Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYX5_LEIIN

TriTrypDb:

LINF_200018400

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.504
CLV_C14_Caspase3-7	78	82	PF00656	0.705
CLV_NRD_NRD_1	11	13	PF00675	0.557
CLV_NRD_NRD_1	402	404	PF00675	0.452
CLV_PCSK_KEX2_1	143	145	PF00082	0.739
CLV_PCSK_KEX2_1	315	317	PF00082	0.577
CLV_PCSK_KEX2_1	402	404	PF00082	0.452
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.739
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.577
CLV_PCSK_SKI1_1	216	220	PF00082	0.474
CLV_PCSK_SKI1_1	284	288	PF00082	0.441
CLV_PCSK_SKI1_1	302	306	PF00082	0.428
DEG_APCC_DBOX_1	244	252	PF00400	0.556
DEG_APCC_DBOX_1	410	418	PF00400	0.533
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DOC_CDC14_PxL_1	365	373	PF14671	0.433
DOC_CKS1_1	65	70	PF01111	0.606
DOC_MAPK_DCC_7	363	373	PF00069	0.451
DOC_MAPK_gen_1	288	297	PF00069	0.409
DOC_MAPK_MEF2A_6	288	296	PF00069	0.464
DOC_MIT_MIM_1	285	294	PF04212	0.476
DOC_PP1_RVXF_1	300	307	PF00149	0.434
DOC_USP7_MATH_1	103	107	PF00917	0.763
DOC_USP7_MATH_1	112	116	PF00917	0.616
DOC_WW_Pin1_4	273	278	PF00397	0.508
DOC_WW_Pin1_4	315	320	PF00397	0.508
DOC_WW_Pin1_4	40	45	PF00397	0.586
DOC_WW_Pin1_4	47	52	PF00397	0.774
DOC_WW_Pin1_4	64	69	PF00397	0.615
LIG_14-3-3_CanoR_1	189	193	PF00244	0.644
LIG_14-3-3_CanoR_1	2	6	PF00244	0.573
LIG_14-3-3_CanoR_1	206	212	PF00244	0.433
LIG_14-3-3_CanoR_1	302	307	PF00244	0.549
LIG_14-3-3_CanoR_1	384	394	PF00244	0.445
LIG_BRCT_BRCA1_1	229	233	PF00533	0.632
LIG_BRCT_BRCA1_1	302	306	PF00533	0.428
LIG_BRCT_BRCA1_1	317	321	PF00533	0.437
LIG_BRCT_BRCA1_1	338	342	PF00533	0.483
LIG_BRCT_BRCA1_1	49	53	PF00533	0.744
LIG_BRCT_BRCA1_1	72	76	PF00533	0.782
LIG_FHA_1	170	176	PF00498	0.653
LIG_FHA_1	375	381	PF00498	0.470
LIG_FHA_1	65	71	PF00498	0.548
LIG_FHA_2	296	302	PF00498	0.443
LIG_FHA_2	344	350	PF00498	0.490
LIG_LIR_Apic_2	17	21	PF02991	0.605
LIG_LIR_Gen_1	198	209	PF02991	0.598
LIG_LIR_Gen_1	318	329	PF02991	0.434
LIG_LIR_Nem_3	198	204	PF02991	0.617
LIG_LIR_Nem_3	303	309	PF02991	0.477
LIG_LIR_Nem_3	318	324	PF02991	0.278
LIG_LIR_Nem_3	337	343	PF02991	0.555
LIG_LIR_Nem_3	4	8	PF02991	0.583
LIG_NRBOX	290	296	PF00104	0.454
LIG_PCNA_yPIPBox_3	206	215	PF02747	0.540
LIG_PTAP_UEV_1	43	48	PF05743	0.574
LIG_SH2_CRK	122	126	PF00017	0.736
LIG_SH2_STAP1	108	112	PF00017	0.707
LIG_SH2_STAT5	267	270	PF00017	0.450
LIG_SH2_STAT5	309	312	PF00017	0.576
LIG_SH3_3	222	228	PF00018	0.656
LIG_SH3_3	363	369	PF00018	0.482
LIG_SH3_3	41	47	PF00018	0.573
LIG_SH3_3	85	91	PF00018	0.794
LIG_SUMO_SIM_par_1	19	26	PF11976	0.618
LIG_SUMO_SIM_par_1	322	327	PF11976	0.406
LIG_TRAF2_1	151	154	PF00917	0.728
LIG_TRAF2_2	257	262	PF00917	0.671
LIG_WW_1	119	122	PF00397	0.719
MOD_CDK_SPxxK_3	47	54	PF00069	0.630
MOD_CK1_1	106	112	PF00069	0.740
MOD_CK1_1	159	165	PF00069	0.681
MOD_CK1_1	300	306	PF00069	0.438
MOD_CK1_1	352	358	PF00069	0.571
MOD_CK1_1	42	48	PF00069	0.716
MOD_CK2_1	14	20	PF00069	0.594
MOD_CK2_1	295	301	PF00069	0.434
MOD_CK2_1	375	381	PF00069	0.459
MOD_GlcNHglycan	127	130	PF01048	0.744
MOD_GlcNHglycan	153	157	PF01048	0.711
MOD_GlcNHglycan	159	162	PF01048	0.725
MOD_GlcNHglycan	277	280	PF01048	0.485
MOD_GlcNHglycan	377	380	PF01048	0.476
MOD_GlcNHglycan	47	50	PF01048	0.728
MOD_GlcNHglycan	55	58	PF01048	0.754
MOD_GlcNHglycan	94	97	PF01048	0.738
MOD_GSK3_1	152	159	PF00069	0.667
MOD_GSK3_1	162	169	PF00069	0.694
MOD_GSK3_1	195	202	PF00069	0.703
MOD_N-GLC_1	374	379	PF02516	0.482
MOD_N-GLC_1	81	86	PF02516	0.789
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	209	214	PF00069	0.525
MOD_NEK2_1	219	224	PF00069	0.575
MOD_NEK2_1	23	28	PF00069	0.636
MOD_NEK2_1	334	339	PF00069	0.450
MOD_NEK2_1	343	348	PF00069	0.408
MOD_NEK2_1	39	44	PF00069	0.703
MOD_NEK2_1	53	58	PF00069	0.746
MOD_NEK2_1	8	13	PF00069	0.548
MOD_NEK2_2	413	418	PF00069	0.544
MOD_NEK2_2	71	76	PF00069	0.779
MOD_PIKK_1	23	29	PF00454	0.707
MOD_PIKK_1	81	87	PF00454	0.711
MOD_PKA_2	1	7	PF00069	0.576
MOD_PKA_2	157	163	PF00069	0.731
MOD_PKA_2	188	194	PF00069	0.656
MOD_PKA_2	53	59	PF00069	0.701
MOD_PKA_2	8	14	PF00069	0.522
MOD_Plk_1	134	140	PF00069	0.683
MOD_Plk_1	199	205	PF00069	0.602
MOD_Plk_1	219	225	PF00069	0.376
MOD_Plk_1	300	306	PF00069	0.438
MOD_Plk_4	1	7	PF00069	0.626
MOD_Plk_4	103	109	PF00069	0.771
MOD_Plk_4	302	308	PF00069	0.558
MOD_Plk_4	349	355	PF00069	0.432
MOD_Plk_4	413	419	PF00069	0.498
MOD_Plk_4	71	77	PF00069	0.709
MOD_ProDKin_1	273	279	PF00069	0.510
MOD_ProDKin_1	315	321	PF00069	0.499
MOD_ProDKin_1	40	46	PF00069	0.584
MOD_ProDKin_1	47	53	PF00069	0.774
MOD_ProDKin_1	64	70	PF00069	0.615
MOD_SUMO_rev_2	243	251	PF00179	0.560
TRG_DiLeu_BaEn_1	246	251	PF01217	0.600
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.474
TRG_ER_diArg_1	116	119	PF00400	0.779
TRG_ER_diArg_1	401	403	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C6	Leptomonas seymouri	66%	100%
A0A1X0NWG2	Trypanosomatidae	53%	100%
A0A3S7WW26	Leishmania donovani	99%	100%
E9AII7	Leishmania braziliensis	88%	100%
E9AUS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCR4	Leishmania major	97%	100%