LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative calpain-like cysteine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative calpain-like cysteine peptidase
Gene product:
cysteine peptidase - Clan CA - family C2 - putative
Species:
Leishmania infantum
UniProt:
A4HYW1_LEIIN
TriTrypDb:
LINF_200016800
Length:
1014

Annotations

Annotations by Jardim et al.

Proteases, calpain-like cysteine peptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) yes yes: 3
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 16
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 85
NetGPI no yes: 0, no: 87
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 5
GO:0005815 microtubule organizing center 2 1
GO:0005856 cytoskeleton 5 1
GO:0020016 ciliary pocket 2 1
GO:0020038 subpellicular network 2 1
GO:0030863 cortical cytoskeleton 6 1
GO:0036064 ciliary basal body 3 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HYW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYW1

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 88
GO:0006807 nitrogen compound metabolic process 2 88
GO:0008152 metabolic process 1 88
GO:0019538 protein metabolic process 3 88
GO:0043170 macromolecule metabolic process 3 88
GO:0044238 primary metabolic process 2 88
GO:0071704 organic substance metabolic process 2 88
GO:1901564 organonitrogen compound metabolic process 3 88
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 88
GO:0004175 endopeptidase activity 4 88
GO:0004197 cysteine-type endopeptidase activity 5 88
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6 88
GO:0008233 peptidase activity 3 88
GO:0008234 cysteine-type peptidase activity 4 88
GO:0016787 hydrolase activity 2 88
GO:0140096 catalytic activity, acting on a protein 2 88

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.731
CLV_C14_Caspase3-7 496 500 PF00656 0.585
CLV_C14_Caspase3-7 571 575 PF00656 0.552
CLV_C14_Caspase3-7 810 814 PF00656 0.657
CLV_NRD_NRD_1 477 479 PF00675 0.502
CLV_NRD_NRD_1 814 816 PF00675 0.458
CLV_PCSK_KEX2_1 477 479 PF00082 0.482
CLV_PCSK_KEX2_1 867 869 PF00082 0.498
CLV_PCSK_KEX2_1 967 969 PF00082 0.546
CLV_PCSK_KEX2_1 997 999 PF00082 0.585
CLV_PCSK_PC1ET2_1 867 869 PF00082 0.509
CLV_PCSK_PC1ET2_1 967 969 PF00082 0.574
CLV_PCSK_PC1ET2_1 997 999 PF00082 0.648
CLV_PCSK_SKI1_1 320 324 PF00082 0.667
CLV_PCSK_SKI1_1 478 482 PF00082 0.623
CLV_PCSK_SKI1_1 533 537 PF00082 0.347
CLV_PCSK_SKI1_1 624 628 PF00082 0.453
CLV_PCSK_SKI1_1 640 644 PF00082 0.275
CLV_PCSK_SKI1_1 762 766 PF00082 0.342
CLV_PCSK_SKI1_1 909 913 PF00082 0.512
DEG_SCF_FBW7_2 349 354 PF00400 0.591
DEG_SIAH_1 310 318 PF03145 0.476
DOC_CKS1_1 26 31 PF01111 0.594
DOC_PP1_RVXF_1 612 618 PF00149 0.549
DOC_PP1_RVXF_1 770 777 PF00149 0.624
DOC_PP4_FxxP_1 382 385 PF00568 0.383
DOC_PP4_FxxP_1 515 518 PF00568 0.636
DOC_PP4_FxxP_1 595 598 PF00568 0.566
DOC_USP7_MATH_1 240 244 PF00917 0.734
DOC_USP7_MATH_1 582 586 PF00917 0.569
DOC_USP7_MATH_2 548 554 PF00917 0.599
DOC_USP7_UBL2_3 658 662 PF12436 0.567
DOC_USP7_UBL2_3 812 816 PF12436 0.563
DOC_WW_Pin1_4 22 27 PF00397 0.834
DOC_WW_Pin1_4 221 226 PF00397 0.853
DOC_WW_Pin1_4 242 247 PF00397 0.831
DOC_WW_Pin1_4 306 311 PF00397 0.827
DOC_WW_Pin1_4 347 352 PF00397 0.555
DOC_WW_Pin1_4 718 723 PF00397 0.570
DOC_WW_Pin1_4 851 856 PF00397 0.475
LIG_14-3-3_CanoR_1 320 326 PF00244 0.638
LIG_14-3-3_CanoR_1 477 485 PF00244 0.656
LIG_14-3-3_CanoR_1 614 618 PF00244 0.546
LIG_14-3-3_CanoR_1 904 913 PF00244 0.560
LIG_Actin_WH2_2 450 467 PF00022 0.385
LIG_Actin_WH2_2 625 642 PF00022 0.631
LIG_BIR_II_1 1 5 PF00653 0.608
LIG_BIR_III_2 788 792 PF00653 0.469
LIG_BRCT_BRCA1_1 962 966 PF00533 0.540
LIG_Clathr_ClatBox_1 986 990 PF01394 0.391
LIG_CtBP_PxDLS_1 548 552 PF00389 0.472
LIG_deltaCOP1_diTrp_1 775 780 PF00928 0.554
LIG_deltaCOP1_diTrp_1 908 912 PF00928 0.483
LIG_eIF4E_1 737 743 PF01652 0.571
LIG_FHA_1 317 323 PF00498 0.669
LIG_FHA_1 459 465 PF00498 0.426
LIG_FHA_1 479 485 PF00498 0.591
LIG_FHA_1 838 844 PF00498 0.536
LIG_FHA_1 857 863 PF00498 0.513
LIG_FHA_2 11 17 PF00498 0.558
LIG_FHA_2 445 451 PF00498 0.479
LIG_FHA_2 494 500 PF00498 0.565
LIG_FHA_2 747 753 PF00498 0.540
LIG_FHA_2 783 789 PF00498 0.620
LIG_LIR_Apic_2 380 385 PF02991 0.368
LIG_LIR_Gen_1 657 668 PF02991 0.575
LIG_LIR_Gen_1 683 690 PF02991 0.603
LIG_LIR_Gen_1 701 712 PF02991 0.564
LIG_LIR_Gen_1 735 743 PF02991 0.616
LIG_LIR_Gen_1 856 862 PF02991 0.430
LIG_LIR_Gen_1 9 20 PF02991 0.572
LIG_LIR_Gen_1 907 918 PF02991 0.508
LIG_LIR_Nem_3 398 402 PF02991 0.400
LIG_LIR_Nem_3 629 634 PF02991 0.588
LIG_LIR_Nem_3 650 655 PF02991 0.559
LIG_LIR_Nem_3 657 663 PF02991 0.564
LIG_LIR_Nem_3 666 670 PF02991 0.554
LIG_LIR_Nem_3 701 707 PF02991 0.530
LIG_LIR_Nem_3 735 740 PF02991 0.572
LIG_LIR_Nem_3 856 861 PF02991 0.458
LIG_LIR_Nem_3 874 879 PF02991 0.505
LIG_LIR_Nem_3 890 895 PF02991 0.547
LIG_LIR_Nem_3 9 15 PF02991 0.558
LIG_LIR_Nem_3 907 913 PF02991 0.521
LIG_LIR_Nem_3 963 969 PF02991 0.484
LIG_LIR_Nem_3 977 982 PF02991 0.559
LIG_Pex14_2 807 811 PF04695 0.576
LIG_SH2_CRK 279 283 PF00017 0.800
LIG_SH2_CRK 660 664 PF00017 0.566
LIG_SH2_CRK 667 671 PF00017 0.556
LIG_SH2_CRK 715 719 PF00017 0.569
LIG_SH2_CRK 737 741 PF00017 0.548
LIG_SH2_CRK 876 880 PF00017 0.482
LIG_SH2_CRK 892 896 PF00017 0.534
LIG_SH2_GRB2like 473 476 PF00017 0.630
LIG_SH2_GRB2like 817 820 PF00017 0.522
LIG_SH2_NCK_1 279 283 PF00017 0.598
LIG_SH2_NCK_1 286 290 PF00017 0.594
LIG_SH2_NCK_1 737 741 PF00017 0.606
LIG_SH2_PTP2 929 932 PF00017 0.491
LIG_SH2_SRC 631 634 PF00017 0.579
LIG_SH2_STAP1 286 290 PF00017 0.812
LIG_SH2_STAP1 408 412 PF00017 0.422
LIG_SH2_STAP1 641 645 PF00017 0.610
LIG_SH2_STAP1 831 835 PF00017 0.444
LIG_SH2_STAT5 249 252 PF00017 0.597
LIG_SH2_STAT5 438 441 PF00017 0.448
LIG_SH2_STAT5 631 634 PF00017 0.570
LIG_SH2_STAT5 715 718 PF00017 0.592
LIG_SH2_STAT5 748 751 PF00017 0.558
LIG_SH2_STAT5 817 820 PF00017 0.555
LIG_SH2_STAT5 929 932 PF00017 0.438
LIG_SH2_STAT5 947 950 PF00017 0.453
LIG_SH3_1 23 29 PF00018 0.593
LIG_SH3_3 191 197 PF00018 0.765
LIG_SH3_3 23 29 PF00018 0.820
LIG_SH3_3 285 291 PF00018 0.819
LIG_SH3_3 440 446 PF00018 0.420
LIG_SH3_3 515 521 PF00018 0.609
LIG_SH3_3 531 537 PF00018 0.644
LIG_SH3_3 849 855 PF00018 0.461
LIG_SH3_3 938 944 PF00018 0.680
LIG_SH3_3 986 992 PF00018 0.548
LIG_SH3_5 829 833 PF00018 0.533
LIG_SUMO_SIM_anti_2 917 922 PF11976 0.422
LIG_SUMO_SIM_par_1 845 851 PF11976 0.460
LIG_SUMO_SIM_par_1 877 882 PF11976 0.469
LIG_TRAF2_1 105 108 PF00917 0.248
LIG_TRAF2_1 118 121 PF00917 0.248
LIG_TRAF2_1 131 134 PF00917 0.245
LIG_TRAF2_1 144 147 PF00917 0.341
LIG_TRAF2_1 157 160 PF00917 0.391
LIG_TRAF2_1 170 173 PF00917 0.329
LIG_TRAF2_1 19 22 PF00917 0.807
LIG_TRAF2_1 197 200 PF00917 0.796
LIG_TRAF2_1 262 265 PF00917 0.868
LIG_TRAF2_1 267 270 PF00917 0.825
LIG_TRAF2_1 40 43 PF00917 0.597
LIG_TRAF2_1 53 56 PF00917 0.586
LIG_TRAF2_1 66 69 PF00917 0.584
LIG_TRAF2_1 79 82 PF00917 0.594
LIG_TRAF2_1 92 95 PF00917 0.247
LIG_TRAF2_2 182 187 PF00917 0.603
LIG_TRAF2_2 29 34 PF00917 0.602
LIG_TYR_ITIM 387 392 PF00017 0.413
LIG_UBA3_1 387 395 PF00899 0.433
LIG_UBA3_1 806 812 PF00899 0.469
LIG_UBA3_1 920 928 PF00899 0.554
LIG_WRPW_2 535 538 PF00400 0.469
MOD_CDK_SPxK_1 718 724 PF00069 0.566
MOD_CK1_1 580 586 PF00069 0.619
MOD_CK2_1 10 16 PF00069 0.784
MOD_CK2_1 336 342 PF00069 0.551
MOD_CK2_1 444 450 PF00069 0.544
MOD_CK2_1 580 586 PF00069 0.569
MOD_CK2_1 746 752 PF00069 0.631
MOD_CK2_1 879 885 PF00069 0.510
MOD_CMANNOS 808 811 PF00535 0.358
MOD_GlcNHglycan 311 314 PF01048 0.678
MOD_GlcNHglycan 510 513 PF01048 0.556
MOD_GlcNHglycan 634 637 PF01048 0.390
MOD_GlcNHglycan 643 646 PF01048 0.403
MOD_GlcNHglycan 671 674 PF01048 0.351
MOD_GlcNHglycan 775 779 PF01048 0.412
MOD_GlcNHglycan 844 847 PF01048 0.600
MOD_GlcNHglycan 898 901 PF01048 0.505
MOD_GSK3_1 343 350 PF00069 0.540
MOD_GSK3_1 680 687 PF00069 0.569
MOD_GSK3_1 713 720 PF00069 0.594
MOD_GSK3_1 856 863 PF00069 0.504
MOD_N-GLC_1 165 170 PF02516 0.653
MOD_N-GLC_1 402 407 PF02516 0.419
MOD_N-GLC_1 426 431 PF02516 0.441
MOD_N-GLC_1 871 876 PF02516 0.400
MOD_N-GLC_1 896 901 PF02516 0.519
MOD_NEK2_1 198 203 PF00069 0.810
MOD_NEK2_1 343 348 PF00069 0.603
MOD_NEK2_1 425 430 PF00069 0.370
MOD_NEK2_1 453 458 PF00069 0.508
MOD_NEK2_1 572 577 PF00069 0.611
MOD_NEK2_1 627 632 PF00069 0.594
MOD_NEK2_1 663 668 PF00069 0.566
MOD_NEK2_1 690 695 PF00069 0.651
MOD_NEK2_1 807 812 PF00069 0.566
MOD_NEK2_1 896 901 PF00069 0.514
MOD_NEK2_2 684 689 PF00069 0.635
MOD_NEK2_2 960 965 PF00069 0.358
MOD_OFUCOSY 374 381 PF10250 0.279
MOD_PIKK_1 1004 1010 PF00454 0.619
MOD_PIKK_1 198 204 PF00454 0.607
MOD_PIKK_1 216 222 PF00454 0.586
MOD_PIKK_1 550 556 PF00454 0.619
MOD_PIKK_1 860 866 PF00454 0.464
MOD_PKA_2 613 619 PF00069 0.544
MOD_PKA_2 903 909 PF00069 0.608
MOD_Plk_1 362 368 PF00069 0.654
MOD_Plk_1 402 408 PF00069 0.429
MOD_Plk_1 425 431 PF00069 0.428
MOD_Plk_1 690 696 PF00069 0.619
MOD_Plk_1 916 922 PF00069 0.450
MOD_Plk_1 960 966 PF00069 0.520
MOD_Plk_2-3 187 193 PF00069 0.862
MOD_Plk_2-3 692 698 PF00069 0.645
MOD_Plk_4 362 368 PF00069 0.687
MOD_Plk_4 572 578 PF00069 0.580
MOD_Plk_4 627 633 PF00069 0.595
MOD_Plk_4 713 719 PF00069 0.612
MOD_Plk_4 746 752 PF00069 0.580
MOD_Plk_4 916 922 PF00069 0.514
MOD_ProDKin_1 22 28 PF00069 0.833
MOD_ProDKin_1 221 227 PF00069 0.854
MOD_ProDKin_1 242 248 PF00069 0.830
MOD_ProDKin_1 306 312 PF00069 0.817
MOD_ProDKin_1 347 353 PF00069 0.557
MOD_ProDKin_1 718 724 PF00069 0.570
MOD_ProDKin_1 851 857 PF00069 0.479
MOD_SUMO_for_1 980 983 PF00179 0.527
MOD_SUMO_rev_2 187 194 PF00179 0.699
MOD_SUMO_rev_2 691 700 PF00179 0.640
MOD_SUMO_rev_2 752 761 PF00179 0.591
MOD_SUMO_rev_2 874 879 PF00179 0.649
TRG_DiLeu_BaEn_2 447 453 PF01217 0.355
TRG_ENDOCYTIC_2 286 289 PF00928 0.830
TRG_ENDOCYTIC_2 389 392 PF00928 0.392
TRG_ENDOCYTIC_2 631 634 PF00928 0.584
TRG_ENDOCYTIC_2 660 663 PF00928 0.571
TRG_ENDOCYTIC_2 667 670 PF00928 0.561
TRG_ENDOCYTIC_2 715 718 PF00928 0.546
TRG_ENDOCYTIC_2 737 740 PF00928 0.564
TRG_ENDOCYTIC_2 748 751 PF00928 0.601
TRG_ENDOCYTIC_2 876 879 PF00928 0.462
TRG_ENDOCYTIC_2 892 895 PF00928 0.488
TRG_ENDOCYTIC_2 929 932 PF00928 0.412
TRG_ER_diArg_1 317 320 PF00400 0.673
TRG_Pf-PMV_PEXEL_1 478 482 PF00026 0.648

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1W0 Leptomonas seymouri 26% 68%
A0A0N1I8N2 Leptomonas seymouri 29% 100%
A0A0N1IGQ2 Leptomonas seymouri 32% 100%
A0A0N1ILF1 Leptomonas seymouri 40% 100%
A0A0N1IMH1 Leptomonas seymouri 34% 100%
A0A0N1P9P1 Leptomonas seymouri 40% 100%
A0A0N1PCA9 Leptomonas seymouri 35% 100%
A0A0N1PE91 Leptomonas seymouri 27% 100%
A0A0S4JLK6 Bodo saltans 28% 100%
A0A1X0NJ19 Trypanosomatidae 28% 83%
A0A1X0NJK2 Trypanosomatidae 31% 100%
A0A1X0NJX8 Trypanosomatidae 36% 100%
A0A1X0NKX8 Trypanosomatidae 32% 100%
A0A1X0NMT3 Trypanosomatidae 41% 100%
A0A1X0NW89 Trypanosomatidae 55% 100%
A0A1X0NWA6 Trypanosomatidae 30% 100%
A0A1X0NWW1 Trypanosomatidae 40% 100%
A0A3Q8IBS3 Leishmania donovani 97% 100%
A0A3Q8IDD4 Leishmania donovani 34% 100%
A0A3Q8IJT4 Leishmania donovani 26% 100%
A0A3S5H5A5 Leishmania donovani 41% 100%
A0A3S7WW13 Leishmania donovani 27% 92%
A0A3S7WW18 Leishmania donovani 99% 100%
A0A3S7WW41 Leishmania donovani 35% 100%
A0A3S7WW71 Leishmania donovani 40% 100%
A0A3S7X430 Leishmania donovani 34% 100%
A0A3S7X438 Leishmania donovani 30% 100%
A0A3S7X460 Leishmania donovani 35% 100%
A0A3S7X463 Leishmania donovani 27% 100%
A0A3S7X470 Leishmania donovani 35% 100%
A0A422MYU1 Trypanosoma rangeli 52% 100%
A0A422MYX0 Trypanosoma rangeli 38% 100%
A4H3W4 Leishmania braziliensis 41% 100%
A4HE81 Leishmania braziliensis 33% 100%
A4HJ14 Leishmania braziliensis 34% 100%
A4HJ15 Leishmania braziliensis 26% 68%
A4HJ22 Leishmania braziliensis 32% 100%
A4HJ24 Leishmania braziliensis 34% 100%
A4HS39 Leishmania infantum 41% 100%
A4HYN0 Leishmania infantum 99% 100%
A4HYW2 Leishmania infantum 40% 100%
A4HYW3 Leishmania infantum 36% 100%
A4HYW4 Leishmania infantum 27% 100%
A4I1J4 Leishmania infantum 34% 100%
A4I6E4 Leishmania infantum 35% 100%
A4I6E6 Leishmania infantum 35% 100%
A4I6F0 Leishmania infantum 30% 100%
A4I6K4 Leishmania infantum 34% 100%
A4I6K5 Leishmania infantum 27% 100%
A4I6K6 Leishmania infantum 26% 100%
C9ZIE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 94%
C9ZIE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZN52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZY36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E8NHG6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E8NHG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E8NHG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E8NHM2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E8NHM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AIH1 Leishmania braziliensis 85% 100%
E9AIH3 Leishmania braziliensis 40% 100%
E9AIH4 Leishmania braziliensis 35% 100%
E9AK26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AUQ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AUQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AUR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AXM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1J0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B1J1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1J2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B1J6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
Q4Q6L7 Leishmania major 35% 100%
Q4Q6L9 Leishmania major 35% 100%
Q4Q6M0 Leishmania major 31% 100%
Q4Q6M2 Leishmania major 26% 100%
Q4Q6M3 Leishmania major 27% 100%
Q4Q6M4 Leishmania major 33% 100%
Q4Q9U3 Leishmania major 34% 100%
Q4QCS6 Leishmania major 36% 100%
Q4QCS7 Leishmania major 40% 100%
Q4QCS8 Leishmania major 95% 100%
Q4QCS9 Leishmania major 90% 96%
Q9U0T9 Leishmania major 41% 100%
V5B5I4 Trypanosoma cruzi 54% 100%
V5BII7 Trypanosoma cruzi 29% 82%
V5D9Y2 Trypanosoma cruzi 41% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS