DUF3533 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYV8_LEIIN

TriTrypDb:

LINF_200016700

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HYV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	253	255	PF00675	0.385
CLV_PCSK_KEX2_1	253	255	PF00082	0.421
CLV_PCSK_SKI1_1	123	127	PF00082	0.690
CLV_PCSK_SKI1_1	269	273	PF00082	0.477
CLV_Separin_Metazoa	258	262	PF03568	0.635
DEG_Nend_UBRbox_3	1	3	PF02207	0.503
DOC_CKS1_1	170	175	PF01111	0.415
DOC_CYCLIN_RxL_1	266	274	PF00134	0.671
DOC_MAPK_gen_1	66	75	PF00069	0.719
DOC_MAPK_MEF2A_6	227	234	PF00069	0.304
DOC_MAPK_MEF2A_6	68	77	PF00069	0.647
DOC_PP1_RVXF_1	72	78	PF00149	0.656
DOC_PP4_FxxP_1	247	250	PF00568	0.376
DOC_USP7_MATH_1	25	29	PF00917	0.479
DOC_USP7_MATH_1	276	280	PF00917	0.683
DOC_USP7_UBL2_3	269	273	PF12436	0.677
DOC_WW_Pin1_4	169	174	PF00397	0.372
DOC_WW_Pin1_4	87	92	PF00397	0.556
LIG_14-3-3_CanoR_1	68	74	PF00244	0.653
LIG_Actin_WH2_2	100	117	PF00022	0.471
LIG_deltaCOP1_diTrp_1	226	231	PF00928	0.408
LIG_FHA_1	172	178	PF00498	0.356
LIG_FHA_1	52	58	PF00498	0.429
LIG_FHA_1	70	76	PF00498	0.643
LIG_FHA_2	211	217	PF00498	0.511
LIG_LIR_Apic_2	246	250	PF02991	0.436
LIG_LIR_Gen_1	213	220	PF02991	0.385
LIG_LIR_Nem_3	160	166	PF02991	0.412
LIG_LIR_Nem_3	209	214	PF02991	0.432
LIG_LIR_Nem_3	255	259	PF02991	0.575
LIG_LIR_Nem_3	45	50	PF02991	0.383
LIG_LYPXL_yS_3	163	166	PF13949	0.429
LIG_PCNA_PIPBox_1	204	213	PF02747	0.501
LIG_Pex14_2	210	214	PF04695	0.376
LIG_SH2_CRK	122	126	PF00017	0.432
LIG_SH2_CRK	215	219	PF00017	0.424
LIG_SH2_NCK_1	37	41	PF00017	0.408
LIG_SH2_STAP1	215	219	PF00017	0.430
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.488
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.697
LIG_SUMO_SIM_par_1	2	7	PF11976	0.464
LIG_SxIP_EBH_1	78	87	PF03271	0.648
LIG_WRC_WIRS_1	207	212	PF05994	0.447
LIG_WRC_WIRS_1	244	249	PF05994	0.468
MOD_CK1_1	27	33	PF00069	0.347
MOD_CK1_1	80	86	PF00069	0.697
MOD_CMANNOS	228	231	PF00535	0.617
MOD_GlcNHglycan	130	133	PF01048	0.655
MOD_GlcNHglycan	60	63	PF01048	0.468
MOD_GlcNHglycan	79	82	PF01048	0.488
MOD_GSK3_1	153	160	PF00069	0.503
MOD_GSK3_1	206	213	PF00069	0.424
MOD_GSK3_1	289	296	PF00069	0.647
MOD_GSK3_1	58	65	PF00069	0.459
MOD_GSK3_1	69	76	PF00069	0.603
MOD_N-GLC_1	128	133	PF02516	0.708
MOD_NEK2_1	237	242	PF00069	0.353
MOD_NEK2_1	58	63	PF00069	0.395
MOD_NEK2_1	64	69	PF00069	0.611
MOD_NEK2_1	77	82	PF00069	0.472
MOD_NEK2_2	206	211	PF00069	0.424
MOD_NEK2_2	289	294	PF00069	0.645
MOD_PIKK_1	15	21	PF00454	0.533
MOD_PIKK_1	158	164	PF00454	0.428
MOD_PKA_2	73	79	PF00069	0.652
MOD_Plk_1	128	134	PF00069	0.476
MOD_Plk_4	134	140	PF00069	0.494
MOD_Plk_4	206	212	PF00069	0.447
MOD_Plk_4	27	33	PF00069	0.410
MOD_Plk_4	80	86	PF00069	0.637
MOD_ProDKin_1	169	175	PF00069	0.370
MOD_ProDKin_1	87	93	PF00069	0.556
TRG_ENDOCYTIC_2	122	125	PF00928	0.428
TRG_ENDOCYTIC_2	163	166	PF00928	0.427
TRG_ENDOCYTIC_2	182	185	PF00928	0.212
TRG_ENDOCYTIC_2	191	194	PF00928	0.376
TRG_ENDOCYTIC_2	215	218	PF00928	0.376
TRG_ENDOCYTIC_2	256	259	PF00928	0.575
TRG_ER_diArg_1	10	13	PF00400	0.515
TRG_ER_diArg_1	252	254	PF00400	0.621
TRG_ER_diArg_1	281	284	PF00400	0.615
TRG_ER_diLys_1	295	299	PF00400	0.792

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W3	Leptomonas seymouri	55%	100%
A0A3Q8IAV6	Leishmania donovani	99%	100%
A0A422NLI0	Trypanosoma rangeli	24%	100%
E9AIG5	Leishmania braziliensis	78%	100%
E9AUQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCT0	Leishmania major	94%	100%