Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYU4_LEIIN

TriTrypDb:

LINF_200015300

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.719
CLV_NRD_NRD_1	16	18	PF00675	0.778
CLV_NRD_NRD_1	245	247	PF00675	0.684
CLV_NRD_NRD_1	254	256	PF00675	0.597
CLV_NRD_NRD_1	301	303	PF00675	0.740
CLV_NRD_NRD_1	314	316	PF00675	0.769
CLV_PCSK_KEX2_1	16	18	PF00082	0.807
CLV_PCSK_KEX2_1	254	256	PF00082	0.739
CLV_PCSK_KEX2_1	300	302	PF00082	0.743
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.743
CLV_PCSK_SKI1_1	214	218	PF00082	0.703
CLV_PCSK_SKI1_1	261	265	PF00082	0.710
CLV_PCSK_SKI1_1	275	279	PF00082	0.460
CLV_PCSK_SKI1_1	332	336	PF00082	0.634
DEG_APCC_DBOX_1	91	99	PF00400	0.643
DEG_Nend_UBRbox_3	1	3	PF02207	0.751
DOC_CKS1_1	91	96	PF01111	0.657
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.741
DOC_PP2B_LxvP_1	127	130	PF13499	0.675
DOC_PP2B_LxvP_1	59	62	PF13499	0.776
DOC_PP4_FxxP_1	235	238	PF00568	0.667
DOC_PP4_MxPP_1	123	126	PF00568	0.751
DOC_USP7_MATH_1	131	135	PF00917	0.700
DOC_USP7_MATH_1	200	204	PF00917	0.756
DOC_USP7_MATH_1	238	242	PF00917	0.644
DOC_USP7_MATH_1	94	98	PF00917	0.648
DOC_USP7_UBL2_3	240	244	PF12436	0.640
DOC_USP7_UBL2_3	300	304	PF12436	0.744
DOC_USP7_UBL2_3	46	50	PF12436	0.681
DOC_WW_Pin1_4	282	287	PF00397	0.700
DOC_WW_Pin1_4	90	95	PF00397	0.668
LIG_14-3-3_CanoR_1	192	197	PF00244	0.726
LIG_14-3-3_CanoR_1	85	95	PF00244	0.797
LIG_EVH1_2	128	132	PF00568	0.652
LIG_FHA_1	16	22	PF00498	0.776
LIG_FHA_1	322	328	PF00498	0.673
LIG_FHA_1	43	49	PF00498	0.682
LIG_FHA_2	279	285	PF00498	0.699
LIG_FHA_2	61	67	PF00498	0.772
LIG_LIR_Apic_2	100	105	PF02991	0.592
LIG_LIR_Gen_1	72	80	PF02991	0.747
LIG_LIR_Nem_3	72	78	PF02991	0.729
LIG_MYND_1	125	129	PF01753	0.736
LIG_MYND_1	57	61	PF01753	0.781
LIG_SH2_CRK	102	106	PF00017	0.594
LIG_SH2_CRK	75	79	PF00017	0.747
LIG_SH2_GRB2like	75	78	PF00017	0.744
LIG_SH2_NCK_1	102	106	PF00017	0.594
LIG_SH2_STAP1	279	283	PF00017	0.700
LIG_SH2_STAT5	75	78	PF00017	0.744
LIG_SH3_3	122	128	PF00018	0.766
LIG_SH3_3	137	143	PF00018	0.601
LIG_SH3_3	147	153	PF00018	0.653
LIG_SH3_3	280	286	PF00018	0.694
LIG_WW_2	125	128	PF00397	0.737
MOD_CDK_SPK_2	282	287	PF00069	0.700
MOD_CK1_1	134	140	PF00069	0.821
MOD_CK1_1	144	150	PF00069	0.654
MOD_CK1_1	159	165	PF00069	0.558
MOD_CK1_1	42	48	PF00069	0.611
MOD_CK1_1	73	79	PF00069	0.777
MOD_CK2_1	200	206	PF00069	0.728
MOD_CK2_1	60	66	PF00069	0.773
MOD_Cter_Amidation	212	215	PF01082	0.684
MOD_Cter_Amidation	313	316	PF01082	0.772
MOD_GlcNHglycan	114	117	PF01048	0.728
MOD_GlcNHglycan	134	137	PF01048	0.774
MOD_GlcNHglycan	240	243	PF01048	0.637
MOD_GlcNHglycan	28	31	PF01048	0.707
MOD_GlcNHglycan	81	84	PF01048	0.814
MOD_GSK3_1	131	138	PF00069	0.735
MOD_GSK3_1	152	159	PF00069	0.763
MOD_GSK3_1	177	184	PF00069	0.764
MOD_GSK3_1	201	208	PF00069	0.770
MOD_GSK3_1	278	285	PF00069	0.698
MOD_GSK3_1	302	309	PF00069	0.669
MOD_GSK3_1	42	49	PF00069	0.735
MOD_GSK3_1	69	76	PF00069	0.796
MOD_GSK3_1	86	93	PF00069	0.562
MOD_N-GLC_1	1	6	PF02516	0.736
MOD_N-GLC_1	112	117	PF02516	0.778
MOD_N-GLC_1	132	137	PF02516	0.771
MOD_N-GLC_1	306	311	PF02516	0.698
MOD_N-GLC_1	46	51	PF02516	0.768
MOD_NEK2_1	112	117	PF00069	0.778
MOD_NEK2_1	132	137	PF00069	0.771
MOD_NEK2_1	156	161	PF00069	0.771
MOD_NEK2_1	187	192	PF00069	0.670
MOD_NEK2_1	277	282	PF00069	0.694
MOD_NEK2_1	321	326	PF00069	0.745
MOD_NEK2_1	48	53	PF00069	0.740
MOD_PIKK_1	182	188	PF00454	0.766
MOD_PIKK_1	34	40	PF00454	0.771
MOD_PK_1	192	198	PF00069	0.726
MOD_PKA_2	15	21	PF00069	0.803
MOD_PKA_2	314	320	PF00069	0.796
MOD_Plk_1	269	275	PF00069	0.654
MOD_Plk_4	269	275	PF00069	0.659
MOD_Plk_4	278	284	PF00069	0.579
MOD_Plk_4	322	328	PF00069	0.673
MOD_Plk_4	70	76	PF00069	0.749
MOD_ProDKin_1	282	288	PF00069	0.694
MOD_ProDKin_1	90	96	PF00069	0.661
MOD_SUMO_for_1	228	231	PF00179	0.645
TRG_ENDOCYTIC_2	75	78	PF00928	0.744
TRG_ER_diArg_1	301	303	PF00400	0.740
TRG_NLS_Bipartite_1	300	319	PF00514	0.759
TRG_NLS_MonoExtC_3	213	219	PF00514	0.705
TRG_NLS_MonoExtC_3	299	304	PF00514	0.747
TRG_NLS_MonoExtN_4	298	304	PF00514	0.746
TRG_NLS_MonoExtN_4	313	319	PF00514	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKL3	Leishmania donovani	99%	100%