LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HYW9_LEIIN
TriTrypDb:
LINF_200017800
Length:
839

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYW9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYW9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 199 203 PF00656 0.717
CLV_C14_Caspase3-7 358 362 PF00656 0.866
CLV_C14_Caspase3-7 71 75 PF00656 0.624
CLV_C14_Caspase3-7 779 783 PF00656 0.774
CLV_NRD_NRD_1 263 265 PF00675 0.715
CLV_NRD_NRD_1 334 336 PF00675 0.778
CLV_NRD_NRD_1 369 371 PF00675 0.761
CLV_NRD_NRD_1 48 50 PF00675 0.688
CLV_NRD_NRD_1 666 668 PF00675 0.747
CLV_NRD_NRD_1 71 73 PF00675 0.632
CLV_NRD_NRD_1 712 714 PF00675 0.791
CLV_PCSK_FUR_1 367 371 PF00082 0.765
CLV_PCSK_KEX2_1 258 260 PF00082 0.762
CLV_PCSK_KEX2_1 262 264 PF00082 0.682
CLV_PCSK_KEX2_1 369 371 PF00082 0.742
CLV_PCSK_KEX2_1 48 50 PF00082 0.688
CLV_PCSK_KEX2_1 666 668 PF00082 0.680
CLV_PCSK_KEX2_1 712 714 PF00082 0.791
CLV_PCSK_KEX2_1 83 85 PF00082 0.698
CLV_PCSK_KEX2_1 87 89 PF00082 0.759
CLV_PCSK_PC1ET2_1 258 260 PF00082 0.694
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.652
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.698
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.759
CLV_PCSK_PC7_1 259 265 PF00082 0.690
CLV_PCSK_SKI1_1 385 389 PF00082 0.587
CLV_PCSK_SKI1_1 480 484 PF00082 0.612
CLV_PCSK_SKI1_1 620 624 PF00082 0.805
CLV_PCSK_SKI1_1 73 77 PF00082 0.592
DEG_APCC_DBOX_1 368 376 PF00400 0.860
DEG_APCC_DBOX_1 580 588 PF00400 0.698
DEG_SCF_FBW7_2 494 500 PF00400 0.740
DEG_SPOP_SBC_1 295 299 PF00917 0.639
DOC_CKS1_1 188 193 PF01111 0.893
DOC_CKS1_1 319 324 PF01111 0.795
DOC_CKS1_1 494 499 PF01111 0.739
DOC_CKS1_1 559 564 PF01111 0.712
DOC_CYCLIN_RxL_1 379 392 PF00134 0.573
DOC_CYCLIN_RxL_1 709 718 PF00134 0.764
DOC_CYCLIN_yCln2_LP_2 543 549 PF00134 0.458
DOC_MAPK_DCC_7 474 484 PF00069 0.573
DOC_MAPK_gen_1 367 377 PF00069 0.759
DOC_MAPK_gen_1 577 587 PF00069 0.703
DOC_MAPK_MEF2A_6 539 547 PF00069 0.588
DOC_MIT_MIM_1 534 543 PF04212 0.584
DOC_PP1_RVXF_1 383 390 PF00149 0.670
DOC_PP2B_LxvP_1 543 546 PF13499 0.594
DOC_PP2B_LxvP_1 688 691 PF13499 0.831
DOC_PP4_FxxP_1 654 657 PF00568 0.796
DOC_PP4_FxxP_1 743 746 PF00568 0.684
DOC_USP7_MATH_1 159 163 PF00917 0.796
DOC_USP7_MATH_1 170 174 PF00917 0.615
DOC_USP7_MATH_1 208 212 PF00917 0.724
DOC_USP7_MATH_1 254 258 PF00917 0.864
DOC_USP7_MATH_1 294 298 PF00917 0.864
DOC_USP7_MATH_1 320 324 PF00917 0.781
DOC_USP7_MATH_1 344 348 PF00917 0.834
DOC_USP7_MATH_1 397 401 PF00917 0.601
DOC_USP7_MATH_1 549 553 PF00917 0.441
DOC_USP7_MATH_1 60 64 PF00917 0.642
DOC_USP7_MATH_1 621 625 PF00917 0.823
DOC_USP7_MATH_1 65 69 PF00917 0.676
DOC_USP7_MATH_1 673 677 PF00917 0.792
DOC_USP7_MATH_1 754 758 PF00917 0.750
DOC_USP7_MATH_1 806 810 PF00917 0.760
DOC_USP7_UBL2_3 258 262 PF12436 0.728
DOC_USP7_UBL2_3 281 285 PF12436 0.783
DOC_USP7_UBL2_3 569 573 PF12436 0.507
DOC_USP7_UBL2_3 73 77 PF12436 0.608
DOC_USP7_UBL2_3 83 87 PF12436 0.689
DOC_WW_Pin1_4 166 171 PF00397 0.850
DOC_WW_Pin1_4 183 188 PF00397 0.571
DOC_WW_Pin1_4 250 255 PF00397 0.850
DOC_WW_Pin1_4 318 323 PF00397 0.843
DOC_WW_Pin1_4 361 366 PF00397 0.815
DOC_WW_Pin1_4 411 416 PF00397 0.810
DOC_WW_Pin1_4 434 439 PF00397 0.791
DOC_WW_Pin1_4 493 498 PF00397 0.638
DOC_WW_Pin1_4 558 563 PF00397 0.620
DOC_WW_Pin1_4 675 680 PF00397 0.797
LIG_14-3-3_CanoR_1 171 175 PF00244 0.733
LIG_14-3-3_CanoR_1 374 378 PF00244 0.844
LIG_14-3-3_CanoR_1 379 387 PF00244 0.776
LIG_14-3-3_CanoR_1 450 457 PF00244 0.812
LIG_14-3-3_CanoR_1 581 585 PF00244 0.670
LIG_14-3-3_CanoR_1 712 717 PF00244 0.802
LIG_Actin_WH2_2 365 381 PF00022 0.772
LIG_APCC_ABBAyCdc20_2 385 391 PF00400 0.594
LIG_BIR_III_2 766 770 PF00653 0.692
LIG_BRCT_BRCA1_1 118 122 PF00533 0.684
LIG_BRCT_BRCA1_1 650 654 PF00533 0.801
LIG_Clathr_ClatBox_1 544 548 PF01394 0.676
LIG_eIF4E_1 538 544 PF01652 0.581
LIG_FHA_1 188 194 PF00498 0.680
LIG_FHA_1 231 237 PF00498 0.829
LIG_FHA_1 287 293 PF00498 0.782
LIG_FHA_1 319 325 PF00498 0.840
LIG_FHA_1 382 388 PF00498 0.720
LIG_FHA_1 486 492 PF00498 0.689
LIG_FHA_1 493 499 PF00498 0.658
LIG_FHA_1 525 531 PF00498 0.532
LIG_FHA_1 540 546 PF00498 0.563
LIG_FHA_1 628 634 PF00498 0.841
LIG_FHA_1 830 836 PF00498 0.715
LIG_FHA_2 137 143 PF00498 0.685
LIG_FHA_2 307 313 PF00498 0.805
LIG_FHA_2 494 500 PF00498 0.740
LIG_FHA_2 650 656 PF00498 0.799
LIG_FHA_2 91 97 PF00498 0.650
LIG_IBAR_NPY_1 739 741 PF08397 0.738
LIG_Integrin_RGD_1 200 202 PF01839 0.816
LIG_Integrin_RGD_1 817 819 PF01839 0.776
LIG_LIR_Apic_2 651 657 PF02991 0.797
LIG_LIR_Apic_2 742 746 PF02991 0.752
LIG_LIR_Gen_1 384 391 PF02991 0.646
LIG_LIR_Gen_1 473 484 PF02991 0.599
LIG_LIR_Gen_1 517 526 PF02991 0.541
LIG_LIR_Nem_3 161 167 PF02991 0.795
LIG_LIR_Nem_3 384 389 PF02991 0.626
LIG_LIR_Nem_3 473 479 PF02991 0.607
LIG_LIR_Nem_3 517 522 PF02991 0.516
LIG_MYND_1 112 116 PF01753 0.664
LIG_NRBOX 539 545 PF00104 0.582
LIG_PDZ_Class_2 834 839 PF00595 0.848
LIG_PTB_Apo_2 137 144 PF02174 0.647
LIG_PTB_Phospho_1 137 143 PF10480 0.647
LIG_SH2_PTP2 476 479 PF00017 0.691
LIG_SH2_SRC 476 479 PF00017 0.691
LIG_SH2_STAT3 405 408 PF00017 0.605
LIG_SH2_STAT5 476 479 PF00017 0.691
LIG_SH2_STAT5 529 532 PF00017 0.672
LIG_SH3_3 13 19 PF00018 0.837
LIG_SH3_3 185 191 PF00018 0.881
LIG_SH3_3 245 251 PF00018 0.792
LIG_SH3_3 412 418 PF00018 0.782
LIG_SH3_3 422 428 PF00018 0.679
LIG_SH3_3 44 50 PF00018 0.645
LIG_SH3_3 491 497 PF00018 0.730
LIG_SH3_3 518 524 PF00018 0.530
LIG_SH3_3 677 683 PF00018 0.789
LIG_SUMO_SIM_anti_2 373 379 PF11976 0.842
LIG_SUMO_SIM_par_1 480 485 PF11976 0.570
LIG_SUMO_SIM_par_1 798 804 PF11976 0.658
LIG_TRAF2_1 420 423 PF00917 0.781
LIG_TRAF2_1 497 500 PF00917 0.748
LIG_TRAF2_1 93 96 PF00917 0.626
LIG_UBA3_1 584 589 PF00899 0.615
LIG_WRC_WIRS_1 287 292 PF05994 0.783
MOD_CDC14_SPxK_1 186 189 PF00782 0.799
MOD_CDC14_SPxK_1 364 367 PF00782 0.794
MOD_CDC14_SPxK_1 414 417 PF00782 0.788
MOD_CDK_SPK_2 166 171 PF00069 0.861
MOD_CDK_SPK_2 558 563 PF00069 0.605
MOD_CDK_SPxK_1 183 189 PF00069 0.796
MOD_CDK_SPxK_1 361 367 PF00069 0.794
MOD_CDK_SPxK_1 411 417 PF00069 0.776
MOD_CK1_1 117 123 PF00069 0.787
MOD_CK1_1 169 175 PF00069 0.797
MOD_CK1_1 203 209 PF00069 0.773
MOD_CK1_1 3 9 PF00069 0.767
MOD_CK1_1 318 324 PF00069 0.743
MOD_CK1_1 373 379 PF00069 0.826
MOD_CK1_1 381 387 PF00069 0.641
MOD_CK1_1 429 435 PF00069 0.795
MOD_CK1_1 453 459 PF00069 0.809
MOD_CK1_1 466 472 PF00069 0.651
MOD_CK1_1 558 564 PF00069 0.597
MOD_CK1_1 637 643 PF00069 0.853
MOD_CK1_1 68 74 PF00069 0.718
MOD_CK1_1 715 721 PF00069 0.757
MOD_CK1_1 821 827 PF00069 0.718
MOD_CK1_1 829 835 PF00069 0.668
MOD_CK1_1 90 96 PF00069 0.565
MOD_CK2_1 136 142 PF00069 0.734
MOD_CK2_1 203 209 PF00069 0.773
MOD_CK2_1 472 478 PF00069 0.726
MOD_CK2_1 493 499 PF00069 0.647
MOD_CK2_1 649 655 PF00069 0.800
MOD_CK2_1 89 95 PF00069 0.700
MOD_GlcNHglycan 12 16 PF01048 0.754
MOD_GlcNHglycan 2 5 PF01048 0.762
MOD_GlcNHglycan 205 208 PF01048 0.903
MOD_GlcNHglycan 241 244 PF01048 0.776
MOD_GlcNHglycan 344 347 PF01048 0.850
MOD_GlcNHglycan 357 360 PF01048 0.787
MOD_GlcNHglycan 391 394 PF01048 0.662
MOD_GlcNHglycan 428 431 PF01048 0.817
MOD_GlcNHglycan 602 605 PF01048 0.799
MOD_GlcNHglycan 612 615 PF01048 0.831
MOD_GlcNHglycan 623 626 PF01048 0.698
MOD_GlcNHglycan 636 639 PF01048 0.606
MOD_GlcNHglycan 675 678 PF01048 0.841
MOD_GlcNHglycan 723 728 PF01048 0.903
MOD_GlcNHglycan 778 781 PF01048 0.781
MOD_GlcNHglycan 792 795 PF01048 0.587
MOD_GlcNHglycan 8 11 PF01048 0.770
MOD_GlcNHglycan 812 816 PF01048 0.704
MOD_GSK3_1 110 117 PF00069 0.673
MOD_GSK3_1 166 173 PF00069 0.694
MOD_GSK3_1 179 186 PF00069 0.758
MOD_GSK3_1 224 231 PF00069 0.735
MOD_GSK3_1 250 257 PF00069 0.787
MOD_GSK3_1 355 362 PF00069 0.690
MOD_GSK3_1 429 436 PF00069 0.847
MOD_GSK3_1 452 459 PF00069 0.799
MOD_GSK3_1 463 470 PF00069 0.694
MOD_GSK3_1 569 576 PF00069 0.635
MOD_GSK3_1 6 13 PF00069 0.774
MOD_GSK3_1 610 617 PF00069 0.806
MOD_GSK3_1 671 678 PF00069 0.750
MOD_GSK3_1 745 752 PF00069 0.688
MOD_GSK3_1 801 808 PF00069 0.773
MOD_GSK3_1 818 825 PF00069 0.664
MOD_N-GLC_1 151 156 PF02516 0.820
MOD_N-GLC_1 179 184 PF02516 0.722
MOD_N-GLC_1 389 394 PF02516 0.612
MOD_N-GLC_2 731 733 PF02516 0.809
MOD_NEK2_1 151 156 PF00069 0.788
MOD_NEK2_1 179 184 PF00069 0.852
MOD_NEK2_1 224 229 PF00069 0.756
MOD_NEK2_1 286 291 PF00069 0.825
MOD_NEK2_1 389 394 PF00069 0.620
MOD_NEK2_1 452 457 PF00069 0.796
MOD_NEK2_1 547 552 PF00069 0.601
MOD_NEK2_1 610 615 PF00069 0.861
MOD_NEK2_1 648 653 PF00069 0.841
MOD_NEK2_2 43 48 PF00069 0.745
MOD_NEK2_2 524 529 PF00069 0.583
MOD_NMyristoyl 1 7 PF02799 0.773
MOD_PIKK_1 209 215 PF00454 0.774
MOD_PIKK_1 463 469 PF00454 0.666
MOD_PIKK_1 754 760 PF00454 0.657
MOD_PIKK_1 829 835 PF00454 0.636
MOD_PKA_1 262 268 PF00069 0.693
MOD_PKA_1 569 575 PF00069 0.611
MOD_PKA_1 712 718 PF00069 0.783
MOD_PKA_1 87 93 PF00069 0.588
MOD_PKA_2 170 176 PF00069 0.769
MOD_PKA_2 209 215 PF00069 0.797
MOD_PKA_2 262 268 PF00069 0.693
MOD_PKA_2 334 340 PF00069 0.846
MOD_PKA_2 373 379 PF00069 0.842
MOD_PKA_2 580 586 PF00069 0.664
MOD_PKA_2 608 614 PF00069 0.754
MOD_PKA_2 712 718 PF00069 0.787
MOD_PKA_2 87 93 PF00069 0.588
MOD_Plk_1 315 321 PF00069 0.735
MOD_Plk_1 381 387 PF00069 0.687
MOD_Plk_1 818 824 PF00069 0.822
MOD_Plk_4 110 116 PF00069 0.676
MOD_Plk_4 170 176 PF00069 0.769
MOD_Plk_4 224 230 PF00069 0.769
MOD_Plk_4 323 329 PF00069 0.745
MOD_Plk_4 397 403 PF00069 0.494
MOD_Plk_4 524 530 PF00069 0.567
MOD_Plk_4 539 545 PF00069 0.558
MOD_Plk_4 555 561 PF00069 0.421
MOD_Plk_4 580 586 PF00069 0.662
MOD_Plk_4 649 655 PF00069 0.754
MOD_ProDKin_1 166 172 PF00069 0.845
MOD_ProDKin_1 183 189 PF00069 0.576
MOD_ProDKin_1 250 256 PF00069 0.851
MOD_ProDKin_1 318 324 PF00069 0.841
MOD_ProDKin_1 361 367 PF00069 0.815
MOD_ProDKin_1 411 417 PF00069 0.815
MOD_ProDKin_1 434 440 PF00069 0.786
MOD_ProDKin_1 493 499 PF00069 0.638
MOD_ProDKin_1 558 564 PF00069 0.617
MOD_ProDKin_1 675 681 PF00069 0.798
MOD_SUMO_for_1 695 698 PF00179 0.676
MOD_SUMO_rev_2 68 78 PF00179 0.639
MOD_SUMO_rev_2 779 786 PF00179 0.774
MOD_SUMO_rev_2 821 830 PF00179 0.762
TRG_DiLeu_BaEn_1 130 135 PF01217 0.757
TRG_DiLeu_BaLyEn_6 133 138 PF01217 0.699
TRG_ENDOCYTIC_2 24 27 PF00928 0.821
TRG_ENDOCYTIC_2 476 479 PF00928 0.691
TRG_ER_diArg_1 263 266 PF00400 0.776
TRG_ER_diArg_1 367 370 PF00400 0.765
TRG_ER_diArg_1 383 386 PF00400 0.557
TRG_ER_diArg_1 47 49 PF00400 0.691
TRG_ER_diArg_1 712 714 PF00400 0.804
TRG_NES_CRM1_1 371 382 PF08389 0.658
TRG_NES_CRM1_1 534 548 PF08389 0.589
TRG_NLS_Bipartite_1 72 90 PF00514 0.743
TRG_NLS_MonoExtC_3 261 266 PF00514 0.690
TRG_NLS_MonoExtC_3 568 573 PF00514 0.501
TRG_NLS_MonoExtC_3 82 87 PF00514 0.753
TRG_NLS_MonoExtN_4 259 266 PF00514 0.691
TRG_NLS_MonoExtN_4 567 574 PF00514 0.504
TRG_NLS_MonoExtN_4 83 90 PF00514 0.743

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0G6 Leptomonas seymouri 34% 100%
A0A3Q8IAM5 Leishmania donovani 98% 100%
E9AII1 Leishmania braziliensis 56% 93%
E9AUR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 98%
Q4QCS0 Leishmania major 84% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS