Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYU6_LEIIN

TriTrypDb:

LINF_200015500

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.670
CLV_C14_Caspase3-7	370	374	PF00656	0.756
CLV_C14_Caspase3-7	527	531	PF00656	0.837
CLV_C14_Caspase3-7	532	536	PF00656	0.697
CLV_C14_Caspase3-7	540	544	PF00656	0.594
CLV_C14_Caspase3-7	804	808	PF00656	0.693
CLV_NRD_NRD_1	291	293	PF00675	0.637
CLV_NRD_NRD_1	294	296	PF00675	0.623
CLV_NRD_NRD_1	317	319	PF00675	0.814
CLV_NRD_NRD_1	388	390	PF00675	0.755
CLV_NRD_NRD_1	552	554	PF00675	0.776
CLV_NRD_NRD_1	691	693	PF00675	0.827
CLV_NRD_NRD_1	749	751	PF00675	0.625
CLV_NRD_NRD_1	882	884	PF00675	0.699
CLV_NRD_NRD_1	912	914	PF00675	0.696
CLV_PCSK_FUR_1	292	296	PF00082	0.695
CLV_PCSK_KEX2_1	293	295	PF00082	0.636
CLV_PCSK_KEX2_1	317	319	PF00082	0.814
CLV_PCSK_KEX2_1	552	554	PF00082	0.839
CLV_PCSK_KEX2_1	691	693	PF00082	0.812
CLV_PCSK_KEX2_1	749	751	PF00082	0.625
CLV_PCSK_KEX2_1	912	914	PF00082	0.696
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.771
CLV_PCSK_SKI1_1	224	228	PF00082	0.754
CLV_PCSK_SKI1_1	438	442	PF00082	0.673
CLV_PCSK_SKI1_1	568	572	PF00082	0.832
CLV_PCSK_SKI1_1	845	849	PF00082	0.623
CLV_PCSK_SKI1_1	883	887	PF00082	0.696
CLV_PCSK_SKI1_1	945	949	PF00082	0.627
CLV_Separin_Metazoa	221	225	PF03568	0.752
DEG_Nend_UBRbox_3	1	3	PF02207	0.714
DEG_SCF_FBW7_1	896	902	PF00400	0.813
DEG_SCF_FBW7_2	72	77	PF00400	0.782
DEG_SPOP_SBC_1	362	366	PF00917	0.715
DEG_SPOP_SBC_1	486	490	PF00917	0.763
DOC_ANK_TNKS_1	195	202	PF00023	0.642
DOC_ANK_TNKS_1	316	323	PF00023	0.730
DOC_CKS1_1	896	901	PF01111	0.730
DOC_CYCLIN_RxL_1	842	850	PF00134	0.616
DOC_MAPK_gen_1	269	279	PF00069	0.658
DOC_PP4_FxxP_1	279	282	PF00568	0.796
DOC_USP7_MATH_1	261	265	PF00917	0.770
DOC_USP7_MATH_1	282	286	PF00917	0.768
DOC_USP7_MATH_1	33	37	PF00917	0.812
DOC_USP7_MATH_1	362	366	PF00917	0.762
DOC_USP7_MATH_1	487	491	PF00917	0.799
DOC_USP7_MATH_1	537	541	PF00917	0.739
DOC_USP7_MATH_1	545	549	PF00917	0.600
DOC_USP7_MATH_1	597	601	PF00917	0.741
DOC_USP7_MATH_1	654	658	PF00917	0.755
DOC_USP7_MATH_1	66	70	PF00917	0.771
DOC_USP7_MATH_1	669	673	PF00917	0.603
DOC_USP7_MATH_1	676	680	PF00917	0.740
DOC_USP7_MATH_1	717	721	PF00917	0.748
DOC_USP7_MATH_1	739	743	PF00917	0.659
DOC_USP7_MATH_1	765	769	PF00917	0.633
DOC_USP7_MATH_1	784	788	PF00917	0.629
DOC_USP7_MATH_1	836	840	PF00917	0.662
DOC_USP7_MATH_1	843	847	PF00917	0.581
DOC_USP7_MATH_1	857	861	PF00917	0.687
DOC_USP7_MATH_1	930	934	PF00917	0.754
DOC_WW_Pin1_4	225	230	PF00397	0.768
DOC_WW_Pin1_4	345	350	PF00397	0.684
DOC_WW_Pin1_4	363	368	PF00397	0.588
DOC_WW_Pin1_4	400	405	PF00397	0.793
DOC_WW_Pin1_4	422	427	PF00397	0.741
DOC_WW_Pin1_4	64	69	PF00397	0.778
DOC_WW_Pin1_4	647	652	PF00397	0.718
DOC_WW_Pin1_4	70	75	PF00397	0.824
DOC_WW_Pin1_4	707	712	PF00397	0.762
DOC_WW_Pin1_4	780	785	PF00397	0.757
DOC_WW_Pin1_4	808	813	PF00397	0.709
DOC_WW_Pin1_4	895	900	PF00397	0.723
DOC_WW_Pin1_4	920	925	PF00397	0.762
DOC_WW_Pin1_4	932	937	PF00397	0.714
LIG_14-3-3_CanoR_1	224	229	PF00244	0.749
LIG_14-3-3_CanoR_1	245	250	PF00244	0.795
LIG_14-3-3_CanoR_1	396	406	PF00244	0.791
LIG_14-3-3_CanoR_1	438	443	PF00244	0.693
LIG_14-3-3_CanoR_1	538	546	PF00244	0.646
LIG_14-3-3_CanoR_1	661	667	PF00244	0.781
LIG_14-3-3_CanoR_1	749	754	PF00244	0.810
LIG_14-3-3_CanoR_1	820	826	PF00244	0.714
LIG_14-3-3_CanoR_1	861	869	PF00244	0.678
LIG_APCC_ABBA_1	799	804	PF00400	0.747
LIG_BRCT_BRCA1_1	402	406	PF00533	0.794
LIG_BRCT_BRCA1_1	515	519	PF00533	0.846
LIG_EH_1	178	182	PF12763	0.807
LIG_FHA_1	139	145	PF00498	0.830
LIG_FHA_1	217	223	PF00498	0.863
LIG_FHA_1	254	260	PF00498	0.637
LIG_FHA_1	272	278	PF00498	0.723
LIG_FHA_1	455	461	PF00498	0.646
LIG_FHA_1	682	688	PF00498	0.842
LIG_FHA_1	896	902	PF00498	0.727
LIG_FHA_1	933	939	PF00498	0.779
LIG_FHA_2	186	192	PF00498	0.759
LIG_FHA_2	225	231	PF00498	0.786
LIG_FHA_2	301	307	PF00498	0.704
LIG_FHA_2	754	760	PF00498	0.808
LIG_FHA_2	822	828	PF00498	0.619
LIG_GSK3_LRP6_1	647	652	PF00069	0.738
LIG_LIR_Apic_2	22	27	PF02991	0.765
LIG_LIR_Apic_2	278	282	PF02991	0.788
LIG_LIR_Apic_2	36	41	PF02991	0.640
LIG_LIR_Apic_2	949	955	PF02991	0.790
LIG_LIR_Gen_1	248	253	PF02991	0.827
LIG_LIR_Gen_1	331	340	PF02991	0.738
LIG_LIR_Gen_1	573	584	PF02991	0.741
LIG_LIR_Gen_1	763	774	PF02991	0.673
LIG_LIR_Gen_1	946	955	PF02991	0.794
LIG_LIR_Nem_3	248	252	PF02991	0.824
LIG_LIR_Nem_3	278	283	PF02991	0.796
LIG_LIR_Nem_3	331	337	PF02991	0.738
LIG_LIR_Nem_3	405	410	PF02991	0.570
LIG_LIR_Nem_3	53	57	PF02991	0.810
LIG_LIR_Nem_3	763	769	PF02991	0.718
LIG_LIR_Nem_3	823	828	PF02991	0.663
LIG_LIR_Nem_3	946	950	PF02991	0.801
LIG_MAD2	344	352	PF02301	0.609
LIG_MLH1_MIPbox_1	404	408	PF16413	0.787
LIG_MYND_1	349	353	PF01753	0.755
LIG_SH2_CRK	24	28	PF00017	0.738
LIG_SH2_CRK	280	284	PF00017	0.782
LIG_SH2_NCK_1	952	956	PF00017	0.712
LIG_SH2_STAP1	249	253	PF00017	0.827
LIG_SH2_STAP1	410	414	PF00017	0.547
LIG_SH2_STAP1	753	757	PF00017	0.738
LIG_SH2_STAT5	407	410	PF00017	0.671
LIG_SH2_STAT5	54	57	PF00017	0.748
LIG_SH2_STAT5	893	896	PF00017	0.806
LIG_SH3_1	893	899	PF00018	0.808
LIG_SH3_2	197	202	PF14604	0.561
LIG_SH3_3	157	163	PF00018	0.728
LIG_SH3_3	194	200	PF00018	0.776
LIG_SH3_3	343	349	PF00018	0.811
LIG_SH3_3	60	66	PF00018	0.828
LIG_SH3_3	642	648	PF00018	0.682
LIG_SH3_3	866	872	PF00018	0.733
LIG_SH3_3	893	899	PF00018	0.738
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.660
LIG_SUMO_SIM_par_1	871	877	PF11976	0.682
LIG_TRAF2_1	41	44	PF00917	0.724
LIG_TRAF2_1	74	77	PF00917	0.785
MOD_CDK_SPK_2	345	350	PF00069	0.747
MOD_CDK_SPK_2	70	75	PF00069	0.820
MOD_CDK_SPK_2	899	904	PF00069	0.690
MOD_CDK_SPxxK_3	920	927	PF00069	0.647
MOD_CK1_1	127	133	PF00069	0.740
MOD_CK1_1	143	149	PF00069	0.670
MOD_CK1_1	195	201	PF00069	0.762
MOD_CK1_1	365	371	PF00069	0.628
MOD_CK1_1	400	406	PF00069	0.764
MOD_CK1_1	488	494	PF00069	0.800
MOD_CK1_1	528	534	PF00069	0.717
MOD_CK1_1	563	569	PF00069	0.843
MOD_CK1_1	587	593	PF00069	0.814
MOD_CK1_1	652	658	PF00069	0.850
MOD_CK1_1	67	73	PF00069	0.853
MOD_CK1_1	694	700	PF00069	0.775
MOD_CK1_1	805	811	PF00069	0.735
MOD_CK1_1	841	847	PF00069	0.771
MOD_CK1_1	946	952	PF00069	0.797
MOD_CK2_1	185	191	PF00069	0.758
MOD_CK2_1	224	230	PF00069	0.790
MOD_CK2_1	300	306	PF00069	0.705
MOD_CK2_1	508	514	PF00069	0.660
MOD_CK2_1	821	827	PF00069	0.617
MOD_GlcNHglycan	129	132	PF01048	0.639
MOD_GlcNHglycan	134	137	PF01048	0.677
MOD_GlcNHglycan	148	151	PF01048	0.617
MOD_GlcNHglycan	263	266	PF01048	0.658
MOD_GlcNHglycan	300	303	PF01048	0.731
MOD_GlcNHglycan	426	429	PF01048	0.659
MOD_GlcNHglycan	492	495	PF01048	0.827
MOD_GlcNHglycan	508	513	PF01048	0.749
MOD_GlcNHglycan	514	518	PF01048	0.820
MOD_GlcNHglycan	562	565	PF01048	0.823
MOD_GlcNHglycan	671	674	PF01048	0.820
MOD_GlcNHglycan	676	679	PF01048	0.765
MOD_GlcNHglycan	7	10	PF01048	0.771
MOD_GlcNHglycan	753	756	PF01048	0.704
MOD_GlcNHglycan	793	798	PF01048	0.706
MOD_GlcNHglycan	87	93	PF01048	0.776
MOD_GSK3_1	125	132	PF00069	0.636
MOD_GSK3_1	146	153	PF00069	0.692
MOD_GSK3_1	233	240	PF00069	0.697
MOD_GSK3_1	271	278	PF00069	0.771
MOD_GSK3_1	361	368	PF00069	0.705
MOD_GSK3_1	398	405	PF00069	0.615
MOD_GSK3_1	450	457	PF00069	0.792
MOD_GSK3_1	485	492	PF00069	0.698
MOD_GSK3_1	493	500	PF00069	0.722
MOD_GSK3_1	504	511	PF00069	0.824
MOD_GSK3_1	556	563	PF00069	0.805
MOD_GSK3_1	64	71	PF00069	0.846
MOD_GSK3_1	674	681	PF00069	0.721
MOD_GSK3_1	7	14	PF00069	0.680
MOD_GSK3_1	718	725	PF00069	0.702
MOD_GSK3_1	745	752	PF00069	0.665
MOD_GSK3_1	780	787	PF00069	0.773
MOD_GSK3_1	802	809	PF00069	0.632
MOD_GSK3_1	816	823	PF00069	0.653
MOD_GSK3_1	837	844	PF00069	0.697
MOD_GSK3_1	857	864	PF00069	0.808
MOD_GSK3_1	895	902	PF00069	0.813
MOD_LATS_1	183	189	PF00433	0.754
MOD_LATS_1	859	865	PF00433	0.735
MOD_N-GLC_1	146	151	PF02516	0.655
MOD_N-GLC_1	362	367	PF02516	0.623
MOD_N-GLC_1	497	502	PF02516	0.834
MOD_N-GLC_1	579	584	PF02516	0.761
MOD_N-GLC_1	694	699	PF02516	0.849
MOD_N-GLC_1	837	842	PF02516	0.673
MOD_N-GLC_1	930	935	PF02516	0.788
MOD_NEK2_1	124	129	PF00069	0.624
MOD_NEK2_1	578	583	PF00069	0.770
MOD_NEK2_1	584	589	PF00069	0.667
MOD_NEK2_1	815	820	PF00069	0.765
MOD_NEK2_1	938	943	PF00069	0.751
MOD_NEK2_2	275	280	PF00069	0.814
MOD_NEK2_2	843	848	PF00069	0.617
MOD_PIKK_1	129	135	PF00454	0.741
MOD_PIKK_1	237	243	PF00454	0.790
MOD_PIKK_1	254	260	PF00454	0.537
MOD_PIKK_1	328	334	PF00454	0.601
MOD_PIKK_1	652	658	PF00454	0.829
MOD_PIKK_1	838	844	PF00454	0.668
MOD_PK_1	125	131	PF00069	0.644
MOD_PKA_1	555	561	PF00069	0.818
MOD_PKA_1	691	697	PF00069	0.766
MOD_PKA_1	749	755	PF00069	0.734
MOD_PKA_2	124	130	PF00069	0.650
MOD_PKA_2	195	201	PF00069	0.737
MOD_PKA_2	217	223	PF00069	0.650
MOD_PKA_2	233	239	PF00069	0.562
MOD_PKA_2	271	277	PF00069	0.756
MOD_PKA_2	298	304	PF00069	0.643
MOD_PKA_2	313	319	PF00069	0.737
MOD_PKA_2	537	543	PF00069	0.809
MOD_PKA_2	660	666	PF00069	0.815
MOD_PKA_2	669	675	PF00069	0.835
MOD_PKA_2	691	697	PF00069	0.649
MOD_PKA_2	749	755	PF00069	0.734
MOD_PKA_2	805	811	PF00069	0.701
MOD_Plk_1	125	131	PF00069	0.742
MOD_Plk_1	335	341	PF00069	0.687
MOD_Plk_1	372	378	PF00069	0.601
MOD_Plk_1	43	49	PF00069	0.722
MOD_Plk_1	525	531	PF00069	0.750
MOD_Plk_1	579	585	PF00069	0.796
MOD_Plk_1	793	799	PF00069	0.747
MOD_Plk_1	806	812	PF00069	0.681
MOD_Plk_2-3	19	25	PF00069	0.620
MOD_Plk_2-3	504	510	PF00069	0.746
MOD_Plk_2-3	525	531	PF00069	0.711
MOD_Plk_4	247	253	PF00069	0.829
MOD_Plk_4	275	281	PF00069	0.809
MOD_Plk_4	335	341	PF00069	0.660
MOD_Plk_4	402	408	PF00069	0.792
MOD_Plk_4	450	456	PF00069	0.739
MOD_Plk_4	50	56	PF00069	0.811
MOD_Plk_4	579	585	PF00069	0.796
MOD_Plk_4	597	603	PF00069	0.510
MOD_Plk_4	662	668	PF00069	0.643
MOD_Plk_4	784	790	PF00069	0.700
MOD_Plk_4	843	849	PF00069	0.617
MOD_ProDKin_1	225	231	PF00069	0.767
MOD_ProDKin_1	345	351	PF00069	0.684
MOD_ProDKin_1	363	369	PF00069	0.589
MOD_ProDKin_1	400	406	PF00069	0.793
MOD_ProDKin_1	422	428	PF00069	0.740
MOD_ProDKin_1	64	70	PF00069	0.780
MOD_ProDKin_1	647	653	PF00069	0.720
MOD_ProDKin_1	707	713	PF00069	0.763
MOD_ProDKin_1	780	786	PF00069	0.759
MOD_ProDKin_1	808	814	PF00069	0.713
MOD_ProDKin_1	895	901	PF00069	0.726
MOD_ProDKin_1	920	926	PF00069	0.763
MOD_ProDKin_1	932	938	PF00069	0.714
MOD_SUMO_rev_2	105	112	PF00179	0.529
TRG_ENDOCYTIC_2	249	252	PF00928	0.824
TRG_ENDOCYTIC_2	280	283	PF00928	0.792
TRG_ENDOCYTIC_2	410	413	PF00928	0.546
TRG_ENDOCYTIC_2	54	57	PF00928	0.810
TRG_ENDOCYTIC_2	576	579	PF00928	0.819
TRG_ENDOCYTIC_2	95	98	PF00928	0.706
TRG_ER_diArg_1	184	187	PF00400	0.751
TRG_ER_diArg_1	292	295	PF00400	0.616
TRG_ER_diArg_1	317	319	PF00400	0.814
TRG_ER_diArg_1	551	553	PF00400	0.772
TRG_ER_diArg_1	691	693	PF00400	0.842
TRG_ER_diArg_1	911	913	PF00400	0.722
TRG_NLS_MonoCore_2	291	296	PF00514	0.691
TRG_NLS_MonoExtC_3	292	298	PF00514	0.770
TRG_NLS_MonoExtC_3	388	393	PF00514	0.668
TRG_NLS_MonoExtN_4	292	297	PF00514	0.690
TRG_NLS_MonoExtN_4	389	394	PF00514	0.669
TRG_NLS_MonoExtN_4	881	887	PF00514	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBR5	Leishmania donovani	98%	100%
E9AIF4	Leishmania braziliensis	58%	100%
E9AUP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QCU1	Leishmania major	86%	99%