Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935) - putative

Species:

Leishmania infantum

UniProt:

A4HYW6_LEIIN

TriTrypDb:

LINF_200017400

Length:

133

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 15

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 30

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 61
NetGPI	no	yes: 0, no: 61

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0097542	ciliary tip	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2

Expansion

Sequence features

A4HYW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYW6

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	2
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044000	movement in host	4	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044409	entry into host	5	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0044782	cilium organization	5	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.413
CLV_PCSK_KEX2_1	43	45	PF00082	0.340
CLV_PCSK_SKI1_1	44	48	PF00082	0.433
DOC_MAPK_MEF2A_6	52	60	PF00069	0.414
DOC_USP7_UBL2_3	18	22	PF12436	0.373
LIG_FHA_2	122	128	PF00498	0.511
LIG_LIR_Nem_3	24	30	PF02991	0.365
LIG_LIR_Nem_3	87	93	PF02991	0.420
LIG_PDZ_Class_2	128	133	PF00595	0.578
LIG_PTB_Apo_2	29	36	PF02174	0.448
LIG_PTB_Phospho_1	29	35	PF10480	0.448
LIG_Rb_pABgroove_1	56	64	PF01858	0.362
LIG_SH2_STAP1	64	68	PF00017	0.331
LIG_SH2_STAT3	64	67	PF00017	0.396
LIG_SH2_STAT5	93	96	PF00017	0.287
LIG_SH3_4	18	25	PF00018	0.338
MOD_CK1_1	3	9	PF00069	0.605
MOD_GlcNHglycan	2	5	PF01048	0.580
MOD_GSK3_1	17	24	PF00069	0.362
MOD_N-GLC_1	48	53	PF02516	0.358
MOD_NEK2_1	71	76	PF00069	0.334
MOD_NMyristoyl	1	7	PF02799	0.591
MOD_PIKK_1	101	107	PF00454	0.406
MOD_PIKK_1	63	69	PF00454	0.401
MOD_Plk_1	72	78	PF00069	0.390
TRG_DiLeu_BaEn_2	102	108	PF01217	0.355
TRG_ENDOCYTIC_2	27	30	PF00928	0.336
TRG_ER_diArg_1	43	45	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y3	Leptomonas seymouri	39%	100%
A0A0N0P7C3	Leptomonas seymouri	39%	91%
A0A0N1HYV4	Leptomonas seymouri	36%	100%
A0A0N1I5S6	Leptomonas seymouri	32%	86%
A0A0N1I8U4	Leptomonas seymouri	87%	99%
A0A0N1P9P7	Leptomonas seymouri	30%	68%
A0A0N1PCZ0	Leptomonas seymouri	30%	100%
A0A0N1PE11	Leptomonas seymouri	34%	94%
A0A1X0NNW3	Trypanosomatidae	35%	100%
A0A1X0NW79	Trypanosomatidae	31%	67%
A0A1X0NW95	Trypanosomatidae	39%	100%
A0A1X0NWH2	Trypanosomatidae	31%	95%
A0A1X0NWV3	Trypanosomatidae	38%	89%
A0A1X0NXS9	Trypanosomatidae	33%	98%
A0A1X0NXT9	Trypanosomatidae	62%	100%
A0A1X0NYV3	Trypanosomatidae	38%	96%
A0A3Q8I9V9	Leishmania donovani	30%	100%
A0A3Q8IBM6	Leishmania donovani	100%	100%
A0A3Q8IBP3	Leishmania donovani	41%	91%
A0A3Q8IDP8	Leishmania donovani	31%	88%
A0A3Q8IKN9	Leishmania donovani	35%	100%
A0A3R7MB04	Trypanosoma rangeli	32%	100%
A0A3R7MWC6	Trypanosoma rangeli	39%	100%
A0A3S7WW23	Leishmania donovani	29%	98%
A0A3S7WZ86	Leishmania donovani	34%	94%
A0A422MSY8	Trypanosoma rangeli	39%	79%
A0A422MSZ3	Trypanosoma rangeli	38%	100%
A0A422MUY0	Trypanosoma rangeli	36%	89%
A0A422N035	Trypanosoma rangeli	33%	95%
A0A422N058	Trypanosoma rangeli	52%	87%
A4H7N9	Leishmania braziliensis	32%	100%
A4H7P0	Leishmania braziliensis	32%	100%
A4HEG7	Leishmania braziliensis	34%	100%
A4HW29	Leishmania infantum	30%	100%
A4HYW5	Leishmania infantum	41%	100%
A4HYX1	Leishmania infantum	31%	88%
A4HYX3	Leishmania infantum	29%	98%
A4HYX4	Leishmania infantum	35%	100%
A4I1M3	Leishmania infantum	34%	94%
C9ZIF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
C9ZIF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZIF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AIH7	Leishmania braziliensis	35%	100%
E9AIH8	Leishmania braziliensis	89%	100%
E9AII5	Leishmania braziliensis	30%	100%
E9AII6	Leishmania braziliensis	34%	94%
E9APT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AUR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AUR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	88%
E9AUS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AUS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AXQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
P84150	Leishmania major	98%	100%
Q4Q9R4	Leishmania major	34%	100%
Q4QCS4	Leishmania major	40%	100%
Q4QFP8	Leishmania major	31%	100%
Q5SDH3	Leishmania major	31%	88%
Q5SDH4	Leishmania major	29%	100%
Q5SDH5	Leishmania major	35%	100%