Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935) - putative

Species:

Leishmania infantum

UniProt:

A4HYX0_LEIIN

TriTrypDb:

LINF_200017900

Length:

189

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.584
CLV_PCSK_SKI1_1	48	52	PF00082	0.588
DOC_CYCLIN_yClb1_LxF_4	135	140	PF00134	0.483
DOC_PP1_RVXF_1	135	141	PF00149	0.484
DOC_PP1_RVXF_1	46	52	PF00149	0.604
DOC_PP4_FxxP_1	67	70	PF00568	0.741
DOC_USP7_MATH_1	10	14	PF00917	0.726
DOC_USP7_MATH_1	148	152	PF00917	0.508
DOC_USP7_MATH_1	177	181	PF00917	0.489
DOC_USP7_UBL2_3	42	46	PF12436	0.590
DOC_WW_Pin1_4	131	136	PF00397	0.723
LIG_14-3-3_CanoR_1	20	25	PF00244	0.711
LIG_14-3-3_CanoR_1	97	101	PF00244	0.516
LIG_APCC_ABBA_1	38	43	PF00400	0.640
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.468
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.479
LIG_FHA_1	14	20	PF00498	0.610
LIG_FHA_1	54	60	PF00498	0.543
LIG_LIR_Apic_2	64	70	PF02991	0.708
LIG_LIR_Gen_1	28	38	PF02991	0.547
LIG_LIR_Gen_1	95	103	PF02991	0.459
LIG_LIR_Nem_3	28	33	PF02991	0.564
LIG_LIR_Nem_3	95	101	PF02991	0.477
LIG_REV1ctd_RIR_1	112	120	PF16727	0.537
LIG_SH3_3	147	153	PF00018	0.639
LIG_SH3_3	158	164	PF00018	0.477
LIG_SH3_3	171	177	PF00018	0.384
LIG_SH3_3	34	40	PF00018	0.643
LIG_SH3_4	69	76	PF00018	0.731
LIG_TRAF2_1	15	18	PF00917	0.762
LIG_TRAF2_1	92	95	PF00917	0.654
MOD_CDC14_SPxK_1	134	137	PF00782	0.487
MOD_CDK_SPxK_1	131	137	PF00069	0.516
MOD_CK1_1	106	112	PF00069	0.565
MOD_CK1_1	13	19	PF00069	0.656
MOD_CK2_1	12	18	PF00069	0.763
MOD_CK2_1	177	183	PF00069	0.452
MOD_CK2_1	88	94	PF00069	0.681
MOD_GlcNHglycan	11	15	PF01048	0.704
MOD_GlcNHglycan	43	46	PF01048	0.547
MOD_GlcNHglycan	5	8	PF01048	0.774
MOD_GlcNHglycan	90	93	PF01048	0.666
MOD_GSK3_1	106	113	PF00069	0.569
MOD_GSK3_1	9	16	PF00069	0.683
MOD_NMyristoyl	1	7	PF02799	0.624
MOD_PK_1	20	26	PF00069	0.699
MOD_PKA_2	96	102	PF00069	0.568
MOD_Plk_1	106	112	PF00069	0.463
MOD_Plk_4	110	116	PF00069	0.470
MOD_ProDKin_1	131	137	PF00069	0.722
MOD_SPalmitoyl_4	1	7	PF01529	0.624
MOD_SUMO_for_1	136	139	PF00179	0.472
MOD_SUMO_for_1	74	77	PF00179	0.658
MOD_SUMO_rev_2	23	28	PF00179	0.662
MOD_SUMO_rev_2	80	90	PF00179	0.787
TRG_DiLeu_BaEn_4	17	23	PF01217	0.684
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE64	Leptomonas seymouri	43%	100%
A0A3S7WW30	Leishmania donovani	100%	100%
E9AII2	Leishmania braziliensis	74%	100%
E9AUR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCR9	Leishmania major	93%	100%