Endo-1,4-beta-xylanase z-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

unspecified product

Species:

Leishmania infantum

UniProt:

A4HYV9_LEIIN

TriTrypDb:

LINF_200016730

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYV9

Function

Biological processes
Term	Name	Level	Count
GO:0000272	polysaccharide catabolic process	5	4
GO:0005975	carbohydrate metabolic process	3	4
GO:0005976	polysaccharide metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010383	cell wall polysaccharide metabolic process	5	4
GO:0010410	hemicellulose metabolic process	6	4
GO:0016052	carbohydrate catabolic process	4	4
GO:0016998	cell wall macromolecule catabolic process	5	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044036	cell wall macromolecule metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044262	obsolete cellular carbohydrate metabolic process	3	4
GO:0044264	obsolete cellular polysaccharide metabolic process	4	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0044347	cell wall polysaccharide catabolic process	6	4
GO:0045491	xylan metabolic process	7	4
GO:0045493	xylan catabolic process	8	4
GO:0071704	organic substance metabolic process	2	4
GO:1901575	organic substance catabolic process	3	4
GO:2000895	hemicellulose catabolic process	7	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	2
GO:0016787	hydrolase activity	2	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	4
GO:0031176	endo-1,4-beta-xylanase activity	6	2
GO:0097599	xylanase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.362
CLV_NRD_NRD_1	344	346	PF00675	0.362
CLV_NRD_NRD_1	387	389	PF00675	0.456
CLV_PCSK_KEX2_1	204	206	PF00082	0.362
CLV_PCSK_KEX2_1	344	346	PF00082	0.303
CLV_PCSK_KEX2_1	387	389	PF00082	0.456
CLV_PCSK_SKI1_1	355	359	PF00082	0.364
CLV_PCSK_SKI1_1	368	372	PF00082	0.399
DEG_SCF_FBW7_1	129	136	PF00400	0.522
DOC_CKS1_1	130	135	PF01111	0.463
DOC_CKS1_1	5	10	PF01111	0.536
DOC_MAPK_gen_1	204	211	PF00069	0.362
DOC_MAPK_gen_1	344	350	PF00069	0.394
DOC_MAPK_MEF2A_6	204	211	PF00069	0.387
DOC_MAPK_MEF2A_6	240	248	PF00069	0.332
DOC_PP1_RVXF_1	353	359	PF00149	0.363
DOC_PP1_RVXF_1	410	417	PF00149	0.492
DOC_PP4_FxxP_1	27	30	PF00568	0.594
DOC_PP4_FxxP_1	64	67	PF00568	0.458
DOC_USP7_MATH_1	67	71	PF00917	0.514
DOC_USP7_MATH_1	90	94	PF00917	0.554
DOC_WW_Pin1_4	11	16	PF00397	0.629
DOC_WW_Pin1_4	129	134	PF00397	0.417
DOC_WW_Pin1_4	4	9	PF00397	0.673
LIG_APCC_ABBA_1	276	281	PF00400	0.332
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_eIF4E_1	206	212	PF01652	0.387
LIG_FHA_1	130	136	PF00498	0.466
LIG_FHA_1	183	189	PF00498	0.375
LIG_FHA_1	240	246	PF00498	0.335
LIG_FHA_1	271	277	PF00498	0.477
LIG_FHA_1	86	92	PF00498	0.484
LIG_FHA_2	182	188	PF00498	0.387
LIG_FHA_2	284	290	PF00498	0.387
LIG_FHA_2	309	315	PF00498	0.387
LIG_FHA_2	333	339	PF00498	0.440
LIG_FHA_2	49	55	PF00498	0.463
LIG_LIR_Apic_2	26	30	PF02991	0.603
LIG_LIR_Nem_3	203	209	PF02991	0.305
LIG_LIR_Nem_3	328	333	PF02991	0.367
LIG_LIR_Nem_3	59	65	PF02991	0.510
LIG_LYPXL_yS_3	206	209	PF13949	0.332
LIG_MYND_1	129	133	PF01753	0.524
LIG_PCNA_yPIPBox_3	285	299	PF02747	0.440
LIG_SH2_PTP2	148	151	PF00017	0.390
LIG_SH2_PTP2	191	194	PF00017	0.353
LIG_SH2_SRC	148	151	PF00017	0.390
LIG_SH2_SRC	191	194	PF00017	0.332
LIG_SH2_SRC	65	68	PF00017	0.443
LIG_SH2_STAT5	148	151	PF00017	0.371
LIG_SH2_STAT5	176	179	PF00017	0.446
LIG_SH2_STAT5	180	183	PF00017	0.327
LIG_SH2_STAT5	191	194	PF00017	0.213
LIG_SH2_STAT5	210	213	PF00017	0.332
LIG_SH2_STAT5	279	282	PF00017	0.359
LIG_SH2_STAT5	65	68	PF00017	0.533
LIG_SH3_2	153	158	PF14604	0.466
LIG_SH3_3	109	115	PF00018	0.546
LIG_SH3_3	127	133	PF00018	0.333
LIG_SH3_3	148	154	PF00018	0.403
LIG_SH3_3	5	11	PF00018	0.624
LIG_SH3_3	70	76	PF00018	0.526
LIG_SUMO_SIM_anti_2	242	251	PF11976	0.387
LIG_SUMO_SIM_par_1	121	126	PF11976	0.487
LIG_TRAF2_1	184	187	PF00917	0.387
LIG_UBA3_1	244	249	PF00899	0.440
LIG_WRC_WIRS_1	24	29	PF05994	0.626
LIG_WW_1	193	196	PF00397	0.332
MOD_CDK_SPxxK_3	11	18	PF00069	0.628
MOD_CK1_1	200	206	PF00069	0.440
MOD_CK1_1	250	256	PF00069	0.440
MOD_CK1_1	28	34	PF00069	0.643
MOD_CK1_1	334	340	PF00069	0.353
MOD_CK2_1	181	187	PF00069	0.387
MOD_CK2_1	48	54	PF00069	0.460
MOD_CMANNOS	396	399	PF00535	0.320
MOD_GlcNHglycan	1	4	PF01048	0.693
MOD_GlcNHglycan	112	115	PF01048	0.518
MOD_GlcNHglycan	200	203	PF01048	0.440
MOD_GlcNHglycan	252	255	PF01048	0.432
MOD_GlcNHglycan	322	325	PF01048	0.332
MOD_GSK3_1	10	17	PF00069	0.661
MOD_GSK3_1	129	136	PF00069	0.522
MOD_GSK3_1	178	185	PF00069	0.375
MOD_GSK3_1	299	306	PF00069	0.302
MOD_GSK3_1	81	88	PF00069	0.468
MOD_N-GLC_1	56	61	PF02516	0.513
MOD_N-GLC_2	157	159	PF02516	0.559
MOD_NEK2_1	248	253	PF00069	0.440
MOD_NEK2_1	308	313	PF00069	0.330
MOD_NEK2_1	325	330	PF00069	0.380
MOD_PIKK_1	25	31	PF00454	0.690
MOD_PKA_2	163	169	PF00069	0.539
MOD_Plk_1	412	418	PF00069	0.541
MOD_Plk_2-3	270	276	PF00069	0.387
MOD_Plk_2-3	48	54	PF00069	0.460
MOD_Plk_4	412	418	PF00069	0.554
MOD_Plk_4	68	74	PF00069	0.442
MOD_ProDKin_1	11	17	PF00069	0.631
MOD_ProDKin_1	129	135	PF00069	0.412
MOD_ProDKin_1	4	10	PF00069	0.671
MOD_SUMO_rev_2	233	242	PF00179	0.387
TRG_ENDOCYTIC_2	148	151	PF00928	0.371
TRG_ENDOCYTIC_2	206	209	PF00928	0.332
TRG_ENDOCYTIC_2	318	321	PF00928	0.357
TRG_ER_diArg_1	204	206	PF00400	0.362
TRG_ER_diArg_1	343	345	PF00400	0.362
TRG_ER_diArg_1	387	389	PF00400	0.456
TRG_ER_diArg_1	42	45	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM32	Leptomonas seymouri	60%	100%
A0A1X0NWX5	Trypanosomatidae	43%	100%
A0A3Q8IKN0	Leishmania donovani	98%	100%
E9AUQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
P31471	Escherichia coli (strain K12)	25%	100%