LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
calpain-like cysteine peptidase - Clan CA - family C2
Species:
Leishmania infantum
UniProt:
A4HYW5_LEIIN
TriTrypDb:
LINF_200017300
Length:
146

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 2
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 1
Pissara et al. yes yes: 22
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 9
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 43
NetGPI no yes: 0, no: 43
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0097542 ciliary tip 2 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0031253 cell projection membrane 4 1
GO:0060170 ciliary membrane 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098590 plasma membrane region 3 1

Expansion

Sequence features

A4HYW5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYW5

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044000 movement in host 4 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044409 entry into host 5 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0044782 cilium organization 5 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 136 138 PF00675 0.491
CLV_PCSK_KEX2_1 136 138 PF00082 0.499
CLV_PCSK_SKI1_1 30 34 PF00082 0.425
CLV_PCSK_SKI1_1 63 67 PF00082 0.466
DOC_CYCLIN_RxL_1 60 70 PF00134 0.492
DOC_PP2B_LxvP_1 138 141 PF13499 0.653
DOC_USP7_MATH_1 141 145 PF00917 0.477
DOC_USP7_UBL2_3 23 27 PF12436 0.518
LIG_BRCT_BRCA1_1 142 146 PF00533 0.503
LIG_FHA_1 5 11 PF00498 0.620
LIG_FHA_2 40 46 PF00498 0.452
LIG_FHA_2 7 13 PF00498 0.463
LIG_FHA_2 76 82 PF00498 0.334
LIG_LIR_Nem_3 31 37 PF02991 0.410
LIG_PDZ_Class_1 141 146 PF00595 0.487
LIG_SH2_CRK 21 25 PF00017 0.596
LIG_SH2_STAP1 109 113 PF00017 0.407
LIG_SH2_STAP1 58 62 PF00017 0.338
LIG_SH2_STAT3 122 125 PF00017 0.507
LIG_SH2_STAT5 122 125 PF00017 0.535
LIG_SH2_STAT5 21 24 PF00017 0.551
LIG_SH2_STAT5 64 67 PF00017 0.361
LIG_SH3_3 89 95 PF00018 0.333
LIG_SH3_4 23 30 PF00018 0.503
LIG_TRAF2_1 42 45 PF00917 0.474
MOD_CK1_1 6 12 PF00069 0.615
MOD_CK1_1 70 76 PF00069 0.333
MOD_CK2_1 108 114 PF00069 0.434
MOD_CK2_1 39 45 PF00069 0.402
MOD_CK2_1 75 81 PF00069 0.387
MOD_GlcNHglycan 16 19 PF01048 0.690
MOD_GlcNHglycan 72 75 PF01048 0.387
MOD_N-GLC_1 4 9 PF02516 0.540
MOD_N-GLC_1 52 57 PF02516 0.401
MOD_NMyristoyl 1 7 PF02799 0.597
MOD_PIKK_1 67 73 PF00454 0.443
MOD_PKA_2 39 45 PF00069 0.411
MOD_SUMO_rev_2 107 113 PF00179 0.387
MOD_SUMO_rev_2 73 80 PF00179 0.430
TRG_DiLeu_BaEn_2 96 102 PF01217 0.399
TRG_DiLeu_BaEn_4 44 50 PF01217 0.267
TRG_ENDOCYTIC_2 135 138 PF00928 0.577
TRG_ER_diArg_1 135 137 PF00400 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Y3 Leptomonas seymouri 40% 100%
A0A0N0P7C3 Leptomonas seymouri 75% 100%
A0A0N1HYV4 Leptomonas seymouri 32% 100%
A0A0N1I5S6 Leptomonas seymouri 42% 95%
A0A0N1I8U4 Leptomonas seymouri 39% 100%
A0A0N1P9P7 Leptomonas seymouri 32% 75%
A0A1X0NW95 Trypanosomatidae 42% 100%
A0A1X0NWH2 Trypanosomatidae 58% 100%
A0A1X0NWV3 Trypanosomatidae 42% 98%
A0A1X0NXS9 Trypanosomatidae 30% 100%
A0A1X0NXT9 Trypanosomatidae 37% 100%
A0A1X0NYV3 Trypanosomatidae 40% 100%
A0A3Q8I9V9 Leishmania donovani 33% 100%
A0A3Q8IBM6 Leishmania donovani 41% 100%
A0A3Q8IBP3 Leishmania donovani 99% 100%
A0A3Q8IKN9 Leishmania donovani 39% 100%
A0A3R7MWC6 Trypanosoma rangeli 39% 100%
A0A422MSY8 Trypanosoma rangeli 40% 87%
A0A422MSZ3 Trypanosoma rangeli 38% 100%
A0A422MUY0 Trypanosoma rangeli 32% 97%
A0A422N035 Trypanosoma rangeli 49% 100%
A0A422N058 Trypanosoma rangeli 28% 95%
A4H7N9 Leishmania braziliensis 33% 100%
A4H7P0 Leishmania braziliensis 33% 100%
A4HW29 Leishmania infantum 33% 100%
A4HYW6 Leishmania infantum 41% 100%
A4HYX4 Leishmania infantum 39% 100%
C9ZIF2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZIF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZIF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AIH7 Leishmania braziliensis 83% 100%
E9AIH8 Leishmania braziliensis 40% 100%
E9AII3 Leishmania braziliensis 40% 100%
E9AII6 Leishmania braziliensis 43% 100%
E9APT0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AUR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AUR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AUS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 96%
P84150 Leishmania major 41% 100%
Q4QCS4 Leishmania major 94% 100%
Q4QFP8 Leishmania major 33% 100%
Q5SDH5 Leishmania major 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS