Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

unspecified product

Species:

Leishmania infantum

UniProt:

A4HYW0_LEIIN

TriTrypDb:

LINF_200016760

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.292
CLV_NRD_NRD_1	170	172	PF00675	0.436
CLV_NRD_NRD_1	229	231	PF00675	0.521
CLV_NRD_NRD_1	288	290	PF00675	0.528
CLV_NRD_NRD_1	336	338	PF00675	0.515
CLV_NRD_NRD_1	398	400	PF00675	0.535
CLV_NRD_NRD_1	408	410	PF00675	0.528
CLV_NRD_NRD_1	413	415	PF00675	0.526
CLV_NRD_NRD_1	446	448	PF00675	0.531
CLV_NRD_NRD_1	449	451	PF00675	0.535
CLV_NRD_NRD_1	462	464	PF00675	0.538
CLV_NRD_NRD_1	493	495	PF00675	0.548
CLV_NRD_NRD_1	515	517	PF00675	0.513
CLV_NRD_NRD_1	529	531	PF00675	0.504
CLV_NRD_NRD_1	559	561	PF00675	0.525
CLV_NRD_NRD_1	608	610	PF00675	0.518
CLV_PCSK_FUR_1	286	290	PF00082	0.526
CLV_PCSK_FUR_1	447	451	PF00082	0.533
CLV_PCSK_KEX2_1	105	107	PF00082	0.315
CLV_PCSK_KEX2_1	170	172	PF00082	0.436
CLV_PCSK_KEX2_1	229	231	PF00082	0.521
CLV_PCSK_KEX2_1	288	290	PF00082	0.528
CLV_PCSK_KEX2_1	324	326	PF00082	0.535
CLV_PCSK_KEX2_1	384	386	PF00082	0.516
CLV_PCSK_KEX2_1	397	399	PF00082	0.545
CLV_PCSK_KEX2_1	407	409	PF00082	0.529
CLV_PCSK_KEX2_1	413	415	PF00082	0.526
CLV_PCSK_KEX2_1	446	448	PF00082	0.531
CLV_PCSK_KEX2_1	449	451	PF00082	0.535
CLV_PCSK_KEX2_1	515	517	PF00082	0.513
CLV_PCSK_KEX2_1	529	531	PF00082	0.504
CLV_PCSK_KEX2_1	559	561	PF00082	0.525
CLV_PCSK_KEX2_1	610	612	PF00082	0.510
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.315
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.535
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.516
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.510
CLV_PCSK_PC7_1	403	409	PF00082	0.530
CLV_PCSK_PC7_1	555	561	PF00082	0.517
CLV_PCSK_PC7_1	606	612	PF00082	0.515
CLV_PCSK_SKI1_1	171	175	PF00082	0.399
CLV_PCSK_SKI1_1	189	193	PF00082	0.336
CLV_PCSK_SKI1_1	245	249	PF00082	0.476
CLV_PCSK_SKI1_1	375	379	PF00082	0.464
CLV_PCSK_SKI1_1	457	461	PF00082	0.530
DEG_APCC_DBOX_1	558	566	PF00400	0.524
DEG_Nend_UBRbox_3	1	3	PF02207	0.434
DEG_SCF_FBW7_1	299	304	PF00400	0.510
DEG_SCF_FBW7_1	574	579	PF00400	0.505
DOC_ANK_TNKS_1	120	127	PF00023	0.302
DOC_ANK_TNKS_1	248	255	PF00023	0.491
DOC_CKS1_1	291	296	PF01111	0.523
DOC_CKS1_1	540	545	PF01111	0.508
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.243
DOC_MAPK_MEF2A_6	500	507	PF00069	0.484
DOC_MAPK_MEF2A_6	79	87	PF00069	0.285
DOC_MAPK_RevD_3	501	516	PF00069	0.493
DOC_PP2B_LxvP_1	276	279	PF13499	0.484
DOC_PP4_FxxP_1	275	278	PF00568	0.489
DOC_PP4_FxxP_1	540	543	PF00568	0.504
DOC_USP7_MATH_1	135	139	PF00917	0.311
DOC_USP7_MATH_1	198	202	PF00917	0.424
DOC_USP7_MATH_1	213	217	PF00917	0.508
DOC_USP7_MATH_1	301	305	PF00917	0.512
DOC_USP7_MATH_1	596	600	PF00917	0.491
DOC_WW_Pin1_4	290	295	PF00397	0.522
DOC_WW_Pin1_4	297	302	PF00397	0.513
DOC_WW_Pin1_4	306	311	PF00397	0.516
DOC_WW_Pin1_4	342	347	PF00397	0.522
DOC_WW_Pin1_4	386	391	PF00397	0.514
DOC_WW_Pin1_4	489	494	PF00397	0.537
DOC_WW_Pin1_4	539	544	PF00397	0.505
DOC_WW_Pin1_4	553	558	PF00397	0.513
DOC_WW_Pin1_4	572	577	PF00397	0.505
LIG_14-3-3_CanoR_1	385	392	PF00244	0.516
LIG_14-3-3_CanoR_1	413	422	PF00244	0.523
LIG_14-3-3_CanoR_1	46	54	PF00244	0.318
LIG_14-3-3_CanoR_1	500	504	PF00244	0.502
LIG_14-3-3_CanoR_1	508	513	PF00244	0.498
LIG_14-3-3_CanoR_1	534	543	PF00244	0.501
LIG_14-3-3_CanoR_1	559	563	PF00244	0.525
LIG_BRCT_BRCA1_1	2	6	PF00533	0.408
LIG_BRCT_BRCA1_1	536	540	PF00533	0.498
LIG_BRCT_BRCA1_1	64	68	PF00533	0.290
LIG_BRCT_BRCA1_2	2	8	PF00533	0.407
LIG_Clathr_ClatBox_1	161	165	PF01394	0.384
LIG_EVH1_1	276	280	PF00568	0.486
LIG_FHA_1	25	31	PF00498	0.343
LIG_FHA_1	500	506	PF00498	0.489
LIG_FHA_1	79	85	PF00498	0.294
LIG_FHA_2	206	212	PF00498	0.492
LIG_FHA_2	307	313	PF00498	0.524
LIG_FHA_2	486	492	PF00498	0.528
LIG_LIR_Apic_2	48	54	PF02991	0.308
LIG_LIR_Apic_2	524	528	PF02991	0.509
LIG_LIR_Apic_2	537	543	PF02991	0.501
LIG_LIR_Gen_1	241	251	PF02991	0.471
LIG_LIR_Nem_3	117	123	PF02991	0.287
LIG_LIR_Nem_3	241	246	PF02991	0.465
LIG_NRBOX	157	163	PF00104	0.323
LIG_PROFILIN_1	582	588	PF00235	0.441
LIG_PTAP_UEV_1	486	491	PF05743	0.527
LIG_PTB_Apo_2	368	375	PF02174	0.496
LIG_REV1ctd_RIR_1	379	389	PF16727	0.498
LIG_SH2_SRC	525	528	PF00017	0.509
LIG_SH2_STAT3	348	351	PF00017	0.525
LIG_SH2_STAT5	21	24	PF00017	0.303
LIG_SH2_STAT5	55	58	PF00017	0.284
LIG_SH3_1	200	206	PF00018	0.464
LIG_SH3_1	274	280	PF00018	0.488
LIG_SH3_1	466	472	PF00018	0.495
LIG_SH3_1	484	490	PF00018	0.522
LIG_SH3_1	525	531	PF00018	0.507
LIG_SH3_1	580	586	PF00018	0.455
LIG_SH3_2	269	274	PF14604	0.501
LIG_SH3_2	277	282	PF14604	0.492
LIG_SH3_2	490	495	PF14604	0.541
LIG_SH3_2	588	593	PF14604	0.448
LIG_SH3_3	129	135	PF00018	0.289
LIG_SH3_3	200	206	PF00018	0.464
LIG_SH3_3	260	266	PF00018	0.525
LIG_SH3_3	274	280	PF00018	0.488
LIG_SH3_3	466	472	PF00018	0.495
LIG_SH3_3	484	490	PF00018	0.522
LIG_SH3_3	525	531	PF00018	0.507
LIG_SH3_3	568	574	PF00018	0.509
LIG_SH3_3	579	585	PF00018	0.465
LIG_SH3_3	586	592	PF00018	0.441
LIG_SH3_3	595	601	PF00018	0.490
LIG_SH3_3	95	101	PF00018	0.363
LIG_SH3_CIN85_PxpxPR_1	265	270	PF14604	0.517
LIG_SPRY_1	428	433	PF00622	0.511
LIG_TRAF2_1	366	369	PF00917	0.530
MOD_CDC14_SPxK_1	492	495	PF00782	0.545
MOD_CDC14_SPxK_1	556	559	PF00782	0.512
MOD_CDK_SPK_2	306	311	PF00069	0.516
MOD_CDK_SPK_2	489	494	PF00069	0.537
MOD_CDK_SPxK_1	290	296	PF00069	0.523
MOD_CDK_SPxK_1	489	495	PF00069	0.539
MOD_CDK_SPxK_1	553	559	PF00069	0.516
MOD_CDK_SPxK_1	572	578	PF00069	0.508
MOD_CDK_SPxxK_3	306	313	PF00069	0.519
MOD_CDK_SPxxK_3	553	560	PF00069	0.516
MOD_CK1_1	24	30	PF00069	0.337
MOD_CK1_1	45	51	PF00069	0.344
MOD_CK1_1	547	553	PF00069	0.520
MOD_CK1_1	614	620	PF00069	0.505
MOD_CK2_1	205	211	PF00069	0.492
MOD_CK2_1	213	219	PF00069	0.509
MOD_CK2_1	306	312	PF00069	0.518
MOD_CK2_1	485	491	PF00069	0.524
MOD_Cter_Amidation	286	289	PF01082	0.527
MOD_Cter_Amidation	382	385	PF01082	0.504
MOD_Cter_Amidation	444	447	PF01082	0.531
MOD_GlcNHglycan	13	16	PF01048	0.318
MOD_GlcNHglycan	137	140	PF01048	0.290
MOD_GlcNHglycan	348	351	PF01048	0.525
MOD_GlcNHglycan	352	355	PF01048	0.539
MOD_GlcNHglycan	443	446	PF01048	0.526
MOD_GlcNHglycan	566	569	PF01048	0.514
MOD_GlcNHglycan	613	616	PF01048	0.510
MOD_GSK3_1	135	142	PF00069	0.300
MOD_GSK3_1	17	24	PF00069	0.298
MOD_GSK3_1	211	218	PF00069	0.504
MOD_GSK3_1	297	304	PF00069	0.513
MOD_GSK3_1	319	326	PF00069	0.529
MOD_GSK3_1	342	349	PF00069	0.523
MOD_GSK3_1	37	44	PF00069	0.342
MOD_GSK3_1	485	492	PF00069	0.526
MOD_GSK3_1	495	502	PF00069	0.524
MOD_GSK3_1	572	579	PF00069	0.507
MOD_GSK3_1	596	603	PF00069	0.498
MOD_GSK3_1	611	618	PF00069	0.507
MOD_GSK3_1	9	16	PF00069	0.349
MOD_N-GLC_1	441	446	PF02516	0.526
MOD_N-GLC_1	62	67	PF02516	0.294
MOD_N-GLC_2	432	434	PF02516	0.517
MOD_NEK2_1	116	121	PF00069	0.286
MOD_NEK2_1	17	22	PF00069	0.295
MOD_NEK2_1	377	382	PF00069	0.471
MOD_NEK2_1	558	563	PF00069	0.524
MOD_PIKK_1	163	169	PF00454	0.409
MOD_PIKK_1	301	307	PF00454	0.508
MOD_PIKK_1	45	51	PF00454	0.344
MOD_PIKK_1	596	602	PF00454	0.497
MOD_PKA_1	323	329	PF00069	0.533
MOD_PKA_1	384	390	PF00069	0.516
MOD_PKA_1	413	419	PF00069	0.523
MOD_PKA_1	494	500	PF00069	0.531
MOD_PKA_2	223	229	PF00069	0.514
MOD_PKA_2	384	390	PF00069	0.516
MOD_PKA_2	413	419	PF00069	0.523
MOD_PKA_2	440	446	PF00069	0.525
MOD_PKA_2	448	454	PF00069	0.526
MOD_PKA_2	45	51	PF00069	0.344
MOD_PKA_2	462	468	PF00069	0.521
MOD_PKA_2	499	505	PF00069	0.494
MOD_PKA_2	521	527	PF00069	0.515
MOD_PKA_2	533	539	PF00069	0.498
MOD_PKA_2	558	564	PF00069	0.524
MOD_PKA_2	605	611	PF00069	0.518
MOD_PKB_1	397	405	PF00069	0.537
MOD_PKB_1	609	617	PF00069	0.510
MOD_Plk_1	116	122	PF00069	0.280
MOD_Plk_2-3	111	117	PF00069	0.268
MOD_Plk_4	157	163	PF00069	0.323
MOD_Plk_4	377	383	PF00069	0.473
MOD_Plk_4	508	514	PF00069	0.498
MOD_ProDKin_1	290	296	PF00069	0.523
MOD_ProDKin_1	297	303	PF00069	0.512
MOD_ProDKin_1	306	312	PF00069	0.518
MOD_ProDKin_1	342	348	PF00069	0.523
MOD_ProDKin_1	386	392	PF00069	0.514
MOD_ProDKin_1	489	495	PF00069	0.539
MOD_ProDKin_1	539	545	PF00069	0.506
MOD_ProDKin_1	553	559	PF00069	0.516
MOD_ProDKin_1	572	578	PF00069	0.508
TRG_DiLeu_BaEn_2	185	191	PF01217	0.340
TRG_ENDOCYTIC_2	120	123	PF00928	0.267
TRG_ER_diArg_1	200	203	PF00400	0.442
TRG_ER_diArg_1	286	289	PF00400	0.527
TRG_ER_diArg_1	296	299	PF00400	0.519
TRG_ER_diArg_1	357	360	PF00400	0.543
TRG_ER_diArg_1	396	399	PF00400	0.540
TRG_ER_diArg_1	400	403	PF00400	0.535
TRG_ER_diArg_1	407	409	PF00400	0.529
TRG_ER_diArg_1	446	449	PF00400	0.532
TRG_ER_diArg_1	480	483	PF00400	0.515
TRG_ER_diArg_1	514	516	PF00400	0.510
TRG_ER_diArg_1	528	530	PF00400	0.506
TRG_ER_diArg_1	558	560	PF00400	0.524
TRG_ER_diArg_1	609	612	PF00400	0.512
TRG_NLS_Bipartite_1	446	467	PF00514	0.528
TRG_NLS_MonoExtN_4	606	613	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.464