Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935) - putative

Species:

Leishmania infantum

UniProt:

A4HYW8_LEIIN

TriTrypDb:

LINF_200017600

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 101

Expansion

Sequence features

A4HYW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	152	154	PF00082	0.300
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.300
CLV_PCSK_SKI1_1	89	93	PF00082	0.513
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DOC_CKS1_1	76	81	PF01111	0.651
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.537
DOC_PP2B_LxvP_1	20	23	PF13499	0.541
DOC_SPAK_OSR1_1	111	115	PF12202	0.494
DOC_USP7_MATH_1	15	19	PF00917	0.649
DOC_USP7_MATH_1	175	179	PF00917	0.387
DOC_USP7_MATH_1	181	185	PF00917	0.328
DOC_USP7_MATH_2	204	210	PF00917	0.267
DOC_WW_Pin1_4	10	15	PF00397	0.707
DOC_WW_Pin1_4	115	120	PF00397	0.532
DOC_WW_Pin1_4	222	227	PF00397	0.465
DOC_WW_Pin1_4	38	43	PF00397	0.555
DOC_WW_Pin1_4	64	69	PF00397	0.678
DOC_WW_Pin1_4	75	80	PF00397	0.681
LIG_14-3-3_CanoR_1	168	172	PF00244	0.380
LIG_14-3-3_CanoR_1	186	191	PF00244	0.328
LIG_BIR_III_2	223	227	PF00653	0.418
LIG_BRCT_BRCA1_1	169	173	PF00533	0.376
LIG_FHA_1	164	170	PF00498	0.284
LIG_FHA_1	183	189	PF00498	0.350
LIG_FHA_1	99	105	PF00498	0.492
LIG_FHA_2	218	224	PF00498	0.336
LIG_FHA_2	229	235	PF00498	0.534
LIG_FHA_2	55	61	PF00498	0.604
LIG_FHA_2	90	96	PF00498	0.550
LIG_HCF-1_HBM_1	132	135	PF13415	0.267
LIG_LIR_Apic_2	117	123	PF02991	0.553
LIG_LIR_Nem_3	132	138	PF02991	0.329
LIG_LIR_Nem_3	214	218	PF02991	0.360
LIG_PCNA_yPIPBox_3	136	149	PF02747	0.300
LIG_PDZ_Class_2	230	235	PF00595	0.531
LIG_SH2_PTP2	120	123	PF00017	0.471
LIG_SH2_STAP1	165	169	PF00017	0.243
LIG_SH2_STAT3	34	37	PF00017	0.575
LIG_SH2_STAT5	120	123	PF00017	0.497
LIG_SH2_STAT5	165	168	PF00017	0.298
LIG_SH2_STAT5	219	222	PF00017	0.328
LIG_SH3_3	124	130	PF00018	0.559
LIG_SH3_3	22	28	PF00018	0.512
LIG_SH3_3	5	11	PF00018	0.753
LIG_SH3_3	73	79	PF00018	0.705
LIG_SUMO_SIM_par_1	89	95	PF11976	0.490
LIG_UBA3_1	144	152	PF00899	0.300
MOD_CDK_SPK_2	38	43	PF00069	0.555
MOD_CDK_SPxK_1	75	81	PF00069	0.626
MOD_CK1_1	163	169	PF00069	0.243
MOD_CK1_1	18	24	PF00069	0.636
MOD_CK1_1	41	47	PF00069	0.653
MOD_CK1_1	74	80	PF00069	0.640
MOD_CK2_1	186	192	PF00069	0.267
MOD_CK2_1	54	60	PF00069	0.683
MOD_CK2_1	89	95	PF00069	0.592
MOD_GlcNHglycan	20	23	PF01048	0.689
MOD_GlcNHglycan	43	46	PF01048	0.646
MOD_GlcNHglycan	47	50	PF01048	0.660
MOD_GlcNHglycan	62	65	PF01048	0.681
MOD_GlcNHglycan	73	76	PF01048	0.665
MOD_GSK3_1	159	166	PF00069	0.315
MOD_GSK3_1	182	189	PF00069	0.295
MOD_GSK3_1	2	9	PF00069	0.664
MOD_GSK3_1	41	48	PF00069	0.716
MOD_GSK3_1	56	63	PF00069	0.662
MOD_GSK3_1	71	78	PF00069	0.557
MOD_N-GLC_1	159	164	PF02516	0.300
MOD_N-GLC_1	71	76	PF02516	0.639
MOD_NEK2_1	167	172	PF00069	0.497
MOD_NEK2_1	182	187	PF00069	0.380
MOD_NEK2_1	190	195	PF00069	0.378
MOD_NEK2_1	2	7	PF00069	0.566
MOD_NEK2_2	175	180	PF00069	0.376
MOD_NEK2_2	217	222	PF00069	0.360
MOD_PIKK_1	105	111	PF00454	0.522
MOD_PIKK_1	204	210	PF00454	0.376
MOD_PKA_2	167	173	PF00069	0.369
MOD_PKA_2	54	60	PF00069	0.606
MOD_Plk_1	163	169	PF00069	0.407
MOD_Plk_1	175	181	PF00069	0.315
MOD_Plk_1	71	77	PF00069	0.654
MOD_Plk_4	206	212	PF00069	0.495
MOD_ProDKin_1	10	16	PF00069	0.708
MOD_ProDKin_1	115	121	PF00069	0.530
MOD_ProDKin_1	222	228	PF00069	0.473
MOD_ProDKin_1	38	44	PF00069	0.555
MOD_ProDKin_1	64	70	PF00069	0.676
MOD_ProDKin_1	75	81	PF00069	0.680
TRG_DiLeu_BaEn_2	205	211	PF01217	0.360
TRG_ENDOCYTIC_2	135	138	PF00928	0.309
TRG_ENDOCYTIC_2	215	218	PF00928	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I766	Leptomonas seymouri	44%	69%
A0A3Q8IEW9	Leishmania donovani	99%	100%
A0A3R7K2X3	Trypanosoma rangeli	29%	100%
E9AII0	Leishmania braziliensis	47%	100%
E9AUR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCS1	Leishmania major	78%	100%