LeishMANIAdb
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Small myristoylated protein-2,putativewith

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Small myristoylated protein-2,putativewith
Gene product:
small myristoylated protein-2
Species:
Leishmania infantum
UniProt:
A4HYX3_LEIIN
TriTrypDb:
LINF_200018200
Length:
136

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Annotations by Jardim et al.

Membrane associated proteins, Small myristoylated -2,putativewith=GeneDB:LmjF20.1300 SMP-2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 2
Forrest at al. (metacyclic) no yes: 5
Forrest at al. (procyclic) no yes: 7
Silverman et al. no yes: 1
Pissara et al. yes yes: 27
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 55
NetGPI no yes: 0, no: 55
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0097542 ciliary tip 2 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2
GO:0020018 ciliary pocket membrane 6 1
GO:0031090 organelle membrane 3 2
GO:0031253 cell projection membrane 4 2
GO:0060170 ciliary membrane 5 2
GO:0098588 bounding membrane of organelle 4 2
GO:0098590 plasma membrane region 3 2

Expansion

Sequence features

A4HYX3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYX3

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
Term Name Level Count
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0009987 cellular process 1 2
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044000 movement in host 4 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044409 entry into host 5 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0044782 cilium organization 5 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.425
CLV_NRD_NRD_1 41 43 PF00675 0.390
CLV_NRD_NRD_1 8 10 PF00675 0.681
CLV_PCSK_KEX2_1 41 43 PF00082 0.352
CLV_PCSK_PC1ET2_1 41 43 PF00082 0.329
CLV_PCSK_SKI1_1 38 42 PF00082 0.403
CLV_PCSK_SKI1_1 79 83 PF00082 0.505
DOC_USP7_MATH_1 118 122 PF00917 0.561
DOC_USP7_UBL2_3 10 14 PF12436 0.520
LIG_14-3-3_CanoR_1 61 67 PF00244 0.395
LIG_APCC_ABBAyCdc20_2 98 104 PF00400 0.445
LIG_BIR_III_2 115 119 PF00653 0.443
LIG_FHA_1 76 82 PF00498 0.353
LIG_FHA_1 89 95 PF00498 0.273
LIG_Integrin_isoDGR_2 15 17 PF01839 0.327
LIG_LIR_Nem_3 48 52 PF02991 0.378
LIG_LYPXL_yS_3 117 120 PF13949 0.359
LIG_SH3_3 90 96 PF00018 0.311
LIG_SUMO_SIM_anti_2 91 96 PF11976 0.406
LIG_UBA3_1 35 44 PF00899 0.286
MOD_CK1_1 121 127 PF00069 0.667
MOD_CK1_1 4 10 PF00069 0.612
MOD_GlcNHglycan 122 126 PF01048 0.612
MOD_N-GLC_1 4 9 PF02516 0.731
MOD_N-GLC_1 52 57 PF02516 0.359
MOD_N-GLC_1 62 67 PF02516 0.352
MOD_NEK2_1 1 6 PF00069 0.653
MOD_NEK2_1 75 80 PF00069 0.338
MOD_NMyristoyl 1 7 PF02799 0.609
MOD_PIKK_1 53 59 PF00454 0.432
MOD_PKA_2 16 22 PF00069 0.365
MOD_Plk_1 53 59 PF00069 0.380
MOD_Plk_1 62 68 PF00069 0.379
MOD_Plk_1 70 76 PF00069 0.393
MOD_Plk_4 88 94 PF00069 0.346
MOD_SUMO_rev_2 100 107 PF00179 0.463
TRG_ENDOCYTIC_2 117 120 PF00928 0.551
TRG_NLS_MonoCore_2 40 45 PF00514 0.396
TRG_NLS_MonoExtN_4 38 45 PF00514 0.402

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Y3 Leptomonas seymouri 55% 100%
A0A0N1HYV4 Leptomonas seymouri 56% 100%
A0A0N1I5S6 Leptomonas seymouri 41% 88%
A0A0N1I8U4 Leptomonas seymouri 30% 100%
A0A0N1P9P7 Leptomonas seymouri 39% 70%
A0A0N1PCZ0 Leptomonas seymouri 46% 100%
A0A0N1PE11 Leptomonas seymouri 30% 96%
A0A1X0NNW3 Trypanosomatidae 46% 100%
A0A1X0NW79 Trypanosomatidae 45% 69%
A0A1X0NW95 Trypanosomatidae 60% 100%
A0A1X0NWV3 Trypanosomatidae 59% 91%
A0A1X0NXS9 Trypanosomatidae 35% 100%
A0A1X0NXT9 Trypanosomatidae 39% 100%
A0A1X0NYV3 Trypanosomatidae 34% 99%
A0A3Q8I9V9 Leishmania donovani 43% 100%
A0A3Q8IBM6 Leishmania donovani 29% 100%
A0A3Q8IDP8 Leishmania donovani 39% 90%
A0A3Q8IKN9 Leishmania donovani 56% 100%
A0A3R7MB04 Trypanosoma rangeli 44% 100%
A0A3R7MWC6 Trypanosoma rangeli 54% 100%
A0A3S7WW23 Leishmania donovani 100% 100%
A0A3S7WZ86 Leishmania donovani 30% 96%
A0A422MSY8 Trypanosoma rangeli 50% 81%
A0A422MSZ3 Trypanosoma rangeli 54% 100%
A0A422MUY0 Trypanosoma rangeli 41% 91%
A0A422N058 Trypanosoma rangeli 35% 89%
A4H7N9 Leishmania braziliensis 42% 100%
A4H7P0 Leishmania braziliensis 42% 100%
A4HEG7 Leishmania braziliensis 30% 100%
A4HW29 Leishmania infantum 43% 100%
A4HYW6 Leishmania infantum 29% 100%
A4HYX1 Leishmania infantum 39% 100%
A4HYX4 Leishmania infantum 56% 100%
A4I1M3 Leishmania infantum 30% 96%
C9ZIF2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZIF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
C9ZIF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AIH7 Leishmania braziliensis 36% 100%
E9AIH8 Leishmania braziliensis 30% 100%
E9AII3 Leishmania braziliensis 38% 100%
E9AII5 Leishmania braziliensis 78% 100%
E9AII6 Leishmania braziliensis 55% 100%
E9APT0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AUR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AUR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AUS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AUS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9AXQ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
P84150 Leishmania major 29% 100%
Q4Q9R4 Leishmania major 30% 100%
Q4QFP8 Leishmania major 43% 100%
Q5SDH3 Leishmania major 44% 89%
Q5SDH4 Leishmania major 96% 100%
Q5SDH5 Leishmania major 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS