	PF00018	0.591
LIG_SUMO_SIM_par_1	92	97	PF11976	0.638
LIG_UBA3_1	334	341	PF00899	0.417
LIG_WW_3	46	50	PF00397	0.646
MOD_CDK_SPxxK_3	155	162	PF00069	0.481
MOD_CDK_SPxxK_3	562	569	PF00069	0.623
MOD_CK1_1	179	185	PF00069	0.525
MOD_CK1_1	232	238	PF00069	0.479
MOD_CK1_1	317	323	PF00069	0.431
MOD_CK1_1	60	66	PF00069	0.655
MOD_CK2_1	200	206	PF00069	0.417
MOD_CK2_1	238	244	PF00069	0.454
MOD_CK2_1	480	486	PF00069	0.737
MOD_GlcNHglycan	132	135	PF01048	0.505
MOD_GlcNHglycan	249	253	PF01048	0.576
MOD_GlcNHglycan	3	6	PF01048	0.659
MOD_GlcNHglycan	37	40	PF01048	0.624
MOD_GlcNHglycan	482	485	PF01048	0.606
MOD_GlcNHglycan	557	560	PF01048	0.644
MOD_GlcNHglycan	88	91	PF01048	0.593
MOD_GSK3_1	108	115	PF00069	0.649
MOD_GSK3_1	126	133	PF00069	0.628
MOD_GSK3_1	206	213	PF00069	0.417
MOD_GSK3_1	314	321	PF00069	0.416
MOD_GSK3_1	451	458	PF00069	0.600
MOD_GSK3_1	466	473	PF00069	0.670
MOD_GSK3_1	539	546	PF00069	0.655
MOD_N-GLC_1	12	17	PF02516	0.611
MOD_N-GLC_2	227	229	PF02516	0.448
MOD_NEK2_1	1	6	PF00069	0.543
MOD_NEK2_1	220	225	PF00069	0.484
MOD_NEK2_1	264	269	PF00069	0.457
MOD_NEK2_1	335	340	PF00069	0.516
MOD_PIKK_1	168	174	PF00454	0.602
MOD_PIKK_1	229	235	PF00454	0.479
MOD_PIKK_1	264	270	PF00454	0.452
MOD_PIKK_1	474	480	PF00454	0.591
MOD_PIKK_1	488	494	PF00454	0.665
MOD_PK_1	451	457	PF00069	0.578
MOD_PKA_1	130	136	PF00069	0.565
MOD_PKA_2	130	136	PF00069	0.582
MOD_PKA_2	144	150	PF00069	0.396
MOD_PKA_2	235	241	PF00069	0.454
MOD_PKA_2	318	324	PF00069	0.481
MOD_PKA_2	470	476	PF00069	0.715
MOD_Plk_1	248	254	PF00069	0.566
MOD_Plk_4	176	182	PF00069	0.493
MOD_Plk_4	220	226	PF00069	0.482
MOD_Plk_4	238	244	PF00069	0.294
MOD_Plk_4	40	46	PF00069	0.658
MOD_ProDKin_1	155	161	PF00069	0.481
MOD_ProDKin_1	48	54	PF00069	0.558
MOD_ProDKin_1	562	568	PF00069	0.632
MOD_ProDKin_1	68	74	PF00069	0.641
MOD_SUMO_for_1	419	422	PF00179	0.498
TRG_ENDOCYTIC_2	383	386	PF00928	0.452
TRG_ER_diArg_1	130	132	PF00400	0.655
TRG_ER_diArg_1	186	189	PF00400	0.588
TRG_ER_diArg_1	360	362	PF00400	0.417
TRG_ER_diArg_1	407	410	PF00400	0.499
TRG_NES_CRM1_1	183	194	PF08389	0.473
TRG_NES_CRM1_1	292	303	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	361	366	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR0	Leptomonas seymouri	51%	89%
A0A3Q8IA47	Leishmania donovani	100%	100%
A0A3S7WW64	Leishmania donovani	79%	100%
A4HYY0	Leishmania infantum	79%	100%
E8NHJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AIJ1	Leishmania braziliensis	85%	100%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCQ8	Leishmania major	86%	100%
Q4QCQ9	Leishmania major	95%	100%