LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4HYU3_LEIIN
TriTrypDb:
Length:
899

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYU3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYU3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 556 560 PF00656 0.613
CLV_NRD_NRD_1 299 301 PF00675 0.806
CLV_NRD_NRD_1 358 360 PF00675 0.813
CLV_NRD_NRD_1 40 42 PF00675 0.739
CLV_NRD_NRD_1 545 547 PF00675 0.647
CLV_NRD_NRD_1 754 756 PF00675 0.656
CLV_PCSK_KEX2_1 147 149 PF00082 0.840
CLV_PCSK_KEX2_1 299 301 PF00082 0.779
CLV_PCSK_KEX2_1 358 360 PF00082 0.813
CLV_PCSK_KEX2_1 40 42 PF00082 0.739
CLV_PCSK_KEX2_1 545 547 PF00082 0.647
CLV_PCSK_KEX2_1 754 756 PF00082 0.659
CLV_PCSK_PC1ET2_1 147 149 PF00082 0.705
CLV_PCSK_PC7_1 36 42 PF00082 0.747
CLV_PCSK_PC7_1 750 756 PF00082 0.647
CLV_PCSK_SKI1_1 165 169 PF00082 0.799
CLV_PCSK_SKI1_1 638 642 PF00082 0.792
CLV_PCSK_SKI1_1 739 743 PF00082 0.797
DEG_APCC_DBOX_1 298 306 PF00400 0.747
DEG_Kelch_Keap1_1 770 775 PF01344 0.775
DEG_SCF_FBW7_1 719 726 PF00400 0.644
DEG_SPOP_SBC_1 325 329 PF00917 0.829
DEG_SPOP_SBC_1 368 372 PF00917 0.617
DEG_SPOP_SBC_1 561 565 PF00917 0.513
DEG_SPOP_SBC_1 875 879 PF00917 0.773
DOC_CKS1_1 274 279 PF01111 0.658
DOC_CKS1_1 730 735 PF01111 0.828
DOC_CYCLIN_RxL_1 162 172 PF00134 0.796
DOC_CYCLIN_yCln2_LP_2 305 311 PF00134 0.739
DOC_MAPK_gen_1 358 365 PF00069 0.621
DOC_MAPK_MEF2A_6 174 182 PF00069 0.787
DOC_PP1_RVXF_1 636 642 PF00149 0.790
DOC_PP2B_LxvP_1 136 139 PF13499 0.835
DOC_PP2B_LxvP_1 305 308 PF13499 0.780
DOC_PP2B_LxvP_1 379 382 PF13499 0.701
DOC_PP2B_LxvP_1 389 392 PF13499 0.716
DOC_PP2B_LxvP_1 872 875 PF13499 0.770
DOC_PP4_FxxP_1 168 171 PF00568 0.494
DOC_PP4_FxxP_1 193 196 PF00568 0.764
DOC_PP4_FxxP_1 220 223 PF00568 0.782
DOC_USP7_MATH_1 213 217 PF00917 0.536
DOC_USP7_MATH_1 252 256 PF00917 0.803
DOC_USP7_MATH_1 267 271 PF00917 0.594
DOC_USP7_MATH_1 326 330 PF00917 0.803
DOC_USP7_MATH_1 346 350 PF00917 0.487
DOC_USP7_MATH_1 428 432 PF00917 0.767
DOC_USP7_MATH_1 516 520 PF00917 0.593
DOC_USP7_MATH_1 551 555 PF00917 0.678
DOC_USP7_MATH_1 607 611 PF00917 0.638
DOC_USP7_MATH_1 659 663 PF00917 0.784
DOC_USP7_MATH_1 668 672 PF00917 0.698
DOC_USP7_MATH_1 682 686 PF00917 0.566
DOC_USP7_MATH_1 75 79 PF00917 0.787
DOC_USP7_MATH_1 763 767 PF00917 0.815
DOC_USP7_MATH_1 817 821 PF00917 0.783
DOC_USP7_MATH_1 831 835 PF00917 0.567
DOC_USP7_MATH_1 860 864 PF00917 0.818
DOC_USP7_MATH_1 875 879 PF00917 0.585
DOC_USP7_UBL2_3 829 833 PF12436 0.799
DOC_WW_Pin1_4 123 128 PF00397 0.685
DOC_WW_Pin1_4 204 209 PF00397 0.659
DOC_WW_Pin1_4 273 278 PF00397 0.851
DOC_WW_Pin1_4 303 308 PF00397 0.658
DOC_WW_Pin1_4 327 332 PF00397 0.841
DOC_WW_Pin1_4 371 376 PF00397 0.693
DOC_WW_Pin1_4 398 403 PF00397 0.639
DOC_WW_Pin1_4 410 415 PF00397 0.610
DOC_WW_Pin1_4 423 428 PF00397 0.629
DOC_WW_Pin1_4 463 468 PF00397 0.710
DOC_WW_Pin1_4 531 536 PF00397 0.741
DOC_WW_Pin1_4 643 648 PF00397 0.792
DOC_WW_Pin1_4 661 666 PF00397 0.539
DOC_WW_Pin1_4 686 691 PF00397 0.737
DOC_WW_Pin1_4 717 722 PF00397 0.825
DOC_WW_Pin1_4 729 734 PF00397 0.639
DOC_WW_Pin1_4 885 890 PF00397 0.562
DOC_WW_Pin1_4 892 897 PF00397 0.551
DOC_WW_Pin1_4 94 99 PF00397 0.797
LIG_14-3-3_CanoR_1 148 152 PF00244 0.781
LIG_14-3-3_CanoR_1 290 297 PF00244 0.676
LIG_14-3-3_CanoR_1 46 53 PF00244 0.789
LIG_14-3-3_CanoR_1 502 510 PF00244 0.660
LIG_14-3-3_CanoR_1 517 521 PF00244 0.489
LIG_14-3-3_CanoR_1 670 674 PF00244 0.772
LIG_14-3-3_CanoR_1 743 748 PF00244 0.799
LIG_14-3-3_CanoR_1 79 84 PF00244 0.853
LIG_14-3-3_CanoR_1 876 881 PF00244 0.780
LIG_BRCT_BRCA1_1 159 163 PF00533 0.802
LIG_BRCT_BRCA1_1 216 220 PF00533 0.830
LIG_EVH1_1 193 197 PF00568 0.767
LIG_FHA_1 100 106 PF00498 0.680
LIG_FHA_1 130 136 PF00498 0.639
LIG_FHA_1 2 8 PF00498 0.775
LIG_FHA_1 219 225 PF00498 0.674
LIG_FHA_1 263 269 PF00498 0.783
LIG_FHA_1 368 374 PF00498 0.803
LIG_FHA_1 394 400 PF00498 0.633
LIG_FHA_1 438 444 PF00498 0.809
LIG_FHA_1 562 568 PF00498 0.668
LIG_FHA_1 634 640 PF00498 0.758
LIG_FHA_1 729 735 PF00498 0.694
LIG_FHA_1 816 822 PF00498 0.824
LIG_FHA_1 880 886 PF00498 0.552
LIG_FHA_2 147 153 PF00498 0.678
LIG_FHA_2 516 522 PF00498 0.775
LIG_FHA_2 616 622 PF00498 0.829
LIG_FHA_2 9 15 PF00498 0.801
LIG_LIR_Apic_2 190 196 PF02991 0.758
LIG_LIR_Apic_2 217 223 PF02991 0.778
LIG_LIR_Apic_2 408 414 PF02991 0.526
LIG_LIR_Gen_1 496 503 PF02991 0.780
LIG_LIR_Gen_1 757 763 PF02991 0.528
LIG_LIR_Gen_1 775 785 PF02991 0.678
LIG_LIR_Nem_3 23 29 PF02991 0.662
LIG_LIR_Nem_3 496 501 PF02991 0.777
LIG_LIR_Nem_3 757 761 PF02991 0.544
LIG_LIR_Nem_3 775 780 PF02991 0.816
LIG_LIR_Nem_3 867 872 PF02991 0.828
LIG_MYND_1 303 307 PF01753 0.659
LIG_MYND_1 463 467 PF01753 0.816
LIG_PCNA_PIPBox_1 738 747 PF02747 0.610
LIG_PCNA_yPIPBox_3 738 750 PF02747 0.608
LIG_SH2_CRK 745 749 PF00017 0.606
LIG_SH2_SRC 498 501 PF00017 0.779
LIG_SH3_1 191 197 PF00018 0.762
LIG_SH3_1 278 284 PF00018 0.660
LIG_SH3_2 665 670 PF14604 0.631
LIG_SH3_3 122 128 PF00018 0.819
LIG_SH3_3 136 142 PF00018 0.602
LIG_SH3_3 191 197 PF00018 0.813
LIG_SH3_3 199 205 PF00018 0.697
LIG_SH3_3 271 277 PF00018 0.798
LIG_SH3_3 278 284 PF00018 0.700
LIG_SH3_3 305 311 PF00018 0.782
LIG_SH3_3 385 391 PF00018 0.775
LIG_SH3_3 532 538 PF00018 0.613
LIG_SH3_3 598 604 PF00018 0.663
LIG_SH3_3 641 647 PF00018 0.686
LIG_SH3_3 662 668 PF00018 0.687
LIG_SH3_3 69 75 PF00018 0.543
LIG_SH3_3 727 733 PF00018 0.651
LIG_SH3_3 893 899 PF00018 0.557
LIG_SUMO_SIM_par_1 102 108 PF11976 0.624
LIG_TRAF2_1 781 784 PF00917 0.779
LIG_TYR_ITSM 22 29 PF00017 0.802
LIG_WRC_WIRS_1 170 175 PF05994 0.784
MOD_CDK_SPK_2 273 278 PF00069 0.716
MOD_CDK_SPK_2 686 691 PF00069 0.630
MOD_CDK_SPxxK_3 398 405 PF00069 0.766
MOD_CDK_SPxxK_3 885 892 PF00069 0.561
MOD_CK1_1 121 127 PF00069 0.822
MOD_CK1_1 207 213 PF00069 0.845
MOD_CK1_1 238 244 PF00069 0.811
MOD_CK1_1 255 261 PF00069 0.545
MOD_CK1_1 293 299 PF00069 0.693
MOD_CK1_1 315 321 PF00069 0.711
MOD_CK1_1 327 333 PF00069 0.762
MOD_CK1_1 349 355 PF00069 0.812
MOD_CK1_1 367 373 PF00069 0.514
MOD_CK1_1 437 443 PF00069 0.808
MOD_CK1_1 454 460 PF00069 0.541
MOD_CK1_1 539 545 PF00069 0.835
MOD_CK1_1 584 590 PF00069 0.771
MOD_CK1_1 615 621 PF00069 0.794
MOD_CK1_1 689 695 PF00069 0.739
MOD_CK1_1 724 730 PF00069 0.844
MOD_CK1_1 762 768 PF00069 0.812
MOD_CK1_1 770 776 PF00069 0.699
MOD_CK1_1 78 84 PF00069 0.743
MOD_CK1_1 802 808 PF00069 0.693
MOD_CK1_1 819 825 PF00069 0.690
MOD_CK1_1 854 860 PF00069 0.810
MOD_CK1_1 861 867 PF00069 0.712
MOD_CK1_1 94 100 PF00069 0.577
MOD_CK2_1 123 129 PF00069 0.686
MOD_CK2_1 146 152 PF00069 0.677
MOD_CK2_1 237 243 PF00069 0.813
MOD_CK2_1 59 65 PF00069 0.536
MOD_CK2_1 616 622 PF00069 0.838
MOD_CK2_1 766 772 PF00069 0.820
MOD_CK2_1 8 14 PF00069 0.803
MOD_CK2_1 820 826 PF00069 0.665
MOD_CK2_1 861 867 PF00069 0.825
MOD_Cter_Amidation 145 148 PF01082 0.835
MOD_Cter_Amidation 297 300 PF01082 0.779
MOD_Cter_Amidation 356 359 PF01082 0.814
MOD_GlcNHglycan 120 123 PF01048 0.763
MOD_GlcNHglycan 237 240 PF01048 0.818
MOD_GlcNHglycan 254 257 PF01048 0.537
MOD_GlcNHglycan 260 263 PF01048 0.730
MOD_GlcNHglycan 285 288 PF01048 0.827
MOD_GlcNHglycan 292 295 PF01048 0.682
MOD_GlcNHglycan 348 351 PF01048 0.748
MOD_GlcNHglycan 355 358 PF01048 0.764
MOD_GlcNHglycan 360 363 PF01048 0.677
MOD_GlcNHglycan 366 369 PF01048 0.587
MOD_GlcNHglycan 453 456 PF01048 0.748
MOD_GlcNHglycan 480 483 PF01048 0.680
MOD_GlcNHglycan 493 496 PF01048 0.681
MOD_GlcNHglycan 586 589 PF01048 0.580
MOD_GlcNHglycan 59 62 PF01048 0.717
MOD_GlcNHglycan 593 596 PF01048 0.552
MOD_GlcNHglycan 615 618 PF01048 0.824
MOD_GlcNHglycan 761 764 PF01048 0.808
MOD_GlcNHglycan 769 772 PF01048 0.694
MOD_GlcNHglycan 8 11 PF01048 0.615
MOD_GlcNHglycan 804 807 PF01048 0.807
MOD_GlcNHglycan 81 84 PF01048 0.690
MOD_GlcNHglycan 811 814 PF01048 0.777
MOD_GlcNHglycan 852 856 PF01048 0.809
MOD_GSK3_1 157 164 PF00069 0.691
MOD_GSK3_1 169 176 PF00069 0.706
MOD_GSK3_1 2 9 PF00069 0.722
MOD_GSK3_1 200 207 PF00069 0.781
MOD_GSK3_1 214 221 PF00069 0.606
MOD_GSK3_1 251 258 PF00069 0.807
MOD_GSK3_1 289 296 PF00069 0.779
MOD_GSK3_1 320 327 PF00069 0.823
MOD_GSK3_1 345 352 PF00069 0.806
MOD_GSK3_1 363 370 PF00069 0.527
MOD_GSK3_1 435 442 PF00069 0.757
MOD_GSK3_1 55 62 PF00069 0.811
MOD_GSK3_1 607 614 PF00069 0.833
MOD_GSK3_1 657 664 PF00069 0.803
MOD_GSK3_1 682 689 PF00069 0.575
MOD_GSK3_1 717 724 PF00069 0.827
MOD_GSK3_1 75 82 PF00069 0.566
MOD_GSK3_1 759 766 PF00069 0.765
MOD_GSK3_1 809 816 PF00069 0.783
MOD_GSK3_1 850 857 PF00069 0.808
MOD_GSK3_1 875 882 PF00069 0.751
MOD_N-GLC_1 363 368 PF02516 0.758
MOD_N-GLC_1 429 434 PF02516 0.835
MOD_N-GLC_1 435 440 PF02516 0.716
MOD_N-GLC_1 478 483 PF02516 0.623
MOD_N-GLC_1 591 596 PF02516 0.595
MOD_N-GLC_1 861 866 PF02516 0.824
MOD_N-GLC_2 488 490 PF02516 0.630
MOD_NEK2_1 1 6 PF00069 0.796
MOD_NEK2_1 180 185 PF00069 0.776
MOD_NEK2_1 19 24 PF00069 0.500
MOD_NEK2_1 332 337 PF00069 0.726
MOD_NEK2_1 363 368 PF00069 0.798
MOD_NEK2_1 369 374 PF00069 0.716
MOD_NEK2_1 477 482 PF00069 0.579
MOD_NEK2_1 493 498 PF00069 0.751
MOD_NEK2_1 562 567 PF00069 0.530
MOD_NEK2_1 669 674 PF00069 0.530
MOD_NEK2_1 734 739 PF00069 0.668
MOD_NEK2_1 850 855 PF00069 0.756
MOD_NEK2_1 880 885 PF00069 0.767
MOD_NEK2_2 586 591 PF00069 0.615
MOD_PIKK_1 157 163 PF00454 0.806
MOD_PIKK_1 173 179 PF00454 0.527
MOD_PIKK_1 214 220 PF00454 0.833
MOD_PIKK_1 393 399 PF00454 0.636
MOD_PIKK_1 429 435 PF00454 0.778
MOD_PIKK_1 734 740 PF00454 0.799
MOD_PIKK_1 883 889 PF00454 0.585
MOD_PK_1 743 749 PF00069 0.798
MOD_PK_1 842 848 PF00069 0.808
MOD_PKA_1 147 153 PF00069 0.840
MOD_PKA_1 358 364 PF00069 0.810
MOD_PKA_2 147 153 PF00069 0.833
MOD_PKA_2 173 179 PF00069 0.786
MOD_PKA_2 218 224 PF00069 0.654
MOD_PKA_2 289 295 PF00069 0.816
MOD_PKA_2 350 356 PF00069 0.736
MOD_PKA_2 358 364 PF00069 0.756
MOD_PKA_2 45 51 PF00069 0.786
MOD_PKA_2 501 507 PF00069 0.600
MOD_PKA_2 516 522 PF00069 0.479
MOD_PKA_2 628 634 PF00069 0.799
MOD_PKA_2 669 675 PF00069 0.774
MOD_PKA_2 78 84 PF00069 0.851
MOD_PKA_2 850 856 PF00069 0.650
MOD_PKA_2 875 881 PF00069 0.777
MOD_Plk_1 435 441 PF00069 0.757
MOD_Plk_1 842 848 PF00069 0.808
MOD_Plk_2-3 129 135 PF00069 0.637
MOD_Plk_4 100 106 PF00069 0.812
MOD_Plk_4 439 445 PF00069 0.754
MOD_Plk_4 562 568 PF00069 0.625
MOD_Plk_4 586 592 PF00069 0.616
MOD_Plk_4 743 749 PF00069 0.798
MOD_Plk_4 854 860 PF00069 0.756
MOD_ProDKin_1 123 129 PF00069 0.686
MOD_ProDKin_1 204 210 PF00069 0.659
MOD_ProDKin_1 273 279 PF00069 0.849
MOD_ProDKin_1 303 309 PF00069 0.659
MOD_ProDKin_1 327 333 PF00069 0.843
MOD_ProDKin_1 371 377 PF00069 0.696
MOD_ProDKin_1 398 404 PF00069 0.642
MOD_ProDKin_1 410 416 PF00069 0.610
MOD_ProDKin_1 423 429 PF00069 0.627
MOD_ProDKin_1 463 469 PF00069 0.710
MOD_ProDKin_1 531 537 PF00069 0.745
MOD_ProDKin_1 643 649 PF00069 0.793
MOD_ProDKin_1 661 667 PF00069 0.536
MOD_ProDKin_1 686 692 PF00069 0.737
MOD_ProDKin_1 717 723 PF00069 0.826
MOD_ProDKin_1 729 735 PF00069 0.635
MOD_ProDKin_1 885 891 PF00069 0.561
MOD_ProDKin_1 892 898 PF00069 0.549
MOD_ProDKin_1 94 100 PF00069 0.795
MOD_SUMO_for_1 673 676 PF00179 0.547
MOD_SUMO_for_1 690 693 PF00179 0.640
MOD_SUMO_for_1 781 784 PF00179 0.833
TRG_DiLeu_BaEn_4 14 20 PF01217 0.798
TRG_DiLeu_BaLyEn_6 229 234 PF01217 0.640
TRG_DiLeu_BaLyEn_6 300 305 PF01217 0.665
TRG_ENDOCYTIC_2 26 29 PF00928 0.805
TRG_ENDOCYTIC_2 498 501 PF00928 0.779
TRG_ENDOCYTIC_2 745 748 PF00928 0.660
TRG_ER_diArg_1 39 41 PF00400 0.742
TRG_Pf-PMV_PEXEL_1 165 169 PF00026 0.799

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IAU5 Leishmania donovani 94% 100%
E9AUP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
Q4QCU4 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS